Clinical trials: sponsored by University of Virginia
Peripheral Arterial Disease
Ultrasound Cavitation Therapy for CLI
In this study, we will explore how ultrasound exposure of ultrasound contrast agents, which produces beneficial shear-mediated bioeffects, can be used to treat patients with severe non-healing ulcers secondary to peripheral…
- Trial name
- NCT05749250
- Testing
- Acoustic cavitation of ultrasound enhancing agents
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Virginia
Osteo Arthritis Knee
Knee Biofeedback Rehabilitation Interface for Game-based Home Therapy for Patients With Knee Osteoarthritis
Osteoarthritis (OA) is the leading cause of disability in the United States. As osteoarthritis is associated with the lower limb muscle weakness, rehabilitation through quadriceps strengthening is a well-established treatment for…
- Trial name
- KneeBRIGHT (NCT04187092)
- Testing
- KneeBright Group, Standard Rehabilitation group
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Virginia
Ketogenic Diet, Kidney Injury
Ketogenic Dietary Patterns in Young Adults and Kidney Health
This study seeks to assess the kidney health effects of short-term healthful ketogenic diet in young, overweight adults.10 overweight (BMI 25-30 kg/m2) adult participants (ages 20-40 years) without major chronic conditions…
- Trial name
- NCT05350657
- Testing
- Ketogenic Diet
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Ketogenic Diet, Exercise
High Fat Meal and Postprandial TG Levels With and Without Exercise Intervention
The objective of this study is to investigate whether "real-life" bouts of MIE are effective at attenuating PPTL after a meal (either a keto-type brownie (KETO) or a high carb (CON) meal of pasta and sauce), compared to…
- Trial name
- NCT05291767
- Testing
- Diet, Exercise
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Regional Anesthesia Morbidity, Carotid Artery Diseases
Effect of Regional Versus General Anesthesia on Thirty-day Outcomes Following Carotid Endarterectomy: a Matched-pairs Cohort Study.
The goal of this observational study is to assess the effect of regional versus general anesthesia on carotid endarterectomy thirty-day outcomes.
- Conditions
- Regional Anesthesia Morbidity, Carotid Artery Diseases, Perioperative/Postoperative Complications
- Trial name
- NCT05706688
- Testing
- Anesthetic technique (regional versus general)
- Volunteers
- 37,204 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Multiple Myeloma, Acute Myeloid Leukemia
Effects of Prebiotics on Gut Microbiome in Patients Undergoing HSCT
The purpose of this study is to see whether hematopoietic stem cell transplant (HSCT) patients can consistently eat a diet rich in prebiotics.
- Conditions
- Multiple Myeloma, Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Non Hodgkin Lymphoma
- Trial name
- HCTDiet (NCT04629430)
- Testing
- Pre-biotic foods/drinks
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Virginia
Diabetes, Diabetes Mellitus, Type 1
Evaluation of Accuracy of Continuous Glucose Monitoring (CGM) in Patients With End Stage Renal Disease (ESRD) on Intermittent Hemodialysis (iHD).
Recent advances in continuous glucose monitors (CGMs) and availability of commercial CGM products to patients with type 1 and type 2 diabetes has made the use of CGM more widespread.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT04094064
- Testing
- Continuous Glucose Monitor
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Virginia
Breast Cancer Female, Leptomeningeal Metastases
BATs in Patients With Breast Cancer and Leptomeningeal Metastases
This study uses bi-specific antibody (HER2Bi) armed activated T-cells (HER2 BATs) to target breast cancer cells that have metastasized to the membranes surrounding the brain and spinal cord.
- Trial name
- NCT03661424
- Testing
- HER2 BATs
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Virginia
Smoking Cessation
QuitAid Pilot Feasibility Trial
Adult smokers were recruited through an independent pharmacy in rural Appalachia and were randomized to 1 of 8 treatments, including medication and/or therapy from the pharmacist, to help quit smoking.
- Trial name
- NCT05649241
- Testing
- Nicotine patch, Nicotine gum, Medication Therapy Management
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Type1 Diabetes Mellitus
The International Diabetes Closed Loop (iDCL) Trial: Protocol 1
The objective of the study is to assess the efficacy and safety of home use of a Control-to-Range (CTR) closed-loop (CL) system.
