Clinical trials: sponsored by University of Washington
Tricuspid Regurgitation, Heart Failure NYHA Class III
Study of the Clinical Impact of Surgical Correction of Tricuspid Insufficiency in Implantable LVAD Patients
The use of implantable left ventricular assist devices (LVAD) has increased over the last decade; partly because the newer continuous flow pumps feature a smaller design and better durability.
- Conditions
- Tricuspid Regurgitation, Heart Failure NYHA Class III, Heart Failure NYHA Class IV
- Trial name
- NCT02537769
- Testing
- Left ventricular assist device (LVAD), Tricuspid Valve Repair (TVR)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Washington
HIV-2 Infection
RESIST-2: 2nd-line ART for HIV-2 Infection
Prospective, longitudinal, open label, HIV-2 viral load and antiretroviral resistance informed 2nd-line ARV implementation study.
- Trial name
- RESIST-2 (NCT03394196)
- Testing
- HIV-2 Genotypic Drug Resistance Testing using DBS, 2nd line ART ( Zidovudine 300mg BID + Lamivudine 150mg BID or Tenofovir DF 300mg QD + Lamividine 300mg QD or Emtricitabine 200mg QD + Lopinavir/Ritonavir 400/100mg BID), 2nd line ART (Tenofovir DF 300mg QD + Lamividine 300mg QD or Emtricitabine 200mg QD + Lopinavir/Ritonavir 400/100mg BID + Raltegravir 400mg BID )
- Where
- 2 sites in Senegal
- Volunteers
- 152 people
- Sponsor
- University of Washington
Knee Osteoarthritis
Implementation of Tele-Exercise for Management of Knee Osteoarthritis in Older Rural Primary Care Patients
Knee osteoarthritis (OA) is highly prevalent and a leading cause of pain that limits physical functioning in older adults. Clinical practice guidelines recommend physical exercise for managing symptoms of knee OA.
- Trial name
- NCT04706702
- Testing
- Tele-EnhanceFitness
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Washington
Stroke, Sleep Apnea, Obstructive
Stroke and CPAP Outcome Study: A Sham-controlled Trial of CPAP Among Stroke Rehabilitation Patients
The purpose of this study is to assess the effect of continuous positive airway pressure (CPAP) on functional outcome in patients with acute stroke, the investigators conducted a sham-controlled, double-blind pilot trial during…
- Trial name
- SCOUTS (NCT02551757)
- Testing
- Auto-titrating CPAP
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Washington
Suicidal Ideation, Suicide, Attempted
Aftercare Focus Study (AFS): A Clinical Trial to Reduce Short-Term Suicide Risk After Hospitalization
Increasingly, the period after hospital admission is acknowledged as one of extremely high risk for suicidal patients. While it might be hoped that hospitalization would address and resolve suicide risk, a review of international…
- Conditions
- Suicidal Ideation, Suicide, Attempted, Distress, Psychological, Quality of Life
- Trial name
- NCT04693845
- Testing
- Collaborative Assessment and Management of Suicidality, Treatment as Usual
- Volunteers
- 150 people
- Sponsor
- University of Washington
Bipolar Disorder, Posttraumatic Stress Disorder
Study to Promote Innovation in Rural Integrated Telepsychiatry
Background: Community Health Centers care for over 20 million rural, low income and minority Americans every year. Patients often have complex mental health problems such as Posttraumatic Stress Disorder (PTSD) and Bipolar…
- Trial name
- SPIRIT (NCT02738944)
- Testing
- Telepsychiatry Collaborative Care, Telepsychiatry Enhanced Referral
- Where
- 13 sites in United States
- Volunteers
- 1,004 people
- Sponsor
- University of Washington
Sleep Apnea, Obstructive, Stroke
Stroke and CPAP Outcome Study 2
Obstructive sleep apnea (OSA) is associated with impaired stroke recovery. Treatment with continuous positive airway pressure (CPAP) may prevent this but is limited by poor adherence.
- Conditions
- Sleep Apnea, Obstructive, Stroke, Patient Adherence
- Trial name
- SCOUTS2 (NCT02809430)
- Testing
- Continuous Positive Airway Pressure
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Washington
Drinking Behavior
Motivating Campus Change Project Pilot Study
This study tests the optimization and delivery feasibility of personalized feedback interventions to address harmful alcohol use among college students.
- Trial name
- MC2 Pilot (NCT03962751)
- Testing
- Simultaneous Post Feedback Intervention Delivery, Sequential Post Feedback Intervention Delivery, Text Message Boosters
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Washington
Amputation, Artificial Limb
Comparison of Prosthetic Feet for People With Syme's Amputation (XF Symes Study)
The purpose of this study is to compare the functional differences between two types of foot prostheses for people with ankle disarticulation (Syme's) amputations.
