Clinical trials: sponsored by University of Zurich
High Altitude Pulmonary Hypertension
Right Ventricular Function at Rest in Highlanders/Lowlanders
The purpose of the current study is to evaluate the progression of right ventricular function and dimension in Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by performing a cross sectional case-control study.
- Trial name
- NCT03165656
- Where
- Kyrgyzstan
- Volunteers
- 173 people
- Sponsor
- University of Zurich
Pulmonary Hypertension
Acute Exposure to Simulated Hypoxia on Exercise Capacity
Randomized crossover trial in patients with Pulmonary Hypertension (PAH, CTEPH) to assess the acute response to simulated altitude (FiO2:15.1, equivalent to 2500m above sea level) in constant loaded exercise capacity.
- Trial name
- NCT03592927
- Testing
- Simulated Altitude (FiO2: 15.1%)
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University of Zurich
High Altitude Pulmonary Hypertension, Sleep Apnea
Time Course and Prognostic Significance of Pulmonary Artery Pressure in Highlanders.
The purpose of the current study is to evaluate the clinical and physiologic course of Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by performing a longitudinal cohort study.
- Trial name
- NCT03165019
- Where
- Kyrgyzstan
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Chronic Obstructive Pulmonary Disease
Effect of Acetazolamide on Right Ventricular Function During Exercise in Patients With Respiratory Disease at Altitude
This trial will evaluate the effect of acetazolamide (375 mg per day) vs. placebo on right ventricular function during exercise at acute altitude exposure in patients with COPD.
- Trial name
- NCT03167034
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 110 people
- Sponsor
- University of Zurich
Chronic Obstructive Pulmonary Disease
Effect of Acetazolamide on Right Ventricular Function at Rest in Patients With Respiratory Disease at Altitude
This trial will evaluate the effect of acetazolamide (375 mg per day) vs. placebo on right ventricular function at acute altitude exposure in patients with COPD.
- Trial name
- NCT03173508
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 110 people
- Sponsor
- University of Zurich
Pedophilia
From Attention to Behavior: Increasing Behavioral Inhibition
This project will investigate if transcranial direct current stimulation can be used as treatment for Pedophilia. Treatment efficacy will be evaluated with behavioral tasks and the recording of eye-movement.
- Trial name
- tDCS (NCT03825627)
- Testing
- Transcranial Direct Current Stimulation
- Where
- Switzerland
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Hypertension, Pulmonary
Acute Hemodynamic Effect of Acetazolamide in Pulmonary Hypertension
To study the acute effect of acetazolamide (AZA) on pulmonary hemodynamics in patients with pulmonary hypertension (PH) undergoing clinically indicated right heart catheterisation (RHC).
- Trial name
- AcuteAZA (NCT02755259)
- Testing
- Acetazolamide
- Where
- Switzerland
- Volunteers
- 33 people
- Sponsor
- University of Zurich
Pulmonary Hypertension, Chronic Thromboembolic Pulmonary Hypertension
Retrospective Data Analysis of Data From the Zurich PH Registry
The collected data from the Zurich Registry for pulmonary Hypertension (PH) are evaluated in a retrospective analysis. This study examines the number of patients and their exact diagnoses who are treated at the University…
- Conditions
- Pulmonary Hypertension, Chronic Thromboembolic Pulmonary Hypertension, Pulmonary Artery Hypertension
- Trial name
- NCT03198910
- Where
- Switzerland
- Volunteers
- 313 people
- Sponsor
- University of Zurich
Chronic Obstructive Pulmonary Disease
Effect of Short-term Oxygen During CPET in COPD
In a randomized, sham-controlled trial the investigators will test whether supplemental oxygen given during cardiopulmonary exercise testing will improve exercise performance and physiological parameters in patients with chronic…
- Trial name
- NCT03196089
- Testing
- Oxygen application
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Zurich
Pulmonary Hypertension
Acute Exposure of Simulated Hypoxia on Pulmonary Artery Pressure and Right Heart Function (Echo)
Randomized crossover trial in patients with Pulmonary Hypertension (PAH, CTEPH) to assess the acute response to simulated altitude (FiO2:15.1, equivalent to 2500m above sea level) on pulmonary artery pressure and right heart…
- Trial name
- NCT03637088
- Testing
- Simulated Altitude (FiO2: 15.1%)
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University of Zurich
Malignant Pleural Mesothelioma
Re-directed T Cells for the Treatment (FAP)-Positive Malignant Pleural Mesothelioma
MPM patients are not eligible for surgical procedures like decortication or pleuro-pneumectomy and have a median survival of 12 months with palliative chemotherapy.
