Clinical trials: sponsored by University of Virginia
Type 1 Diabetes
Fully Automated Closed Loop Control in Adolescents With Type 1 Diabetes
The study team will be comparing two investigational Artificial Pancreas (AP) systems that the UVA Center for Diabetes Technology has developed.
- Trial name
- RocketAP (NCT04545567)
- Testing
- RocketAP, USS Virginia
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Virginia
Healthy, Cystic Fibrosis (CF)
MRI for Non-Invasive Imaging in Neonates and Children
The purpose of this study is to develop rapid MRI techniques for imaging the lung with hyperpolarized helium-3 gas as an inhaled contrast agent.
- Conditions
- Healthy, Cystic Fibrosis (CF), Asthma, Bronchopulmonary Dysplasia (BPD)
- Trial name
- NCT02163681
- Testing
- Hyperpolarized Helium-3 MRI of the chest
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Type 1 Diabetes Mellitus
Glycemic Profiles And Insulin Delivery Across The Menstrual Cycle In Women With Type 1 Diabetes
This is an observational study. Forty females with type 1 diabetes (age 18-40) using a continuous glucose monitor and an insulin pump will be enrolled for a 3-month data collection.
- Trial name
- NCT04665999
- Testing
- Continuous Glucose Monitor
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Virginia
Corona Virus Infection, SARS-CoV 2
Convalescent Plasma for Treatment of COVID-19 Patients With Pneumonia
This is a single arm phase II trial to assess efficacy and confirm safety of infusions of anti-SARS-CoV-2 convalescent plasma in hospitalized patients with acute respiratory symptoms,with or without confirmed interstitial…
- Conditions
- Corona Virus Infection, SARS-CoV 2, SARS Pneumonia, Pneumonia
- Trial name
- NCT04374565
- Testing
- High-Titer Anti-SARS-CoV-2 (COVID 19) Convalescent Plasma
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- University of Virginia
Lymphoma, T-Cell
Durvalumab in Different Combinations With Pralatrexate, Romidepsin and Oral 5-Azacitidine for Lymphoma
This is an open-label, Phase 1/2a, dose-finding study with an initial phase 1 portion, articulated in four separate treatment arms, followed by a dedicated phase 2 for qualifying treatment Arm(s).
- Trial name
- NCT03161223
- Testing
- Durvalumab, Pralatrexate, Romidepsin
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- University of Virginia
Type 1 Diabetes Mellitus
Glucagon Counterregulation in Type 1 Diabetes
The purpose of this study is to find out whether the combination of insulin and pramlintide is better than insulin alone at helping the pancreas release glucagon in response to a low blood sugar episode.
- Trial name
- NCT03547427
- Testing
- Basal insulin alone, Basal pramlintide and reduced basal insulin, CGM
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Virginia
Postoperative Pain, Hip Arthroscopy
PENG Block for Arthroscopic Hip Surgery
This randomized, double-blinded, placebo-controlled trial seeks to evaluate the analgesic efficacy of the pericapsular nerve group block in the setting of outpatient hip arthroscopy.
- Trial name
- PENG (NCT04508504)
- Testing
- Preop PENG block, Ropivacaine 0.5% Injectable Solution, Normal Saline
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Breast Cancer
IRB-HSR# 13957: IV Lidocaine for Patients Undergoing Primary Breast Cancer Surgery:
The purpose of this study is to determine whether a local anesthetic drug (lidocaine) given during anesthesia intravenously (IV) through a needle in your vein,), can: 1. Help decrease pain after surgery. 2.
- Trial name
- NCT01204242
- Testing
- Lidocaine
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- University of Virginia
Hypotension, Pregnancy
Intravenous Ondansetron to Attenuate the Hypotensive, Bradycardic Response to Spinal Anesthesia in Healthy Parturients
The investigators hypothesize that given prophylactically, intravenous ondansetron will attenuate the drop in blood pressure and heart rate frequently seen after spinal anesthesia.
- Trial name
- NCT01414777
- Testing
- ondansetron
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Virginia
Pregnancy, Eclampsia
Microcirculatory and Tissue and Cerebral Oxygenation in Preeclampsia and Normal Pregnancy: An Observation Study
Preeclampsia is a disease of pregnancy affecting 3% to 8% of all pregnancies and is a major cause of maternal and perinatal morbidity and mortality.
