Clinical trials: sponsored by University of Zurich
Mumps, Measles
Immunity in Persons Fully Vaccinated Against Measles, Mumps and Rubella and Responses to Booster Vaccination
The purpose of this study is to investigate the immunity of persons fully vaccinated against measles, mumps and rubella and to examine the course of immunity after booster vaccination.
- Conditions
- Mumps, Measles, Rubella
- Trial name
- MIPS (NCT05894395)
- Testing
- MMR booster vaccination (as M-M-R-VaxPro)
- Where
- 2 sites in Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Iron Deficiency (Without Anemia)
Effect of Low-dose Versus Standard-dose Iron Supplementation on the Gut Microbiome
Iron deficiency is a common problem that is often treated with the administration of oral iron. Most of the iron is not absorbed and remains in the intestine, where it influences the balance of gut bacteria.
- Trial name
- NCT05467423
- Testing
- Iron
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Hypercapnic Respiratory Failure
Novel ECCO2R Device for Hypercapnic Respiratory Failure
The objective of this study is to assess the efficacy and safety of this new Prismalung+ membrane in its intended clinical setting by demonstrating a reduction in ventilatory parameters and pulmonary energy load or the successful…
- Trial name
- NCT05316532
- Testing
- Prismalung + treatment
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University of Zurich
Critical Illness, ARDS
The RIsk Stratification in COVID-19 Patients in the ICU Registry
The Risk stratification in COVID-19 patients in the ICU (RISC-19-ICU) registry was founded during the emerging SARS-CoV-2 pandemic.
- Conditions
- Critical Illness, ARDS, Inflammatory Response, COVID-19
- Trial name
- RISC-19-ICU (NCT04357275)
- Testing
- ICU treatment
- Where
- Switzerland
- Volunteers
- 10,000 people
- Sponsor
- University of Zurich
Altitude Hypoxia, Perfusion; Complications
The Pre-acclimatization Augmented Extreme Altitude Expedition
The aim of this study is to investigate the effect of pre-acclimatization in a nitrogen tent at home, ventilated with a slightly increased nitrogen percentage, in preparation for an expedition at extreme altitude.
- Trial name
- PRAGMAX (NCT05517044)
- Testing
- Nitrogen tent preacclimatization to high altitude
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Peanut Allergy
Identification of Anaphylactogenic Antibodies in Peanut Allergy
This project intends the analysis and profiling of specific antibodies against major peanut allergens in peanut allergic individuals and molecular cloning of human antibodies against major peanut allergens.
- Trial name
- NCT02821286
- Testing
- Observational study
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Spinal Cord Injuries
Lower Extremity Outcome Measures in SCI
Lower extremity (LE) function of patients with a spinal cord injury (SCI) will be assessed in an observational project with a cross-sectional and a longitudinal study design.
- Trial name
- NCT04032314
- Where
- Switzerland
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Hearing Loss, Attention Impaired
Exploiting the Potential of Neural Attentional Control to Overcome Hearing Impairment
This study will improve the understanding of the cerebral mechanisms that underlie the control of auditory selective attention and evaluate the potential of neuromodulation to enhance neural attention control as a possible way to…
- Conditions
- Hearing Loss, Attention Impaired, Tinnitus
- Trial name
- NeurAttContr (NCT05513352)
- Testing
- tACS - transcranial alternating current stimulation, NF - Neurofeedback
- Where
- Switzerland
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Postoperative Pain, Postoperative Nausea
Evaluation of Patient Stress Level Caused by Radiological Investigations in Early Postoperative Phase After Craniotomy
Postoperative imaging after neurosurgical intervention is usually performed in the first 72 hours after surgery. Postoperative radiological examinations in the first 72 hours provide accurate assessment of postoperative resection…
- Trial name
- IPAST-CRANIO (NCT05112575)
- Testing
- Postoperative imaging with magnetic resonance imaging or computed tomography
- Where
- Switzerland
- Volunteers
- 152 people
- Sponsor
- University of Zurich
Epilepsy Intractable
Multicenter Comparison of Interictal HFO as a Predictor of Seizure Freedom
In drug-resistant focal epilepsy, interictal high frequency oscillations (HFO) recorded from intracranial EEG (iEEG) may provide clinical information for delineating epileptogenic brain tissue.
- Trial name
- multiHFO (NCT05332990)
- Testing
- HFO analysis
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- University of Zurich
Pre-Eclampsia; Complicating Pregnancy, Blood Loss
Blood Loss and Preeclampsia
Study of blood loss in preeclamptic patients using mathematical formulae
- Conditions
- Pre-Eclampsia; Complicating Pregnancy, Blood Loss, Coagulation Disorder
- Trial name
- NCT04777097
- Testing
- Blood sample
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- University of Zurich
Epilepsy, Tumor
Recording High Frequency Oscillations in Patients With Tumors and Epilepsy
The investigators want to characterize high-frequency oscillations (HFOs) in intracranial recordings, which may occur as markers of epileptogenic tissue and also under physiological stimulation.
