Clinical trials: sponsored by University of Washington
Multiple Sclerosis
Coping and Adjusting to Living With Multiple Sclerosis
The purpose of this project is to test a brief, telephone-based psychological intervention, CBT-UT, to improve the ability to tolerate uncertainty-and thereby to reduce distress-in people with a recent diagnosis of Multiple…
- Trial name
- CALMS (NCT04300816)
- Testing
- CBT for Uncertainty Tolerance, Traditional CBT
- Where
- United States
- Volunteers
- 242 people
- Sponsor
- University of Washington
Opioid-use Disorder, Emergency Department
Emergency Department Longitudinal Integrated Care
The overarching goal of this investigation is to develop and determine the feasibility of a multi-component intervention adapted from a collaborative care framework initiated in the ED for patients at risk for opioid use…
- Trial name
- ED-LINC (NCT03699085)
- Testing
- ED-LINC
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Washington
Nephrolithiasis
The Use of Belladonna and Opium Suppository in the Treatment of Postoperative Stent Pain
The purpose of this study is to determine if preemptive B\&O suppository placement will decrease post-operative pain in patients undergoing ureteral stent placement.
- Trial name
- B&O (NCT03332056)
- Testing
- Belladonna and Opium
- Volunteers
- 71 people
- Sponsor
- University of Washington
Locally Advanced Lung Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8
ADMIRAL Trial: Adaptive Mediastinal Radiation With Chemo-Immunotherapy
This phase II trial studies two questions in patients with stage III NSCLC: 1) does it improve cancer control to add the drug Durvalumab, a type of immunotherapy, earlier in the treatment course; and 2) by intensifying treatment…
- Conditions
- Locally Advanced Lung Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8, Stage IIIA Lung Cancer AJCC v8, Stage IIIB Lung Cancer AJCC v8
- Trial name
- NCT04372927
- Testing
- Cisplatin, Durvalumab, Etoposide
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Washington
Metastatic Head and Neck Squamous Cell Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma
Durvalumab, Tremelimumab and Hypofractionated Radiation Therapy in Treating Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
This phase I/II trial studies the side effects of durvalumab, tremelimumab and hypofractionated radiation therapy in treating patients with head and neck squamous cell carcinoma that has come back (recurrent) or that has spread…
- Trial name
- NCT03522584
- Testing
- Durvalumab, Laboratory Biomarker Analysis, Stereotactic Body Radiation Therapy
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Washington
PTSD
A Scalable, Community-based Program for War and Refugee Trauma
In low and middle-income countries, access to state-of-the-art mental health care is often limited. Islamic Trauma Healing (ITH) is a manualized mosque-based, lay-led group intervention aimed at healing the individual and…
- Trial name
- ITH (NCT05890482)
- Testing
- Islamic Trauma Healing
- Where
- 2 sites in Somalia
- Volunteers
- 200 people
- Sponsor
- University of Washington
Rheumatic Heart Disease, Valvular Disease
Role of Statins In Slowing Rheumatic Heart Disease (RHD) Progression
The goal of this study is to address specific implementation questions necessary and sufficient to ensure the feasibility of the larger randomized trial examining the efficacy of statin medications in slowing rheumatic heart…
- Trial name
- NCT04575857
- Testing
- Atorvastatin
- Where
- Nepal
- Volunteers
- 100 people
- Sponsor
- University of Washington
Death, Sudden, Cardiac
Genomics of Sudden Cardiac Arrest
Sudden cardiac arrest (SCA) is a sudden, unexpected loss of heart function. It is a leading cause of death, and more than 400,000 people in the United States die each year as a result of SCA.
- Trial name
- GenSCA (NCT00661128)
- Where
- United States
- Volunteers
- 14,862 people
- Sponsor
- University of Washington
Urinary Tract Infection
Single Dose Monurol for Treatment of Acute Cystitis
Urinary tract infecton (UTI) is a very common problem in young healthy women, afflicting approximately one-half of women by their late 20's.
- Trial name
- NCT00976963
- Testing
- TMP/SMX, Fosfomycin
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Washington
Rheumatic Heart Disease
Rheumatic Heart Disease Research and Screening in Nepal: A Feasibility Study
Rheumatic Heart Disease (RHD) remains a significant public health problem in lower and middle-income countries, accounting for over 300,000 deaths world-wide.
