Clinical trials: sponsored by University of Zurich
Bereavement
Cultural Adaptation of a Self-help App for Grieving Syrian Refugees in Switzerland
The goal of this pilot RCT is to investigate the acceptability and feasibility of an unguided culturally adapted self-help app for grieving Syrian refugees in Switzerland.
- Trial name
- NCT06246708
- Testing
- Self-help app with information for grieving Syrian Refugees, Wait-list
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Cognitive Decline, Fall
MOVE for Your MIND
Among the most promising interventions targeting both cognitive and functional decline, is Exercise. However, evidence regarding exercise interventions among seniors with cognitive impairment are inconclusive, likely due to…
- Trial name
- NCT03384602
- Testing
- Dalcroze Eurhythmics Program, home exercise strength program
- Where
- Switzerland
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Infant, Premature, Diseases, Respiratory Distress Syndrome
Functional Residual Capacity During Different Levels of High-flow in Preterm Infants
Although there is a widespread use of HighFlow therapy around the world, there is still uncertainty about the most appropriate initial HighFlow level after nasal continuous positive airway pressure therapy.
- Trial name
- FunkFlow (NCT05237622)
- Testing
- High Flow
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Zurich
High Altitude Pulmonary Hypertension, Sleep Apnea
HAPH Registry: Time Course and Prognostic Significance of Pulmonary Artery Pressure in Highlanders.
The purpose of the current study is to evaluate the clinical and physiologic course of Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by performing a longitudinal cohort study.
- Trial name
- NCT06489730
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Preterm Birth, Respiratory Distress Syndrome
Surfactant Nebulization for the Early Aeration of the Preterm Lung
Respiratory distress syndrome is the most common cause of respiratory failure in preterm infants. Treatment consists of respiratory support and exogenous surfactant administration.
- Conditions
- Preterm Birth, Respiratory Distress Syndrome, Surfactant Deficiency Syndrome Neonatal
- Trial name
- SUNSET (NCT04315636)
- Testing
- Surfactant nebulisation
- Where
- Switzerland
- Volunteers
- 32 people
- Sponsor
- University of Zurich
Apnea of Prematurity, Infant, Premature, Diseases
Effect of High Frequency Oscillatory Highflow Nasal Cannula on Desaturations and Bradycardia in Preterm Infants
This study evaluates the effect of non-invasive high frequency oscillations applied via a highflow nasal cannula ('Osciflow') compared to highflow nasal cannula without oscillations (HF) on desaturations and bradycardia in…
- Trial name
- Osciflow (NCT04327466)
- Testing
- Osciflow, Highflow
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Sepsis
HFIP Ex-vivo Study
Sepsis, a multi organ failure caused by infectious diseases, is a major health burden with an average mortality rate of 26%. Cells of the innate immune system of hosts recognize specific patterns of pathogenic bacteria and…
- Trial name
- NCT04059263
- Where
- Switzerland
- Volunteers
- 36 people
- Sponsor
- University of Zurich
Soft Tissue Lesions
Validation of Ultra Sound (US) Elastography
This is a prospective, single-center, non-randomised, non-blinded trial with US Elastography of Patients referred to our institution to assess soft tissue and organ lesions.
- Trial name
- USE (NCT02773264)
- Testing
- Ultrasound
- Where
- Switzerland
- Volunteers
- 308 people
- Sponsor
- University of Zurich
Tuberculosis Infection
Safety and Tolerability of Chlorquine in Addition to Anti-tuberculosis Therapy
In vitro and in vivo data show promising results of adjunctive use of Chloroquine to standard tuberculosis therapy as Chloroquine enhances animicrobial effectiveness against intracellular MTB.
- Trial name
- NCT05443178
- Testing
- Nivaquine ® (Chloroquine)
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Lung; Node
Diagnosis of Peripheral Lung Nodules Using Cryobiopsy
Since the traditional radial endobronchial ultrasound guided biopsy technique of solitary pulmonary nodules using the forceps has several shortcomings, the purpose of this study is to investigate a new biopsy technique using the…
- Trial name
- Cryo-Nodule (NCT04885595)
- Testing
- Forceps biopsy and cryobiopsy
- Where
- Switzerland
- Volunteers
- 54 people
- Sponsor
- University of Zurich
Lung Transplant Rejection, Lung Transplant Failure and Rejection
Comparison of Transbronchial Cryobiopsy and Forceps Biopsy in Lung Transplant Recipients
CLAD is defined as loss of lung function after other factors, particularly infections have been excluded. Readily accessible diagnostic procedures to detect acute cellular rejection at the earliest possible occasion is crucial…
- Trial name
- Kryo-LUTPL (NCT05006742)
- Testing
- CB study arm, FB-CB study arm
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University of Zurich
Mastocytosis, Hypertryptasemia
Mastocytosis Registry (of Zurich)
The study aims to summarize patients with mastocytosis and hypertryptasämia (without underlying mastocytosis or no bone marrow biopsy) in relation to demographic information, clinical progress and treatment courses.
