Clinical trials: sponsored by University of Virginia
Sleep Initiation and Maintenance Disorders
Effectiveness of Internet Cognitive Behavioral Therapy Intervention for Treating Insomnia
This study will evaluate the effectiveness of an online cognitive behavioral therapy intervention in improving sleep, mood, and cognitive functioning in people with insomnia.
- Trial name
- NCT00328250
- Testing
- Cognitive behavioral treatment (CBT) delivered over the Internet
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Virginia
Coronary Artery Disease
IRB-HSR# 14296 The Use of the Intrathoracic Pressure Regulator (ITPR) to Improve Systemic Blood Pressure in Patient Undergoing CABG Surgery
Briefly, after the induction of anesthesia and the placement of TEE, hemodynamic variables (pulmonary and systemic blood pressure, central and pulmonary venous pressure, cardiac output, calculated SVR, etc.) will be collected.
- Trial name
- NCT01205594
- Testing
- ITPR
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Virginia
Cushing's Disease
Preoperative Bexarotene Treatment for Cushing's Disease
The objective of this pilot study is to establish the safety and tolerability of short-term therapy with bexarotene in patient's with Cushing's disease, and study the clinical, biochemical, and cellular effects of a preoperative…
- Trial name
- NCT00845351
- Testing
- Bexarotene
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Virginia
Ankle Sprain
Effects of Talocrural Joint Mobilizations in the Treatment of Subacute Lateral Ankle Sprains
The goal is to determine if standard therapy including joint mobilizations of the ankle performed 3 times per week for 2 weeks will increase self-reported function and decrease pain in patients with mild lateral ankle sprains.
- Trial name
- NCT01117909
- Testing
- Mobilization therapy in addition to standard therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Virginia
Type 2 Diabetes, Microvascular Dysfunction
Less Invasive Detection and Treatment of Very Early Coronary Artery Disease in Patients With Diabetes Mellitus
This protocol focuses on the development of a noninvasive method of early coronary artery disease detection in diabetes. The overall hypothesis is that risk factors for the metabolic syndrome will predict invasive findings on…
- Trial name
- NCT00797186
- Testing
- Intensive risk factor management
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Virginia
Lateral Ankle Sprain
The Effects of Gentle Movements at the Ankle in Individuals With Diminished Range of Motion
The purpose of this study is the examine the effects of gentle movements applied to the ankle joint and stretching on self-reported function, ankle motion and stiffness in individuals who have suffered from an ankle sprain within…
- Trial name
- NCT01119092
- Testing
- Grade IV AP joint mobilizations
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Virginia
Cancer of the Cervix
Cetuximab, Cisplatin, and Radiotherapy in Women With Locally Advanced Cervical Carcinoma
The anti-tumor activity of cetuximab prior to chemoradiotherapy and the safety and tolerability of cetuximab with concurrent chemoradiation will be determined in women with locally advanced or metastatic cervical carcinoma.
- Trial name
- NCT00292955
- Testing
- Cetuximab
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Virginia
Central Lines in ICU Patients
Ethanol Lock for Prevention of Central Line-Associated Blood Stream Infections
Vascular access via central venous lines (CVL) is essential to the care of many patients in the intensive care setting. While the value of these lines for the management of critically ill patients is generally accepted, the…
- Trial name
- NCT01344590
- Testing
- Normal Saline, Ethanol 70% pharmaceutical grade
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Virginia
Amphetamine Dependence
Dose Response of Mirtazapine to Methamphetamine Induced Interest, Mood Elevation and Reward
The primary purpose of this study is to determine if Mirtazapine will produce a decrease in interest in the drug, a decrease in mood elevation, and/or a decrease in reward when given before methamphetamine compared to placebo.
- Trial name
- NCT00600145
- Testing
- Mirtazapine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Virginia
Inflammatory Bowel Disease
Non-invasive Imaging of GI Inflammation Using Microbubble Contrast Enhanced Ultrasonography
Inflammatory bowel disease (IBD) is a common chronic inflammatory disorder, but a noninvasive method of assessing disease location, severity, and extent is currently not available.
- Trial name
- NCT00591669
- Testing
- Definity
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Virginia
Pancreatic Cancer
Radiotherapy With Chemotherapy as Neoadjuvant Therapy of Resectable and Borderline Resectable Pancreas Cancer
The purpose of this study is to determine safety and to obtain preliminary estimates of the rate of major pathologic response of neoadjuvant accelerated fraction, standard dose radiation given with chemotherapy in patients with…
- Trial name
- NCT01333332
- Testing
- Capecitabine, Standard Dose Acclerated Fraction Radiotherapy
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Virginia
Gastroesophageal Reflux
Serial Exhaled Breath pH Monitoring
This study will seek to determine the amount of acids a person with a chronic cough that is suspected to be related to acid reflux breathes out after coughing.
