Clinical trials: sponsored by University of Washington
Insomnia Related to Osteoarthritis Pain
OsteoArthritis and Therapy for Sleep
Osteoarthritis (OA) pain affects 50 percent of older adults, more than half of whom also experience significant sleep disturbance.
- Trial name
- OATS (NCT02946957)
- Testing
- Cognitive Behavior Therapy for Insomnia, Education Only Control
- Where
- United States
- Volunteers
- 327 people
- Sponsor
- University of Washington
Voluntary Medical Male Circumcision
Text-based Follow-up in Zimbabwe's Voluntary Medical Male Circumcision Program
Voluntary medical male circumcision (VMMC) in sub-Saharan Africa is safe: the average rate of moderate and severe adverse events (AEs) at the country level is 0.8%, corresponding to 99% of men healing without incident.
- Trial name
- 2WT (NCT03119337)
- Testing
- Text-based follow-up
- Where
- 5 sites in Zimbabwe
- Volunteers
- 780 people, healthy volunteers welcome
- Sponsor
- University of Washington
Physical Activity, Aging
Physical Therapists - Recommending EnhanceFitness to Expand Reach
The goal of the study is to develop and test an intervention toolkit to increase the enrollment in EnhanceFitness (an evidence-based group physical activity program for older adults) at Young Men Christian Association (YMCA)…
- Trial name
- PT-REFER (NCT03139461)
- Testing
- PT-REFER Capacity-building Toolkit
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Washington
Metabolism
Impact of Probiotics on Drug, Vitamin, and Hormone Metabolism
This is an open-label, fixed sequence study of the effect of probiotics supplementation on drug, vitamin, and hormone metabolism.
- Trial name
- NCT04281407
- Testing
- Visbiome
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Washington
Recurrent Melanoma, Stage IV Skin Melanoma
Phase II Trial of Stereotactic Body Radiotherapy Followed by Ipilimumab in Treating Patients With Stage IV Melanoma
This phase II trial studies how well stereotactic body radiotherapy and ipilimumab work in treating patients with stage IV melanoma.
- Trial name
- NCT01970527
- Testing
- Ipilimumab, Laboratory Biomarker Analysis, Pharmacological Study
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Washington
HER2-positive Breast Cancer, Male Breast Cancer
Vaccine Therapy in Treating Patients Receiving Trastuzumab For HER2-Positive Stage IIIB-IV Breast Cancer
This phase II trial is studying how well vaccine therapy works in treating patients receiving trastuzumab for HER2-positive stage IIIB- IV breast cancer.
- Conditions
- HER2-positive Breast Cancer, Male Breast Cancer, Stage IIIB Breast Cancer, Stage IIIC Breast Cancer
- Trial name
- NCT00343109
- Testing
- HER-2/neu intracellular domain protein, leukapheresis, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Washington
HER2-positive Breast Cancer, Male Breast Cancer
Vaccine Therapy in Combination With Rintatolimod and/or Sargramostim in Treating Patients With Stage II-IV HER2-Positive Breast Cancer
This randomized phase I/II trial studies the side effects and best dose of rintatolimod when given together with vaccine therapy and sargramostim (GM-CSF) to see how well it works in treating patients with stage II-IV human…
- Conditions
- HER2-positive Breast Cancer, Male Breast Cancer, Recurrent Breast Cancer, Stage II Breast Cancer
- Trial name
- NCT01355393
- Testing
- HER-2/neu peptide vaccine, sargramostim, rintatolimod
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Washington
Chronic HIV Infection
Point-of-care Viral Load Testing to Enable Streamlined Care and Task Shifting for Chronic HIV Care
Effective management of patients on antiretroviral therapy (ART) is essential to improve clinical outcomes and prevent HIV transmission, but monitoring life-long ART for over 15 million HIV-infected people has become a challenge…
- Trial name
- STREAM (NCT03066128)
- Testing
- Point-of-care viral load testing, Lab-based viral load testing
- Where
- South Africa
- Volunteers
- 390 people
- Sponsor
- University of Washington
Hiv
Tenofovir Adherence to Rapidly Guide and Evaluate PrEP and HIV Therapy
Adherence to antiretroviral therapy (ART) and pre-exposure prophylaxis (PrEP) are critical to the success of HIV treatment and therapeutic prevention.
- Trial name
- TARGET (NCT03012607)
- Testing
- Truvada
- Where
- Thailand
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Washington
Chalazion
Local 5-Fluorouracil Injection for the Treatment of Chalazia: A Prospective, Comparative Study
Local injection of 5-fluorouracil into a chalazion (stye) is as effective as local injection of triamcinolone (steroid) and incision and curettage for treatment of chalazia.
