Clinical trials: sponsored by University of Utah
Non Small Cell Lung Cancer
Tumor Treating Fields for Locally Advanced NSCLC
The goal of this open-label, Phase 1 clinical trial is to determine the safety of TTFields started concurrently with SOC chemoradiation and during consolidation durvalumab in locally advanced, unresectable stage III non-small…
- Trial name
- NOVOCURE (NCT06124118)
- Testing
- carboplatin chemotherapy, NovoTTF-200T (TTFields) System, Durvalumab
- Sponsor
- University of Utah
Heart Transplant Failure and Rejection
Precision Guided Tacrolimus Dosing in Pediatric Heart Transplant
Immunosuppressive therapy is required to prevent organ rejection, however, dosing of immunosuppressive agents is complicated by patient-specific differences impacting the body's absorption and elimination of these agents.
- Trial name
- NCT04380311
- Testing
- Tacrolimus Dosing Support Tool
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- University of Utah
Physical Inactivity
Pacific Islander Physical Activity Project
This proposed longitudinal study will examine the influences of neighborhood factors and momentary contextual and psychosocial factors, which the investigators call acute precipitants, on physical activity (PA) adoption and…
- Trial name
- PiPA (NCT06523946)
- Testing
- Diabetes Prevention Program (DPP) (shortened)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Utah
Participation
Using Nudges to Recruit for Health-Related Research
The goal of this clinical trial is to examine the effect of using behavioral nudges in recruitment into a minimal risk interview study among healthy adult volunteers.
- Trial name
- NCT06857903
- Testing
- Recruitment nudges
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Utah
Endometrial Neoplasms
Time Restricted Eating (TRE) Among Native Hawaiian/Pacific Islander Women at Risk for Endometrial Cancer
The long-term goal of this study is to determine the efficacy of time restricted eating (TRE) for improving metabolic health and preventing endometrial cancer.
- Trial name
- TIMESPAN (NCT04763902)
- Testing
- Time Restricted Eating (TRE) Schedule, Control Schedule
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Utah
Low Back Pain, Opioid Use
Neural Mechanisms of Meditation for Opioid-Treated Chronic Low Back Pain
The purpose of this research study is to see how a mindfulness meditation-based intervention affects pain. Specifically, we are interested in understanding the pain-relieving brain mechanisms of mindfulness meditation-based…
- Trial name
- NCT05607381
- Testing
- Meditation, Usual care
- Where
- 2 sites in United States
- Volunteers
- 188 people
- Sponsor
- University of Utah
Skin Cancer
Undergraduate Skin Cancer Prevention Trial
The proposed study is a Multiphase Optimization Strategy (MOST) that uses factorial experiments to evaluate individual and combined effects of intervention components to improve intervention efficiency.
- Trial name
- RISE-UP (NCT05634252)
- Testing
- Education, Action Plan, UV Photo
- Where
- United States
- Volunteers
- 528 people, healthy volunteers welcome
- Sponsor
- University of Utah
Recurrent Prostate Carcinoma, Metastatic Malignant Neoplasm in the Bone
Salvage Oligometastasectomy and Radiation Therapy in Recurrent Prostate Cancer
This phase II trial studies how well surgery and radiation therapy work in treating patients with prostate cancer that has come back or spread to other parts of the body.
- Conditions
- Recurrent Prostate Carcinoma, Metastatic Malignant Neoplasm in the Bone, Metastatic Malignant Neoplasm in the Lymph Nodes, Oligometastasis
- Trial name
- SOAR (NCT03796767)
- Testing
- Hypofractionated Radiation Therapy, Intensity-Modulated Radiation Therapy, Metastasectomy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
Non-Small Cell Lung Cancer Metastatic
Staggered, Chemo-Immunotherapy With Durvalumab, MEDI4736 Pemetrexed & Carboplatin (PC) for Metastatic Non-Squamous NSCLC
This is a Phase II, open label, randomized study of durvalumab in combination with pemetrexed and carboplatin in eligible adult patients with locally advanced or metastatic non-small cell lung cancer.
- Trial name
- STAGGER (NCT04163432)
- Testing
- Durvalumab, Pemetrexed, Carboplatin
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Utah
Lung Cancer
Digital Health Implementation Strategies to Improve Lung Cancer Screening Among Safety-Net Clinics
The long-term goal of this program of research is to increase the reach of Lung Cancer Screening (LCS) among low-resource healthcare settings and populations.
