Clinical trials: sponsored by University of Virginia
Diabetes Mellitus, Type 1
Development of a Comprehensive AP Training Curriculum for Adults
An e-learning training program is to prepare people with diabetes and their physicians on the use of UVA's Artificial Pancreas prototype -- Diabetes Assistant (DiAs).
- Trial name
- NCT02434094
- Testing
- eDAPT on-line training program
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Virginia
Hypertension
Blood Pressure Response to Sodium in the Diet
Previous studies have demonstrated that single nucleotide polymorphisms (SNPs) of the sodium-bicarbonate co-transporter gene (SLC4A5) are associated with hypertension.
- Trial name
- NCT01899495
- Testing
- High sodium diet and low sodium diet
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Urinary Retention, Urinary Tract Infections
Effect of Active vs. Passive Voiding Trials on Time to Discharge, Urinary Tract Infection, and Urinary Retention
Urinary retention is a common problem, particularly in hospitalized patients. When a Foley catheter is removed, a patient must be monitored for urinary retention.
- Trial name
- NCT02886143
- Testing
- Active Voiding Trial, Passive Voiding Trial
- Volunteers
- 274 people
- Sponsor
- University of Virginia
Aneurysm
EffectiveNess and SAfety of Small ANeurysm COiling Trial
To compare the safety and efficacy of treating small aneurysms with coils specially designed for small aneurysms to historically reported rates of safety and efficacy for the treatment of larger aneurysms.
- Trial name
- NANO (NCT02167997)
- Where
- 19 sites in United States, Canada
- Volunteers
- 252 people
- Sponsor
- University of Virginia
Osteoporotic Vertebral Compression Fractures
Cost Effectiveness and Efficacy of Kyphoplasty and Vertebroplasty Trial
Randomized trial comparing cost effectiveness and efficacy of kyphoplasty vs vertebroplasty for the treatment of painful, osteoporotic vertebral compression fractures.
- Trial name
- NCT00279877
- Testing
- Kyphoplasty
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- University of Virginia
Intracranial Aneurysm, Abdominal Aortic Aneurysm
UVA Brain and Aortic Aneurysm Study
The purpose of this study is to examine the percentage of patients who present with abdominal aortic aneurysms (AAA) will also have intracranial aneurysms (IA) and conversely; to examine the percentage of patients who present…
- Trial name
- BAAS (NCT02869464)
- Testing
- Imaging-Ultrasound, Imaging-MRA, DNA, RNA testing
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- University of Virginia
Pregnancy
Sleep Efficiency and Quantification After Labor Epidural Analgesia
The specific aim is to attempt to quantify the amount and efficiency of sleep that parturients receive after placement of labor epidural analgesia.
- Trial name
- Actiwatch (NCT02862951)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Virginia
Peripheral Arterial Disease, Intermittent Claudication
Zibotentan, an Endothelin Receptor Antagonist, Patients With Intermittent Claudication
Peripheral artery disease (PAD) is a major complication of atherosclerosis when blockages in the arteries to leg reduce blood flow and one of the resulting problems is termed intermittent claudication (IC).
- Trial name
- NCT01890135
- Testing
- Zibotentan (ZD4054)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Virginia
Diabetes Mellitus, Type 1
Full Day and Night Closed-Loop With DiAs Platform
The overall aim of this proposed research is to determine the safety, feasibility and efficacy of the Diabetes Assistant (DiAs) controller in day and night closed-loop control in children and adolescents with type 1 diabetes over…
- Trial name
- NCT02147860
- Testing
- Diabetes Assistant (DiAs) with USS Virginia, Sensor Augmented Pump Therapy
- Where
- 2 sites in United States
- Volunteers
- 44 people
- Sponsor
- University of Virginia
Rectal Cancer
Feasibility Study to Develop Sentinel Lymph Node Mapping in Rectal Cancer Patients
The purpose of this study is to see if investigators can develop a technique to identify sentinel lymph nodes in the rectum for rectal cancer patients with the use of a radiotracer (Tc-sulfur colloid), a dye (Spot), and imaging…
- Trial name
- NCT02112240
- Testing
- Intraoperative Mobile Gamma Camera imaging, Endoscopic injection of 99mTc-sulfur colloid, Endoscopic injections of Spot
- Where
- United States
- Sponsor
- University of Virginia
Crohn's, Ulcerative Colitis
Single-dose Linaclotide for Capsule Endoscopy Preparation
Video capsule endoscopy is an important procedure that can be used by doctors to find abnormalities in the small intestine, especially those that can cause bleeding.
