Clinical trials: sponsored by University of Virginia
Fibromyalgia
Cranial Electrical Stimulation Effects on Symptoms in Persons With Fibromyalgia
The purpose of this study is to determine the effects of mild cranial electrical stimulation on pain, fatigue, sleep disturbances, perceived stress, blood pressure, and functional status in persons with fibromyalgia.
- Trial name
- NCT00928720
- Testing
- CES device
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Virginia
Breast Cancer
Immune Effects in Patients Treated With Whole Breast Irradiation
The purpose of this study is to obtain data to determine whether whole breast irradiation (WBI) differentially influences the frequency of components of innate and adaptive immunity and their relative functional activity, to…
- Trial name
- NCT03567044
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Virginia
Ventilation, Breathing
Pilot Evaluation Comparing Regional Distribution of Ventilation During Lung Expansion Therapy
The primary purpose of this study is to determine if there is a significant difference in regional distribution of ventilation when comparing eupneic tidal ventilation with Incentive Spirometry (I.S.) and EzPAP® lung expansion…
- Conditions
- Ventilation, Breathing, Atelectasis
- Trial name
- NCT03083379
- Testing
- Volumetric Incentive Spirometry, EzPAP® POSITIVE AIRWAY PRESSURE
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Glioblastoma, Glioma
Early-Phase Study to Assess Inhibitor Ribociclib in Patients With Recurrent Glioblastoma or Anaplastic Glioma
This is a single-institution, open-label, early-phase study to assess the ability of ribociclib (LEE011) to inhibit CDK4/CDK6/Rb/E2F signaling and cell proliferation/viability in core and infiltrating tumor tissues obtained from…
- Trial name
- NCT02345824
- Testing
- Ribociclib
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Virginia
Polycystic Ovary Syndrome, Hyperandrogenism
Effects of Androgen Blockade on Sensitivity of the GnRH Pulse Generator to Suppression by Estradiol and Progesterone
The purpose of this study is to understand the effects of elevated male hormones in adolescent girls and how they effect the development of polycystic ovary syndrome (PCOS).
- Trial name
- NCT01428193
- Testing
- Flutamide, Progesterone, estrace
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Virginia
Hypoxemia, Hypoxia
Non Contact Measurement of Vital Signs
The purpose of this study is to test the accuracy of a web cam-based biomedical device developed at UVA (not FDA-approved) that is designed to measure heart rate, respiratory rate, and oxygen saturation without requiring any…
- Trial name
- NCT02287220
- Testing
- Non-Contact Oximetry
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Virginia
Type 1 Diabetes Mellitus
Exercise Activity-Based Bolus Decisions in Type 1 Diabetes
The purpose of the study is to demonstrate safety and feasibility of a decision support system aimed at improving activity-related insulin boluses in Type 1 Diabetes.
- Trial name
- NCT03394352
- Testing
- Activity on Board, Usual Diabetes Care
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Virginia
Peritonitis
SIS Multicenter Study of Duration of Antibiotics for Intraabdominal Infection
The major hypothesis to be tested is that the treatment of intraabdominal infections that have been adequately treated operatively or by percutaneous techniques with three to five days of antibiotics will result in outcomes…
- Trial name
- NCT00657566
- Testing
- duration of antibiotics
- Where
- 23 sites in United States, Canada
- Volunteers
- 518 people
- Sponsor
- University of Virginia
Ankle Sprains, Ankle Injuries
Effects of Gait Biofeedback and Impairment-based Rehabilitation in Individuals With Chronic Ankle Instability
Individuals with chronic ankle instability (CAI) have demonstrated altered gait patterns. Gait training may be necessary to address these alterations as protocols focusing solely on strength or balance have not been shown to…
- Trial name
- NCT03507803
- Testing
- Gait Biofeedback
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Virginia
Chronic Kidney Disease, Kidney Disease
Growth Hormone Secretagogue MK-0677's Effect on Lean Body Mass in Chronic Kidney Disease Stage 4/5 Subjects
This year-long investigator-initiated study is designed to determine effects of MK-0677, a GH secretagogue, in renal patients. It is a double-blind, placebo-controlled trial employing the following procedures: Informed consent…
- Trial name
- NCT01343641
- Testing
- MK-0677
- Where
- United States
- Sponsor
- University of Virginia
Cavernous Malformations,Cerebral and/or Spinal
Oral Propanolol for Surgically Inaccessible Cavernous Malformations
The purpose of this study is to evaluate the role of propranolol as an alternative treatment for cavernous malformation in patients that may not be ideal candidates for surgery.