- Trial name
- NCT00330603
- Testing
- Serial exhaled breath collections
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- University of Virginia
Diarrheal Disorder
Long-term Impact and Intervention for Diarrhea in Brazil
The primary objectives of this study are to determine the effect of 1 year supplementation of Vitamin A, Zinc, and Vitamin A plus Zinc compared to placebo on the Height for Age Z Score (HAZ) and the number of episodes of diarrhea…
- Trial name
- NCT00133406
- Testing
- Glutamine, Vitamin A, glycine
- Where
- Brazil
- Volunteers
- 321 people
- Sponsor
- University of Virginia
Crohn's Disease
Pravastatin Therapy in Patients With Active Crohn's Disease: A Pilot Study
The primary objective of this study is to provide data regarding clinical and immunologic activity of oral doses of pravastatin 80mg administered daily for 6 consecutive weeks, for the treatment of active Crohn's disease as shown…
- Trial name
- NCT00599625
- Testing
- Pravastatin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Virginia
Rupture of Anterior Cruciate Ligament
Quadriceps Function Prior to Anterior Cruciate Ligament Reconstruction
Patients who are diagnosed with an isolated tear of the anterior cruciate ligament and scheduled for arthroscopic reconstruction using bone-patellar tendon-bone autograft will be recruited to participate.
- Trial name
- NCT00971451
- Testing
- cryotherapy, TENS
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Virginia
Melanoma
Trial for the Evaluation of the Effect of Systemic Low-dose Interleukin-2 (IL-2) on the Immunogenicity of a Vaccine Comprising Synthetic Melanoma Peptides Administered With Granulocyte-macrophage Colony-stimulating Factor (GM-CSF)-In-Adjuvant, in Patients With High Risk Melanoma
This clinical pilot study will test the hypothesis that systemic low-dose IL-2 therapy significantly enhances the immunologic efficacy of a vaccine comprising melanoma peptides plus GM-CSF-in-adjuvant.
- Trial name
- MEL36 (NCT00928902)
- Testing
- low-dose IL-2, melanoma vaccine
- Volunteers
- 41 people
- Sponsor
- University of Virginia
Traumatic Brain Injury
IRB-HSR# 14299: The Use of the Intrathoracic Pressure Regulator (ITPR) to Improve Cerebral Perfusion Pressure in Patients With Altered Intracranial Elastance
Patients who have a functioning intracranial pressure-monitoring device (either a subarachnoid bolt, or an intraventricular catheter) in place, and are either sedated, intubated, and mechanically ventilated (i.e.
- Trial name
- NCT01205607
- Testing
- ITPR -5 mm Hg then -9 mm Hg, ITPR -9 & then -5mm Hg
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Virginia
CABG
IRB-HSR# 15084 A Prospective, Unblinded, Controlled Study to Evaluate the Effect of the ITPR in Patients Undergoing OPCAB Surgery
Participants undergoing Off-CABG will be randomized 1:1 to one of the following groups: treatment with CirQlator TM Intrathoracic Pressure Regulator (ITPR) no ITPR .Anesthesia will be standardized for both groups.
- Trial name
- NCT01205620
- Testing
- ITPR, No intervention
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Virginia
Knee Pain, Hip Pain
Effects of Lumbosacral Joint Mobilization/Manipulation on Lower Extremity Muscle Neuromuscular Response
The purpose of this study is to gain a better understanding of the effects of lumbopelvic manual therapy on lower extremity biomechanics and arthrogenic muscle response.
- Conditions
- Knee Pain, Hip Pain, Ankle Pain, Lumbopelvic Pain
- Trial name
- NCT00601341
- Testing
- lumbosacral joint manipulation, lumbar passive range of motion, No active intervention
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Ankle Sprain, Ankle Injuries
Effects of Proximal and Distal Tibiofibular Joint Manipulation on Lower Extremity Muscle Activation, Ankle Range of Motion, and Functional Outcome Scores in Individuals With Chronic Ankle Instability
The overall aim of this project is to determine the effect of a tibiofibular joint manipulation on the neuromuscular response of the fibularis longus and soleus muscles in individuals with chronic ankle instability.
- Conditions
- Ankle Sprain, Ankle Injuries, Sprain
- Trial name
- NCT00601471
- Testing
- proximal tibiofibular manipulation, distal tibiofibular manipulation, no intervention
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- University of Virginia