Clinical trials: sponsored by University of Zurich
Altitude Hypoxia
Effect of Acetazolamide on Sleep Disordered Breathing in Lowlanders Older Than 40 Years at Altitude
Randomized, placebo controlled trial evaluating the effect of acetazolamide on sleep disordered breathing in lowlanders older than 40 years travelling from 760 m to 3'100 m.
- Trial name
- NCT03536507
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Chronic Obstructive Pulmonary Disease
Effect of Acetazolamide on Lung Water Content by Ultrasound in Patients With Respiratory Disease at Altitude
This trial will evaluate the effect of acetazolamide (375 mg per day) vs. placebo on lung water content by ultrasound at acute altitude exposure in patients with Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- NCT03540901
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 112 people
- Sponsor
- University of Zurich
Urinary Stress Incontinence
Multisystem Cell Therapy for Improvement of Urinary Continence
The rising success of cell therapies places an increasing burden on health care costs. Consequently, the need to reduce production costs while maintaining quality has been widely acknowledged.
- Trial name
- MUSIC (NCT03439527)
- Testing
- Muscle Precursor Cells (MPCs), ATMP
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- University of Zurich
Healthy
Validity and Reliability of Jump Height
The primary objective is to test intratester and intertester reliability of maximum jump height using the sensor Orthelligent Pro.
- Trial name
- NCT05024396
- Testing
- maximum jump height
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Tinnitus, Subjective
ICCAC-ToNF & Tinnitus
Prevalence of chronic subjective tinnitus is rising with age and associated with maladaptive oscillatory changes in auditory as well as non-auditory regions of the brain such as the insula and the anterior cingulate cortex which…
- Trial name
- ICCAC (NCT03895047)
- Testing
- tomographic EEG Neurofeedback Training
- Where
- Switzerland
- Volunteers
- 36 people
- Sponsor
- University of Zurich
Chronic Obstructive Pulmonary Disease
Effect of Acetazolamide on Postural Control in Patients With Respiratory Disease at Altitude
In this trial, the investigators will evaluate the effect of acetazolamide (375 mg per day) vs. placebo on postural control at acute altitude exposure in patients with COPD.
- Trial name
- NCT03177811
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 127 people
- Sponsor
- University of Zurich
Altitude Hypoxia
Effect of Acetazolamide on Postural Control in Lowlanders Older Than 40 Years at Altitude
Randomized, placebo controlled trial evaluating the effect of acetazolamide on postural control in lowlanders older than 40 years travelling from 760 m to 3'100 m.
- Trial name
- NCT03536429
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Altitude Hypoxia
Effect of Acetazolamide on Visuo-motor Learning in Lowlanders Older Than 40 Years at Altitude
Randomized, placebo controlled trial evaluating the effect of acetazolamide on visuo-motor learning performance in lowlanders older than 40 years travelling from 760 m to 3'100 m.
- Trial name
- NCT03536520
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Altitude Hypoxia
Effect of Acetazolamide on Maximal Exercise Performance in Lowlanders Older Than 40 Years at Altitude
Randomized, placebo controlled trial evaluating the effect of acetazolamide on maximal exercise performance in lowlanders older than 40 years travelling from 760 m to 3'100 m.