- Trial name
- iDCL (NCT02985866)
- Testing
- Artificial Pancreas, Sensor Augmented Therapy
- Where
- 7 sites in United States
- Volunteers
- 127 people
- Sponsor
- University of Virginia
Bone Metastases
Rapid Radiation Therapy for Painful Osseous Metastatic Disease
The purpose of this research study is to evaluate the safety and effectiveness of an experimental workflow that may result in a faster way to plan and deliver radiation for the treatment of pain caused by metastatic bone tumors…
- Trial name
- NCT01391234
- Testing
- STAT RT planning and delivery workflow
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Virginia
Type1 Diabetes Mellitus
Efficacy of inControl Advice: A Decision Support System (DSS) for Diabetes
The purpose of this study is to reduce the frequency of hypoglycemia and severe hypoglycemic events in subjects who use insulin pens to treat their Type 1 Diabetes Mellitus (T1DM).
- Trial name
- DSS (NCT03093636)
- Testing
- Continuous Glucose Monitor (CGM)+Decision Support System (DSS), Continuous Glucose Monitor (CGM) alone
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of Virginia
Mammographic Breast Density, Mammography
Contrast-enhanced Spectral Mammography (CESM) Breast Cancer Screening
The purpose of this study is to evaluate how well women may adopt a Contrast-enhanced Spectral Mammography (CESM) as their yearly breast screening test compared to the standard 2-D or 3-D mammogram.
- Trial name
- S-CESM (NCT04904757)
- Testing
- Contrast-enhanced spectral mammography (CESM)
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Nonadherence
Pilot RCT of Pos4Health for Nonadherent HIV+ Substance Users
This project has developed a patient-centered eHealth intervention; specifically, an Internet intervention, targeting multiple issues and nonadherence in HIV.
- Trial name
- NCT02837250
- Testing
- Pos4Health, Patient Education
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Virginia
Parkinsons Disease
Exercise Dosing Trial for Individuals With Parkinson's Disease
This is a prospective, pre-post intervention study to evaluate the effect of a high-intensity, aerobic exercise program on outcomes of cognition, mood, gait, balance, cardiorespiratory fitness, neuromuscular performance, fatigue…
- Trial name
- PDEX (NCT02676804)
- Testing
- High-intensity, aerobic exercise.
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Virginia
Bleeding, Procedural Complication
Bleeding in Hospitalized Patients With Liver Disease Undergoing Invasive Procedures
Patients with cirrhosis are frequently hospitalized and often undergo procedures. Knowledge surrounding bleeding risk is sparse and practice patterns vary across centers in regards to bleeding prophylaxis.
- Conditions
- Bleeding, Procedural Complication, Cirrhosis, Liver, Coagulation Disorder, Blood
- Trial name
- PROC-BLeeD (NCT04076605)
- Where
- United States
- Volunteers
- 1,182 people
- Sponsor
- University of Virginia
Genetic Predisposition
GIA in Cascade Testing
The objective of this pilot study is to evaluate the feasibility and acceptability of GIA in sharing genetic test results with family members. To determine the utility of GIA in sharing information.
- Trial name
- GIA (NCT04142333)
- Testing
- GIA
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Analgesia
Liposomal Bupivacaine Versus Non-liposomal Bupivacaine for Total Shoulder Arthroplasty
The objective of this study is to validate the analgesic efficacy of admixed Liposomal bupivacaine (LB) + bupivacaine compared with plain bupivacaine when injected for interscalene nerve block (ISNB) for total shoulder…
- Trial name
- NCT04974385
- Testing
- Liposomal bupivacaine, Bupivacaine
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Infant, Premature
Prematurity-Related Ventilatory Control: Role in Respiratory Outcomes
The objective of this common multicenter protocol is to test the hypothesis that algorithmic tools using clinical Neonatal Intensive Care Unit (NICU) cardiorespiratory monitoring data can detect ventilatory control instability…
- Trial name
- Pre-Vent (NCT03174301)
- Where
- United States
- Volunteers
- 739 people
- Sponsor
- University of Virginia
Metastatic Breast Cancer, Breast Cancer
A Pilot Study of the Combination of Entinostat With Capecitabine in High Risk Breast Cancer After Neo-adjuvant Therapy
The purpose of this study is to learn about the safety and side effects of combining entinostat, an investigational drug, with capecitabine, a drug commonly used in breast cancer (BC), in both participants with metastatic breast…
- Trial name
- Breast49 (NCT03473639)
- Testing
- Entinostat, Capecitabine
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- University of Virginia