Clinical trials: sponsored by University of Virginia
Cryptosporidiosis
Cryptosporidiosis and Enteropathogens in Bangladesh
The purpose of this study is to explore the role of anti-parasite antibody in protection of children from the parasitic infection cryptosporidiosis.
- Trial name
- NCT02764918
- Where
- Bangladesh
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Type 1 Diabetes, Hyperglycemia, Postprandial
Effect of Postprandial Hyperglycemia on Vasculature in Type 1 Diabetes and Healthy Adults
To the investigator's knowledge, there are no data available in the current literature regarding the acute effects of postprandial hyperglycemia and insulin timing on myocardial perfusion in people with type 1 diabetes (T1D).
- Trial name
- WBH001 (NCT04730882)
- Testing
- Mixed Meal
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Normal, PCOS
Determining How Quickly Progesterone Slows LH Pulse Frequency
The rapidity with which progesterone (P) suppresses daytime lutenizing hormone (LH) (and by inference gonadotropin releasing hormone (GnRH)) pulse frequency is unknown.
- Trial name
- CRM001 (NCT00594217)
- Testing
- oral micronized progesterone suspension
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Identify Postoperative Delirium Using Exhaled Gas Patterns
Organic Compounds and Postoperative Delirum
This study involves collecting exhaled breath containing hundreds of volatile organic compounds (VOCs) that are present in very low quantity (parts per billion).
- Trial name
- NCT05875220
- Testing
- No intervention
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Concussion, Intermediate
Magnesium and Riboflavin Treatment for Post-Concussion Headache
This clinical trial will try to determine if the supplements magnesium and riboflavin will reduce the pain and duration of headaches in persons diagnosed with a concussion.
- Trial name
- NCT06260072
- Testing
- magnesium and riboflavin supplement
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- University of Virginia
Alzheimer Disease, Gut Biome
Gut Microbiome and Blood Indices in Patients With AD and Their Spousal Caregivers
Spousal caregivers of Alzheimer's Dementia (AD) patients have an elevated risk of developing AD in the future. Past studies have shown the presence of serum indicators correlated with gut biome dysfunction in AD patients.
- Trial name
- NCT05601856
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Cervical Cancer
A Randomized Study to Compare a Hydrogel Packing System to Standard Packing During HDR Brachytherapy for Cervical Cancer
In this study, a new, low cost packing system ("BrachyGel VHPS") is being tested as a packing option during brachytherapy along with standard options to make sure that it keeps the unrelated organs away from radiation at least as…
- Trial name
- NCT04499521
- Testing
- BrachyGel VHPS
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Virginia
Glioblastoma, Glioblastoma Multiforme
Phase I EGFR BATs in Newly Diagnosed Glioblastoma
This is a phase I trial using EGFR Bi-armed Activated T-cells (BATs) in combination with standard of care temozolomide (TMZ) and radiation (RT) in patients with glioblastoma (GBM).
- Trial name
- NCT03344250
- Testing
- EGFR BATs with TMZ following SOC RT/TMZ, Weekly EGFR BATs following SOC RT/TMZ
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Virginia
Smoking Cessation
Establishing the Effectiveness of Publicly Available Smoking Cessation Resource
The purpose of this study is to evaluate the effectiveness of SmokefreeTXT, a smoking cessation text messaging program currently available to anyone in the United States through www.smokefree.gov, and to compare cessation…
- Trial name
- NCT05055778
- Testing
- SmokefreeTXT
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Anxiety
Web-based Interpretation Training For Anxiety
The study aims to develop a web-based Cognitive Bias Modification infrastructure to train interpretations, and evaluate the usability, acceptability, and feasibility of the program to reduce anxiety symptoms.
- Trial name
- NCT02382003
- Testing
- Positive Cognitive Bias Modification - Interpretation, 50/50 Cognitive Bias Modification - Interpretation, Anxious Imagery Prime
- Where
- United States
- Volunteers
- 807 people
- Sponsor
- University of Virginia
Anxiety
Interpretation Training to Reduce Anxiety: Evaluating Technology-based Delivery Models and Methods to Reduce Attrition
The project aims to compare effectiveness and target engagement of CBM-I delivered via computer vs. mobile phone, and test if adding minimal human contact for participants at risk of dropout improves retention and outcomes.
