Clinical trials: sponsored by University of Zurich
Glioblastoma
Avastin Plus Radiotherapy in Elderly Patients With Glioblastoma
The purpose of this study is to explore the efficacy of bevacizumab combined with radiotherapy compared with radiotherapy alone in the treatment of newly diagnosed glioblastoma in the elderly. Trial with medicinal product
- Trial name
- ARTE (NCT01443676)
- Testing
- Bevacizumab, Radiation therapy
- Where
- Switzerland
- Volunteers
- 75 people
- Sponsor
- University of Zurich
Diabetes Mellitus, Type 2, Obesity
Role of Interleukin-6 in Exercise
The purpose of the study is to understand the role of interleukin-6 during physical activity in patients with type 2 diabetes.
- Trial name
- Exil-6 (NCT01073826)
- Testing
- Sport, Tocilizumab, Sitagliptin
- Where
- Switzerland
- Volunteers
- 56 people
- Sponsor
- University of Zurich
Burn Injury
Evaluation of Single-dose Pharmacokinetics of Intravenous Daptomycin in Patients With Thermal Injury
The purpose of this study is to determine single dose pharmacokinetics of daptomycin consecutively in 10 patients on three different time points after severe burn injury.
- Trial name
- NCT02241941
- Testing
- Daptomycin
- Where
- Switzerland
- Sponsor
- University of Zurich
Prostate Cancer
Intervention Trial Evaluating Focal Therapy Using High Intensity Focused Ultrasound for the Treatment of Prostate Cancer
The investigators aim to evaluate cancer control, genitourinary, rectal and overall health-related quality of life outcomes and effectiveness of focal therapy for localised prostate cancer using High Intensity Focused Ultrasound…
- Trial name
- NCT02265159
- Testing
- Focal Therapy Using High Intensity Focused Ultrasound
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Astigmatism, Glaucoma
Influence of Trabeculectomy and Phaco-trabeculectomy on Corneal Astigmatism
This study investigates the effects of trabeculectomy and combined phacoemulsification plus trabeculectomy on corneal astigmatism.
- Trial name
- NCT02945202
- Testing
- Biometry, Refraction, Corneal Topography
- Volunteers
- 150 people
- Sponsor
- University of Zurich
Effect of High Altitude
Kyrgyz Asthma Rehabilitation at High Altitude
prospective controlled interventional trial evaluating the efficacy of a 3-weeks asthma rehabilitation program at high altitude (3200m) and low altitude (760m) on lung function and asthma control.
- Trial name
- NCT02741583
- Testing
- altitude rehabilitation program, rehabilitation program
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University of Zurich
Opioid Use, Unspecified With Other Opioid-induced Disorder
Methylnaltrexone Pharmacokinetics in Neurointensive Care Patients
Assessment of pharmacokinetic parameters of once daily subcutaneously administered methylnaltrexone in 10 evaluable neurointensive care patients.
- Trial name
- RELZH12 (NCT01889290)
- Testing
- Methylnaltrexone
- Where
- Switzerland
- Volunteers
- 9 people
- Sponsor
- University of Zurich
Pulmonary Disease, Chronic Obstructive
Validation of the 1-minute Sit-to-stand Test in Patients With COPD
This is a study to provide an in-depth validation of the 1-minute sit-to-stand test as a measure of exercise capacity in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- STAND-UP (NCT02441725)
- Testing
- 1-minute sit-to-stand test
- Where
- Switzerland
- Volunteers
- 55 people
- Sponsor
- University of Zurich
Vestibular Diseases
Gaze and Stair Walking in Patients With Vestibular Dysfunction
The aim of this study is to assess the differences in gaze and gait during the stair and ramp negotiation (+transition to normal level walking) between healthy controls and vestibular patients (fallers and non-fallers).
- Trial name
- Gaze (NCT02417545)
- Where
- Switzerland
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Colorectal Liver Metastases
Impact of Pre-operative Bevacizumab on Complications After Resection of Colorectal Liver Metastases
Hypothesis of the study: Neoadjuvant chemotherapy with Bevacizumab impairs postoperative outcome after resection of colorectal liver metastases.