- Conditions
- Crohn's, Ulcerative Colitis, Gastrointestinal Bleeding
- Trial name
- NCT02465385
- Testing
- Linaclotide
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Virginia
Endometrial Cancer
Bristol-Myers Squibb Dasatinib Src Inhibition in Endometrial Cancer
The purpose of this study is to see if the investigators can measure inhibition of a protein, Src (named for Sarcoma), in tissue and blood in patients with a diagnosis of endometrial cancer.
- Trial name
- NCT01482728
- Testing
- Dasatinib
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Virginia
Coronary Artery Disease
Haptoglobin Polymorphism as a Determinant of Adverse Outcome After Cardiac Surgery in Diabetic Patients
Specific aim 1a will test the hypothesis that diabetic patients with 2-2 haptoglobin genotype have higher indices of postoperative myocardial injury (creatine kinase MB isoenzyme , Troponin I ) and renal injury (as indicated by…
- Trial name
- NCT02771808
- Testing
- biomarker samples
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- University of Virginia
Tuberculosis, HIV
DNA Sequencing of MDR TB in Eastern Siberia
This is protocol is generated in response to the exploratory R21 from the National Institutes of Health/National Institute of Allergy and Infectious Diseases (NIH/NIAID) for US-Russia collaborative research in HIV/tuberculosis…
- Trial name
- NCT02508610
- Where
- Russia
- Volunteers
- 630 people
- Sponsor
- University of Virginia
Deformity of Spine
HemoSonics-UVA Spinal Surgery
This study compares the results of current standard coagulation measurement devices to the Quantra System, a new device, using small amount of extra blood obtained during routine blood draws in neurosurgery patients.
- Trial name
- NCT02418923
- Testing
- Procedure: Blood specimen collection
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Virginia
Very Low Birth Weight Infants
Safety and Tolerability of Lactoferrin in Very Low Birth Weight Infants
To evaluate the safety and tolerability of three different lactoferrin doses in preterm infants
- Trial name
- NCT02731092
- Testing
- Lactoferrin
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Virginia
Pancreatic Ductal Adenocarcinoma
Phase 0 Biodistribution of Novel Imaging for Resectable Pancreatic Cancer
The purpose of this clinical trial is to study an experimental drug called PTP-01 that is being used as an imaging agent to diagnosis pancreatic cancer.
- Trial name
- NCT01962909
- Testing
- PTP-01
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Virginia
Coronary Artery Disease
Expression of Angiogenic Factors in Myocardial Tissue
The purpose of this study is to evaluate whether angiogenesis is decreased in diabetic patients with coronary artery disease compared to non-diabetics with coronary artery disease.
- Trial name
- NCT01414621
- Testing
- atrial tissue sample
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Virginia
Scoliosis
IRB-HSR# 14145 R,S Methadone: Analgesia and Pharmacokinetics in Adolescents Undergoing Scoliosis Correction
This is a pilot study to determine the pharmacokinetics of (R,S) methadone in adolescents. A total of approximately 15 patients will be required.
- Trial name
- NCT01205256
- Testing
- methadone
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Virginia
Diabetes Type 1
The Effect of Type 1 Diabetes on Pan-Arterial Vascular Function and Insulin Sensitivity in Humans
Arterial vascular disease is the major cause of morbidity and mortality for Type 1 diabetic patients (DM1). Metabolic insulin resistance (metIR), even in the absence of hyperglycemia, conveys a 1.5 to 3-fold increased CVD risk in…
- Trial name
- EJB046 (NCT02490124)
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Virginia