Clinical trials: sponsored by University of Zurich
Kidney Stones
The Role Of FGF23, Klotho, And Sclerostin In Kidney Stone Formers
Kidney stones are very common in industrialized countries and the lifetime risk is about 10 to 15% in this population. Kidney stones are composed of inorganic and organic components.
- Trial name
- NCT01526304
- Testing
- no intervention
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- University of Zurich
Severe Degenerative Mitral Regurgitation
Predictors of Postoperative Left Ventricular Function in Patients Undergoing Mitral Valve Repair for Severe Degenerative Mitral Regurgitation
The aim of the study is to investigate whether a predictive score (combination of several validated predictors) better predicts postoperative left ventricular function than any single predictor in patients undergoing mitral valve…
- Trial name
- NCT01519050
- Testing
- mitral valve repair
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Kidney Stones
Extracorporal Shockwave Lithotripsy Versus Retrograde Intrarenal Surgery for the Treatment of Kidney Stones
The purpose of this study is to compare two established modalities for the treatment of kidneystones: ESWL (extracorporal shockwave-lithotripsy) vs. URS (uretero-reno-scopy with stone-extraction).
- Trial name
- NCT01514032
- Testing
- Extracorporal shockwave lithotripsy, Retrograde intrarenal surgery
- Where
- Switzerland
- Volunteers
- 230 people
- Sponsor
- University of Zurich
Overactive Bladder
Bryophyllum Versus Placebo for Overactive Bladder
E: The pharmacological effect of Bryophyllum pinnatum could be shown on uterine smooth muscle cells, on spontaneous and oxytocin-stimulated contractions.
- Trial name
- NCT01127126
- Where
- Switzerland
- Volunteers
- 22 people
- Sponsor
- University of Zurich
Study Not Related to a Disease. Nutrition Study Without Drug Administration.
The Influence of Different Food Componente on Zinc Absorption in Young Adults Consuming Zinc Fortified Porridges Prepared From Maize, Beans and Sorghum: a Series of Six Similar Randomized, Single-blind Studies
The influence of different food componente on zinc absorption in young adults consuming zinc fortified porridge's prepared from maize, beans and sorghum: a series of six similar randomized, single-blind studies.
- Trial name
- NCT01210794
- Where
- Switzerland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Healthy
Pharmacokinetic Study: Effect of 25(OH)D and Vitamin D3 on Serum 25(OH)D
We compare the effect of HyD (25-hydroxyvitamin D) and vitamin D3 in their effect on 25-hydroxyvitamin D plasma levels over a course of 4 month. This is a pharmacokinetic study including 35 postmenopausal women.
- Trial name
- NCT00718276
- Testing
- 25(OH)D, vitamin D3
- Where
- Switzerland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Coronary Artery Disease
Effect of Eplerenone on Endothelial Function in Patients With Stable Coronary Heart Disease
The aim of the present study is to investigate wether endothelial dysfunction associated with stable coronary artery disease is altered by selective aldosterone antagonism with Eplerenone as potential anti-inflammatory drug…
- Trial name
- NCT00427284
- Where
- Switzerland
- Volunteers
- 42 people
- Sponsor
- University of Zurich
Atherosclerosis
Natural History of Atherosclerosis
20 patients will be recruited. The aim of the study is to determine the natural progression of atherosclerotic disease.
- Trial name
- NCT00918541
- Where
- 3 sites in Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Amphetamine-Related Disorders, Amphetamine Abuse
Investigation of Serotonin Neurotransmission in MDMA Users Using Combinated Dexfenfluramine Challenge and PET Imaging
Illicit use of the psychostimulant "Ecstasy" (3,4-methylenedioxymethamphetamine, MDMA) is considered a major public health issue.
- Trial name
- DEXFEN_PET (NCT01296802)
- Testing
- dexfenfluramine
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Psychiatric Disorders
Influence of Oxytocin on the Startle Reflex and on Its Modulation
Oxytocin (OXT) is currently regarded as a crucial neuropeptide in the mediation of various human social behaviors, e.g. social affiliation, social recognition, and the modulation of anxiety, mood, and aggression.
