Clinical trials: sponsored by University of Virginia
Encopresis
Internet-based Treatment of Early Childhood Fecal Incontinence
Encopresis, also known as fecal incontinence, is the voluntary or involuntary passage of stools causing soiling of clothes by a child over 4 years of age.
- Trial name
- NCT00067769
- Testing
- Internet-based intervention UCanPoopToo, treatment as usual
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Chronic Ankle Instability
Effects Of Rehabilitation Incorporating Gait Training On Clinical Measures Associated With Chronic Ankle Instability
This is a randomized controlled trial (RCT) regarding the conservative treatment of chronic ankle instability (CAI) with an impairment based rehabilitation program.
- Trial name
- NCT02533037
- Testing
- Traditional Instability Tools, Ankle Destabilization Shoes
- Volunteers
- 26 people
- Sponsor
- University of Virginia
Post-Traumatic Stress Disorder
Effectiveness of a Web-based Intervention for Guardians of Children Whose One Parent Has Murdered the Other
This study will determine whether a specialized Web site geared for the guardians of children whose one parent has murdered the other can increase guardian capabilities, reduce guardian stress, and improve child behavior and…
- Trial name
- NCT00737035
- Testing
- Interactive Healthcare Communication Application, Control Web sites
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Virginia
Gadolinium Toxicity
In Vitro Study of the Effect of Gadolinium Contrast on Fibrocytes
Gadolinium contrast agents are frequently administered for MRI imaging. Very little is known of its toxicity outside of patients with reduced renal function.
- Trial name
- NCT02512796
- Testing
- Gadolinium contrast dye
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Type 1 Diabetes Mellitus
A Clinical Study of the Performance of a Glucose Blinding Protein-Based Continuous Glucose Monitor (GBP CGM)
The purpose of this study is to assess the accuracy of the Becton Dickenson (BD) Technologies Glucose Binding Protein-Based Continuous Glucose Monitor (GBP CGM) in patients with Type 1 diabetes during low (goal glucose 55 mg/dL)…
- Trial name
- SMA002 (NCT01469715)
- Testing
- GBP CGM
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Virginia
Hepatitis C Virus
Effects of Sho-saiko-to, a Herbal Formula, in Reducing Viral Load in Hepatitis C
The purpose of this study is to (1) determine the effects of the herbal formula Sho-saiko-to (SST) compared to placebo in treating hepatitis C virus (HCV) in persons who have not responded to the current conventional therapy…
- Trial name
- NCT00633230
- Testing
- standardized herbal formula, Sho-saiko-to (SST)
- Sponsor
- University of Virginia
Transthoracic Esophagectomy
Observational Study of Sublingual Microcirculatory Blood Flow Characteristics in Patients Undergoing Transthoracic Esophagectomy
Microcirculatory alterations occur in critically ill patients and those undergoing major surgeries. The severity of perioperative microvascular alterations appear to be related to the severity of organ dysfunction after surgery.
- Trial name
- NCT02263664
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Virginia
Hypotension
Long Time Interval Analysis for Non Invasive Measurement of Cardiac Output
A group of engineers at Michigan State developed a novel waveform analysis technique ("Long Time Interval Analysis" [LTIA]) that attempts to estimate cardiac output non-invasively.
- Trial name
- NCT02473588
- Testing
- Retia Medical Long Time Interval Analysis
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Virginia
Morbid Obesity, Endometrial Pathology
Study of Menstrual Irregularities and Endometrial Pathology in Women Undergoing Bariatric Surgery
Objectives: Given the profound impact of obesity on the genesis of endometrial cancer, this study proposes to prospectively evaluate the baseline prevalence of menstrual irregularities and endometrial pathology in morbidly obese…
- Conditions
- Morbid Obesity, Endometrial Pathology, Menstrual Irregularities
- Trial name
- NCT01473186
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Non-alcoholic Steatohepatitis, Fatty Liver
Omega 3 Fish Oil Supplements vs. Placebo for Patients With Non-alcoholic Steatohepatitis (NASH)
Nonalcoholic steatohepatitis (NASH) occurs in 2-3% of the US population and carries a 15-20% chance of progression to cirrhosis. It is closely associated with obesity, hyperlipidemia and insulin resistance.