- Trial name
- CTS (NCT02025023)
- Testing
- 5-fluorouracil Injection, Triamcinolone Acetonide, Incision and Curettage
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Washington
Marginal Zone Lymphoma, Recurrent Marginal Zone Lymphoma
Carfilzomib With or Without Rituximab in the Treatment of Waldenstrom Macroglobulinemia or Marginal Zone Lymphoma
This phase II trial studies how well carfilzomib with or without rituximab work in treating patients with Waldenstrom macroglobulinemia or marginal zone lymphoma that is previously untreated, has come back, or does not respond to…
- Conditions
- Marginal Zone Lymphoma, Recurrent Marginal Zone Lymphoma, Recurrent Waldenstrom Macroglobulinemia, Refractory Marginal Zone Lymphoma
- Trial name
- NCT03269552
- Testing
- Carfilzomib, Laboratory Biomarker Analysis, Rituximab
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Washington
Cystic Fibrosis
Saline Hypertonic in Preschoolers
The purpose of this study is to assess whether inhalation of 7% hypertonic saline (HS) twice daily for 48 weeks improves the lung clearance index by multiple breath nitrogen washout in comparison with inhalation of 0.9% isotonic…
- Trial name
- SHIP (NCT02378467)
- Testing
- 7% Hypertonic Saline (HS), 0.9% Isotonic Saline (IS)
- Where
- 25 sites in United States, Canada
- Volunteers
- 150 people
- Sponsor
- University of Washington, the Collaborative Health Studies Coordinating Center
Metastatic Malignant Neoplasm in the Brain, Primary Brain Neoplasm
18F-FLT PET/CT in Measuring Cell Proliferation in Patients With Brain Tumors
This pilot clinical trial studies fluorine F 18 fluorothymidine (FLT) positron emission tomography (PET)/computed tomography (CT) in measuring cell proliferation in patients with brain tumors.
- Conditions
- Metastatic Malignant Neoplasm in the Brain, Primary Brain Neoplasm, Recurrent Brain Neoplasm
- Trial name
- NCT02167204
- Testing
- Computed Tomography, Fluorothymidine F-18, Positron Emission Tomography
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Washington
Child Malnutrition
Developing Low-Cost Universal Malnutrition Screening for Low Income Countries - the MAMMS Trial
Acute malnutrition affects 52 million children, costs $2.1 trillion globally, and contributes to 45% of deaths among children under five years of age.
- Trial name
- NCT03967015
- Testing
- Maternal Administered Malnutrition Monitoring System (MAMMS)
- Where
- 3 sites in Kenya
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Washington
Male Breast Cancer, Recurrent Breast Cancer
Vorinostat in Treating Patients With Stage IV Breast Cancer Receiving Hormone Therapy
This pilot clinical trial studies vorinostat in treating patients with stage IV breast cancer receiving hormone therapy. Vorinostat may help hormone therapy work better by making tumor cells more sensitive to the drug.
- Conditions
- Male Breast Cancer, Recurrent Breast Cancer, Stage IV Breast Cancer
- Trial name
- NCT01720602
- Testing
- vorinostat, anastrozole, letrozole
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Washington
Gonadotropin Deficiency
ITT-5 Mechanisms of Spermatogenesis in Man
The purpose of this investigational drug study is to determine how much male hormone, testosterone, is needed to maintain sperm production in the testis.
- Trial name
- ITT-5 (NCT02147964)
- Testing
- Testosterone 1% Gel, Acyline, Dutasteride
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Washington
Small Cell Carcinoma
Paclitaxel and Nortriptyline Hydrochloride in Treating Patients With Relapsed Small Cell Carcinoma
This phase I trial studies the side effects and best dose of nortriptyline hydrochloride when given together with paclitaxel in treating patients with small cell carcinoma that has come back.
- Trial name
- NCT02881125
- Testing
- Nortriptyline Hydrochloride, Paclitaxel
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Washington
Pelvic Fracture Pubic Rami Multiple - Unstable Closed
Use of Virtual Reality for Pelvic External Fixator Removal
Assessing the role of virtual reality in decreasing pain and improving patient satisfaction in outpatient removal of pelvic external fixator constructs.
- Trial name
- NCT04202315
- Testing
- Virtual Reality
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Washington
Shingles
Immune Response to Shingles Vaccination
The purpose of this study is to learn more about the immune response to varicella zoster virus (VZV).
- Trial name
- NCT02624375
- Testing
- Zoster Vaccine Live
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Washington
Sporadic Amyotrophic Lateral Sclerosis
Mexiletine in Sporadic Amyotrophic Lateral Sclerosis
The purpose of this research study is to find out whether the drug mexiletine will be effective in lowering motor neuron electrical activity in the brains and nerves in the arms of people with ALS.
- Trial name
- Mexiletine-2 (NCT02781454)
- Testing
- Mexiletine
- Where
- 10 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Washington
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