- Trial name
- NCT04086641
- Testing
- Crossover foot, Energy Storing Foot
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Washington
Prostate Adenocarcinoma
Mechanisms of Metabolic and Hormone Action on Plaque Formation in Brain and Carotid Vessels in Patients With Prostate Adenocarcinoma
This trial studies the mechanisms of metabolic and hormone action on plaque formation in brain and carotid vessels in patients with prostate adenocarcinoma.
- Trial name
- NCT03718338
- Testing
- Evaluation, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Washington
Depression, Loneliness
A Smartphone Intervention for Relational and Mental Well Being
The primary aim of this study is to provide and evaluate a phone-based intervention to improve relational and mental well-being during the COVID-19 crisis.
- Conditions
- Depression, Loneliness, Relation, Interpersonal, Covid19
- Trial name
- NCT04629755
- Testing
- Intervention
- Where
- United States
- Volunteers
- 1,765 people, healthy volunteers welcome
- Sponsor
- University of Washington
Schizoaffective Disorder, Schizophrenia
Effectiveness of a Mobile Texting Intervention for People With Serious Mental Illness
Testing an mHealth mobile interventionist texting program on illness management.
- Conditions
- Schizoaffective Disorder, Schizophrenia, Bipolar Disorder, Major Depressive Disorder
- Trial name
- NCT03062267
- Testing
- Mobile Interventionist
- Where
- 2 sites in United States
- Volunteers
- 49 people
- Sponsor
- University of Washington
Parkinson Disease, Mitochondrial
Measures of Mitochondria Dysfunction in PD
This study evaluates metabolic and functional parameters in the skeletal muscle of Parkinson's disease patients for comparison to a set of healthy age-matched controls.
- Trial name
- NCT04300608
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Washington
Post-Traumatic Stress Disorder
Patient-Centered Collaborative Care for Preventing Post-Traumatic Stress Disorder After Traumatic Injury
This study will evaluate the effectiveness of patient-centered collaborative care that combines behavioral therapy and drug therapy as compared to usual care in reducing symptoms of post-traumatic stress disorder in people who…
- Trial name
- TSOS II (NCT00270959)
- Testing
- Cognitive Behavioral Therapy, Motivational Interviewing, FDA-Approved Anti-Anxiety Medications
- Where
- United States
- Volunteers
- 207 people
- Sponsor
- University of Washington
Diurnal Residual Limb Fluid Volume Fluctuation
Accommodating for Residual Limb Fluid Volume Change
The purpose of this study is to quantify residual limb fluid volume changes between morning and afternoon hours, and to determine if fluid volume change is correlated with activity.
- Trial name
- AM-PM (NCT02124876)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Washington
HIV/AIDS
Motivation Matters Study
The study aims to develop and evaluate the efficacy and causal mechanisms of an interactive SMS intervention to optimize individual health and secondary HIV prevention benefits of ART in HIV-positive FSWs.
- Trial name
- MM (NCT02627365)
- Testing
- Individualized, interactive short messaging intervention
- Where
- Kenya
- Volunteers
- 119 people
- Sponsor
- University of Washington
HIV Infections, HSV-2 Infection
Immunogenetic Modulators of Mucosal Protection From HIV-1
This is a single site, prospective, observational study that seeks to assess changes in mucosal immunity that occur as a result of HIV-1 exposure, HSV-2 infection, and/or pre-exposure prophylaxis (PrEP) usage to prevent HIV-1…
- Trial name
- Kinga (NCT03701802)
- Where
- Kenya
- Volunteers
- 812 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV, ART
Delivery Optimization for Antiretroviral Therapy (The DO ART Study)
The investigators propose the Delivery Optimization for Antiretroviral Therapy Study - The DO ART Study - a prospective randomized study of strategies to optimize community-based ART initiation, monitoring and resupply among…
- Trial name
- DO ART (NCT02929992)
- Testing
- ART initiation in the home, Mobile Van Refill and Monitoring, Clinic ART Initiation
- Where
- 2 sites in South Africa, Uganda
- Volunteers
- 1,539 people, healthy volunteers welcome
- Sponsor
- University of Washington
Depression
Volunteer-Delivery of Behavioral Activation
In response to large numbers of senior center clients who suffer untreated depression and the dearth of geriatric mental health providers, the investigators have simplified a Behavioral Activation intervention to match the skill…
- Trial name
- NCT03371771
- Testing
- Volunteer-delivered Behavioral Activation, MSW-delivered Behavioral Activation
- Where
- 4 sites in United States
- Volunteers
- 55 people
- Sponsor
- University of Washington
Menorrhagia
Copper IUD Treatment Observation Study
Studies indicate that bleeding irregularities and dysmenorrhea are common reasons for copper IUD method discontinuation. Some evidence suggests that non-steroidal anti-inflammatory medications (NSAIDs) can help improve bleeding…
- Trial name
- CITROS (NCT02519231)
- Testing
- Naproxen
- Where
- 5 sites in United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Washington
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