- Trial name
- NCT03523650
- Testing
- Propranolol Oral Tablet
- Where
- United States
- Volunteers
- 346 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Indomethacin Therapy, Patent Ductus Arteriosus
The Use of B-type Natriuretic Peptide (BNP) to Predict Closure of a Patent Ductus Arteriosus (PDA) in Premature Infants
A patent ductus arteriosus (PDA) is associated with increased morbidity in premature infants. Standard indomethacin treatment is associated with intestinal and renal morbidity.
- Trial name
- NCT00500305
- Testing
- Withhold standard INDO dose if BNP < 100 pg/ml
- Volunteers
- 60 people
- Sponsor
- University of Virginia
Aspirin-Sensitive Asthma With Nasal Polyps, Samter's Syndrome
Mechanisms of Alcohol Sensitivity in AERD
The purpose of this study is to determine what type of reactions in the body may be responsible for the respiratory symptoms that occur when patients with Aspirin Exacerbated Respiratory Disease (AERD) drink alcoholic beverages.
- Trial name
- NCT03441438
- Testing
- Water, Red wine, Polyphenolic Compounds
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Diabetes Mellitus, Type 1
International Diabetes Closed Loop (iDCL) Trial: Research Site Training Protocol
The objective of the study is for clinical staff to gain experience using the proposed artificial pancreas system named inControl and the inControl Cloud and assess 24/7 in-home usability prior to initiating a large randomized…
- Trial name
- NCT02844517
- Testing
- Artificial Pancreas
- Where
- 10 sites in United States, France and 2 more
- Volunteers
- 43 people
- Sponsor
- University of Virginia
Peripheral Artery Disease
Lovaza Therapy of Peripheral Arterial Disease
Sixty patients with mild-to-moderate PAD (ABI 0.4-0.9) and hypertriglyceridemia (>200 mg/dl) already treated with statins will be imaged at baseline and randomized to Lovaza and placebo for 12 months.
- Trial name
- NCT00569686
- Testing
- lovaza
- Where
- United States
- Sponsor
- University of Virginia
Intracranial Hypertension
The Use of Near Infrared Spectroscopy (NIRS) to Estimate Intracranial Pressure (ICP)
The aim of this study is to determine whether we can predict the intracranial pressure using near infra-red spectroscopy
- Trial name
- NCT01850069
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Virginia
Colonization
Topical Umbilical Cord Care for the Prevention of Colonization and Invasive Infections
Umbilical catheters are necessary for many infants admitted to the Newborn Intensive Care Unit (NICU)and utilized when indicated for up to 7 to 14 days.
- Trial name
- NCT01886001
- Testing
- Povidone-Iodine, Chlorhexidine, Pluronic
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of Virginia
Chronic Systolic Heart Failure, Paroxysmal VT
Cardiac MRI for Optimal Heart Failure Outcomes With CRT Upgrades
This study will investigate the use of cardiac MRI in patients with standard ICDs and pacemakers to inform how cardiac resynchronization therapy (CRT) can best be implemented in these patient and which patients are the best…
- Trial name
- NCT03504891
- Testing
- MRI prior to CRT Upgrade, MRI prior to de novo CRT
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Virginia
Happiness
Enduring Happiness and Continued Self-Enhancement
Over the past several decades, a new science of subjective well-being has produced insights into the factors that make people happy-from cultivating strong relationships to pursuing the right goals.
- Trial name
- ENHANCE (NCT02782611)
- Testing
- ENHANCE: Enduring Happiness and Continued Self-Enhancement
- Where
- 2 sites in United States, Canada
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Method of Tubal Ligation at the Time of Cesarean Section
Standard Tubal Ligation Versus Salpingectomy for Sterilization at the Time of Cesarean Delivery
The objective of this study is to evaluate the feasibility and safety of salpingectomy versus standard tubal ligation in women undergoing surgical sterilization at the time of a planned cesarean delivery.
- Trial name
- NCT03028623
- Testing
- Salpingectomy, Tubal ligation
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Virginia