Clinical trials: sponsored by University of Virginia
Acute Coronary Syndrome
Echocardiographic Molecular Imaging for POC Detection of Ischemia
Molecular imaging with myocardial contrast echocardiography (MCE) relies on the non-invasive detection of targeted microbubbles (MBs) or other acoustically active agents.
- Trial name
- NCT07762495
- Testing
- Myocardial Contrast Echo (MCE) molecular imaging with Sonazoid
- Volunteers
- 80 people
- Sponsor
- University of Virginia
Small Intestine Bacterial Overgrowth
Comparative Efficacy of Antibiotics for Small Intestine Bacterial Overgrowth in Bangladeshi Children
The purpose of this Phase IIa study is to identify the most effective antibiotic regimen to treat small intestine bacterial overgrowth (SIBO) in impoverished Bangladeshi children.
- Trial name
- NCT07451171
- Testing
- Trimethoprim-sulfamethoxazole (TMP/SMX), Metronidazole, Amoxicillin-Clavulanate (4:1 formulation)
- Where
- Bangladesh
- Volunteers
- 60 people
- Sponsor
- University of Virginia
Osteo Arthritis Knee, Knee Pain Chronic
Optimizing Pain Self-Management in Total Knee Arthroplasty
The purpose of this study is to investigate the efficacy of a positive affect enhancing intervention designed to reduce pain and augment reward system function in knee osteoarthritis (KOA) patients undergoing total knee…
- Conditions
- Osteo Arthritis Knee, Knee Pain Chronic, Surgery
- Trial name
- NCT06038240
- Testing
- Savoring Meditation, Pain Self-Management and Education
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Virginia
Mental Health Issue, Breast Cancer
Evaluating Digital Micro-Interventions to Reduce Distress and Increase Wellbeing in Breast Cancer Survivors
Digital mental and behavioral health interventions have potential to significantly improve accessibility for the large number of breast cancer survivors who need treatments.
- Trial name
- NCT07160439
- Testing
- Digital Micro-Interventions
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Virginia
Type2 Diabetes
Effect of Exercise and/or Liraglutide on Vascular Dysfunction and Insulin Sensitivity in Type 2 Diabetes ( ZQL007)
The primary objective of this study is to examine whether exercise training alone, liraglutide treatment alone or exercise training plus liraglutide treatment increases cardiac and muscle capillary blood volume, improves vascular…
- Trial name
- ZQL007 (NCT03883412)
- Testing
- Exercise, Liraglutide
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Heart Failure Preserved Ejection Fraction, Epicardial Adipose Tissue
Epicardial Adipose Tissue Composition and Heart Failure With Preserved Ejection Fraction
This study seeks to develop improved cardiac MRI (CMR) methods to quantify epicardial adipose tissue (EAT) composition and to demonstrate the advantages of EAT composition imaging (a) in advancing the understanding of the…
- Trial name
- NCT07178145
- Testing
- GLP-1RA
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- University of Virginia
Epilepsy
Bridging the Treatment Gap by Expanding Access to Care for People With Epilepsy in Kenya (BEACON)
This cluster randomized trial aims to learn about the effectiveness of task-sharing supported by an epilepsy medical records system (EMRS) (hereafter referred to as BEACON) with patient-tracking data in improving treatment…
- Trial name
- BEACON (NCT06623994)
- Testing
- Task sharing with Epilepsy Medical Record Systems
- Where
- Kenya
- Volunteers
- 650 people
- Sponsor
- University of Virginia
Insomnia, Depression
Evaluating the Impact of Digital Behavioral Interventions to Address Insomnia and Depression in Breast Cancer Survivors Using an Adaptive Design
Co-occurring symptoms of insomnia and depression is very common in breast cancer survivors, and it is critical that scalable and easily accessible digital behavioral interventions are made available.
- Trial name
- NCT07721064
- Testing
- Digital Insomnia Program, Digital Mental Health Program, Psychoeducation
- Where
- United States
- Volunteers
- 747 people
- Sponsor
- University of Virginia
Healthy Subjects
Optimizing Ultrasound-induced Anti-inflammation in Human Subjects
This is a feasibility study to determine whether pulsed ultrasound stimulation targeting the splenic nerve or the cervical vagus nerve can elicit an anti-inflammatory immune response in healthy volunteers.
- Trial name
- NCT05685108
- Testing
- Ultrasound stimulation intensity, Ultrasound stimulation site
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Huntington Disease, Parkinson Disease
Modification of Threat Interpretation Bias to Reduce Anxiety in Neurodegenerative Movement Disorders (Aim 3)
The purpose of this study is to assess preliminary efficacy of a tailored cognitive bias modification for interpretation (CBM-I) app for reducing anxiety in Huntington's disease and Parkinson's disease.
