Clinical trials: sponsored by University of Utah
Substance Use Disorders (SUD), Pregnancy
Culturally Engaged REcovery: MOms Connected Through Native communitY
Pregnant and postpartum American Indian and Alaska Native people (Native mothers) face a more than two-fold higher risk of maternal mortality compared to non-Hispanic White mothers.
- Conditions
- Substance Use Disorders (SUD), Pregnancy, Maternal Morbidity and Mortality, Cultural Adaptation
- Trial name
- CEREMONY (NCT06747442)
- Testing
- Cradleboard Journey
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- University of Utah
MRI Scans
New MRI Methods Applied to Heart Failure With Preserved Ejection Fraction (HFpEF)
This study's main specific aims are; 1. To develop robust acquisition and reconstruction methods specifically for the study of microvascular cardiac remodeling with MRI which will include very innovative quantitative perfusion…
- Trial name
- NCT04600115
- Testing
- Adenosine, Regadenoson, O-15 labeled radioactive water
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Utah
Borderline Resectable Pancreatic Adenocarcinoma, Locally Advanced Pancreatic Ductal Adenocarcinoma
Losartan and Hypofractionated Rx After Chemo for Tx of Borderline Resectable or Locally Advanced Pancreatic Cancer
This phase I trial studies the side effects of losartan and hypofractionated radiation therapy after chemotherapy in treating patients with pancreatic cancer that may or may not be removed by surgery (borderline resectable) or…
- Conditions
- Borderline Resectable Pancreatic Adenocarcinoma, Locally Advanced Pancreatic Ductal Adenocarcinoma, Locally Advanced Unresectable Pancreatic Adenocarcinoma, Stage II Pancreatic Cancer AJCC v8
- Trial name
- SHAPER (NCT04106856)
- Testing
- Hypofractionated Radiation Therapy, Losartan, Losartan Potassium
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Utah
HIV Infections
A Stigma Reduction Intervention at Time of Entry Into Antenatal Care to Improve PMTCT Services in Tanzania
This study will pilot test a brief, scalable intervention called Maisha (Swahili for life), to address HIV stigma for women presenting to antenatal care in Tanzania and male partners who accompany them.
- Trial name
- Maisha (NCT03600142)
- Testing
- Mashia
- Where
- Tanzania
- Volunteers
- 1,539 people, healthy volunteers welcome
- Sponsor
- University of Utah
Family Caregivers, Dementia
Financial Counseling for Dementia Family Caregivers in Early and Middle Adulthood
The goal of this National Institutes of Health (NIH) Stage 1a study is to develop and pilot test a research- and community-informed financial counseling and advocacy (FCA) intervention for dementia family caregivers in early and…
- Conditions
- Family Caregivers, Dementia, Financial Wellbeing, Financial Coaching
- Trial name
- FCA 4 FC-EAMA (NCT07681401)
- Testing
- Financial Counseling and Advocacy
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Utah
Brain Metastases
Stereotactic Radiosurgery Dose Escalation for Brain Metastases
This is a Phase I dose escalation and expansion trial. The purpose of this study is to determine the maximum tolerated dose of radiation received during stereotactic radiosurgery in patients with brain metastases who have never…
- Trial name
- NCT02390518
- Testing
- Stereotactic Radiosurgery
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- University of Utah
Relapsed or Refractory B-cell Non-Hodgkin Lymphoma
Tazemetostat in Combination With Zanubrutinib and Anti-CD20 Monoclonal Antibody in Relapsed or Refractory B-cell Non-Hodgkin Lymphoma
The purpose of this clinical trial is to learn if the study drug Tazemetostat combined with Zanubrutinib and anti-CD20 monoclonal antibody is safe and effective in treating patients with relapsed or refractory indolent B-cell…
- Trial name
- TARZAN (NCT06824701)
- Testing
- Zanubrutinib, Rituximab, Obinutuzumab
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Utah
Pain, Acute, Anxiety Acute
Brief Postoperative Pain Management Intervention: Meaning Making Amendment
This single-site, two-arm, parallel-group randomized controlled trial will enroll adults undergoing total knee or hip replacement surgery.
- Trial name
- NCT07676500
- Testing
- Mindfulness + Meaning Making Questions, Mindfulness + Implementation Questions
- Where
- United States
- Volunteers
- 576 people
- Sponsor
- University of Utah
Diabetes Mellitus, Type 1
National Institute of Diabetes and Digestive Kidney Diseases* Share Plus: Continuous Glucose Monitoring With Data Sharing in Older Adults With Type 1 Diabetes* and Their Care Partners to Improve Time in Range and Reduce Diabetes Distress.
The purpose of this study is to test the Share plus intervention aimed at improving the use of data sharing between people with diabetes and their care partners in order to maximize the benefits of continuous glucose monitoring.
