Clinical trials: sponsored by University of Zurich
Macular Degeneration
VEGF-antagonism and Endothelial Function in Age-related Macular Degeneration (AMD)
The objective of this study is to evaluate the effects of 2 intravitreal injections with Ranibizumab or Avastin on endothelial function in subjects with neovascular macular degeneration compared to patients with dry AMD.
- Trial name
- NCT00727753
- Testing
- Ranibizumab, Bevacizumab, No treatment
- Where
- Switzerland
- Volunteers
- 54 people
- Sponsor
- University of Zurich
Healthy
The Effect of L-lysine on Human Gastrointestinal Secretion: A Dose-finding Study Applying Magnetic Resonance Imaging (MRI)
This is a pilot dose-finding study, which is performed with a randomized, double-blind, 3-armed, unbalanced, cross-over study design.
- Trial name
- NCT01579799
- Testing
- L-lysine
- Where
- Switzerland
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Back Pain
The Influence of High Heeled Shoes on the Sagittal Balance of the Spine and Whole Body
The purpose of this study is to investigate the influence of high heeled shoes on the sagittal balance of the spine and the whole body.
- Trial name
- NCT02254694
- Testing
- high heeled shoes
- Where
- Switzerland
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Chronic Obstructive Pulmonary Disease (COPD)
Patients With Chronic Obstructive Pulmonary Disease At Altitude
The purpose of this study is to investigate the effect of a stay at moderate altitude on exercise performance of patients with chronic obstructive lung disease.
- Trial name
- NCT01875133
- Testing
- altitude exposure
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University of Zurich
Chronic Obstructive Pulmonary Disease
Nocturnal Breathing and Sleep in Patients With Chronic Obstructive Pulmonary Disease Staying at Altitude
The purpose of this study is to evaluate whether nocturnal breathing and sleep of patients with chronic obstructive pulmonary disease (COPD) are disturbed during a stay at moderate altitude.
- Trial name
- NCT01870830
- Testing
- Altitude exposure
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University of Zurich
Prosthetic Vascular Graft Infection
Vascular Graft Infections
Background: Vascular grafts are increasingly implanted due to an increasing prevalence of atherosclerosis and diabetes, and about 1-6% of vascular procedures are complicated by infection.
- Trial name
- VASGRA (NCT01821664)
- Testing
- Prosthetic vascular graft
- Where
- Switzerland
- Volunteers
- 1,800 people
- Sponsor
- University of Zurich
Robot-aided Arm Therapy, Brain Injury, Motor Relearning Programme, Activities of Daily Living
Robot-Aided Neurorehabilitation of the Upper Extremities
Task-oriented repetitive movement can improve movement performance in patients with neurological or orthopedic lesions. The application of robotics can serve to assist, enhance, evaluate, and document neurological and orthopedic…
- Trial name
- NCT02434237
- Where
- Switzerland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Healthy
Quantitative MR Methods for Lipid Emulsions
Quantitative MR methods will be validated for the non-invasive imaging of GI processing of lipid emulsions in 18 (12+6) healthy subjects.
- Trial name
- Q-MRemulsion (NCT02226029)
- Testing
- Lipid emulsion
- Where
- Switzerland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Irritable Bowel Syndrome
1H-19F Gastrointestinal MRI in Health and IBS
The aim of this project is to demonstrate and validate the ionizing radiation free and non invasive assessment of small intestinal anatomy, content and function in healthy and disease by a newly developed combined proton (1H) and…
- Trial name
- NCT01347918
- Testing
- 19F capsule, sterculia
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Glycogen Storage Disease Type 1 (GSD 1)
Overnight Feeding Study in Glycogen Storage Disease Type 1
In this clinical cross-over study, we will compare the efficacy of different oral nutrition regimens for night-time glucose control in adult GSD 1 patients.