- Trial name
- NCT00681408
- Testing
- Omega 3 Fish Oil supplements
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Virginia
Carriage of Bordetella Pertussis
Bordetella Pertussis Carriage in College-aged Students
The objective in this observational cohort study of young adults sampled at three intervals during the academic year is to ascertain if there is carriage of B. pertussis in asymptomatic individuals.
- Trial name
- NCT02215564
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Diabetes Mellitus, Type 2
Lifestyle Modification for Type 2 Diabetes Involving Reduction of After-meal Blood Glucose Elevations
The purpose of this study is to determine if a lifestyle modification program (GEM) that focuses on reducing after-meal blood glucose elevations can improve blood glucose control in people with type 2 diabetes.
- Trial name
- NCT02432391
- Testing
- GEM
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- University of Virginia
Diabetes Mellitus, Type 1
Diabetes Assistant (DiAs) Control-to-Range (CTR) Nocturnal Closed-Loop Camp Study
The primary goal is to test the function of the Diabetes Assistant (DiAs) enhanced control-to-range (CTR) controller in a closely monitored diabetes camp setting. The camp setting will allow us to obtain pilot efficacy data.
- Trial name
- NCT01973413
- Testing
- Diabetes Assistant (DiAs), Tandem t:slim Insulin Pump, Dexcom G4 Platinum sensor
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Virginia
Sinusitis
Comparison of Nasal Saline Irrigation Bottle Contamination Between Two Solutions
Rhinosinusitis is one of the most prevalent diseases within the United States and leads to decreased quality of life for patients suffering from this condition.
- Trial name
- NCT02413125
- Testing
- ChitoRhino irrigation solution, Normal saline
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Stroke
Study of Tenecteplase (TNK) in Acute Ischemic Stroke (TNK-S2B)
The purpose of this study is to determine which of 3 different doses of tenecteplase (TNK) is better for treating stroke patients and if TNK offers an advantage over currently available treatment with tissue plasminogen activator…
- Trial name
- NCT00252239
- Testing
- tenecteplase, tissue plasminogen activator, tPA
- Where
- 9 sites in United States
- Volunteers
- 112 people
- Sponsor
- University of Virginia
Muscle Cramps, Cirrhosis
Safety and Efficacy of Baclofen for Treatment of Muscle Spasms in Patients With Cirrhosis: A Pilot Study
The purpose of this study is to determine the safety and efficacy of the medication Baclofen for treatment of muscle cramps in patients with cirrhosis.
- Trial name
- NCT02298868
- Testing
- Baclofen
- Volunteers
- 10 people
- Sponsor
- University of Virginia
Melanoma
Pilot Study of Infrared Imaging of Cutaneous Melanoma
Design: this is a pilot study of infrared imaging of cutaneous lesions in patients and volunteers with and without clinically detectable melanoma, and with one or more palpable cutaneous lesions eligible for this imaging study.
- Trial name
- MEL49 (NCT00937690)
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Melanoma (Skin)
Vaccine Therapy Plus Interleukin-2 in Treating Patients With Stage III or Stage IV Melanoma
RATIONALE: Vaccines made from melanoma cells may make the body build an immune response to and kill tumor cells. Colony-stimulating factors such as GM-CSF may increase the number of immune cells found in the bone marrow or…
- Trial name
- NCT00003222
- Testing
- aldesleukin, gp100 antigen, incomplete Freund's adjuvant
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Virginia
Intraocular Melanoma, Melanoma (Skin)
Vaccine Therapy in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed By Surgery
RATIONALE: Vaccines may make the body build an immune response to kill tumor cells. PURPOSE: This phase II trial is studying how well vaccine therapy works in treating patients with stage III or stage IV melanoma that cannot be…
- Trial name
- NCT00089206
- Testing
- incomplete Freund's adjuvant, multi-epitope melanoma peptide vaccine, sargramostim
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Virginia
Intracerebral Aneursym
HydroCoil Cerebral Aneurysm Treatment Trial
The study will compare clinical and angiographic outcomes in patients receiving Hydrocoil aneurysm treatment versus patients receiving non-HydroCoil aneurysm treatment.
- Trial name
- HCAT (NCT01195129)
- Testing
- MicroVention Hydrogel coil, Non-hydrogel coils
- Where
- 11 sites in United States
- Volunteers
- 215 people
- Sponsor
- University of Virginia