- Trial name
- MastoR (NCT06466889)
- Where
- Switzerland
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Stroke
Precision Sensorimotor Neurorehabilitation Through Personalized Stimulation Loops
Stroke is the most common neurological disease in the elderly population and accounts for substantial disability and health care costs. Disability is largely driven by mobility deficits caused by impaired gait.
- Trial name
- StimuLOOP-S (NCT06466772)
- Testing
- Hyper-personalized feedback (HPF intervention), Targeted auditory stimulation during sleep (TASS verum intervention)
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University of Zurich
Major Depressive Disorder
Whole-body Hyperthermia for Depression
The goal of this clinical trial is to test the efficacy of whole-body hyperthermia in major depression. The main question it aims to answer is: Does whole-body hyperthermia alleviate symptoms of depression? Participants will be…
- Trial name
- NCT06323785
- Testing
- Active whole-body hyperthermia
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Quality of Life, Stroke, Acute
Cerebrovascular Disease: Quality of Life (CODE: QoL)
The goal of this observational study is to learn about quality of life, stress and caregiver burden in patients with stroke and their caregivers.
- Conditions
- Quality of Life, Stroke, Acute, Sexual Behavior, Stress
- Trial name
- CODE:QoL (NCT06443268)
- Testing
- questionnaire, hair samples, blood samples, clinical exam
- Where
- Switzerland
- Volunteers
- 680 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Brain Tumor, Brain Metastases
Closed vs. Open Face Masks for Cranial Radiotherapy
The aim of the study is to evaluate whether open-face masks improve patient comfort/preference whilst maintaining immobilization performance as known for closed masks in patients undergoing whole or partial cranial radiotherapy.
- Conditions
- Brain Tumor, Brain Metastases, Small Cell Lung Cancer, Meningioma
- Trial name
- NCT04079595
- Testing
- Head immobilization mask
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University of Zurich
Prostate Cancer
Adaptive MR-guided SBRT for Localized Prostate Cancer
The purpose of this study is to evaluate a technical feasibility of MR-guided SBRT fraction dose adaptation for low-risk, intermediate-risk and low-volume metastatic prostate cancer. .
- Trial name
- NCT04571762
- Testing
- Stereotactic Body Radiation Therapy (SBRT)
- Volunteers
- 12 people
- Sponsor
- University of Zurich
Osteoarthritis of Multiple Joints of Ankle or Foot, Healthy
Effects of Opioids and NSAIDs on Sympathetic Nervous System and Vascular Function
Evaluation of the effect of different analgesic treatments (Tramadol, Paracetamol, Diclofenac) on sympathetic nerve activity, blood pressure, heart rate, heart rate, and vascular function in osteoarthritis patients and healthy…
- Trial name
- OPIOVASC (NCT03781544)
- Testing
- Tramadol, Paracetamol, Diclofenac
- Where
- Switzerland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Vocal Fatigue
Prevalidation of the First German Version of the Vocal Fatigue Index (VFI)
Vocal fatigue has been described as a common complaint in patients with voice disorders, however to date there is no standardized questionnaire in german language to assess specific symptoms.
- Trial name
- VFI (NCT03378609)
- Testing
- Vocal Fatigue Index (VFI)
- Where
- Switzerland
- Volunteers
- 81 people
- Sponsor
- University of Zurich
Leptomeningeal Metastasis, Leptomeningeal Disease
Standardized Clinical Assessment of Patients With Leptomeningeal Metastasis
The goal of this project is to develop and validate a reproducible scorecard for the neurological assessment of patients with leptomeningeal metastases that can be used in clinical trials including such patients, as well as in…
- Conditions
- Leptomeningeal Metastasis, Leptomeningeal Disease, Leptomeningeal Neoplasms, Leptomeningeal Cancer
- Trial name
- NANO-LM (NCT06417710)
- Testing
- Neurological Assessment
- Where
- 3 sites in United States, Netherlands and 1 more
- Volunteers
- 200 people
- Sponsor
- University of Zurich
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