Clinical trials: sponsored by University of Zurich
Dementia, Mild, Depressive Disorder
Dignity Therapy for Patients With Early Dementia and Their Family
Developed by Harvey M. Chochinov in 2005, Dignity Therapy (DT) invites individuals with life-limiting illnesses to reflect on matters of importance to them and compiles them in a narrative document for the patient to share.
- Trial name
- DTD (NCT03692988)
- Testing
- Dignity Therapy
- Where
- Switzerland
- Volunteers
- 54 people
- Sponsor
- University of Zurich
Acute Respiratory Distress Syndrome, Cardiogenic Shock
Closed Loop Mechanical Ventilation and ECMO
Mechanical ventilation and ECMO are both technologies interacting on gas exchange. Nevertheless, besides a consensus paper, no evidence-based guidelines regarding protective lung ventilation on ECMO exist to date.
- Trial name
- NCT04925518
- Testing
- Closed Loop Mechanical Ventilation, Conventional Mechanical Ventilation
- Volunteers
- 62 people
- Sponsor
- University of Zurich
Septic Shock, Cytokine Storm
Cytokine Adsorption in Severe, Refractory Septic Shock
Septic shock and the underlying dysregulated inflammatory host-response remain a major contributor to mortality in critically ill patients. Cytokine adsorption represents an attractive approach to the treatment of septic shock.
- Trial name
- NCT04910893
- Testing
- Cytokine Adsorption, Standard of Care
- Volunteers
- 48 people
- Sponsor
- University of Zurich
Cardiogenic Shock
Viability of Pulsioflex Monitoring in ICU
Goal of the Study is to Study the precision of semi-invasive cardiac index monitoring by means of the ProAQT (PULSION Medical Systems SE) sensor, whereby the pulmonary artery catheter will serve as gold standard.
- Trial name
- NCT04911985
- Testing
- Measurement of the Cardiac Output/ Cardiac Index
- Where
- Switzerland
- Volunteers
- 42 people
- Sponsor
- University of Zurich
Cardiogenic Shock, Cardiorenal Syndrome
Levosimendan Infusion in Critically Ill Patients With Cardiogenic Shock
To determine whether Levosimendan infusion in patients with cardiogenic shock and cardiorenal syndrome refractory to standard inotropic therapy, improves hemodynamics and renal function, whilst being safe.
- Conditions
- Cardiogenic Shock, Cardiorenal Syndrome, Acute Kidney Failure
- Trial name
- NCT04917497
- Testing
- Levosimendan
- Volunteers
- 43 people
- Sponsor
- University of Zurich
Acute Phase Biomarkers, Medical ICU Admitted Patients
MR-proADM and CT-proET-1 During ICU Treatment
This pilot-study will be a prospective, single-centre, observational study including 100 critically ill patients consecutively admitted to the medical intensive care unit (ICU) of the University hospital of Zurich, Switzerland…
- Trial name
- MR-proADM (NCT03651635)
- Testing
- Blood sampling for MR-proADM & CT-proET-1
- Where
- Switzerland
- Volunteers
- 533 people
- Sponsor
- University of Zurich
Bariatric Surgery Candidate
Dietary Fibers and Satiety in Bariatric Patients
The primary objective is to evaluate the effect of a viscous and fermentable dietary fibre on ad libitum eating in morbidly obese patients before and 6 month after Roux-en-Y gastric bypass (RYGB) surgery.
- Trial name
- FIBAR (NCT03573258)
- Where
- Switzerland
- Volunteers
- 8 people
- Sponsor
- University of Zurich
Acute Mountain Sickness
Effect of Acetazolamide on Acute Mountain Sickness in Lowlanders Older Than 40 Years
Randomized, placebo controlled trial evaluating efficacy of acetazolamide in preventing acute mountain sickness in lowlanders older than 40 years travelling from 760 m to 3'100 m.
- Trial name
- NCT03561675
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 349 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Covid19, ARDS
Long-Term Functional, Quality-of-Life, Neuropsychological and Cognitive Outcomes in COVID-19 Critical Illness Survivors
The corona virus disease 2019 (COVID-19), suddenly incepted in December 2019 in Wuhan, China, leading to one of the greatest health care emergencies of the last century.
- Conditions
- Covid19, ARDS, Critical Illness, Neurocognitive Dysfunction
- Trial name
- LUNGTERMcov (NCT04881266)
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University of Zurich
Ulcerative Colitis
Anthocyanin Rich Extract (ACRE) in Patients With Ulcerative Colitis
This study evaluates the efficacy and safety of a bilberry derived anthocyanin-rich extract in patients with ulcerative colitis.
