Clinical trials: sponsored by University of Zurich
Hearing Loss, Complete
Evaluation of a Bio-inspired Coding Strategy for Cochlear Implant Users
This study will determine the facilitation, refractoriness and spatial spread effects of auditory nerve fiber responses to electrical stimulation via a cochlear implant.
- Trial name
- EBCS (NCT03726684)
- Testing
- Coding strategy for cochlear implants
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Heart Failure
Differential Vascular and Endocrine Effects of Valsartan/Sacubitril in Heart Failure With Reduced Ejection Fraction
The objective of this study is to evaluate whether valsartan/sacubitril leads to a superior improvement in endothelial function and endocrine status compared to valsartan alone.
- Trial name
- VASCEND (NCT03168568)
- Where
- Switzerland
- Volunteers
- 79 people
- Sponsor
- University of Zurich
Lung Disease, Wrist Fracture
Tomosynthesis of Pathologies of the Chest and Skeletal Structures in Comparison to CT
The investigators propose tomosynthesis as a imaging method in between of x-ray and CT. The expected value of this project is the definition of proven indications for tomosynthesis, which allow replacing CT.
- Trial name
- NCT02464280
- Testing
- Tomosythesis scan of the lung or the wrist, CT scan of the lung or the wrist, conventional X-ray of the lung or the wrist
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University of Zurich
Healthy
Beyond the Self and Back: Neuropharmacological Mechanisms Underlying the Dissolution of the Self
The aim of the study is to identify neural signatures, behavioral and phenomenological expressions of self-related processes including: sense of agency, semantic distinction between self and other, selflessness (altruism), social…
- Trial name
- NCT03736980
- Testing
- Psilocybine
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Idiopathic Lung Fibrosis, Idiopathic Pulmonary Fibrosis
Breath Analysis in Lung Fibrosis
The aim of the study is to answer the question whether a disease specific profile of breath in patients with idiopathic lung fibrosis can be detected by an untargeted metabolomic study using exhaled breath analysis by mass…
- Trial name
- NCT02437448
- Testing
- No intervention
- Where
- Switzerland
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Exhaled Breath, Mass Spectrometry
Breath Analysis in Healthy Controls
The purpose of this study is to detect a specific profile of breath in healthy subjects by an untargeted metabolomic study using exhaled breath analysis by mass spectrometry.
- Conditions
- Exhaled Breath, Mass Spectrometry, Healthy Subjects
- Trial name
- NCT02595632
- Testing
- No intervention
- Where
- Switzerland
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Spinal Cord Injury
Longitudinal Morphometric Changes Following SCI
In patients with chronic spinal cord injury, imaging of the spinal cord and brain above the level of the lesion provides evidence of neural degeneration; however, the spatial and temporal patterns of progression and their…
- Trial name
- NCT02149511
- Where
- Switzerland
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Sensorineural Hearing Loss (Disorder)
Single-sided Deafness and Cochlear Implants
As the left and right hemisphere are specialized for different auditory tasks, the proposed study aims at demonstrating different consequences of right or left-sided deafness for the affected individual.
- Trial name
- NCT01749592
- Testing
- cochlear implant
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Zurich
Neurogenic Bladder Dysfunction
Transcutaneous Tibial Nerve Stimulation for Treating Neurogenic Lower Urinary Tract Dysfunction
Many patients with neurological diseases suffer from neurogenic lower urinary tract dysfunction (NLUTD), which often severely impairs quality of life, due to urinary urgency with or without incontinence and voiding dysfunction.
- Trial name
- NCT02859844
- Testing
- Transcutaneous Tibial Nerve Stimulation (TTNS)
- Where
- 2 sites in Switzerland
- Volunteers
- 9 people
- Sponsor
- University of Zurich
Double-blind Design, Sham-controlled
Neurostimulation in Chronic and Episodic Migraine
Currently, successful prevention of migraine is not sufficiently achieved by (prophylactic) drug therapy. In contrast, neurophysiologically guided treatments might provide an alternative avenue, since these can normalize brain…
- Conditions
- Double-blind Design, Sham-controlled, Randomized
- Trial name
- NCT03237754
- Testing
- tDCS device from neuroConn
- Where
- Switzerland
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Stroke, Ischemic
Microcirculation and Plasticity After Stroke
Reperfusion is the main goal of early medical interventions after stroke, such as thrombolysis and thrombectomy. Recanalization works only if applied early - the earlier the better, but with a statistical cutoff of 4.5 hours…
- Trial name
- IMPreST (NCT04035746)
- Testing
- Observation of microcirculation and plasticity of the brain
- Where
- Switzerland
- Volunteers
- 49 people
- Sponsor
- University of Zurich
Healthy
PET/MRI Imaging of Glutamate Release in the Brain
Based on PET (18-PSS232) and MRI, glutamate release after N-acetylcystein challenge will be monitored in human brains.