- Trial name
- NCT03536455
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Precapillary Pulmonary Hypertension, Interstitial Lung Disease
Patients With Pulmonary Hypertension or Interstitial Lung Disease at Altitude - Effect of Oxygen on Exercise Performance
The purpose of this study is to investigate the effect of travelling to moderate altitude and of nocturnal oxygen therapy during a stay at moderate altitude on exercise performance of patients with pulmonary hypertension or with…
- Trial name
- NCT02143687
- Testing
- Moderate altitude sojourn, Low altitude sojourn, Oxygen
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Coronary Artery Disease
Dynamic CT Myocardial Perfusion Imaging
This study aims at evaluating the feasibility of CT myocardial perfusion imaging in daily clinical practice and compare it to SPECT perfusion imaging in order to assess sensitivity and specifity of CT myocardial perfusion imaging…
- Trial name
- NCT02593838
- Testing
- CT-MPI and SPECT-MPI
- Where
- Switzerland
- Volunteers
- 43 people
- Sponsor
- University of Zurich
Malignant Pleural Mesothelioma
Intracavitary Cisplatin-Fibrin Localized Chemotherapy After P/D or EPP for Malignant Pleural Mesothelioma
The aim is to introduce a new therapeutic method of intracavitary chemotherapy (cisplatin) combined with a fibrin carrier (Vivostat®) after pleurectomy/decortication or extrapleural pneumonectomy in a phase I and II study for…
- Trial name
- NCT01644994
- Testing
- intracavitary cisplatin-fibrin
- Where
- Switzerland
- Volunteers
- 47 people
- Sponsor
- University of Zurich
Burn Injury, Soft Tissue Injury
Phase I Study for Autologous Dermal Substitutes and Dermo-epidermal Skin Substitutes for Treatment of Skin Defects
The purpose of this study is the evaluation of the safety of autologous tissue-engineered dermal substitutes "denovoDerm" (first arm) and dermo-epidermal skin substitutes "denovoSkin" (second arm) transplanted onto the wound bed…
- Conditions
- Burn Injury, Soft Tissue Injury, Skin Necrosis, Scars
- Trial name
- NCT02145130
- Testing
- denovoDerm, denovoSkin
- Where
- 2 sites in Switzerland
- Volunteers
- 12 people
- Sponsor
- University of Zurich
Osteoporosis, Frailty
Spitex-SpiTal-Autonomie-Reha-Kraft
The primary purpose of this study is to test if the STARK comprehensive autonomy health care package improves lower extremity function over time at 6 weeks, 3, 6 and 12 months after hip or pelvis fracture compared to the standard…
- Conditions
- Osteoporosis, Frailty, Hip Fractures
- Trial name
- STARK (NCT03154684)
- Testing
- STARK intervention, Standard of Care
- Where
- Switzerland
- Volunteers
- 5 people
- Sponsor
- University of Zurich
Kidney Transplantation
Multiparametric MRI for Assessment of Changes of Renal Hemodynamics After Fistula Closure in Kidney Transplant Patients
Assessment of changes of renal hemodynamics by multiparametric MRI after closure of AVF access.
- Trial name
- FISCLO (NCT05015231)
- Testing
- Echocardiography and MRI
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Volemia in Dialysis Patients
Role of Biomarkers in Patients Undergoing Dialysis Treatment
A precise volume status assessment is critical to improve outcome of patients on dialysis. Yet, accurate assessment of fluid status remains a challenge.
- Trial name
- DRYWEIGHT (NCT02962635)
- Testing
- bioelectrical impedance measurement and biomarker measurement
- Where
- Switzerland
- Volunteers
- 45 people
- Sponsor
- University of Zurich
Sleep Inertia, Caffeine
Delayed-release Bedtime Caffeine and Sleep Inertia Symptoms Immediately Upon Awakening
Sleep inertia (sometimes also referred to as sleep drunkenness) is a disabling state of increased sleepiness, impaired mood and reduced vigilance immediately upon awakening.
- Conditions
- Sleep Inertia, Caffeine, Placebo
- Trial name
- NCT04975360
- Testing
- Caffeine
- Where
- Switzerland
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Zurich
ARDS, Human, Coronavirus
Sevoflurane in COVID-19 ARDS (SevCov)
The purpose of this trial is to study the effect of initial temporary sevoflurane sedation on mortality and persistent organ dysfunction (POD) in survivors at day 28 after ICU admission in the population of patients suffering…
- Trial name
- NCT04355962
- Testing
- Sevoflurane, Intravenous drug
- Where
- 4 sites in Switzerland
- Volunteers
- 68 people
- Sponsor
- University of Zurich
Covid19
Long COVID in Military Organisations
A prospective, longitudinal cohort study designed to follow-up on 500 Swiss military personnel who tested in 2020 for SARS-CoV-2 (regardless of whether positive or negative, but with a known test result).
- Trial name
- LoCoMo (NCT04942249)
- Testing
- No intervention
- Where
- Switzerland
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Hypertensive Ischemic Leg Ulcer, Calciphylaxis
Pathophysiology of Martorell Hypertensive Ischemic Leg Ulcer (HYTILU)
Martorell hypertensive ischemic leg ulcer is a severe type of skin necrosis (skin infarction) which occurs in long-term hypertensive subjects.
- Trial name
- NCT01578382
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- University of Zurich
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