Clinical trials: sponsored by University of Zurich
Hepatitis C, HIV
Swiss HCVree Trial
The investigators aim at investigating the efficacy of grazoprevir/elbasvir ±ribavirin in HIV-positive MSM participating in the SHCS in a broader setting of coinfected MSM.
- Trial name
- HCVree (NCT02785666)
- Testing
- grazoprevir/elbasvir, ribavirin, Behavioural Intervention
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- University of Zurich
Inflammatory Bowel Diseases
Differential EBI2 Expression Upon Allelic Status of the rs9557195 Polymorphism
EBI2 is a risk gene for inflammatory bowel diseases (rs9557195). Patients of the Swiss IBD cohort study have been genotyped for the allelic status of EBI2.
- Trial name
- NCT03633409
- Where
- Switzerland
- Volunteers
- 340 people
- Sponsor
- University of Zurich
Improve Healthy Ageing in Seniors; Prevent Disease at Older Age
DO-HEALTH / Vitamin D3 - Omega3 - Home Exercise - Healthy Ageing and Longevity Trial
The European population is aging rapidly which poses a challenge on the individual, the European societies, and health care systems.
- Trial name
- DO-HEALTH (NCT01745263)
- Testing
- Vitamin D3, Omega 3 fatty acids, Strength Home Exercise
- Where
- 7 sites in Austria, France and 3 more
- Volunteers
- 2,157 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Psoriasis
Steroids Added to Dithranol and Narrow Band UVB(Ultraviolet B) (UVBnb) in Psoriasis
Objective(s): (i) To assess the effect of adjunctive topical steroids in the combined treatment with UVBnb and dithranol on the remission time after therapy till a relapse of psoriasis defined as 50% loss of PASI (Psoriasis Area…
- Trial name
- DIPSO (NCT01429870)
- Testing
- Steroid active treatment
- Where
- Switzerland
- Sponsor
- University of Zurich
Investigating Spinal Atrophy in Patients With Spinal Injury
Plasticity of Grey and White Matter in Response to Motor Skill Training in Healthy Individuals and Those With Spinal Cord Injury
We aim to investigate the effect of motor skill training of the upper and lower limbs on the function and structure of the CNS as measured by neuroimaging parameters sensitive to changes in tissue volume and density and the…
- Trial name
- NCT02148887
- Where
- Switzerland
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Delayed Gastric Emptying
Reference Values for Gastric Emptying
Healthy volunteers will ingest a 13C-octaoate containing test meal and 13C in expiratory air will be followed. Normal values will be calculated data of these tests.
- Trial name
- 13C (NCT02397577)
- Testing
- Solid test meal, liquid test meal on two separate occations
- Where
- Switzerland
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Hiatus Hernia
Effects of Position and a Test Meal on Esophago-gastric Junction Morphology and Function Assessed by High-resolution Impedance Manometry (HRM)
Retrospective analysis for HRM measurements using liquid swallows and a test meal for the presence of hiatal hernia. The investigators will correlate hernia descriptions with presence of acidic reflux and clinical complaints.
- Trial name
- NCT02397616
- Testing
- high resolution esophageal manometry
- Where
- Switzerland
- Volunteers
- 380 people
- Sponsor
- University of Zurich
Salmonella Infection Non-Typhoid
Interaction Between Non-typhoid Salmonella, Host Microbiota, and Immune System During Acute Infection and Remission
Stool and blood samples from patients with a non-typhoid Salmonella infection will be collected during an observation period of six months and analyzed for changes in the microbiota diversity and composition, mutation rates in…
- Trial name
- NCT03494101
- Testing
- Blood samples, Stool samples, Clinical information
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Vestibular, Perception
Verticality Perception - Effects of Prolonged Roll-tilt in Healthy Human Subjects
The long-term goal of this research is to advance our knowledge of how the brain combines the information of multiple sensory systems coding for spatial orientation and how adaptation to vestibular imbalance influences spatial…
- Trial name
- NCT02760173
- Testing
- perception of vertical after static roll-tilt over 5min
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Zurich
Verticality Perception, Self-motion Perception
Altered Vestibular Perception and Transcranial Magnetic Stimulation
The long-term goal of this research is to advance our knowledge of how information from the labyrinth is brought to perception and how adaptation to vestibular imbalance influences motion sensation.