- Trial name
- NCT07213648
- Testing
- MindTrails-Movement, Waitlist Control
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- University of Virginia
Menopause
Exercise Training Intensity and Nitrate Supplementation in Post-Menopausal Females
Menopause greatly increases cardiovascular disease risk (CVD). Current exercise guidelines are inadequate to ameliorate this risk and higher intensity exercise may be necessary for cardiovascular benefits in postmenopausal…
- Trial name
- NCT06480695
- Testing
- Nitrate-Rich Beetroot Juice, High Intensity Exercise, Moderate Intensity Exercise
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Bone Strength, Bone Density
Role of Estrogen on Skeletal Outcomes in FHA
The purpose of this study is to assess whether the natural form of estrogen (17-beta estradiol) given as a patch so that it is absorbed through your skin, is better at improving bone strength over 1 year than natural estrogen…
- Conditions
- Bone Strength, Bone Density, FHA (Functional Hypothalamic Amenorrhea)
- Trial name
- NCT07010146
- Testing
- transdermal 17β-E2 with cyclic progestin, oral 17β-E2 with cyclic progestin, transdermal EE+LNG
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of Virginia
Females, Males
The Effects of Vitamin C on Acute-Exercise in Postmenopausal Females
This study is looking at whether vitamin C can help improve oxidative stress and blood vessel health in females after menopause.
- Conditions
- Females, Males, Menopause, Sedentary
- Trial name
- PM-VitC (NCT07109115)
- Testing
- Vitamin C (Ascorbic Acid)
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Tobacco Use Cessation, Tobacco Use Disorder
Feasibility of a Medical-Legal Partnership Model to Connect Coal Miners QuitAid
Coal miners in Central Appalachia have among the highest rates of tobacco and nicotine product (TNP) use of any occupational group and face elevated rates of lung cancer and coal workers' pneumoconiosis ("black lung").
- Conditions
- Tobacco Use Cessation, Tobacco Use Disorder, Nicotine Dependence, Smokeless Tobacco Use
- Trial name
- NCT07694492
- Testing
- QuitAid (pharmacist-delivered MTM), Nicotine Replacement Therapy (NRT)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Tobacco Use Cessation
VergeRx for Smokers Not Ready to Quit
This study uses a factorial optimization experiment to identify which treatment components help adults who smoke and are not ready to quit in the next 30 days (smokers not ready to quit, or SNRTQ) achieve smoking cessation.
- Trial name
- NCT07693660
- Testing
- VergeRx, SmokefreeTXT, NRT Lozenge (Combination)
- Where
- United States
- Volunteers
- 592 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Breast Cancer Female
Pre-Operative Window of ET to Inform RT Decisions (POWER II)
This is a Phase III, multisite exploratory study for women ≥ 65 years of age with early stage estrogen receptor positive (ER+) breast cancer.
- Trial name
- POWER II (NCT06507618)
- Testing
- Tamoxifen, Letrozole, Anastrozole, or Exemestane
- Where
- 6 sites in United States
- Volunteers
- 354 people
- Sponsor
- University of Virginia
Mental Health Issue, Breast Cancer
A Pre-post Pilot of a Smartphone Intervention
Digital mental and behavioral health interventions have potential to significantly improve accessibility for the large number of breast cancer survivors who need treatments.
- Trial name
- NCT07665346
- Testing
- Digital Micro-Interventions
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Virginia
Fetal Alcohol Spectrum Disorders, Pregnancy
CARRII Native Intervention Optimization Trial
The purpose of this study is to identify the best combination of new intervention components to use with CARRII, the first automated online intervention for alcohol-exposed pregnancies (AEP).
- Conditions
- Fetal Alcohol Spectrum Disorders, Pregnancy, Alcohol-Related Disorders, Drinking, Alcohol
- Trial name
- NCT07547696
- Testing
- CARRII Native Cores
- Where
- United States
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Prolonged Grief Disorder
Psilocybin for Prolonged Grief Disorder
The primary purpose of this study is to explore the feasibility of conducting a clinical trial on the effects of psilocybin for individuals with prolonged grief disorder (PGD).
- Trial name
- NCT06724289
- Testing
- Psilocybin 25 mg, Functional Magnetic Resonance Imaging (fMRI)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Alcohol Exposed Pregnancy, Unplanned Pregnancy
Optimizing a Digital AEP Risk Intervention With Native Women and Communities
The purpose of Aim 1 of the study is to gather quantitative and qualitative information to inform the development of a digital app tailored for Native American women to help them avoid a pregnancy affected by alcohol.
- Conditions
- Alcohol Exposed Pregnancy, Unplanned Pregnancy, Alcohol Use, Unspecified, Contraception Use
- Trial name
- CARRIINative (NCT06324929)
- Testing
- CARRII Native Rapid Pilot Testing
- Where
- United States
- Volunteers
- 407 people, healthy volunteers welcome
- Sponsor
- University of Virginia