- Trial name
- NIDDK T1D (NCT05937321)
- Testing
- Share plus intervention, Control group
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- University of Utah
Anesthesia
Detecting Post-surgical Respiratory Compromise and Prompting Patients to Self-rescue: An Early Feasibility Study
This study will explore the feasibility of an idea to use standard, FDA-approved patient monitors to detect ventilatory depression and then play a recorded nurse's voice to prompt patients by name to breathe.
- Trial name
- NCT02962557
- Testing
- NM3, Phillips Medical, Wallingford CT: verbal prompts to breathe with an optional shoulder shake
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Utah
Metastatic Castration-resistant Prostate Cancer
XL092 in Patients With Metastatic Castration-Resistant Prostate Cancer
The purpose of this study is to determine how well the study drug XL092 is helping to treat a participant's cancer after 16 weeks of treatment.
- Trial name
- PRO-XL (NCT06568562)
- Testing
- XL092
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Utah
Sacroiliac Joint Complex, Low Back Pain
Conventional vs Bipolar SIJ RFA for Treatment of Sacroiliac Joint Pain
Specific Aims The sacroiliac joint complex (SIJC) is a diathrodial, synovial joint and posterior ligamentous network that receives both anterior innervation from the lumbosacral plexus as well as posterior sensory innervation via…
- Trial name
- NCT05409443
- Testing
- Nimbus Sacroiliac Joint Radiofrequency Ablation (N-SIJRFA), Conventional Sacroiliac Joint Radiofrequency Ablation (C-SIJRFA)
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
Acetabular Labrum Tear
Intra-articular Platelet-Rich Plasma for Acetabular Labral Tears
Platelets are small cells found in the blood that help form clots and stop bleeding. Platelet-rich plasma is blood that contains more platelets than normal and can be given to help people with pain.
- Trial name
- PRP for ALT (NCT06332352)
- Testing
- PRP
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Utah
Metastatic Hormone-sensitive Prostate Cancer (mHSPC)
Optimal PSA Triggered Individual Management of Androgen Sensitive Prostate Cancer
The purpose of this study is to evaluate intermittent relugolix + androgen receptor pathway inhibitor (ARPI) in patients with metastatic hormone-sensitive prostate cancer (mHSPC) achieving optimal PSA response.
- Trial name
- OPTIMAS (NCT07216248)
- Testing
- relugolix + ARPI, Intermittent- Relugolix or androgen deprivation therapy (ADT) + ARPI, relugolix or androgen deprivation therapy (ADT) + ARPI
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- University of Utah
Hypertension, Pregnancy Induced, Hypertension Complicating Pregnancy
Optimizing Cardiovascular Preventive Care for Women Following Hypertensive Disorders of Pregnancy
Cardiovascular disease is the leading cause of death among women in the United States, and women with hypertensive disorders of pregnancy have a 2-fold higher risk for cardiovascular disease later in life compared to women with…
- Conditions
- Hypertension, Pregnancy Induced, Hypertension Complicating Pregnancy, Preeclampsia, Cardiovascular Diseases
- Trial name
- NCT05826925
- Testing
- Decision aid
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Utah
Geographic Atrophy From Age-related Macular Degeneration
Lesion-tailored, Fundus-controlled Perimetry in Geographic Atrophy (GA).
The goal of this observational study is to evaluate changes in retinal sensitivity over time in patients with geographic atrophy due to age related macular degeneration who are receiving pegcetacoplan as part of routine clinical…
- Trial name
- FCPGA-2025 (NCT07582042)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Utah
Obesity, Child
Scaling up Building Healthy Families
Evidence-based interventions for childhood obesity (EBI-CO) can improve children's weight status, but families in rural areas and small cities have limited access to the interdisciplinary healthcare teams recommended to deliver…
- Trial name
- NCT07404839
- Testing
- Building Healthy Families Program
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Utah
Non Small Cell Lung Cancer, Secondary Lung Cancer
Precision-exercise-prescription for Lung Cancer Patients Undergoing Surgery: The PEP Study
This is a Phase 3 study aimed at investigating the effects of a personalized exercise program (PEP) in NSCLC patients (stage I, II, IIIa) and secondary lung cancer patients undergoing surgical treatment at the University of Utah…
- Trial name
- PEP (NCT03306992)
- Testing
- Personalized Exercise Program
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- University of Utah
Cutibacterium Acnes
Do Wound Protectors Reduce Contamination in Total Shoulder Arthroplasty?
Prosthetic joint infection is a devastating complication of shoulder arthroplasty. A relatively novel method of preventing PJI has been with the use of a wound protection device.
- Trial name
- NCT06513182
- Testing
- No Alexis orthopaedic protector, Alexis orthopaedic protector
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Utah
Shoulder Injuries
Rehabilitation With the Shoulder Pacemaker
The investigators purpose of the proposed study is to use the FDA approved Shoulder Pacemaker device in patients undergoing reverse shoulder arthroplasty and study the functional outcomes compared to a standard post-operative…
- Trial name
- NCT06501859
- Testing
- Standard of care physical therapy, Shoulder pacemaker with physical therapy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Utah