- Trial name
- LUNG-IS (NCT07716280)
- Testing
- Text Messages (TM+), Chat bot (CA), Video
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University of Utah
Opioid Abuse, Prescription Opioid Abuse
Community Pharmacy-Based Prescription Drug Monitoring Program Opioid Risk Assessment Tool
This goal of this observational study is to develop and test the Opioid Risk Reduction Clinical Decision Support (ORRCDS) tool. The tool will be an opioid medication risk screener and decision support platform that will be used…
- Trial name
- PharmTool (NCT05706311)
- Testing
- Clinical Decision Support Tool (Moderate Risk), Clinical Decision Support Tool (High Risk), Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Utah
Opioid Abuse (Disorder), Stimulant Use Disorders
Optimizing Pregnancy and Treatment Interventions for Moms 3.0
We want to learn if Patient Navigation helps pregnant Medicaid members with opioid use disorder, with or without stimulant use disorder, stay in care, use medications for opioid use disorder, reduce substance use, and connect…
- Trial name
- OPTI-Mom (NCT07586917)
- Testing
- Patient Navigation
- Where
- United States
- Volunteers
- 429 people
- Sponsor
- University of Utah
Narcolepsy, Narcolepsy Type 1
Decreasing Nightmares in Adults With Narcolepsy
The purpose of this clinical trial is learn whether a behavioral (non-medication) treatment can reduce nightmares in adults with narcolepsy. All participants will receive the treatment and will complete three assessments.
- Conditions
- Narcolepsy, Narcolepsy Type 1, Narcolepsy With Cataplexy, Narcolepsy Without Cataplexy
- Trial name
- DAWN (NCT06383806)
- Testing
- Imagery Rehearsal Therapy (IRT)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Utah
Congenital Heart Disease in Children, Hypoxia
Fetal Cerebrovascular Autoregulation in Congenital Heart Disease and Association With Neonatal Neurobehavior
Determine 1) the impact of abnormal fetal cerebrovascular physiology with neurodevelopmental delay (ND) outcomes and 2) how this relationship is modified by patient and environmental factors such as chronic congenital heart…
- Conditions
- Congenital Heart Disease in Children, Hypoxia, Neurodevelopmental Disorders, Complex Congenital Heart Disease
- Trial name
- NCT05767385
- Testing
- Single Arm, Neonatal Neurobehavioral Scale
- Where
- 5 sites in United States
- Volunteers
- 104 people
- Sponsor
- University of Utah
Atrophy, Inflammation
Metformin and ACLR Muscle Recovery
The purpose of this research study is to determine if Metformin taken after anterior cruciate ligament reconstruction (ACLR) surgery can decrease muscle fibrosis, cellular senescence and improve leg strength.
- Conditions
- Atrophy, Inflammation, Weakness, Muscle
- Trial name
- NCT07699367
- Testing
- Metformin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Utah
Prostate Carcinoma
Massage for Prostate Cancer-Related Fatigue (mPROSTATE)
This phase II trial investigates the effect of massage in decreasing prostate cancer-related fatigue. Massage therapy has well known health benefits.
- Trial name
- mPROSTATE (NCT05067777)
- Testing
- Swedish Massage Therapy (SMT), Light Touch (LT) Control, Waitlist Control (WLC)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Utah
Alzheimer Disease, Mild Cognitive Impairment
LEADing Dementia End-of-Life Planning Conversations
Advance care planning is important for all adults, but perhaps even more so for the 5.7 million persons with Alzheimer's disease or related dementia (ADRD), due to the progressive and protracted cognitive deterioration associated…
- Trial name
- LEAD (NCT05909189)
- Testing
- LEADing Dementia End-of-Life Planning Conversations
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Utah
Melanoma, Child
Family Lifestyles, Actions, and Risk Education Intervention: Version 2
The overall purpose of this study is to determine the efficacy of the Family Lifestyles, Actions, and Risk Education (FLARE) intervention in improving melanoma preventive behaviors.
- Trial name
- FLARE (NCT04201223)
- Testing
- FLARE Intervention
- Where
- United States
- Volunteers
- 752 people, healthy volunteers welcome
- Sponsor
- University of Utah
Relapsed or Refractory B-cell Non-Hodgkin Lymphoma, Mantle Cell Lymphoma
Pemigatinib in Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphomas
The purpose of this clinical trial is to learn if the study drug pemigatinib is effective in treating patients with relapsed or refractory B-cell non-Hodgkin lymphomas.
- Conditions
- Relapsed or Refractory B-cell Non-Hodgkin Lymphoma, Mantle Cell Lymphoma, Marginal Zone Lymphoma
- Trial name
- NCT06300528
- Testing
- Pemigatinib
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Utah
Metastatic Castration-resistant Prostate Cancer
Bortezomib in Patients With Metastatic Castration-Resistant Prostate Cancer With PTEN Deletion
The goal of this clinical trial is to test the anti-tumor activity of bortezomib in participants with Metastatic Castration Resistant Prostate Cancer (mCRPC) with PTEN Deletion.
- Trial name
- BORXPTEN (NCT06029998)
- Testing
- Bortezomib
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Utah