Clinical trials: sponsored by University of Virginia
Sepsis
Impact of Heart Rate Characteristics Monitoring in Neonates
Hypothesis: Fewer neonates managed using information from heart rate characteristics (HRC) will require intubation and mechanical ventilation as a result of sepsis and sepsis-like illness.
- Trial name
- HeRO (NCT00307333)
- Testing
- HeRO heart rate characteristics monitor
- Where
- 8 sites in United States
- Volunteers
- 3,003 people
- Sponsor
- University of Virginia
Cardiovascular Diseases
Plethysmography as a Useful Intraoperative Monitor
Data from both the traditional invasive cardiac monitors and the Nonin will be collected simultaneously. The investigators will analyze Nonin data for peak and trough variation with respiration, area under the curve, time from…
- Trial name
- NCT01843244
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Virginia
Breast Cancer
Vaccine Therapy in Treating Patients With Stage III or Stage IV Breast Cancer
RATIONALE: Vaccines made from peptides may help the body build an effective immune response to kill tumor cells. Giving booster vaccinations may make a stronger immune response and kill more tumor cells.
- Trial name
- NCT00304096
- Testing
- synthetic breast cancer peptides-tetanus toxoid-Montanide ISA-51 vaccine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Virginia
Gastroesophageal Reflux, Apnea
Study of Erythromycin in GER-Associated Apnea of the Newborn
To evaluate the relationship of reflux and apnea and to determine whether the administration of erythromycin improves the incidence of GER and GER-associated apnea, bradycardic and/or desaturation events in a prospective…
- Conditions
- Gastroesophageal Reflux, Apnea, Bradycardia
- Trial name
- SEGAN (NCT01825473)
- Testing
- Erythromycin, Multi-channel intra-luminal impedance (MII) pH monitoring
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Breast Cancer, Osteoporosis
Letrozole With or Without Zoledronate in Treating Healthy Postmenopausal Women With High Breast Density
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming, growing, or coming back. Estrogen can cause the growth of breast cancer cells.
- Trial name
- NCT00114270
- Testing
- letrozole, zoledronic acid
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Virginia
Healthy
Study of Glucagon, Ghrelin and Growth Hormone as Counterregulatory Hormones
Glucagon has been used for decades as a test of growth hormone (GH) reserve. The pathway by which GH is stimulated by glucagon is not established.
- Trial name
- NCT01795235
- Testing
- Saline, Glucagon, Atenolol
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Restless Legs Syndrome
Safety and Efficacy of Rasagiline in Restless Legs Syndrome
The purpose of this study is to find out if rasagiline improves RLS symptoms. We also want to make sure rasagiline is safe to give people with RLS.
- Trial name
- RAS-RLS (NCT01192503)
- Testing
- rasagiline
- Where
- 8 sites in United States
- Volunteers
- 52 people
- Sponsor
- University of Virginia
Hyperglycemia, Hypoglycemia
Pilot Study of Intensive Care Unit Continuous Glucose Monitoring
The investigators believe that there remains a gap in implementing insulin infusions in critically ill patients to maximize the benefit and minimize adverse events like episodes of hypoglycemia.
- Trial name
- NCT01301053
- Testing
- Current UVA intensive care insulin protocol, Current UVA intensive care insulin protocol with "brakes"
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Virginia
Hypertension
Effect of Gene Variants on Dopamine Receptor Natriuretic Responses
Hypothesis to be tested: Dopamine D1-like receptor-induced natriuresis is impaired in humans with G protein-related kinase 4 gene variants.
- Trial name
- NCT00592150
- Testing
- fenoldopam
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Diabetes Mellitus, Type 1
Blood Glucose Awareness Training for Parents
The purpose of this study is to test a training program for parents of children with T1DM.