- Trial name
- NCT02511691
- Testing
- 18F-PSS232
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Hospital-acquired Pneumonia, Healthcare Associated Infection
Modular Prevention Bundle for Non-ventilator-associated Hospital-acquired Pneumonia (nvHAP)
Background: Hospital acquired pneumonia (HAP) is divided in two distinct groups, ventilator-associated pneumonia (VAP) and non-ventilator-associated HAP (nvHAP).
- Conditions
- Hospital-acquired Pneumonia, Healthcare Associated Infection, Infection Prevention
- Trial name
- NCT03361085
- Testing
- nvHAP Prevention Bundle
- Where
- Switzerland
- Volunteers
- 45,000 people
- Sponsor
- University of Zurich
Telemedicine, Exercise
Feasibility of a Blended Therapy Approach
Exercise is an important part of therapy guidelines in the rehabilitation of rare diseases (RDs) as Haemophilia and Myositis. The aim of this study is not to evaluate a new therapy intervention, but to evaluate the delivery of…
- Conditions
- Telemedicine, Exercise, Feasibility, Myositis
- Trial name
- bletheRD (NCT03713151)
- Testing
- Dividat FIT
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Pregnancy
Corneal Biomechanics During Pregnancy
It is known that intraocular pressure changes during pregnancy. Collagen structure changes during pregnancy to enable softening of the symphysis, whitening of the birth chanel, and, thus, ultimately to enable delivery of a child.
- Trial name
- CorvisPreg (NCT04433689)
- Testing
- Non-Contact measurement of corneal properties
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Hypogonadism, Pre-frail Seniors
Effects of Transdermal Testosterone and/or Monthly Vitamin D on Fall Risk in Pre--frail Hypogonadal Seniors
The overall purpose of this study is to test the individual and combined effect of transdermal testosterone and/or Vitamin D in reducing fall risk and improve function in pre-frail hypogonadal senior men.
- Trial name
- T&D (NCT02419105)
- Testing
- Testosterone, Colecalciferol
- Where
- Switzerland
- Volunteers
- 91 people
- Sponsor
- University of Zurich
COPD
Long-term Effects of a 3-month Pedometer-based Program to Enhance Physical Activity in Patients With Severe COPD
Long-term evaluation of a coaching program which helps patients with severe COPD to increase their daily step count, in addition to usual care.
- Trial name
- NCT03114241
- Testing
- Intervention
- Where
- Switzerland
- Volunteers
- 74 people
- Sponsor
- University of Zurich
Subarachnoid Haemorrhage (SAH)
Sevoflurane in Subarachnoidal Haemorrhage
Feasibility and safety of short term application of sevoflurane in patients with SAH treated with aneurysm coiling or clipping in the setting of a neurointensive care unit.
- Trial name
- Sevoflurane (NCT02946437)
- Testing
- Sevoflurane, Propofol, Midazolam
- Where
- Switzerland
- Sponsor
- University of Zurich
Cluster Headache
Circadian Changes of the Hypothalamic Activity in Patients Suffering From Cluster Headache
Cluster headache attacks do not occur randomly throughout the day, but have a clear circadian rhythmicity. The aim of this study is to investigate circadian changes of the brain, the autonomic nervous system and pain processing…
- Trial name
- NCT04409977
- Testing
- MRI examination
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Corona Virus Infection, ARDS
Microbiota in COVID-19 Patients for Future Therapeutic and Preventive Approaches
In light of the rapidly emerging pandemic of SARS-CoV-2 infections, the global population and health care systems are facing unprecedented challenges through the combination of transmission and the potential for severe disease.
- Conditions
- Corona Virus Infection, ARDS, Coinfection
- Trial name
- MICRO-COV (NCT04410263)
- Testing
- Sampling (EDTA blood, pharyngeal and nose swabs, bronchoalveolar lavage ,urine)
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- University of Zurich
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