Clinical trials: sponsored by University of Virginia
Chronic Kidney Disease, Secondary Hyperparathyroidism
Effects of Vitamin D on Renal Blood Flow, Proteinuria and Inflammation in Patients With Chronic Kidney Disease
Active forms of vitamin D and its analogs are used to treat elevated parathyroid hormone levels and bone disease in chronic kidney disease (CKD).
- Trial name
- NCT01426724
- Testing
- Contrast Enhanced Ultrasonography
- Where
- United States
- Sponsor
- University of Virginia
Focus is on Healthy Subjects
Validation of Pulse Wave Doppler Demodulation Algorithm for the Continuous, Non-invasive Measurement of Blood Flow Velocity
The investigators hypothesize that performance of fast-Fourier transformation on the raw Doppler signals obtained from ascending aortic blood flow will recreate the pulse wave Doppler trace visualized on modern echocardiography…
- Trial name
- NCT01750125
- Testing
- measure ascending aortic blood flow with pulse wave Doppler
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Cardiovascular Disease
Validation of Peripheral Pressure Volume Loops and Ultrasound-derived "Cardiac Power" by Comparison With Invasive Left Ventricular Pressure Volume Loops
The investigators will generate pressure-flow loops and pressure-volume loops from aortic and left ventricular pressure waveforms and Doppler (desc.
- Trial name
- NCT01750450
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Type 1 Diabetes Mellitus
Pramlintide Combined With Model Predictive Control Algorithm
This is a scientific research study that will look at how a "closed-loop" system and the drug Pramlintide may work together to improve blood sugar control in people with type 1 diabetes mellitus.
- Trial name
- ALM002 (NCT01434862)
- Testing
- Closed loop with pramlintide, Closed loop without pramlintide, Open loop with pramlintide
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Virginia
Type I Diabetes Mellitus
Accuracy of Blood Glucose Detection by Diabetes Alert Dogs
Even though there is growing interest in and use of trained Diabetes Alert Dogs (DADs) as a way to monitor blood glucose in type 1 diabetes (T1D), no scientific studies have confirmed the ability of DADs to accurately detect…
- Trial name
- NCT02126605
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Virginia
Type 1 Diabetes Mellitus
Evaluation of a Simulation-Based Educational Tool for Personalized Feedback in Insulin Therapy Management
This study combines data collection and simulation-based education, and it will enroll up to 36 adults with T1DM who already have experience with insulin pump therapy and some experience with a continuous glucose monitor (CGM).
- Trial name
- NCT01767831
- Testing
- iBOLUSED
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Virginia
Healthy
Use of Near Infrared Spectroscopy to Measure Intracranial ScvO2
The purpose of this study is to determine whether analysis of near infrared absorbance signals that occur at different frequencies might provide information about the difference in oxygen saturation between arterial and venous…
- Trial name
- NCT01746576
- Testing
- Use of impedance threshold device during spontaneous ventilation
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Bladder Cancer
Study of BCG + Aminophylline Toxicity When Used in the Treatment of Bladder Cancer
The purpose of this study is to evaluate whether a new potential treatment for non invasive bladder cancer is safe and if it leads to side effects such as irregular heart rate, agitation, or burning with urination.
