Clinical trials: sponsored by University of Virginia
Sinusitis, Nasal Polyps
Association of Periostin Levels and Chronic Sinusitis
The purpose of this study is to see if a protein in blood, called periostin, can determine if patients have chronic sinusitis. This protein is in everyone's body, but the level of the protein may indicate certain conditions such…
- Trial name
- NCT02071667
- Testing
- Blood draw
- Where
- United States
- Sponsor
- University of Virginia
Non Small Cell Lung Cancer
Phase I Study of Induction Therapy With VELCADE and Vorinostat in Patients With Surgically Resectable Non-Small Cell Lung Cancer
The purpose of this study is to find out what effects (both good and bad) two medications (VELCADE and Vorinostat) have on patients who have certain types of lung cancer.
- Trial name
- NCT00731952
- Testing
- Velcade and Vorinostat
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Virginia
Injuries, Ankle, Sprain of Foot
Multisegmented Foot Motion in Patients With Lateral Ankle Sprains and Chronic Ankle Instability
Lateral ankle sprains (LAS) and chronic ankle instability (CAI) are common musculoskeletal injuries that are a result of inversion injury during sport.
- Trial name
- NCT02697461
- Testing
- Intrinsic Foot Strengthening, Joint Mobilization
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Common Cold
Effect of Probiotic on the Innate and Adaptive Host Response to Rhinovirus (EPIARR)
The study is designed to assess the effect of ingestion of a probiotic on innate and adaptive host responses to rhinovirus infection.
- Trial name
- EPIARR (NCT01669603)
- Testing
- Bifidobacterium lactis Bl-04, Rhinovirus
- Where
- United States
- Volunteers
- 789 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Stress Fracture, Ultrasound Therapy
Comparison of Ultrasound and X-ray as Screening Tests for Diagnosis of Lower Extremity Stress Fracture.
Hypothesis: Diagnostic ultrasound is an appropriate screening test for acute stress fracture in the lower extremity and is superior to x-ray.
- Conditions
- Stress Fracture, Ultrasound Therapy, Musculoskeletal Ultrasound
- Trial name
- NCT03116360
- Testing
- Diagnostic Ultrasound
- Volunteers
- 200 people
- Sponsor
- University of Virginia
Atherosclerosis
RNA Cloning and Visualization in Human Atherosclerosis
The research objectives of this project are as follows: 1. Obtain high-quality human atherosclerotic arterial samples from diseased donors. 2.
- Trial name
- NCT01928095
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Virginia
Chronic Kidney Disease, End Stage Renal Disease
Growth Hormone Secretagogue MK-0677 Effect on IGF-1 Levels in ESRD Patients
The objective of this study is to determine MK-0677 increases IGF-1 in patients with end stage renal disease (ESRD) on hemodialysis.
- Trial name
- NCT00395291
- Testing
- MK-0677
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of Virginia
Insomnia, Sleep Initiation and Maintenance Disorders
An Interactive Internet Intervention for Adults With Insomnia
This study will compare the efficacy of an interactive Internet intervention for adult insomnia (Sleep Healthy Using the Internet; SHUTi) to that of a static educational website to improve sleep, mood related symptoms, perceived…
- Trial name
- SHUTi (NCT01438697)
- Testing
- Internet Intervention, Patient Education Website
- Where
- United States
- Volunteers
- 303 people
- Sponsor
- University of Virginia
Infant, Premature, Diseases
VentFirst Pilot: Ventilating Preterm Infants During Delayed Cord Clamping
Delayed clamping of the umbilical cord (DCC) has been shown to have some benefits for preterm infants. Initiation of breathing before cord clamping is also thought to be beneficial.
- Trial name
- NCT02391389
- Testing
- CPAP or PPV during DCC
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Virginia
Melanoma
Combination Therapy of Topical Imiquimod Plus Multipeptide Vaccination for Cutaneous Metastases of Melanoma
The purpose of the study is to determine 1) the safety of administration of topical 5% imiquimod cream with or without administration of a peptide-based vaccine in patients with cutaneous metastases of melanoma and 2) evaluate…
- Trial name
- MEL53 (NCT01264731)
- Testing
- MELITAC 12.1, Imiquimod
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Virginia
Type 1 Diabetes Mellitus
Insulin Sensitivity, Impaired Counterregulation, and Glucose Variability
This protocol will investigate physiological parameters including insulin sensitivity and counterregulatory function using a mixed meal test and induced hypoglycemia in subjects with type I diabetes.
