Clinical trials: sponsored by University of Zurich
Nose Deformity
Clinical Effect of a Nasal Former in Nasal Deformities
Investigation of the effect of customized nasal braces in the correction of nasal deformities with and without prior corrective surgery. Trial with medicinal product
- Trial name
- NCT02348931
- Testing
- Use of customized nasal brace (Nasella) for nose deformities, corrective surgery
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Glaucoma Patients and Healthy Controls
Choroidal Thickness in Glaucoma Patients and Healthy Controls
With the new software tool (EDI, enhanced depth imaging) of the Spectralis® spectral-domain optical coherence tomography (SD-OCT) it is possible to visualize and measure the choroidal thickness.
- Trial name
- NCT01293474
- Testing
- Spectralis® SD-OCT, Heidelberg Engineering GmbH, H
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Glaucoma Patients and Healthy Controls
Reproducibility of RNFL Circle Scans With ART-Function of Heidelberg Spectralis SD-OCT Software Version 5.3
To assess the improvement in reproducibility of 100 vs. 16 averaged images by Automatic Real Time (ART) using Spectralis™ Spectral Domain-Optical Coherence Tomography (SD-OCT, Heidelberg Engineering GmbH, Heidelberg, Germany) in…
- Trial name
- NCT01299233
- Testing
- Spectralis® SD-OCT, Heidelberg Engineering GmbH, H
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Glaucoma, Ocular Hypertension
Efficacy of Selective Laser Trabeculoplasty in Patients Under Treatment With Topical Prostaglandines
Retrospective analysis of efficacy of selective laser trabeculoplasty in patients under treatment with topical prostaglandins compared to patients without topical prostaglandins is performed.
- Trial name
- NCT01467440
- Testing
- Selective Laser Trabeculoplasty
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University of Zurich
Healthy Participants
Comparison of Different Portable Tonometers (Icare Pro, TONO-Pen AVIA, Perkins Tonometer, PASCAL Hand Held Dynamic Contour Tonometer)
In different cases intraocular pressure (IOP) have to measured in lying position. Therefore a lot of portable tonometers have been established.
- Trial name
- NCT01325324
- Testing
- measurement of intraocular pressure
- Where
- Switzerland
- Volunteers
- 25 people
- Sponsor
- University of Zurich
Glaucoma, Ocular Hypertension
Efficacy of Selective Laser Trabeculoplasty in Pseudophakic Patients
Retrospective analysis of efficacy of selective laser trabeculoplasty in pseudophakic patients compared to phakic patients is performed.
- Trial name
- NCT01467388
- Testing
- selective laser trabeculoplasty (SLT)
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University of Zurich
Actinic Keratosis
Open Uncontrolled Validation Study for the German Version of the Actinic Keratosis Quality of Life Questionnaire (AKQoL)
The objective of this study is to translate the "AKQoL"-questionnaire which measures the quality of life of patients with actinic keratosis into German and to validate it for the Swiss population.
- Trial name
- AKQOLVS (NCT02325661)
- Testing
- cognitive interviewing
- Where
- Switzerland
- Volunteers
- 34 people
- Sponsor
- University of Zurich
Postprandial Fatigue
Role of Interleukin-1 in Postprandial Fatigue - The Cheesecake Study
The aim of the study is to investigate, if postprandial fatigue symptoms after ingestion of a high-fat, high-carbohydrate meal are regulated by Interleukin (IL)-1 and can be prevented by inhibition of IL-1 using a single dose…
- Trial name
- NCT01810549
- Testing
- Anakinra
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Solar Lentigines
Comparative Study of the Therapy of Solar Lentigines With a Q-switched Rubin Laser Versus a Bleaching Cream
Benign pigmented lesions as solar lentigines are a common finding in Caucasian individuals. Their removal may be requested for aesthetic reasons.
- Trial name
- NCT02153697
- Testing
- Q-switched SINON Ruby Laser, Pigmanorm Cream
- Where
- Switzerland
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Overactive Bladder Syndrome
Colonization of the Female Urethra With Mycoplasma Hominis, Ureaplasma Urealyticum, Chlamydia Trachomatis, or Neisseria Gonorrhea in Patients With Lower Urinary Tract Symptoms
The purpose of this study is to assess the prevalence of mycoplasma hominis, ureaplasma urealyticum, neisseria gonorrhea, and chlamydia trachomatis in women with overactive bladder symptoms, and to correlate these findings with…
- Trial name
- NCT01559623
- Testing
- retrospective data analysis
- Where
- Switzerland
- Volunteers
- 766 people
- Sponsor
- University of Zurich
Restless Leg Syndrome, Iron Deficiency Anemia
Restless Legs Syndrome With Iron Deficiency or Anaemia in the 3rd Trimester of Pregnancy
In pregnancy Restless Legs Syndrome(RLS) is more common than in the general population. During pregnancy iron tablets are the only available safe medication but their efficacy is rather poor.
