Clinical trials: sponsored by University of Zurich
Schizophrenia
The Effect of Sertindole on Sensory Gating and Cognition in Schizophrenic Patients
This study aims to investigate whether the atypical antipsychotic and mixed 5-HT2/D2 antagonist sertindole modulates or improves both subcortical and cortical information processing in schizophrenic patients who had not or…
- Trial name
- NCT00629252
- Testing
- Sertindole, Risperidone
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Gastroesophageal Reflux Disease, Healthy Volunteers
Measurement of Gastric Secretion by MRI Under Inhibition by ProtonPump Inhibitors in Healthy Subjects & in GERD Patients
This study bases on the successfully completed project SNF 320000-112006 (EK 1152 and SwissMedic 2005dr2207e) and will document the physiological effects of inhibited gastric secretion on the volume as well as the acidity of…
- Trial name
- NCT01212614
- Testing
- MRI, non invasive 13C-breath test, 24h-intragastric / esophageal pH monitoring
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- University of Zurich
Obstructive Sleep Apnea
The Effects of Provent® on Obstructive Sleep Apnea During Continuous Positive Airway Pressure Therapy Withdrawal
Randomised, placebo-controlled trial of continuous positive airway pressure therapy (CPAP) versus Provent® and Placebo-Provent® to define the effects of Provent® on the severity of obstructive sleep apnea, daytime symptoms as…
- Trial name
- NCT01332175
- Testing
- Provent®, CPAP
- Where
- 3 sites in Switzerland, United Kingdom
- Volunteers
- 67 people
- Sponsor
- University of Zurich
Aortic Rupture
Analysis of Risk Factors for Death After Blunt Traumatic Rupture of the Thoracic Aorta
Aortic injuries after blunt thoracic trauma are compared to the great incidence of accidents relatively rare, but potentially serious leading to death at scene in most of the cases.
- Trial name
- NCT01632774
- Where
- Switzerland
- Volunteers
- 85 people
- Sponsor
- University of Zurich
Rheumatoid Arthritis, Inflammatory Myositis
Rituximab-induced Pulmonary Function Changes
Measuring lung function (FVC, FEV1, DLCO) before, during and after treatment with rituximab in patients with rheumatoid arthritis or inflammatory myositis.
- Trial name
- NCT01632124
- Testing
- Lung function measurement
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University of Zurich
Colorectal Polyps
Colorectal Polypectomy Upon Insertion And Withdrawal Or Upon Withdrawal Only?
The investigators aim to assess the procedure time and miss rate of polyps when performing polypectomy in the colon on the way up* and down or only on the way down.
- Trial name
- NCT01607827
- Testing
- Polyp removal upon insertion and withdrawal, Polyp removal upon withdrawal only
- Where
- Switzerland
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Preterm Infants
Executive Function in Preterm Born Children: An Integrative Approach From Genetics to Brain Function
Hd-EEG and MRI measures are used to study the maturation of functional networks in order to identify the neural circuits underlying executive and memory processes in children born preterm.
- Trial name
- NCT01615523
- Testing
- MRI, EEG and cognitive testing
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Technical and Non-technical Training of Airway Management on ICU
iCOMtrain, Development and Evaluation of a Combined Training of Technical and Non-Technical Skills During the Management of Simulated Incidents in Intensive Care
The normal, the anticipated difficult and the unanticipated difficult airway are trained in the patient safety simulation center (University Hospital Zürich) and the training is being observed by video installation.
- Trial name
- NCT01609829
- Testing
- SAFE (situation, all together, fly on, evaluate)
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University of Zurich
Complications of Medical Care, Nec in ICD9CM_2011
HandSAFE - Development and Evaluation of a Handover Tool for Doctors and Nurses
A handover Tool for doctors and nurses improves the quality of handovers compared to handovers that are being conducted without a tool.
- Trial name
- HandSAFE (NCT01609777)
- Testing
- SBAR
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University of Zurich
Myocardial Ischemia, Acute Coronary Syndrome
Myeloid-Related Protein in Evaluation of Acute Chest Pain in the Emergency Departement
The purpose of the study is the evaluation of multiple biomarkers related to acute coronary syndromes, including myeloid-related protein 8/14 (MRP 8/14), along with established clinical markers, for early diagnosis and risk…
- Conditions
- Myocardial Ischemia, Acute Coronary Syndrome, Myocardial Infarction, Coronary Occlusion
- Trial name
- MyRiAD (NCT00657436)
- Where
- Switzerland
- Volunteers
- 403 people
- Sponsor
- University of Zurich
Surgery, Diverticulitis
Hartmann's Versus Primary Anastomosis in Left-sided Colon Perforation
The purpose of this multi-center randomized trial is to identify any differences in the complication rates of patients undergoing Hartmann's (end colostomy) versus Primary Anastomosis (with defunctioning ileostomy) for left-sided…
- Conditions
- Surgery, Diverticulitis, Neoplasms, Postoperative Complications
- Trial name
- ColonPerfRCT (NCT01233713)
- Testing
- Hartmann's operation, Primary anastomosis
- Where
- 4 sites in Switzerland
- Volunteers
- 62 people
- Sponsor
- University of Zurich
Neoplasms
Agreement Among Expert Radiologists in Diagnosing Primary Liver Tumors by Magnetic Resonance Imaging (MRI)
The purpose of this multicenter study is to evaluate the agreement among expert radiologists in interpreting magnetic resonance images (MRI) assessing common primary liver tumours in non-cirrhotic patients.