- Trial name
- BPK005 (NCT01439672)
- Testing
- Mixed meal and insulin challenge
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Virginia
Hypovolemia
Response of Pulse Pressure Variation in PA Catheter Tracing to IV Fluid Bolus in the ICU
The investigators hypothesize that analysis of blood pressure will allow doctors to predict whether or not blood flow from the heart (cardiac output) increases after intravenous fluids are given.
- Trial name
- NCT02419404
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Virginia
Rectal Neoplasms
Sentinel Lymph Node Mapping in Rectal Cancer
The purpose of this study is to develop a technique that allows physicians to identify the first lymph nodes draining from a rectal tumor (the sentinel lymph nodes).
- Trial name
- NCT02869152
- Testing
- Endoscopic injection of 99mTc-sulfur colloid, Endoscopic injection of ICG, Endoscopic injection of Spot
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Virginia
Back Pain
IRB-HSR # 14073 Investigation of Pelvic Girdle Dysfunction in the Low Back Pain Population
The subjects will undergo a specific physical exam of tests reported to be diagnostic of sacroiliac joint (SIJ) pain prior to receiving the routine injection in the SIJ that which is being performed as part of their normal…
- Trial name
- NCT02950129
- Testing
- SIJ pain diagnostic tests
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Virginia
Coronary Artery Disease
HemoSonics-UVA HemoSonics-UVA Cardiac Surgery Clinical Study Protocol
This study compares the results of current standard coagulation measurement devices to the Quantra System, a new device, using small amount of extra blood obtained during routine blood draws in cardiac surgery patients.
- Trial name
- NCT02456467
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Virginia
Critical Illness
Impact of Gender on Hospitalized Patients
The purpose of this study is to better understand the relationship between gender (being a man or a woman), infections caught in the hospital, and serious illness.
- Trial name
- NCT00843557
- Where
- United States
- Volunteers
- 2,400 people
- Sponsor
- University of Virginia
Vaccine Virus Shedding
Assessment of Community Transmission of Sabin Type 2 Virus in Bangladesh
The Strategic Advisory Group of Experts on Immunization (SAGE) has set a plan to replace trivalent oral polio vaccine (tOPV) with bivalent OPV (bOPV) plus inactivated polio vaccine (IPV) in routine immunization globally, to be…
- Trial name
- NCT02477046
- Testing
- tOPV, bOPV, IPV
- Where
- Bangladesh
- Volunteers
- 810 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Plasma Concentration of Antibiotics
Pharmacokinetics of Bolus Versus Continuous Cefazolin Infusion in Patients Undergoing Major Surgery
Abstract The administration of an antibiotic preoperatively is an important intervention that helps to reduce the risk of post-operative health-care associated infections (HCAI).
- Trial name
- NCT02058979
- Testing
- BOLUS INFUSION (Ancef), CONTINUOUS INFUSION (Ancef)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Virginia
Fetal Alcohol Spectrum Disorders
Contraception and Alcohol Risk Reduction Internet Intervention Randomized Trial
The goal of the proposed research is to develop and pilot test a novel Internet intervention to reduce the risk of Alcohol-exposed pregnancy (AEP).
- Trial name
- CARRII (NCT02128880)
- Testing
- CARRII, CARRII Education
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Diabetes Mellitus, Type 1, Pregnancy
BGAT (Blood Glucose Awareness Training) for Users Who Might Become Pregnant
Ineffective management of blood glucose (BG) levels during preconception and pregnancy has been associated with severe maternal and fetal complications in women with type 1 diabetes (T1DM).
- Trial name
- Bump2Be (NCT02508779)
- Testing
- Bump2be, Routine Care
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Virginia