Clinical trials: sponsored by University of Virginia
Type 1 Diabetes Mellitus
USS Virginia Closed-Loop Versus SAP Therapy for Hypoglycemia Reduction in T1D
This is a randomized, controlled trial of Unified Safety System (USS) Virginia closed-loop versus sensor-augmented pump (SAP) therapy for hypoglycemia prevention in subjects with type 1 diabetes and hypoglycemia unawareness…
- Trial name
- NCT02302963
- Testing
- AP System (DiAs or inControl) with USS Virginia
- Where
- 2 sites in United States
- Volunteers
- 85 people
- Sponsor
- University of Virginia
Diabetes Mellitus, Type 1
Optimizing Closed-Loop Control of Type 1 Diabetes Mellitus in Adolescents
The purpose of this study is to use a closed-loop Control-to-Range (CTR) system in adolescents with type 1 diabetes in an outpatient setting, and to evaluate the CTR system's ability to significantly improve blood glucose levels…
- Trial name
- NCT01890954
- Testing
- Diabetes Assistant (DiAs)
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Virginia
Type 1 Diabetes Mellitus
The International Diabetes Closed Loop (iDCL) Trial: Clinical Acceptance of the Artificial Pancreas (DCLP3 Extension)
This is a 3-month extension study (DCLP3 Extension) following a primary trial (DCLP3 or NCT03563313) to assess efficacy and safety of a closed loop system (t:slim X2 with Control-IQ Technology) in a large randomized controlled…
- Trial name
- NCT03591354
- Testing
- t:slim X2 with Control-IQ Technology & Dexcom G6 CGM, t:slim X2 with Basal-IQ & Dexcom G6 CGM
- Where
- 7 sites in United States
- Volunteers
- 164 people
- Sponsor
- University of Virginia
End Stage Renal Disease, Vascular Access Patency
Determine the Safety/Efficacy of Ticagrelor for Maintaining Patency of Arterio-Venous Fistulae Created for Hemodialysis
This study is a randomized, placebo-controlled, single blind clinical trial. Seventy patients with ESRD on chronic HD and a functioning AVF will be recruited.
- Trial name
- NCT02335099
- Testing
- ticagrelor
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Virginia
Clostridium Difficile Infection
Alanyl-glutamine Supplementation of Standard Treatment for C. Difficile Infection
The aim of this study is to test the efficacy of alanyl-glutamine supplementation in the treatment of C. difficile infection. We hypothesize that alanyl-glutamine when given with standard antibiotic treatment for C.
- Trial name
- NCT02053350
- Testing
- Alanyl-glutamine
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Virginia
Healthy Volunteers
Hallmarks of Protective Immunity in Sequential Rhinovirus Infections in Humans
The primary objective of this study is to assess the relationship between rhinovirus specific T-cell immunity and the human host response to primary rhinovirus challenge and subsequent secondary challenge with either homologous…
- Trial name
- NCT02796001
- Testing
- human rhinovirus, no intervention
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Alcohol Abuse
Prevention of Alcohol Related Incidents in the US Air Force
Alcohol misuse poses significant public health concerns in the U.S. military. A Brief Alcohol Intervention (BAI) have been shown to reduce alcohol related incidents among Airmen undergoing training.
- Trial name
- AFIV (NCT01398319)
- Testing
- Group Brief Alcohol Intervention, Group Brief Alcohol Intervention Booster, Bystander Intervention
- Where
- United States
- Volunteers
- 26,231 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Initial Efficacy of Quit Line, Efficacy of Secondary Reengagement Intervention
Enhancing the Efficacy of Smoking Quit Line in the Military (AFIII Renewal)
This study is a randomized clinical trial designed to measure the effectiveness of three QL interventions for smokers who failed to quit an initial smoking cessation intervention, but remain motivated to quit smoking.
- Trial name
- Freedom (NCT02201810)
- Testing
- Rate reduction intervention, Recycling Group, Choice Group
- Where
- United States
- Volunteers
- 614 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Type1 Diabetes Mellitus
A Pilot Test of t:Slim X2 With Control-IQ Technology
A 36-48 hour admission testing the t:slim X2 with Control-IQ Technology
- Trial name
- NCT03368937
- Testing
- Tandem t:slim X2 with Control-IQ Technology
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Virginia
Vasculogenic Erectile Dysfunction
Low Intensity Linear Shockwave Therapy for Erectile Dysfunction
MoreNovaED is a Linear Shockwaves (LISW) device in which shockwaves are focused onto line segments for improved organ coverage. Shockwaves produced by MoreNovaED are aimed at the left and right corpora cavernosa and the crura.