- Trial name
- NCT01245777
- Testing
- ferric carboxymaltose
- Where
- 2 sites in Switzerland
- Volunteers
- 15 people
- Sponsor
- University of Zurich
Squamous Cell Carcinoma
Single-center Investigator Initiated Pilot Study Investigating the Tumor Response of Squamous Cell Carcinoma Lesions in Patients Under Lapatinib Treatment
Primary cutaneous squamous cell carcinomas (SCCs) are epithelial carcinomas with a high frequency of EGF-R expression. EGFR is an important regulator of tumour progression and proliferation in several types of cancer.
- Trial name
- NCT01666431
- Testing
- Lapatinib
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- University of Zurich
Skin Diseases
Online Question-answering and Conventional Consultation With a Dermatologist
Comparison of online question-answering system and conventional consultation for dermatological questions: same diagnosis? same information, which had been collected? same recommendations about treatment? what were the relevant…
- Trial name
- NCT01969422
- Testing
- observation
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Obstructive Sleep Apnoea (OSA)
Breath Analysis in Obstructive Sleep Apnoea
Clinical trial in patients with obstructive sleep apnoea that are randomised to either continue or withdraw continuous positive airway pressure therapy to identify a disease-specific exhaled breath pattern by mass spectrometry.
- Trial name
- NCT02050425
- Testing
- CPAP
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Healthy
Fit Over 45 - a Health Promotion Project for Inactive Female Hospital Staff Age 45+ From the University Hospital of Zürich
Background: Despite the well-known benefits of exercise, 64% of the Swiss population do not fulfill the public health recommendation of physical activity.
- Trial name
- NCT01033110
- Testing
- Exercise and Nutrition Education
- Where
- Switzerland
- Volunteers
- 108 people
- Sponsor
- University of Zurich
Heart Failure, Post Cardiac Surgery
Robotic Assisted Rehabilitation for Heart Failure Patients and Patients After Cardiac Surgery
Robotic assisted gait therapy with the Lokomat® as a new method for rehabilitation in advanced heart failure and after cardiac surgery.
- Trial name
- NCT02146196
- Testing
- 4 weeks robotic assisted training with the Lokomat®, One week robotic assisted gait training with the Lokomat®
- Where
- Switzerland
- Volunteers
- 12 people
- Sponsor
- University of Zurich
Knee Osteoarthritis
Zurich Multiple Endpoint Vitamin D Trial in Knee OA Patients
This is a 2-year double-blind randomized controlled trial in 287 community-dwelling individuals age 60 years or older undergoing uni-lateral total knee replacement due to severe OA of the knee.We compare an oral dose of 2000 IU…
- Trial name
- NCT00599807
- Testing
- Vitamin D3 (cholecalciferol)
- Where
- Switzerland
- Volunteers
- 273 people
- Sponsor
- University of Zurich
Chronic Obstructive Pulmonary Disease
Mechanisms of Vascular Damage in Patients With Chronic Obstructive Pulmonary Disease
A randomised controlled trial will be performed to evaluate the effects of lung volume reduction surgery (LVRS) in patients with COPD on systemic inflammation, oxidative stress, endothelial function, arterial stiffness and blood…
- Trial name
- NCT01020344
- Testing
- Lung volume reduction surgery
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Intimal Proliferation, Immunosuppression
Intracoronary Analysis of Cardiac Allograft Vasculopathy by Means of Optical Coherence Tomography
Randomized prospective multi-center imaging study which investigates the impact of different immunosuppressive protocols (Everolimus (Certican®) or Mycophenolate mofetil (CellCept®)) on cardiac allograft vasculopathy (CAV) in…
- Trial name
- OCTandCAV (NCT02254668)
- Testing
- Protocol with Everolimus (Certican®), Protocol with Mycophenolate mofetil (CellCept®)
- Where
- Switzerland
- Volunteers
- 278 people
- Sponsor
- University of Zurich
Healthy
Role of the Catechol-O-methyltransferase (COMT) in the Physiological Regulation of Vigilance
In this study, pharmacologic effects of COMT inhibition during sleep deprivation in healthy subjects in dependence of their Val158Met genotype of COMT are studied.
- Trial name
- NCT02080715
- Testing
- Tolcapone
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
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