Clinical trials: sponsored by University of Washington
Depression, Anxiety
Group Retreat Psilocybin Therapy for Healthcare Clinicians With Loss of Meaning in Their Work and Symptoms of Depression
In this single-arm Phase 2 study, the researchers are assessing the feasibility of the group retreat format for clinicians and explores different 'doses' of preparation. A sequential dose-escalation design is used.
- Trial name
- NCT07565909
- Testing
- Psilocybin
- Volunteers
- 72 people
- Sponsor
- University of Washington
Hiv
Systems Analysis and Improvement Approach to Improve Integration of HIV Prevention and Treatment Services
East and Southern Africa is home to 6.2% of the world's population but includes 54% of all people living with HIV (PLWH). In this region, three out of five PLWH are women, and there is a particularly high burden of HIV amongst…
- Trial name
- FP HIV SCALE (NCT05404958)
- Testing
- Systems Analysis and Improvement Approach (SAIA)
- Where
- Kenya
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Washington
Down Syndrome, Gross Motor Delay
Up, Down, and All Around: Evaluating Mobility Devices for Young Children With Developmental Disabilities and Delays
This research study will examine young children with Down syndrome's initial experiences with mobility devices. Children's biomechanics and exploration will be quantified while they are using both an overground partial bodyweight…
- Conditions
- Down Syndrome, Gross Motor Delay, Cerebral Palsy
- Trial name
- NCT06591559
- Testing
- Permobil Explorer Mini, Portable Mobility Aid for Children (PUMA)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Washington
HER2-positive Breast Cancer
Multiparametric MRI for Assessing Breast Cancer Response to Anti-HER2 Therapy
This is a single institution, observational research study in which patients are observed using DWI/DCE MRI imaging before and after receiving neoadjuvant anti-HER2 therapy.
- Trial name
- NCT03738553
- Testing
- MRI, Trastuzumab
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Washington
Transgender Persons
Effect of Testosterone Treatment on Drug Metabolism and Transport
This project will evaluate the effect of gender-affirming testosterone treatment on how other medications are processed by the body.
- Trial name
- NCT05116293
- Testing
- Midazolam oral solution, Digoxin Oral Tablet, Acetaminophen Oral Tablet
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Washington
Discrimination, Racial, Communication
PRISM Race and Communication Pilot RCT
This is a pilot randomized trial of 60 patients to test feasibility, acceptability and efficacy of PRISM to improve resilience and facilitate improved patient-clinician communication in racially minorities patients with serious…
- Conditions
- Discrimination, Racial, Communication, Chronic Illness, Bias, Racial
- Trial name
- NCT04915079
- Testing
- Promoting Resilience in Stress Management (PRISM)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Washington
Medication-related Osteonecrosis of the Jaw, Bisphosphonate-related Osteonecrosis of the Jaw
Pentoxifylline and Tocopherol (PENTO) in the Treatment of Medication-related Osteonecrosis of the Jaw (MRONJ)
The overall purpose of this project is to answer the following clinical question: Among Medication-Related Osteonecrosis of the Jaw (MRONJ) patients, do those who are treated with the Pentoxifylline and Tocopherol (PENTO) regimen…
- Conditions
- Medication-related Osteonecrosis of the Jaw, Bisphosphonate-related Osteonecrosis of the Jaw, Avascular Necrosis
- Trial name
- NCT03040778
- Testing
- Pentoxifylline, Tocopherol
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Washington
HIV-1-infection, HIV Disease Progression
Comparing Immune Activation and Latent HIV Reservoir Size Between People Living With HIV on Tenofovir-containing Versus NRTI-free ART
The goal of the project is to determine the difference in immune activation and HIV reservoir size between People living with HIV (PWH) on tenofovir-containing antiretroviral therapy (ART) versus PWH on nucleoside reverse…
- Conditions
- HIV-1-infection, HIV Disease Progression, Inflammation, HIV
- Trial name
- NCT05584397
- Testing
- Venipuncture, Targeted physical medical exam, Urine pregnancy test
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Washington
PTSD, Physical Injury
A Deployment Focused Pragmatic Trial of Optimal Stepped Care Intervention Targeting PTSD and Comorbidity for Acutely Hospitalized Injury Survivors Treated in US Trauma Care Systems
This investigation is a randomized pragmatic trial of a brief stepped care intervention delivered from an acute care medical trauma center that may both reduce the symptoms of posttraumatic stress disorder (PTSD) and diminish…
- Trial name
- TSOS 8 (NCT05632770)
- Testing
- Stepped Collaborative Care, American College of Surgeons (ACS) Required Screening and Referral (Usual Care)
- Where
- United States
- Volunteers
- 424 people
- Sponsor
- University of Washington
Endometrial Cancer
Social Interventions for Support During Treatment for Endometrial Cancer and Recurrence
The SISTER study is a randomized trial, looking at various modalities of social support for Black patients undergoing treatment for endometrial cancer.
- Trial name
- SISTER (NCT04930159)
- Testing
- Facilitated group support, 1:1 Peer Support
- Where
- 11 sites in United States
- Volunteers
- 252 people
- Sponsor
- University of Washington
Dementia, Mild, Depression
Decision Making Tool for Firearm Storage
This is a one-arm pilot study testing the feasibility and acceptability of a decision aid about safe firearm storage.
