Clinical trials: sponsored by University of Zurich
Prosthesis and Implants, Surgical Site Infection
Effect of Photodynamic Therapy on Skin Microbiome. Single Center Study (PHOMIC-III)
The overarching aim of this research project is to prevent orthopedic implant-associated infections. This study aims to investigate if PDT has an effect on bacterial skin colonization in order to improve skin antisepsis…
- Conditions
- Prosthesis and Implants, Surgical Site Infection, Prosthetic Joint Infection, Postoperative Wound Infection Deep Incisional Surgical Site
- Trial name
- NCT05676801
- Testing
- Photodynamic Therapy
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Postpartum Hemorrhage
Oxytocin i.m./i.v. Versus Carbetocin i.v. in Elective Cesarean Sections
Objective is to proof non-inferiority of intramyometrial and intravenous oxytocin application compared to intravenous carbetocin for prevention of postpartum hemorrhage in planned, uncomplicated cesarean deliveries.
- Trial name
- NCT03651882
- Testing
- Oxytocin, Carbetocin
- Where
- Switzerland
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Prion Diseases
Therapeutic Antibodies Against Prion Diseases From PRNP Mutation Carriers
The human Prion diseases can be classified into sporadic, acquired and inherited forms. Inherited forms usually manifest in higher age so there have to be factors preventing Prion propagation in young mutation carriers.
- Trial name
- PRNP (NCT02837705)
- Testing
- blood draw
- Where
- 7 sites in United States, Austria and 5 more
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Toxoplasmosis, Rhd
Measuring the Prevalence of Toxoplasmosis and Its Socio-economic Consequences
The investigators propose a fast and inexpensive procedure to determine the prevalence of the Toxoplasmosis infection (Toxoplasma Gondii) in the general population, using response times in a cognitive task instead of costly…
- Trial name
- EconToxo (NCT05860998)
- Testing
- Presence of Toxoplasma gondii IgG Antibodies
- Volunteers
- 120 people
- Sponsor
- University of Zurich
Chronic Rejection of Lung Transplant
Noninvasive Early Detection of Lung Allograft Dysfunction After Lung Transplantation With Multiple Breath Washout Test
Chronic rejection, more commonly called bronchiolitis obliterans syndrome (BOS), is the leading cause of death beyond the first year post lung transplantation.
- Trial name
- NCT05586906
- Testing
- Multiple Breath Washout (MBW) tests
- Where
- Switzerland
- Volunteers
- 90 people
- Sponsor
- University of Zurich
Pre-Term
MusicHyperBrain Study With Preterm Infants and Their Parents
Inter-personal brain coupling between preterm infants, their parents and a musician during Creative Music Therapy using functional near-infrared imaging (fNIRI) hyperscanning and systemic physiology measurements
- Trial name
- NCT05383586
- Testing
- Creative Music Therapy
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Zurich
Weight Loss, Fatigue
Swiss Frailty Network and Repository
Physical frailty is an age-related medical syndrome defined by a decline in multiple body systems, thus causing increased vulnerability, even in the face of minor stressors (1) It has been linked to multiple negative health…
- Conditions
- Weight Loss, Fatigue, Physical Frailty, Weakness, Muscle
- Trial name
- SFNR (NCT04516642)
- Where
- Switzerland
- Volunteers
- 1,500 people
- Sponsor
- University of Zurich
Benign Paroxysmal Positional Vertigo
Evaluation of the Prevalence of BPPV and Longterm Effects of Its Therapy Using the Rotundum Device in Retirement Homes
Benign paroxysmal positional vertigo (BPPV) is one of the most common types of vertigo, especially in elderly. Therefore the investigators have set the goal to evaluate the prevalence of BPPV and its therapy using the Rotundum…
- Trial name
- NCT03643354
- Testing
- Epley maneuver/Barbeque maneuver
- Where
- Switzerland
- Volunteers
- 453 people
- Sponsor
- University of Zurich
Dental Implants
Two Implants Versus One Implant With a Cantilever - a Randomized Controlled Clinical Trial
The aim of the present study is to test whether there is a difference in the marginal bone level change between implants with and without cantilevers.