- Trial name
- BCG (NCT01240824)
- Testing
- aminophylline
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Virginia
Spinal Cord Injury, Pressure Ulcers
Development and Feasibility of an Internet Intervention for Adults With Spinal Cord Injury to Prevent Pressure Ulcers
The investigators propose to test the feasibility of iSHIFTup (Internet Skin Health Intervention For Targeted Ulcer Prevention) for adults with spinal cord injury (SCI) to prevent serious pressure ulcers (PrUs) and promote…
- Trial name
- iSHIFTup (NCT01885962)
- Testing
- iSHIFTup
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Diabetes Mellitus, Type 1
Phase 2 Study of Adaptive Insulin Meal Supervisor (AIMS) in Adults With Type 1 Diabetes Mellitus
In this study, a closed-loop Adaptive Insulin Meal Supervisor system (AIMS) utilizing continuous glucose monitoring (CGM), a subcutaneous insulin pump and standard pramlintide therapy will be applied in individuals with type 1…
- Trial name
- NCT01839370
- Testing
- Closed Loop with Pramlintide
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Virginia
Hematologic Malignancies
Conditioning Treatment With Umbilical Cord Blood Transplant for Hematologic Malignancies
This is a phase II study to assess the day 180 event free and overall survival after administration of a specified combination of fludarabine, busulfan, Total Body Irradiation (TBI), and thymoglobulin reduced intensity…
- Trial name
- NCT01622556
- Testing
- Fludarabine, Busulfan, Thymoglobulin
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Virginia
Breastfeeding
Prenatal Education Video Study
A randomized, controlled trial will be conducted during which pregnant women will be randomized to receive the intervention - viewing a prenatal education video about how to breastfeed an infant - or the sham intervention …
- Trial name
- PEVS (NCT01623128)
- Testing
- Prenatal video
- Where
- 2 sites in United States
- Volunteers
- 522 people
- Sponsor
- University of Virginia
Contrast Induced Acute Kidney Injury
Monitoring Renal Blood Flow With Contrast Enhanced Ultrasound During Coronary Angiogram
Contrast induced nephropathy (CN) is a common cause of acute kidney injury and is associated with increased morbidity and mortality and healthcare cost.
- Trial name
- NCT01544036
- Testing
- perflutren
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of Virginia
Melanoma (Skin)
Paclitaxel and GM-CSF in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed By Surgery
RATIONALE: Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00278122
- Testing
- sargramostim, paclitaxel
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Virginia
Non Small Cell Lung Cancer, Chronic Obstructive Pulmonary Disease
Study of Use of CTC in NSCLC
The purpose of this study is to assess whether the detection of circulating tumor cells (CTC) could be used as a tool to earlier diagnose, more accurately predict treatment response / failure and predict overall survival in…
- Trial name
- NCT01990651
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Diabetes Mellitus, Type 1
Early Feasibility Study 2 of Outpatient Control-to-Range - Testing System Efficacy (France)
An unblinded, randomized, cross-over design with each patient participating in two 40-hour outpatient admissions: (a) Experimental involving automated Control-to-Range (CTR) and (b) Control using Continuous Glucose Monitor…
- Trial name
- NCT01742741
- Testing
- Diabetes Assistant (DiAs)
- Where
- France
- Volunteers
- 5 people
- Sponsor
- University of Virginia
Burn
Comparison of a Water-soluble Topical Antimicrobial to Silver Sulfadiazine in Partial Thickness Burns
Partial thickness burns are a common, painful injury requiring a great deal of resources in their care. Silver sulfadizine is a commonly-used topical antimicrobial, but is difficult to remove due to its lipid base.
- Trial name
- NCT01926392
- Testing
- water-soluble therapy, silver sulfadiazine
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Virginia
Aging
Effect of Fasting on Ghrelin and Growth Hormone in Healthy Young and Older Adults
The overall objective of this study is to determine the extent to which circulating ghrelin levels (total and bioactive ghrelin) are regulated by nutritional state and age.
- Trial name
- NCT01922973
- Testing
- Fasting
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Line Insertion Site, Central Line-associated Bloodstream Infection (CLABSI)
Umbilical Cord Care for the Prevention of Colonization
Umbilical catheters are necessary for many infants admitted to the Newborn Intensive Care Unit (NICU)and utilized when indicated for up to 7 to 14 days.
- Trial name
- NCT01893060
- Testing
- Povidone-Iodine, Chlorhexidine gluconate, Pluronic Cream
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Virginia
Multiple Myeloma
Autologous Stem Cell Transplantation and Maintenance Therapy for Multiple Myeloma
This trial will determine the feasibility and efficacy of lenalidomide as maintenance therapy in Multiple Myeloma patients treated with dose intensive chemotherapy (Melphalan 200 mg/m2) with autologous PBSC transplant.
- Trial name
- AMM-2011 (NCT01617213)
- Testing
- Melphalan, Lenalidomide
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Virginia