- Trial name
- NCT03843086
- Testing
- Low Intensity Linear Shockwave Device for the treatment of Erectile Dysfunction
- Sponsor
- University of Virginia
Thoracic
Pharmacokinetics of Single-Dose Liposomal Bupivacaine in Surgeon Performed Intercostal Nerve Blocks
Post-surgery pain management is critical for ensuring timely patient recovery and minimizing complications. Part of the multimodal approach to managing severe acute pain in the days following surgeries is the use of nerve blocks.
- Trial name
- NCT03708198
- Testing
- Liposomal Bupivacaine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Virginia
Relapsing Remitting Multiple Sclerosis
Utilization of the Ketogenic Diet in Patient With Relapsing Remitting MS
The purpose of this study is to evaluate the benefits of a low-carbohydrate, high-fat diet (ketogenic diet) in up to 50 subjects with relapsing-remitting multiple sclerosis (RRMS), a chronic neuro-inflammatory disease.
- Trial name
- NCT03718247
- Testing
- Modified Atkins diet
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Virginia
Congenital Heart Disease, Oral Aversion
Nasal vs. Oral Intubation for Neonates Requiring Cardiac Surgery
Often, infants struggle to feed orally after surgery for congenital heart disease and may require supplemental feeding interventions at discharge.
- Trial name
- NCT05378685
- Testing
- Endotracheal intubation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Virginia
Obesity, Hyperandrogenemia
Etiological Factors of Obesity-Associated Hyperandrogenemia in Peripubertal Girls
The purpose of this study is to learn if obese pre- and early pubertal girls with hyperandrogenemia (HA) are more insulin resistant (i.e., have lower insulin-stimulated glucose disposal) compared to obese peripubertal girls…
- Conditions
- Obesity, Hyperandrogenemia, Polycystic Ovary Syndrome
- Trial name
- CRM002 (NCT00928759)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Virginia
COPD
Interleukin-5 Receptor Expression in COPD
At visit one, after the subject has signed the consent form, subjects will answer questions and have maximum reversibility lung function test to determine if they are eligible to proceed with the study.
- Trial name
- NCT03984799
- Testing
- Bronchoscopy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Virginia
Shin Splint, Running-related Injury
Gait-Training Using Wearable Sensors
The overarching purpose of this project is to use sensor-derived patterns to guide running interventions during in-field training scenarios for runners with exercise-related lower leg pain.
- Trial name
- NCT04270565
- Testing
- In-Field Gait-Training, Home Exercise
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Virginia
Hyperandrogenism
Sleep-wake Changes of Luteinizing Hormone Frequency in Pubertal Girls With and Without High Testosterone
The purpose of this study is to determine whether sleep-wake changes of luteinizing hormone pulse frequency are different in early pubertal girls with high testosterone levels compared to early pubertal girls with normal…
- Trial name
- CRM005 (NCT00930007)
- Testing
- Blood sampling
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Family Caregivers, Cancer
The Better Sleep for Supporters With Insomnia Study
This study will identify whether - and if so, how - tailoring would increase adoption of and benefit from an interactive internet intervention for insomnia called SHUTi (Sleep Healthy Using the Internet) for cancer caregivers.
- Conditions
- Family Caregivers, Cancer, Insomnia, Sleep Initiation and Maintenance Disorders
- Trial name
- BeSSI (NCT04661306)
- Testing
- SHUTi (Sleep Healthy Using the Internet)
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Virginia
Vascular Stiffness, Insulin Sensitivity
Effect of Hyperglycemia on Microvascular Perfusion in Healthy Adults
The investigators are studying the effects of Hyperglycemia on vascular function and insulin sensitivity on healthy adults
- Trial name
- EJB050 (NCT03520569)
- Testing
- Octreotide, Insulin, Dextrose 20% solution
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Thyroid Cancer, Thyroid Nodule
Voice Outcomes Following Thyroidectomy
This is an observational study of voice outcomes in participants following thyroidectomy or another head and neck surgery that does not involve risk to the larynx other than risks incurred due to intubation alone.
- Trial name
- NCT03657654
- Testing
- No intervention: observational only
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Virginia