- Trial name
- ACRE (NCT04000139)
- Testing
- Standardized anthocyanin-rich extract
- Where
- 6 sites in Switzerland
- Volunteers
- 48 people
- Sponsor
- University of Zurich
Covid19, ARDS
Assessment of Lung Mechanics in COVID-19 Acute Respiratory Distress Syndrome
This study is meant to assess the lung mechanics in SARS-CoV-2 induced acute respiratory failure. A precise characterisation of lung mechanics and heart-lung-interactions might allow a better understanding of SARS-CoV-2 induced…
- Trial name
- LungMechCoV-19 (NCT04597853)
- Testing
- Assessment of lung mechanics and heart-lung interactions
- Where
- Switzerland
- Volunteers
- 25 people
- Sponsor
- University of Zurich
Non Anemic Patients With Iron Deficiency (Low Ferritin Value)
Effect Of Intravenous Iron Versus Placebo On Muscle Oxidative Capacity And Physical Performance in Premenopausal Women
Effect of intravenous iron substitution (iron carboxymaltose (Ferinject®), total dose 15 mg/ kg (maximal dose: 1000mg) in 250 ml 0.9 % NaCl; intravenous infusion in 20 min)in non-anemic premenopausal women with iron deficiency on…
- Trial name
- NCT01374776
- Testing
- intravenous iron carboxymaltose
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- University of Zurich
Kidney Transplantation, Rental Transplantation
Effectiveness of an APN-led Self-management Program in Patients in the First Year After Renal Transplantation
The aim of this study is to investigate the effectiveness of the program in patients after renal transplantation using a randomized controlled trial design.
- Trial name
- SMP-NEP (NCT02282124)
- Testing
- Self-management program with monthly sessions, Usual Care, containing one session
- Where
- Switzerland
- Volunteers
- 122 people
- Sponsor
- University of Zurich
COVID-19
Convalescent Plasma Therapy - Zurich Protocol
This is an open-label, single-center, phase I study to assess the safety and efficacy of convalescent plasma therapy (CPT) obtained from donors who were tested positive for SARS-CoV-2 and fully recovered from the infection and…
- Trial name
- CPT-ZHP (NCT04869072)
- Testing
- Convalescent plasma
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Thoracic Aortic Aneurysm Without Rupture, Obstructive Sleep Apnea
Obstructive Sleep Apnoea in Adolescents With Thoracic Aortic Aneurysm
The objective of this prospective cohort study is to determine the prevalence of obstructive sleep apnoea (OSA) in patients with and without thoracic aortic aneurysm.
- Trial name
- OSA in TAA (NCT03400319)
- Where
- Switzerland
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Migraine
Diary-based Study on the Course of Hormone-withdrawal Migraines
Single centered diary-based study to identify course and characteristics of hormone withdrawal headaches/migraines in users of combined hormonal contraceptives Objectives of the Research Project: to identify the course and…
- Trial name
- NCT04012593
- Testing
- Diary
- Where
- Switzerland
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Altered Waking States of Consciousness in Healthy Humans
Characterization of Altered Waking States of Consciousness in Healthy Humans
Altered waking states of consciousness and its underlying functional organization have gained increasing interest in recent years, i.e. in identifying the neural basis of consciousness.
- Trial name
- NCT03853577
- Testing
- TMS/EEG
- Where
- Switzerland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Travel Health, Mobile Health Technology (mHealth)
TOURIST 2: Tracking Of Urgent Risks In Swiss Travelers
New mobile Health (mHealth) technology creates an opportunity to approach travel medicine research in a different way, revolutionising our understanding of risks to travellers.
- Conditions
- Travel Health, Mobile Health Technology (mHealth), Elderly Travelers, Chronic Diseased Travelers
- Trial name
- TOURIST2 (NCT03262337)
- Testing
- none, this is an observational study
- Where
- 2 sites in Switzerland
- Volunteers
- 793 people
- Sponsor
- University of Zurich
Severe Covid-19
Therapeutic Plasma Exchange as an Adjunctive Strategy to Treat Coagulopathy and Inflammation in Severe Covid-19
Randomized controlled trial to analyse adjuvant therapeutic plasma exchange (TPE) in severe Covid-19 associated coagulopathy and systemic inflammation compared to current standard of care (SOC).
- Trial name
- PExCoV (NCT04613986)
- Testing
- therapeutic plasmaexchnage
- Volunteers
- 20 people
- Sponsor
- University of Zurich
Central Line-associated Bloodstream Infection (CLABSI), Catheter-related Bloodstream Infection
Effect of Vancomycin After Catheter Replacement
Randomized controlled trial of the effect of a single-dose intravenous Vancomycin after catheter replacement for suspected central line-associated bloodstream infection on resolution of infection in critically ill patients.
- Trial name
- VanCat (NCT04856878)
- Testing
- Vancomycin
- Volunteers
- 100 people
- Sponsor
- University of Zurich
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