- Trial name
- NCT01722149
- Testing
- Adoptive Transfer of re-directed T cells
- Where
- Switzerland
- Volunteers
- 4 people
- Sponsor
- University of Zurich
Squamous Cell Carcinoma
Metastases of Cutaneous Squamous Cell Carcinoma in Organ Transplant Recipients. The "SCOPE-ITSCC Metastases Study"
The investigators hypothesize that a low number of SCC in OTR will metastasize.
- Trial name
- NCT01976468
- Testing
- SCC metastasis
- Where
- 2 sites in Netherlands, Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Depressive Disorder, Major, Bipolar Disorder
Characterization of the Prosocial and Prosexual Effects of GHB
The purpose of this study is to determine whether gamma-Hydroxybutyrate (GHB) has prosocial and prosexual effects in healthy male participants, and to characterize these putative effects via behavioral tests, functional magnetic…
- Conditions
- Depressive Disorder, Major, Bipolar Disorder, Autistic Disorder
- Trial name
- NCT02342366
- Testing
- GHB 35 mg/kg p.o., GHB 20 mg/kg p.o.
- Where
- Switzerland
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Skin Cancer
Skin Cancer in Swiss Transplant Cohort Study
It's known that organ transplant recipients with long-term drug-induced immunosuppression have a increase of the life-time incidence of squamous cell carcinoma.
- Trial name
- SCSTCS (NCT02361229)
- Where
- Switzerland
- Volunteers
- 4,000 people
- Sponsor
- University of Zurich
Heart Cancer, Kidney Cancer
Cancer Development In Organ Transplant Recipients
The investigators will determine the cancer risk in organ transplant recipients compared to the general population with the help of statistical analysis.
- Conditions
- Heart Cancer, Kidney Cancer, Lung Cancer, Pancreas Cancer
- Trial name
- NCT02333279
- Where
- Switzerland
- Volunteers
- 1,800 people
- Sponsor
- University of Zurich
Psoriasis, Atopic Dermatitis/ Eczema
Haut-Tief Patient Education on Psoriasis and Eczema
'Haut-Tief' (Skin Deep) is an educational, stress reducing program for patients with psoriasis or atopic dermatitis. A range of support activities will be offered in order to learn effective self-management strategies and…
- Trial name
- NCT02205593
- Testing
- Control
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University of Zurich
Lung Transplantation, Chronic Lung Allograft Dysfunction
Lung Clearance Index and Lung Allograft Dysfunction
The aim of this project is to evaluate the ability of the lung clearance index (LCI) to detect early chronic lung allograft failure (CLAD) in adult lung transplant recipients over a period of 3 years.
- Conditions
- Lung Transplantation, Chronic Lung Allograft Dysfunction, Rejection Lung Transplant
- Trial name
- NCT03850002
- Testing
- Early detection of CLAD by Lung Clearance Index (LCI)
- Sponsor
- University of Zurich
Pancreatic Cancer
Adjuvant Versus Neoadjuvant Plus Adjuvant Chemotherapy in Resectable Pancreatic Cancer
The outcome of patients with resected pancreatic cancer has significantly been improved by adjuvant chemotherapy. However, a large proportion of patients cannot receive adjuvant chemotherapy due to surgical complications.
- Trial name
- NCT01314027
- Testing
- Neoadjuvant Chemotherapy with gemcitabine/oxaliplatin, adjuvant chemotherapy with gemcitabine
- Where
- 5 sites in Belgium, France and 2 more
- Volunteers
- 38 people
- Sponsor
- University of Zurich
Patients in Septic Shock
The Effects of a Polyethyleneimine-coated Membrane (oXiris™) for Hemofiltration Versus Polymyxin B- Immobilized Fibre Column (Toraymyxin™) for Hemoperfusion on Endotoxin Activity and Inflammatory Conditions in Septic Shock- A Randomized Controlled Pilot Study (ENDoX-study)
Septic shock has a high mortality risk despite the availability of various treatments. Endotoxin, that is present in the cell walls of gram-negative bacteria, is a potent trigger of innate immunity.
- Trial name
- NCT01948778
- Testing
- oXiris™ filter, Toraymyxin Filter, Standard of Care
- Where
- Switzerland
- Volunteers
- 38 people
- Sponsor
- University of Zurich
Venous Insufficiency of Leg
SOCKNLEG Compression Stocking Kit : User Friendliness
The investigators aim to evaluate the user friendliness of a newly designed leg compression stocking kit, the SOCKNLEG, compared to a standard leg compression stocking of the same compression strength, the SIGVARIS Cotton.
- Trial name
- SOCKNLEGZH (NCT03429959)
- Testing
- SOCKNLEG, SIGVARIS Cotton
- Where
- Switzerland
- Volunteers
- 47 people
- Sponsor
- University of Zurich
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