- Trial name
- NCT00875147
- Testing
- bevacizumab
- Where
- 3 sites in France, Spain and 1 more
- Volunteers
- 163 people
- Sponsor
- University of Zurich
Non-alcoholic Steatohepatitis (NASH)
Treatment of Non-alcoholic Steatohepatitis (NASH) Patients With Vitamin D
Test the efficacy of vitamin D to improve non-alcoholic steatohepatitis with regard to biochemical and histological parameters. Trial with medicinal product
- Trial name
- NCT01571063
- Testing
- Vitamin D3
- Where
- 2 sites in Switzerland
- Volunteers
- 22 people
- Sponsor
- University of Zurich
Atrial Fibrillation, Sleep Apnea, Obstructive
Origin of Premature Atrial Beats Induced by Simulated Obstructive Sleep Apnea
There is accumulating evidence for obstructive sleep apnea (OSA) as an independent risk factor for paroxysmal atrial fibrillation and for high recurrence rates of atrial fibrillation after ablation therapy.
- Conditions
- Atrial Fibrillation, Sleep Apnea, Obstructive, Atrial Premature Complexes
- Trial name
- NCT02269774
- Testing
- Standard pulmonary vein isolation
- Where
- Switzerland
- Volunteers
- 2 people
- Sponsor
- University of Zurich
Inflammation, Thrombosis
Investigation on the Effect of Smoking on the Expression of Pro- and Anti-thrombotic, Anti-oxidative, and Inflammatory Markers in Humans
Investigation on the effect of smoking on thrombus formation in humans. The expression of pro- and anti-thrombotic, anti-oxidative, and inflammatory markers will be assessed in 25-50 year old healthy smokers and non-smokers.
- Conditions
- Inflammation, Thrombosis, Smoking
- Trial name
- NCT02198937
- Testing
- Blood sample
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Gastric Cancer
Gastric Cancer Metastasized to the Central Nervous System (CNS)
Descriptive registry to investigate frequency of HER-2 positive gastric cancer involving CNS. Exploration of additional prognostic factors for brain involvement from gastric cancer.
- Trial name
- NCT01456455
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- University of Zurich
Insomnia Disorder
Is Internet-based Self-help Effective for the Treatment of Insomnia Disorder?
The Swiss company mementor has recently developed an interactive self-help intervention for the treatment of insomnia entitled mementor somnium. This programme is based on the guidelines for cognitive-behavioural therapy.
- Trial name
- NCT02629913
- Testing
- mementor somnium, wait list
- Where
- Switzerland
- Volunteers
- 56 people
- Sponsor
- University of Zurich
Glaucoma
GAT-DCT-Discordance Due to Corneal Properties
IOP is measured with two devices (Dynamic Contour Tonometry (DCT) and Goldmann applanation tonometry (GAT)).
- Trial name
- NCT01474070
- Testing
- Intraocular Pressure Measurement
- Where
- Switzerland
- Volunteers
- 112 people
- Sponsor
- University of Zurich
Healthy
Digestion of Biopolymer Based Lipid Emulsions
In this randomized, double blind, unbalanced three way crossover trial, four lipid emulsions will be assessed on three study days.
- Trial name
- BioLE (NCT02865486)
- Testing
- Lipid emulsion
- Where
- Switzerland
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Intracerebral Hemorrhage, Arterio-venous Malformation
Multicenter Validation of the AVICH Score
The primary objective of this multicenter study is to validate the AVICH score in terms of patient outcome prediction in AVM patients with associated ICH. Secondary objectives are the impact of pretreatment of the AVICH score.
- Trial name
- AVICH (NCT02920645)
- Testing
- AVM-related ICH
- Volunteers
- 500 people
- Sponsor
- University of Zurich
Chronic Idiopathic Urticaria
Efficacy Study of Canakinumab to Treat Urticaria
Evaluation whether canakinumab leads to improvement of urticaria
- Trial name
- URTICANA (NCT01635127)
- Testing
- Canakinumab
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Zurich
Other Specified Inflammatory Disorders of Skin or Subcutaneous Tissue, Pyoderma Gangrenosum
Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases
This study investigates the genetic architecture of Neutrophil-Mediated Inflammatory Skin Diseases. After collecting informed consent, all patients' clinical phenotype is graded at inclusion with a detailed case report form and a…
- Conditions
- Other Specified Inflammatory Disorders of Skin or Subcutaneous Tissue, Pyoderma Gangrenosum, Erosive Pustular Dermatosis of the Scalp, Sweet's Syndrome
- Trial name
- NEUTROGENE (NCT01952275)
- Testing
- Collection of biological samples
- Where
- Switzerland
- Volunteers
- 600 people
- Sponsor
- University of Zurich
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