- Trial name
- NCT03498651
- Testing
- Cognitive Bias Modification - Interpretation training, Coaching, Online psychoeducation about anxiety
- Where
- United States
- Volunteers
- 1,748 people
- Sponsor
- University of Virginia
Atopic Dermatitis, Allergy
Bathing Babies and Allergy
Atopic dermatitis (AD) is a chronic allergic skin disease with onset in early childhood and increasing prevalence in Westernized countries. Current well newborn guidelines for washing babies with soap were adopted by U.S.
- Trial name
- BBA (NCT03050658)
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Pulmonary Disease, Chronic Obstructive
The ROAM Research Study Therapy (LTOT) Version
The purpose of this research is to test a device being developed that can see how patients use oxygen therapy over a long period of time.
- Trial name
- ROAM (NCT06810323)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Virginia
Cholangiocarcinoma
Cell-Surface Plectin in the Diagnosis of Cholangiocarcinoma from ERCP-directed Biliary Samples
Cholangiocarcinoma is a malignancy that is most-often diagnosed with ERCP-directed cytology brushings of the biliary tree, but the yield on this cytology has been previously shown to only be 5%-40%.
- Trial name
- NCT06651346
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Virginia
Hypertension
Pharmacokinetics of Berkeley Life Oral Nitrate Supplementation
The purpose of the study is to examine the way that a nitric oxide supplement moves through the body. Specifically, the relationship between saliva and blood concentration of the supplement and the elapsed time since taking the…
- Trial name
- NCT06777108
- Testing
- Inorganic Nitrate
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Virginia
Gestational Diabetes
GDM: Insulin with or Without Metformin?
This will be a randomized trial of patients with gestational diabetes who start hypoglycemic therapy with metformin but eventually require insulin.
- Trial name
- NCT06781775
- Testing
- Metformin + Insulin, Insulin
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of Virginia
Gestational Diabetes
Fetal Cardiac Function Parameters and HbA1c As Screening for Gestational Diabetes Mellitus
This is a prospective cohort study to assess the predictive value of fetal cardiac parameters, the change in fetal cardiac parameters (CFP), HbA1c, and/or the change in HbA1c (ΔHbA1c) for gestational diabetes.
- Trial name
- NCT05019508
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Preeclampsia, Pregnancy Related
Low Dose Aspirin for Preterm Preeclampsia Preventionmg/day Dose in High-risk Patients
This will be a randomized, open-label, controlled trial of patients at high risk of developing preeclampsia examining 81 mg/day vs 162mg/day daily acetylsalicylic acid (ASA) use.
- Trial name
- NCT05514847
- Testing
- Aspirin 81Mg Ec Tab, Aspirin 162Mg Ec Tab
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Huntington Disease, Parkinson Disease
Measurement and Modification of Threat Interpretation Bias in Neurodegenerative Movement Disorders (Aims 2 & 3)
The purpose of this study is conduct a pilot open trial of a web-based cognitive bias modification intervention to reduce anxiety symptoms in persons with Huntington's disease and persons with Parkinson's disease.
- Trial name
- NCT05126862
- Testing
- MindTrails
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Virginia
Bladder Cancer, Non-muscle-invasive Bladder Cancer
Pre-Habilitation with Mindfulness and Exercise for Patients Undergoing Radical Cystectomy (PRIMER Trial)
The PRIMER (Pre-Habilitation With Mindfulness and Exercise for Patients Undergoing Radical Cystectomy) trial is a pilot designed to estimate the feasibility of integrating a home-based pre-operative exercise and mindfulness…
- Conditions
- Bladder Cancer, Non-muscle-invasive Bladder Cancer, Muscle-Invasive Bladder Carcinoma
- Trial name
- PRIMER (NCT05790850)
- Testing
- Pre-operative physical exercise, Pre-operative mindfulness meditation practice
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Virginia