- Trial name
- NCT01066299
- Testing
- Syntocinon®, inactive nasal spray
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Glaucoma
Clinical Application of Sensimed Triggerfish Sensor (TS) With Wireless Signal Transmission for Continuous Intraocular Pressure Measurement
The study objective is to investigate the clinical applicability of continuous IOP measurement using TS with radio transmission over 24 hours. Trial with medical device
- Trial name
- NCT01467453
- Testing
- Triggerfish
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Prostate Cancer
Comprehensive Analysis of Hypoxia in Prostate Cancer: Diagnostic Markers and Prognostic Significance
A single-center cohort study to identify uni- and multivariate associations between marker gene expression and clinico-pathological parameters for the detection of robust and novel prognostic tools in prostate cancer
- Trial name
- NCT01191099
- Testing
- Pimonidazol
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- University of Zurich
Glaucoma
Evaluation of Filtering Blebs Using the "Wuerzburg Bleb Classification Score" Compared to Other Clinical Findings, e.g. the Intraocular Pressure (IOP)
It is well established to assess the functionality of a filtering bleb by intraocular pressure (IOP), either as an absolute value or as a percent reduction, and by the need of additional antiglaucoma drugs.
- Trial name
- NCT01287442
- Testing
- Trabeculectomy
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Ocular Adnexal Mucosa-Associated Lymphoid Tissue Lymphoma
Lymphoma in the Orbit
Imaging techniques have considerably improved over the last decades and ocular adnexal lymphomas (OALs) nowadays can be detected.
- Trial name
- NCT01302912
- Testing
- Lymphoma-Biopsy
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University of Zurich
Cardiac On-pump Surgery
Organ Protection With Sevoflurane Postconditioning After Cardiac Surgery With Cardiopulmonary Bypass
Organ protection, volatile anesthetics, postconditioning. Sedation of patients on ICU after cardiac surgery with cardiopulmonary bypass with either propofol or sevoflurane.
- Trial name
- NCT00924222
- Testing
- Sevoflurane, Propofol
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- University of Zurich
Esophageal Motility Disorders
Observational Field Study of Acute Esophageal Food Bolus Impaction by Mean Esophageal Manometry and 24h-pH-monitoring
The aim of this study is to evaluate standard investigations performed in patients with bolus impaction in a prospective observational field study. In bolus impaction, ingested food boluses have to be endoscopically removed.
- Trial name
- NCT01447823
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University of Zurich
Chronic Granulomatous Disease
Gene Therapy for X-linked Chronic Granulomatous Disease (CGD) in Children
The aim of the study is to evaluate the side effects and risks after infusion of retroviral gene corrected autologous CD34+ cells of the peripheral blood of chemotherapy conditioned (busulphan) children with chronic granulomatous…
- Trial name
- XCGDinChildren (NCT00927134)
- Testing
- retroviral SF71-gp91phox transduced CD34+ cells
- Where
- Switzerland
- Volunteers
- 2 people
- Sponsor
- University of Zurich
Recurrent Glioblastoma Planned for Reoperation
Patupilone (EPO 906) in Patients With Recurrent or Progressive Glioblastoma
Patupilone trial for patients with recurrent glioblastoma, which are planned for re-operation. Objectives: prolongation of PFS compared to patients with re-operation only, Patupilone tumor concentrations, pharmacokinetic…
- Trial name
- NCT00715013
- Testing
- Patupilone
- Volunteers
- 9 people
- Sponsor
- University of Zurich
Type 2 Diabetes
The Swiss Glucose Variability Study
The purpose of this study is to explore long term glucose variability of a combination therapy of metformin and vildagliptin compared to a metformin - gliclazide combination.
- Trial name
- NCT01426737
- Testing
- Vildagliptin
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University of Zurich
Allergy
Phase II Study to Standardize Allergen Extracts: Determination of Biological Activity in HEP Units
Today a variety of diagnostic tools to detect allergenic agents are available such as skin tests, provocation tests and blood tests.
- Trial name
- NCT01412528
- Testing
- Allergen extracts
- Where
- Switzerland
- Volunteers
- 160 people
- Sponsor
- University of Zurich
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