- Trial name
- NCT06382194
- Testing
- Decision aid
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Washington
Muscle Invasive Bladder Carcinoma, Stage II Bladder Cancer AJCC v8
Sacituzumab Govitecan Before Radical Cystectomy for the Treatment of Non-Urothelial Muscle Invasive Bladder Cancer
This phase II trial tests whether sacituzumab govitecan given before radical cystectomy works in treating patients with non-urothelial bladder cancer.
- Conditions
- Muscle Invasive Bladder Carcinoma, Stage II Bladder Cancer AJCC v8, Stage IIIA Bladder Cancer AJCC v8
- Trial name
- NCT05581589
- Testing
- Lymphadenectomy, Radical Cystectomy, Sacituzumab Govitecan
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Washington
Chronic Pain
Adapting and Implementing a Nurse Care Management Model to Care for Rural Patients With Chronic Pain
Chronic pain affects over 20% U.S. adults and has debilitating effects on quality of life and physical and mental health. Individuals living in rural communities experience higher rates of chronic pain as well as poorer health…
- Trial name
- AIM-CP (NCT06407115)
- Testing
- Cognitive Behavioral Therapy (CBT), Exercise Counseling and tele-EnhanceFitness, Care Coordination
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- University of Washington
Heart Arrest, Implantable Defibrillator User
Effectiveness of Exercise After an ICD
This study will test an exercise intervention (E-ICD) following an implantable cardioverter defibrillator.
- Conditions
- Heart Arrest, Implantable Defibrillator User, Physical Activity
- Trial name
- E-ICD (NCT03544489)
- Testing
- E-ICD Intervention
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- University of Washington
Acute Kidney Failure, Acute Kidney Insufficiency
Kidney Precision Medicine Project (KPMP) - COVID-19 Protocol
Since its inception, KPMP has developed sophisticated protocols for collection and analysis of human kidney tissue, and for collection of biofluids.
- Conditions
- Acute Kidney Failure, Acute Kidney Insufficiency, Acute Renal Failure, Acute Renal Injury
- Trial name
- NCT05384899
- Where
- 4 sites in United States
- Volunteers
- 90 people
- Sponsor
- University of Washington
Mental Health, Health Services
BASIS Optimization
The objective of the BASIS R34 pilot study is to test the impact of eBASIS in a randomized controlled trial (RCT). Consistent with IMPACT's IQM, the study tests effects of eBASIS on treatment fidelity and youth outcomes, compared…
- Conditions
- Mental Health, Health Services, Evidence Based Programs in Schools
- Trial name
- BASIS R34 (NCT06672835)
- Testing
- eBASIS, eAttention Control
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Washington
Alcohol Drinking, Tobacco Use
Journey of Transformation Curriculum for Native American Youth
The investigators will conduct a waitlist control trial to test the efficacy of the Journey of Transformation-Native Youth Health Leadership Program (JOT) in terms of delaying or reducing tobacco and other substance use and…
- Conditions
- Alcohol Drinking, Tobacco Use, Substance Use, Sexual Behavior
- Trial name
- JOT (NCT05731713)
- Testing
- Journey of Transformation-Native Youth Health Leadership Program curriculum
- Where
- United States
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- University of Washington
Mild Traumatic Brain Injury; Concussion
CORE (Cognitive Optimization Through Rehabilitation and Education) Study
Mild traumatic brain injury (mTBI) affects millions of individuals worldwide every year. It has long been thought that the vast majority of individuals who sustain a mTBI experience natural recovery with little or no intervention…
- Trial name
- CORE (NCT06859996)
- Testing
- Tools for Rehabilitation and Cognitive Care (On-TRACC), Brain Health psychoeducation
- Where
- 2 sites in United States
- Volunteers
- 354 people
- Sponsor
- University of Washington
Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma
Clonal Hematopoiesis and Therapy-Emergent Myeloid Neoplasms in Patients With Cancers, CHANCES Study
This study is being done to investigate clonal hematopoiesis and therapy-emergent myeloid neoplasms in patients with ovarian or other solid cancers.
- Conditions
- Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma, Recurrent Primary Peritoneal Carcinoma, Recurrent Malignant Solid Neoplasm
- Trial name
- NCT06295965
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- University of Washington
Acute Biphenotypic Leukemia, Acute Myeloid Leukemia
Venetoclax and CLAG-M for the Treatment of Acute Myeloid Leukemia and High-Grade Myeloid Neoplasms
This phase I/II trial finds the best dose, side effects and how well giving venetoclax in combination with cladribine, cytarabine, granulocyte colony-stimulating factor, and mitoxantrone (CLAG-M) in treating patients with acute…
- Conditions
- Acute Biphenotypic Leukemia, Acute Myeloid Leukemia, Mixed Phenotype Acute Leukemia, Myeloid Neoplasm
- Trial name
- NCT04797767
- Testing
- Cladribine, Cytarabine, Mitoxantrone
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Washington
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