- Trial name
- NCT01649531
- Testing
- 1 Implant, 2 Implants
- Where
- Switzerland
- Volunteers
- 36 people
- Sponsor
- University of Zurich
Implant-supported Single Crowns
Monolithic Zirconia Crowns for Single Implants in the Molar Region: a Multicenter Clinical Trial
The aim of the present study is to test whether or not the use of translucent monolithic zirconia crowns bonded to a titanium base abutment perform similar to porcelain-fused-to-metal crowns on single implants in the posterior…
- Trial name
- MonoZrO2crown (NCT02272491)
- Testing
- ZrO2 (Straumann CARES), PFM crown (Straumann Gold)
- Where
- Switzerland
- Volunteers
- 83 people
- Sponsor
- University of Zurich
Dislocation of Midcarpal Joint
Arthroscopic Midcarpal Wrist Arthrodesis: Clinical and Functional Outcomes
All cases of midcarpal wrist arthritis treated surgically with arthroscopic partial wrist fusion with cannulated screws from January 2015 to December 2017 will be reviewed.
- Trial name
- NCT03763552
- Testing
- arthroscopic wrist arthrodesis
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- University of Zurich
Adherence, Medication, Heart Failure
Medication Adherence in Heart Failure After Hospitalisation
To explore medication adherence in patients who were hospitalised due to heart failure.
- Trial name
- NCT05233644
- Where
- Switzerland
- Volunteers
- 72 people
- Sponsor
- University of Zurich
Lung Diseases, Interstitial Lung Disease
Thorax MRI for Evaluation of Lung Morphology, Ventilation and Perfusion
In spite of the considerable technical difficulties, several publications confirm the potential that T1-maps and MRI to characterize pathological changes in lung tissue.
- Trial name
- NCT04719078
- Testing
- MRI of the chest
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
COPD Exacerbation
Nurse-led Integrated Care in COPD Patients With a Pulmonary Exacerbation
The aim of the study is to evaluate the effect and effectiveness of the nurse-led integrated care programme for the management of COPD (Chronic Obstructive Pulmonary Disease) exacerbations on patients' quality of life…
- Trial name
- NICCO (NCT04011332)
- Testing
- Integrated Care Model
- Where
- Switzerland
- Volunteers
- 69 people
- Sponsor
- University of Zurich
Vaccine Reaction
SARS-CoV-2 Antibodies and Virus Neutralisation in a Cohort Vaccinted Against COVID-19
Analysis of SARS-CoV-2 antibodies and serum virus neutralisation in vaccinated heath care personnel. Analysis of virus neutralisation as a function of age, gender, and history of COVID-19 infection.
- Trial name
- DER-CoV2-001 (NCT04979871)
- Testing
- Venous bleeding
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Distress, PTSD
Scaling-up Psychological Interventions With Syrian Refugees in Switzerland (STRENGTHS_CH): RCT
The current refugee crisis across the Middle East and Europe has large effects on individual refugees' psychological well-being, as well as on the healthcare systems of countries hosting refugees.
- Conditions
- Distress, PTSD, Anxiety, Depression
- Trial name
- NCT04574466
- Testing
- Problem Management Plus
- Where
- Switzerland
- Volunteers
- 54 people
- Sponsor
- University of Zurich
Lower Urinary Tract Dysfunction
Urodynamic Assessment of the Lower Urinary Tract: Water vs. Air - Synchrony
Comparison of water-perfused (WP) and air-charged (AC) catheters for invasive urodynamic investigation (UDI) regarding consistency, features and artifacts.
- Trial name
- NCT04036123
- Testing
- Urodynamic investigation
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University of Zurich
Disease With a Risk for Chronicity
Sensing Physical Activity to Evaluate and Monitor a Routine Aftercare Program (SensE-M)
Conditions such as multiple sclerosis (MS) and cardiovascular diseases (CVDs) are severe and prevalent health conditions which decrease life expectancy and increase morbidity.
- Trial name
- SensE-M (NCT05243407)
- Where
- Switzerland
- Volunteers
- 23 people
- Sponsor
- University of Zurich
COPD, Muscle Weakness
Low-load Blood Flow Restriction Training in COPD
Peripheral muscle weakness is a predominant problem in patients with COPD and treated using exercise training in pulmonary rehabilitation.
- Trial name
- LL-BFRT COPD (NCT04151771)
- Testing
- Low-load blood flow restriction training, Usual outpatient pulmonary rehabilitation
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
HIV Preexposure Prophylaxis
The SwissPrEPared Study
Nested within the SwissPrEPared Program, the "SwissPrEPared Study" - a large, multicentric, nation-wide cohort study - aims to longitudinally follow individuals asking for PrEP prescription over a period of 3 years.
- Trial name
- NCT03893188
- Where
- 41 sites in Switzerland
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University of Zurich
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