- Trial name
- NCT01961076
- Testing
- overnight nutrition regime
- Where
- Switzerland
- Volunteers
- 5 people
- Sponsor
- University of Zurich
Rheumatic, Dermatologic Disorders
Yellow Fever Vaccination Under Low Dose Methotrexate Therapy
Travelers (n = 30, 15 taking low-dose methotrexate (MTX), 15 healthy controls (HC), seeking travel advice in one of the following Swiss Travel Centers (Aarau, Basel, Bern, Geneva, Lausanne, Zurich) and who have an indication for…
- Trial name
- MTX_YF (NCT02383680)
- Testing
- Yellow Fever Vaccination
- Where
- 6 sites in Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Zurich
HIV, Hepatitis C
THISTLE - The HIV-HCV Silibinin Trial
Chronic hepatitis C virus (HCV) is a major cause of morbidity and mortality worldwide with an estimated number of 180 million infected patients.
- Trial name
- THISTLE (NCT01816490)
- Testing
- Intravenous Silibinin (iSIL)
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Zurich
Fabry Disease
Sleepiness and Sleep-disordered Breathing in Fabry Disease. A Prospective Cohort Study.
Prospective, observational cohort study to investigate the prevalence of sleepiness and sleep-related breathing disorders in patients with Fabry disease (FD).
- Trial name
- NCT01947634
- Testing
- ResMed Apnea Link plus
- Where
- Switzerland
- Volunteers
- 52 people
- Sponsor
- University of Zurich
Postoperative Complication
Effect of Remote Ischemic Preconditioning on Postoperative Complications in Visceral Surgery
Remote Ischemic Preconditioning (RIPC) is mediated by intermittent brief episodes (5-10 minutes) of short ischemia in a limb (i.e. arm), followed by reperfusion.
- Trial name
- RIPC (NCT02375269)
- Testing
- RIPC with a tourniquet
- Where
- Switzerland
- Volunteers
- 526 people
- Sponsor
- University of Zurich
Postoperative Complications
Development and Validation of a Morbidity Index for Complications in Minor and Major Abdominal Surgery
The aim is to develop and validate a morbidity index for postoperative complications in patients undergoing visceral surgery.
- Trial name
- NCT00782704
- Where
- Switzerland
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Healthy
How do Patients, Nurses and Physicians Perceive Negative Postoperative Events?
The purpose of this study is to assess how patients, nurses and physicians perceive negative events following surgical procedures.
- Trial name
- NCT00785096
- Testing
- Questionnaire
- Where
- Switzerland
- Volunteers
- 615 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Acute Renal Failure
Development and Validation of an Enhanced Prediction Score for Postoperative Acute Renal Failure After Liver Resection
Post-operative acute renal failure is a severe post-operative complication and is associated with high mortality. The enhanced prediction score, including pre-as well as intra-operative predictors accurately predicted ARF…
- Trial name
- NCT01318798
- Where
- Switzerland
- Volunteers
- 549 people
- Sponsor
- University of Zurich
Liver Regeneration
Study of the Protective Effect of Mechanism of Pentoxyfilline After Major Liver Resection Under Inflow Occlusion (Pringle Manoeuvre)
The investigators hypothecate that pentoxyfilline increase significantly the liver regeneration and reduces significantly ischemia and reperfusion (I/R) injury in major liver using aspartate aminotransferase (AST) and alanine…
- Trial name
- NCT00957619
- Testing
- pentoxyfilline
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Bleeding
TXA in the EMS on the Helicopter and the Ambulance
Coagulopathy in trauma increases mortality and morbidity. Early administration of tranexamic acid (TXA) seems to improve survival and outcome.
- Trial name
- TXASRZREGA (NCT02354885)
- Testing
- Tranexamic Acid
- Where
- 2 sites in Switzerland
- Volunteers
- 50 people
- Sponsor
- University of Zurich
Bleeding
Massive Transfusion Protocol With Coagulation Algorithm
In 2008 at the University Hospital Zurich (USZ) a massive transfusion protocol was introduced. Based on laboratory diagnostics and point of care (POC) devices including ROTEM.
- Trial name
- NCT02350101
- Testing
- Rotational thromboelastometry
- Volunteers
- 243 people
- Sponsor
- University of Zurich
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