- Trial name
- NCT00315991
- Testing
- Blood Glucose Awareness Training for Parents
- Where
- 2 sites in United States
- Volunteers
- 77 people
- Sponsor
- University of Virginia
Neurodevelopmental Outcomes
Neurodevelopmental Outcomes and Fluconazole Prophylaxis
The purpose of this study is to compare the neurodevelopmental outcome and quality of life between the fluconazole-treated and the placebo-treated patients that were enrolled in a fluconazole prophylaxis study that occurred in…
- Trial name
- NDFP (NCT00975949)
- Testing
- Survey
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Virginia
Premature Birth of Newborn
Premature Infant Exposure to Noise Generated by Respiratory Support
Infants in neonatal intensive care units are increasing exposed to non-invasive ventilatory support modes (nasal continuous positive airway pressure - NCPAP and high flow nasal cannula: >1 L/min flow - HFNC).
- Trial name
- NCT01748214
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Virginia
Type 1 Diabetes Mellitus
Feasibility Study of a Portable Artificial Pancreas System in Type 1 Diabetes Mellitus (T1DM) - Montpellier
A single arm, single treatment study is proposed to assess the feasibility of a portable artificial pancreas system outside of a hospital based clinical research center.
- Trial name
- HomeCTR1_1 (NCT01447979)
- Testing
- portable artificial pancreas system with Control-To-Range algorithms
- Where
- France
- Volunteers
- 5 people
- Sponsor
- University of Virginia
Type 1 Diabetes Mellitus
Pilot Study 1 of Outpatient Control-to-Range - System and Monitoring Testing
A single arm, single treatment study is proposed to assess the feasibility of a portable artificial pancreas system outside of a hospital based clinical research center.
- Trial name
- NCT01470807
- Testing
- portable artificial pancreas system with CTR algorithms
- Where
- Italy
- Volunteers
- 5 people
- Sponsor
- University of Virginia
Neonatal Infection, Neonatal Necrotizing Enterocolitis
Study to Determine if Gloving in Addition to Hand Hygiene Will Prevent Invasive Infections and Necrotizing Enterocolitis
The purpose of this study is to compare the additional use of gloves (with handwashing before and after gloving) for all patient contact while infants have intravenous (central or peripheral) access in a RCT.
- Trial name
- NCT01729000
- Testing
- Gloves
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- University of Virginia
Retinopathy of Prematurity
Time Outside Target Oxygen Saturation Range in Preterm Infants and Long Term Outcomes and Preterm Infants
The purpose of this study is to determine if there is a relationship between time spent out the targeted oxygen saturation range in preterm infants is associated with long-term outcomes such as Retinopathy of Prematurity.
- Trial name
- SAT01ROP (NCT00845624)
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Nicotine Withdrawal, Marijuana Dependence
Medications Development for the Treatment of Cannabis Related Disorders
The primary objective of this application is to test the neurobehavioral mechanisms and effects of aprepitant as a new cessation agent for cannabis, tobacco or both.
- Conditions
- Nicotine Withdrawal, Marijuana Dependence, Cannabis Dependence, Nicotine Dependence
- Trial name
- MTC (NCT01204723)
- Testing
- Active Aprepitant
- Where
- 2 sites in United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Alcohol-induced Cue-craving, Alcohol Sensitivity
A Gene by Medication Interaction to the Acute Effects of Alcohol
Alcohol dependence, or "alcoholism", affects approximately 14 million Americans. Currently, only three pharmacotherapies (disulfiram, naltrexone, and acamprosate) have been approved for the treatment of alcohol dependence and…
- Trial name
- ATX (NCT01343628)
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Myocardial Infarction, Heart Failure
Randomized Controlled Cluster Trial of Resident Pay for Performance and Cardiovascular Outcomes
The purpose of this study is to determine if a pay for performance model in contrast to the traditional "fee for service" model may improve the number of patients discharged being treated in accordance with Joint Commission on…
- Trial name
- NCT01590290
- Testing
- financial compensation
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Virginia
Encopresis
Internet Intervention for Childhood Encopresis
This study will evaluate the effectiveness of an Internet intervention designed to reduce the behaviors and symptoms of pediatric encopresis.
- Trial name
- NCT00767403
- Testing
- Internet Intervention + Stepped Care, Internet Intervention, Patient Education Website
- Where
- United States
- Volunteers
- 290 people
- Sponsor
- University of Virginia