- Trial name
- NCT02184130
- Testing
- transcranial magnetic stimulation and motion stimuli
- Where
- Switzerland
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Vestibular Perception, Damaged Vestibular System
Spatial Orientation and Vestibular Function
Spatial orientation is achieved through central integration of various sensory inputs and prior knowledge in a statistically optimal way based on the reliability of the different signals.
- Trial name
- NCT02212847
- Testing
- vestibular stimulation
- Where
- Switzerland
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Healthy
Verticality Perception Assessed by the Haptic Vertical
The investigators previously shown that a rotating optokinetic stimulus results in shifts of the subjective visual vertical in healthy human subjects. However, the origin of these shifts is still poorly understood.
- Trial name
- NCT02980432
- Testing
- changes in whole-body roll position and visual/haptic stimuli presented
- Where
- Switzerland
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Huntington's Disease
Exercise Effects in Huntington's Disease
Huntington's disease (HD) is an incurable and fatal disorder characterised by progressive degeneration of the basal ganglia and the cerebral cortex.
- Trial name
- NCT01879267
- Testing
- Exercise training
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University of Zurich
Trochlear Nerve Diseases
Measuring Cyclotorsion on Scanning Laser Ophthalmoscopy (SLO)-Fundus Photographs
Pre-Study: Evaluation of the inter- and intrarater reliability of the integrated algorithm by Heidelberg Spectralis for measuring cyclotorsion on SLO-fundus fotographs, and assessment of the influence of measuring with or without…
- Trial name
- CySLO (NCT02631369)
- Testing
- Heidelberg Spectralis OCT device
- Where
- Switzerland
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Gut Microbiota and Sleep in Infants
Infant Sleep Behaviour and Gut Microbacteria
The overarching study aim is to evaluate the development of sleep behavior and gut microbiota (GMB), and their potential interaction, during the vulnerable period of the first year of life.
- Trial name
- SDEGU (NCT02836119)
- Where
- Switzerland
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Psoriasis of Scalp, Psoriasis Vulgaris
Apremilast Treatment for Pruritus and Quality of Life in Scalp Psoriasis
A phase 4 multicenter, randomized, placebo-controlled Study evaluating the Effect of Apremilast on Pruritus and Quality of Life of Patients with moderate-to-severe Scalp Psoriasis
- Trial name
- APRESCALP (NCT03553433)
- Testing
- Apremilast 30mg
- Where
- 4 sites in Switzerland
- Volunteers
- 90 people
- Sponsor
- University of Zurich
HIV Infection
Raltegravir in the Swiss HIV Cohort Study
Since June 2007, raltegravir has been available in Switzerland within a named patient program for patients who have virologic failure, triple class experience and resistance, and no other treatment options.
- Trial name
- NCT00904644
- Testing
- Raltegravir
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University of Zurich
Adipose Tissue, Brown, Insulin Resistance
Effect of Fluvastatin on Brown Fat Activity
The purpose of this study is to elucidate the effects of Fluvastatin on brown adipose tissue activity in humans.
- Conditions
- Adipose Tissue, Brown, Insulin Resistance, Clinical Trial
- Trial name
- FluvaBAT (NCT03189511)
- Testing
- Fluvastatin
- Where
- 2 sites in Switzerland
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Patients Undergoing Major Abdominal Surgery
Peri-operative Expression Analysis of Pancreatic Stone Protein in a Surgical Study Population
The purpose of this study is to analyze the peri-operative expression of pancreatic stone protein and pancreatitis-associated protein in surgical patients following major abdominal surgery by blood samples.
- Trial name
- NCT01258179
- Testing
- Analysis of PSP and PAP from venous blood samples
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Anemia, Iron Deficiency
Impact of Preoperative Treatment of Anemia and Iron Deficiency in Cardiac Surgery on Outcome.
We are performing the above prospective randomized trial in 1'000 patients undergoing cardiac surgery. The study will answer the question of whether preoperative treatment of anemia or iron deficiency indeed improves transfusion…
- Trial name
- NCT02031289
- Testing
- Erythropoietin/Ferric carboxymaltose/Vitamin B12/Folic Acid
- Where
- Switzerland
- Volunteers
- 1,003 people
- Sponsor
- University of Zurich
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