- Trial name
- NCT05250154
- Where
- Nepal
- Volunteers
- 2,438 people
- Sponsor
- University of Washington
Out-Of-Hospital Cardiac Arrest
Clinical Trial of Sodium Nitrite for Out of Hospital Cardiac Arrest
In this clinical study, a total of 1500 patients with out-of-hospital cardiac arrest in Seattle/King County will be enrolled. This will be a randomized clinical trial and patients will receive either two different doses of IV…
- Trial name
- SNOCAT (NCT03452917)
- Testing
- sodium nitrite 45 mg, sodium nitrite 60 mg
- Where
- United States
- Volunteers
- 1,502 people
- Sponsor
- University of Washington
Cystic Fibrosis, Contraception
Assessment of Contraceptive Safety and Effectiveness in Cystic Fibrosis
The long-term goal is to study the safety and effectiveness of hormonal contraception for women with cystic fibrosis (CF) and contribute to national guidelines that the Cystic Fibrosis Foundation and the Centers for Disease…
- Trial name
- CASE4CF (NCT04568980)
- Where
- 10 sites in United States
- Volunteers
- 562 people, healthy volunteers welcome
- Sponsor
- University of Washington
Cystic Fibrosis
MENstrual Symptom Tracking to Understand and Assess (Women) Living With Cystic Fibrosis
Cystic fibrosis (CF) affects men and women equally, but after the onset of puberty, women with CF have a lower life expectancy than men with CF.
- Trial name
- MENSTRUAL (NCT04620096)
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of Washington
Breast Cancer
Design of Chatbot Persona for Breast Cancer Screening Outreach Among Black Women
Breast cancer screening disparities among Black women persist despite health system recognition and outreach. However, current evidence on how to tailor and optimize implementation strategies for breast cancer screening outreach…
- Trial name
- NCT05472064
- Testing
- Persona: Primary care doctor, Persona: Breast cancer survivor, Communication Style: Direct
- Where
- United States
- Volunteers
- 550 people
- Sponsor
- University of Washington
HIV Infections, Pregnancy Related
mWACh-PrEP: A SMS-based Support Intervention to Enhance PrEP Adherence During Pregnancy and Breastfeeding
In high HIV prevalence regions, women are at high risk for HIV during pregnancy and breastfeeding. To protect women and reach elimination of mother-to-child HIV transmission, the World Health Organization recommends offering oral…
- Conditions
- HIV Infections, Pregnancy Related, Adherence, Medication
- Trial name
- NCT04472884
- Testing
- mWACh-PrEP, Standard of Care
- Where
- 4 sites in Kenya
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Washington
Cannabis Use
A Hybrid Effectiveness-Implementation Trial of a School-Based Teen Marijuana Checkup
A hybrid effectiveness-implementation trial that is designed to assess the effectiveness of an intervention (The Teen Marijuana Check-Up) when delivered in real world settings.
- Trial name
- TMCU5 (NCT03111667)
- Testing
- Teen Marijuana Check Up, Treatment as Usual, Gold Standard Coaching
- Where
- United States
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- University of Washington
Stress, Depression
Latina Friends Motivating the Soul (ALMA)
Latina immigrant women are particularly vulnerable to depression and anxiety due to the social and economic stressors they face, including high levels of poverty, low levels of education, family obligations, exposure to violence…
- Conditions
- Stress, Depression, Anxiety
- Trial name
- NCT03749278
- Testing
- Latina Friends Motivating the Soul (ALMA)
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Washington
HIV
Early ART Initiation Among HIV-positive Pregnant Women in Central Mozambique
The overall objective of the study is to develop and test a pilot intervention in central Mozambique to implement the new WHO "Option B+" guidelines that seek to increase the proportion of HIV-positive pregnant women in six…
- Trial name
- NCT02371265
- Testing
- Adherence and retention package
- Where
- Mozambique
- Volunteers
- 761 people
- Sponsor
- University of Washington
Alcohol Use Disorder
Harm Reduction With Pharmacotherapy (HaRP)
The goal of this study is to test the efficacy of extended-release naltrexone and harm reduction counseling in reducing alcohol-related harm among homeless people with alcohol dependence.
- Trial name
- HaRP (NCT01932801)
- Testing
- XR-NTX, HRC
- Where
- United States
- Volunteers
- 308 people
- Sponsor
- University of Washington
Depression, Depression in Old Age
Technology-enabled Task-sharing for Depression in Primary Care
This study will explore and test the feasibility, acceptability, usability, and preliminary effectiveness of a technology-enabled intervention for depression using task-sharing in primary care.
- Trial name
- NCT04055155
- Where
- United States
- Sponsor
- University of Washington
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