- Trial name
- NCT02351583
- Testing
- CytoCam, NIRS Artinis PortaLite with OxySoft softwear
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Virginia
Type 1 Diabetes, Insulin Sensitivity/Resistance
Effect of GLP-1 on Microvascular Insulin Responses in Type 1 Diabetes
GLP-1 increases skeletal and cardiac microvascular perfusion and improves insulin's microvascular responses in human subjects with T1DM, leading to improved metabolic insulin responses, endothelial function, and increased muscle…
- Trial name
- KML001 (NCT04133922)
- Testing
- GLP-1, Insulin, Dextrose 20 % in Water
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Virginia
Pregnancy
Handheld 3D Lumbar Spine Navigation: A Clinical Validation Study RM002
Currently, at UVA, handheld ultrasound devices (like those used to view an unborn baby) are only two dimensional. The Accuro is a three dimensional handheld ultrasound device.
- Trial name
- NCT02442973
- Testing
- Control group (CG): standard practice, Ultrasound group (UG):, Accuro SpineView3D™
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of Virginia
Low Back Pain
Accuro Versus Traditional Landmark Palpation Technique to Determine Accurate Spinal Level for Procedures
Currently, at UVA, handheld ultrasound devices (like those used to view an unborn baby) are only two dimensional. The Accuro is a three dimensional handheld ultrasound device.
- Trial name
- NCT02862964
- Testing
- identify L4/L5
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- University of Virginia
Anesthesia,Obstetrical
Palpation and ACCURO for Placing Spinal in C-section
The Accuro is a three dimensional handheld ultrasound device. This device uses sound waves to create pictures of the spine in three dimensions.
- Trial name
- NCT03090295
- Testing
- Palpation and Accuro
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Virginia
Eustachian Tube Disorder
Evaluating Changes in Middle Ear Pressure Caused by CPAP
This study is an investigation into the effect that CPAP has on the pressure in the middle ear. It will evaluate the middle ear pressure and ear drum appearance at multiple levels of CPAP pressure delivered via a full face mask.
- Trial name
- NCT02882022
- Testing
- Continuous positive airway pressure
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Virginia
Tuberculosis
Diagnostics and Pharmacotherapy for Severe Forms of TB (DMID 15-0100)
Major Research Aim: To study novel molecular diagnostics and the pharmacokinetic variability among a spectrum of TB disease states, including severe forms of TB like disseminated TB, TB meningitis and drug resistant TB, among…
- Trial name
- NCT03559582
- Volunteers
- 478 people
- Sponsor
- University of Virginia
Tuberculosis, HIV Infections
Improving HIV/Tuberculosis Outcomes in Irkutsk
The investigators propose to examine the prospective influence of substance use patterns on HIV/tuberculosis adherence, pharmacokinetics and disease progression while developing novel methods for early detection and correction of…
- Conditions
- Tuberculosis, HIV Infections, Substance Use
- Trial name
- NCT03819374
- Where
- Russia
- Volunteers
- 53 people
- Sponsor
- University of Virginia
COVID19
Clinical Validation of New Injection Molded Flocked Nasopharyngeal Swabs in Response to the COVID-19 Pandemic
The SARS-CoV-2 pandemic has resulted in an international shortage of the nasopharyngeal (NP) swabs used to collect sample for virological testing.
- Trial name
- NCT04368260
- Testing
- Control swab, Prototype swab
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Type2 Diabetes, Insulin Sensitivity
Effects of Empagliflozin on Cardiac Microvasculature and Insulin Sensitivity in Subjects With Type 2 Diabetes
The aim is to test in T2DM patients, whether, compared to placebo, 12 weeks of SGLT-2 inhibitor improves post-absorptive, post-insulin infusion or postprandial insulin action to enhance Cardiac Muscle vascular function and…
- Trial name
- EJB051 (NCT04203927)
- Testing
- Empagliflozin 25 MG
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Virginia
Asthma
Lung Fluid and Peripheral Blood Neutrophil IL-5 Surface Receptor in Children With Asthma
The pattern of lower airway inflammation in asthma is heterogeneous, but in many patients, the polymorphonuclear neutrophil (PMN) is the predominant granulocyte infiltrating the airspaces.
- Trial name
- NAIL-5 (NCT02866487)
- Testing
- Bronchoscopy
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Virginia