Clinical trials: sponsored by University of Zurich
Spinal Cord Injury
Upper Limb Activity in Human SCI Rehabilitation
Functional recovery following SCI in adults is limited. Improvements in the quality of life of affected persons are associated with the recovery of functions that allow independent living, for example use of the arms and hands.
- Trial name
- NCT02098122
- Where
- Switzerland
- Volunteers
- 182 people
- Sponsor
- University of Zurich
Brain Tumor, Hydrocephalus
Linking Digital Smartphone Behaviour With Brain Function
This study will thus examine daily behaviour based on smartphone use and link it to the neurological and neuropsychological status as well as to neuroradiological studies that are part of the clinical routine.
- Conditions
- Brain Tumor, Hydrocephalus, Arteriovenous Malformations
- Trial name
- SmartSurgery (NCT03516162)
- Testing
- There is no study-specific intervention
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Chronic Obstructive Pulmonary Disease (COPD)
Patients With Chronic Obstructive Pulmonary Disease at Altitude - Effect of Nocturnal Oxygen on Exercise Performance
The purpose of this study is to investigate the effect of nocturnal oxygen therapy during a stay at moderate altitude on exercise performance of patients with chronic obstructive lung disease.
- Trial name
- NCT02143609
- Testing
- oxygen
- Where
- Switzerland
- Volunteers
- 32 people
- Sponsor
- University of Zurich
Chronic Obstructive Pulmonary Disease (COPD)
Effect of Acetazolamide on Cognition in Patients With Respiratory Disease at Altitude
Randomized, placebo controlled trial evaluating the effect of acetazolamide on cognition in lowlanders with chronic obstructive pulmonary disease travelling from 760 m to 3200 m.
- Trial name
- NCT03165890
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 78 people
- Sponsor
- University of Zurich
Anxiety Disorders
Optimizing Psychotherapy for Anxiety Disorders
Anxiety disorders are highly prevalent and are associated with a high burden of disease, costs and individual impairment worldwide.
- Trial name
- OPTIMAX (NCT03945617)
- Testing
- Unified Treatment Protocol
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University of Zurich
Neurogenic Lower Urinary Tract Dysfunction, Multiple Sclerosis
Supraspinal Control of Lower Urinary Tract Function in Healthy Controls and Patients With Bladder Dysfunction
The purpose of this study is to provide profound insight into the supraspinal neuronal mechanisms and networks responsible for lower urinary tract (LUT) control and to verify, amend or adjust neuronal circuitry models established…
- Conditions
- Neurogenic Lower Urinary Tract Dysfunction, Multiple Sclerosis, Overactive Bladder, Spinal Cord Injury
- Trial name
- NCT01768910
- Testing
- fMRI, bladder filling, bladder cooling
- Where
- 2 sites in Switzerland
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Hypoxia, Brain
CO2 (Carbon Dioxide) - Cerebral Oxygenation
Several projects in high altitude research in environments with a low oxygen partial pressure (hypobaric hypoxia) leading to hypoxemia showed, that cerebral perfusion and cerebral performance could be improved by adding C02…
- Trial name
- NCT03338907
- Testing
- Oxycarbon (5% CO2+ 95% O2)
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Developmental Delay (Disorder)
Creative Music Therapy for Premature Infants
This study investigates whether creative music therapy applied to premature infants will facilitate brain growth and development at term equivalent assessed by magnetic resonance imaging.
- Trial name
- NCT02434224
- Testing
- Music Therapy
- Where
- Switzerland
- Volunteers
- 81 people
- Sponsor
- University of Zurich
Clinical High Risk for Psychosis
Evaluation of the Treatment Approach ROBIN
The prevention of schizophrenia and other psychotic disorders has led researchers to focus on early identification of individuals at Clinical High Risk (CHR) for psychosis and to treat the at-risk symptoms in the pre-psychotic…
- Trial name
- Robin (NCT03829527)
- Testing
- Psychotherapy
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Head Injury Trauma, Hyperventilation
Hyperventilation in Patients With Traumatic Brain Injury
Elevated intracranial pressure is a dangerous and potentially fatal complication after traumatic brain injury. Hyperventilation is a medical intervention to reduce elevated intracranial pressure by inducing cerebral…
- Trial name
- NCT03822026
- Testing
- Hyperventilation test
- Where
- Switzerland
- Volunteers
- 11 people
- Sponsor
- University of Zurich
Chronic Obstructive Pulmonary Disease (COPD)
Patients With Chronic Obstructive Pulmonary Disease at Altitude - Effect of Nocturnal Oxygen on Breathing and Sleep
The purpose of this study is to investigate the effect of nocturnal oxygen therapy during a stay at moderate altitude on breathing and sleep of patients with chronic obstructive lung disease.