- Trial name
- MRevaluation (NCT01234701)
- Testing
- Non-invasive Magnetic Resonance Imaging (MRI), Liver resection, Histopathology diagnosis of resected liver specimen
- Where
- 10 sites in United States, France and 4 more
- Volunteers
- 108 people
- Sponsor
- University of Zurich
Prediabetes / Type 2 Diabetes
Small Dense Low-density Lipoprotein in Patients With Prediabetes and Type 2 Diabetes
It is known that small dense LDL particles are associated with an increased cardiovascular risk. LDL particles can be separated by gradient gel electrophoresis (GGE) according to their size.
- Trial name
- NCT01584856
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University of Zurich
Diabetic Gastroparesis
Gastric vs Jejunal Feeding in Diabetic Gastroparesis
Diabetic 'Gastroparesis' or 'Gastroenteropathy' is a condition in which patients suffer episodes of nausea, vomiting, abdominal bloating and pain after eating.
- Trial name
- NCT00944593
- Testing
- Jejunal Feed, Normal Saline
- Where
- Switzerland
- Sponsor
- University of Zurich
Lichen Planus (LP)
Lichen Planus Mucosae at USZ, Efficacy of Oral Alitretinoin
This is a single center, prospective, open label, single arm, investigator initiated pilot study investigating the effect of alitretinoin on severe lichen planus with mucosal manifestations.
- Trial name
- NCT01538732
- Testing
- alitretinoin
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Zurich
Physical Activity
Active Over 45: A Step-up Jogging Program in Inactive Female Hospital Staff Aged 45+
Background: Inactive individuals face motivational obstacles for becoming and staying physically active. Therefore, sustainable physical activity promotion programs tailored to reach inactive individuals are needed.
- Trial name
- NCT01531660
- Testing
- step-up jogging program
- Where
- Switzerland
- Volunteers
- 68 people
- Sponsor
- University of Zurich
Rheumatoid Arthritis
Effect of TNF-Inhibition Combined With Conventional DMARDs on Cervical Pannus in Patients With RA and Cervical Spine Involvement
Atlantoaxial subluxation (AAS) is a complication of rheumatoid arthritis (RA) due to pannus formation around the odontoid process of C2 of the cervical spine. It occurs frequently in 15-30% of all RA patients.
- Trial name
- NCT01292616
- Testing
- therapy with disease-modifying anti rheumatic drugs (DMARD)
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- University of Zurich
Non-alcoholic Fatty Liver Disease
Prospective Cohort Study in Patients With NAFLD
To assess the importance of intracellular signalling pathways and its deregulation in adiposity and diabetes-related insulin resistance, liver tissue samples of patients suffering from non-alcoholic fatty liver disease (NAFLD)…
- Trial name
- NCT00575133
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- University of Zurich
Fatty Liver, Surgery
Liver Fat Quantification by Magnetic Resonance Imaging (MRI) - Prediction of Postoperative Complications
The purpose of this study is to objectively quantify liver fat content (LFC) by Magnetic Resonant Imaging (MRI) prior to major liver surgery, and to investigate its association with post-operative complications.
- Trial name
- MRsteatosis (NCT01234714)
- Testing
- Non-invasive Magnetic Resonance Imaging (MRI), Major liver resection
- Where
- 2 sites in Switzerland
- Volunteers
- 84 people
- Sponsor
- University of Zurich
Inflammatory Bowel Disease
Azathioprine & Allopurinol in Inflammatory Bowel Disease Patients
Main Study Objectives: The study is conducted to evaluate the minimal allopurinol and azathioprine doses that, in combination, produce therapeutic 6-TGN levels evaluate the safety and tolerability of the different…
- Trial name
- NCT00849368
- Testing
- Azathioprine / Allopurinol
- Where
- Switzerland
- Volunteers
- 6 people
- Sponsor
- University of Zurich
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