- Trial name
- HFO (NCT02320136)
- Testing
- cognitive testing
- Volunteers
- 120 people
- Sponsor
- University of Zurich
Movement Disorders, Epilepsy
Target Planning for Placement of DBS-electrodes and Follow-up of the Clinical Efficacy of Stimulation
Deep brain stimulation (DBS) has been established as therapy for severe forms of Parkinson's disease and other indications. A common target for stimulation is the subthalamic nucleus (STN).
- Trial name
- NCT01210781
- Testing
- deep brain stimulation (DBS)
- Where
- Switzerland
- Volunteers
- 500 people
- Sponsor
- University of Zurich
End Stage Renal Disease
Pilot Feasibility Study of Combined Kidney and Hematopoietic Stem Cell Transplantation to Cure End-stage Renal Disease
This pilot study of combined kidney and hematopoietic stem cell transplantation attempts to establish a protocol to induce immunological tolerance as a new strategy to prevent renal graft rejection.
- Trial name
- NCT02176434
- Testing
- Kidney and hematopoietic stem cell transplantation, hematopoietic stem cell
- Where
- Switzerland
- Volunteers
- 16 people
- Sponsor
- University of Zurich
Nasal Blockage, Nasal Obstruction
Subjective and Objective Outcome of Septoplasty With or Without Infundibulotomy
Septoplasty is one of the most common procedures in rhinology. In many centers and private institutions, an infundibulotomy is performed in addition to septoplasty without evidence of significant improvement for the patient.
- Conditions
- Nasal Blockage, Nasal Obstruction, Septum; Deviation
- Trial name
- InfundSPL (NCT05698940)
- Testing
- Infundibultomy
- Where
- Switzerland
- Volunteers
- 35 people
- Sponsor
- University of Zurich
Mild Cognitive Impairment, Healthy
Imaging Tau Deposition in the Brain of Elderly Subjects
Cerebral accumulation of tau and beta-amyloid are major factors of Alzheimer's disease pathology. A novel Positron Emission Tomography (PET) tracer (18-F-AV-1451) now offers the ability to study tau protein deposition in vivo in…
- Conditions
- Mild Cognitive Impairment, Healthy, Alzheimer Disease, Neurocognitive Disorders
- Trial name
- Add-Tau (NCT02958670)
- Testing
- 18F-AV-1451 (Tau-PET tracer)
- Where
- Switzerland
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Hypophosphatemia
Effects of Treatments for Anemia and Iron Deficiency on the Electrolyte Balance in Lung Transplant Recipients: A Special Focus on Hypophosphatemia
The aim of this study is to generate evidence regarding hypophosphatemia after iron infusion in lung transplant recipients in context of anemia and/or iron deficiency.
- Trial name
- NCT06112236
- Testing
- no intervention
- Where
- Switzerland
- Volunteers
- 250 people
- Sponsor
- University of Zurich
Respiratory Insufficiency Syndrome of Newborn, Breastfeeding Status
Oxytocin Administration Prior Planned Caesarean Section
Spontaneous vaginal delivery of a healthy infant provokes a unique surge in stress hormone concentrations (e.g. AVP (arginine vasopressin) /copeptin) incommensurable with child or adult levels measured in any other situation.
- Trial name
- NCT03693885
- Testing
- Oxytocin challenge test (OCT)
- Where
- 5 sites in Switzerland
- Volunteers
- 1,450 people
- Sponsor
- University of Zurich
Pulmonary Vascular Disease, Pulmonary Arterial Hypertension
High Altitude (HA) Residents With Pulmonary Vascular Diseseases (PVD), Pulmonary Artery Pressure (PAP) Assessed at HA (2840m) vs Sea Level (LA)
To study the effect of relocation from 2840m (Quito) to sea level (Pedernales) in patients with pulmonary vascular diseases (PVD) defined as pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension (PH)…
- Conditions
- Pulmonary Vascular Disease, Pulmonary Arterial Hypertension, Chronic Thromboembolic Pulmonary Hypertension
- Trial name
- NCT06092424
- Testing
- Relocation from HA to LA
- Where
- Switzerland
- Volunteers
- 36 people
- Sponsor
- University of Zurich
Pulmonary Vascular Disorder, Pulmonary Artery Hypertension
HA Residents With PVD, Pulmonary Artery Pressure (PAP) Assessed at HA (2840m) With and Without Supplemental Oxygen Therapy (SOT)
To study the effect of SOT in patients with pulmonary vascular diseases (PVD) defined as pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension (PH) who permanently live >2500m on pulmonary artery…
- Conditions
- Pulmonary Vascular Disorder, Pulmonary Artery Hypertension, Chronic Thromboembolic Pulmonary Hypertension
- Trial name
- NCT06084559
- Testing
- Supplemental oxygen therapy
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- University of Zurich
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