- Trial name
- NCT02150590
- Testing
- Oxygen
- Where
- Switzerland
- Volunteers
- 32 people
- Sponsor
- University of Zurich
Chronic Obstructive Pulmonary Disease (COPD)
Effect Of Acetazolamide On Altitude Related Illness In Patients With Respiratory Disease
Randomized, placebo controlled trial evaluating efficacy of acetazolamide in preventing altitude related adverse health effects (ARAHE) in lowlanders with chronic obstructive lung disease travelling from 760 m to 3200 m.
- Trial name
- NCT03156231
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 185 people
- Sponsor
- University of Zurich
Chronic Obstructive Pulmonary Disease
Effect of Acetazolamide on Sleep Related Breathing Disturbances in Patients With Respiratory Disease at Altitude
In this trial, the investigators will evaluate the effect of acetazolamide (375 mg per day) vs. placebo on sleep related breathing disturbances at altitude in patients with COPD.
- Trial name
- NCT03177850
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 185 people
- Sponsor
- University of Zurich
Effect of High Altitude
Effect of High Altitude Exposure, Acclimatization and Re-exposure on Right Ventricular Function in Lowlanders
Prospective interventional trial in lowlanders evaluating effect of acute exposure, acclimatization and re-exposure to high altitude
- Trial name
- NCT02730156
- Testing
- Altitude exposure
- Where
- Switzerland
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Effect of High Altitude
Effect of High Altitude Exposure, Acclimatization and Re-exposure on Postural Control in Lowlanders
Prospective interventional trial in lowlanders evaluating the effect of acute exposure, acclimatization and re-exposure to high altitude on postural control
- Trial name
- NCT02730182
- Testing
- altitude exposure
- Where
- Switzerland
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Effect of High Altitude
Effect of High Altitude Exposure, Acclimatization and Re-exposure on Cerebral Autoregulation in Lowlanders
Prospective interventional trial in lowlanders evaluating the effect of acute exposure, acclimatization and re-exposure to high altitude on cerebral autoregulation
- Trial name
- NCT02829255
- Testing
- altitude exposure
- Where
- Switzerland
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Zurich
ARDS, Human, Burns
Predictive Factors, Demographics and Mortality for ARDS in Burn Patients
This retrospective study characterizes the clinical course and identifies four independent predictors of Acute Respiratory Distress Syndrome (ARDS) after burn injury (post-burn ARDS; pbARDS).
- Conditions
- ARDS, Human, Burns, Lung Diseases
- Trial name
- NCT03807232
- Volunteers
- 400 people
- Sponsor
- University of Zurich
Hypertension, Resistant to Conventional Therapy
How to Test Success of a Renal Denervation
The study aimed to assess the success of a clinically indicated renal denervation by different tests and correlate the results of the tests with the clinical outcome.
- Trial name
- NCT02559882
- Where
- Switzerland
- Volunteers
- 11 people
- Sponsor
- University of Zurich
Stable Coronary Heart Disease
Cocoa Flavanol and Coronary Vasomotion Vascular Function in Patients With Coronary Artery Disease
The aim of the present study is to investigate whether the ingestion of a cocoa flavanol-containing drink compared to a flavanol-free drink, improves coronary vasomotion and platelet function in patients with overt coronary…
- Trial name
- NCT02520466
- Testing
- flavanol-rich drink vs flavanol-free drink
- Where
- 2 sites in Switzerland
- Volunteers
- 37 people
- Sponsor
- University of Zurich
Escherichia Coli Infections
Effects of Nutritional Fat on the Growth of Intestinal E. Coli
Recent experiments in the lab of Prof. WD Hardt revealed, that in mice, 24 h exposure to a high-fat diet results in a breakdown of colonization resistance against Salmonella typhimurium.
- Trial name
- NCT03800147
- Testing
- "Mutaflor Suspension" (E. coli Nissle 1917), Blood samples, Stool samples
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Zurich