Clinical trials: sponsored by University of Zurich
Healthy Volunteers
Effect of Systemic Ropivacaine on Hyperalgesia, Flare Reaction and Peripheral Nerve Excitability
The purpose of this study is to compare the effect of intravenous ropivacaine and lidocaine on the receptive field of primary sensory afferents and their influence on the vascular bed. *Trial with medicinal product
- Trial name
- NCT00900913
- Testing
- ropivacaine (Naropin)
- Where
- Switzerland
- Volunteers
- 34 people
- Sponsor
- University of Zurich
Recurrent Herpes Labialis
Place Controlled Study to Treat Recurrent Herpes Labialis.
About 80% of the worldwide population is positive on HSV antibodies. In the United States the lifetime prevalence of recurrent herpes labialis is estimated at 20% to 40%, with approximately 100 million episodes occurring in the…
- Trial name
- NCT00914745
- Testing
- Ointment
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University of Zurich
Healthy
Effects of Dietary Fructose on Glucose and Lipid Metabolism in Healthy Human Subjects
The increasing intake of fructose has been associated with an increase in obesity among US children and adolescents, but its "dose dependent" effects on insulin sensitivity and lipid metabolism has not been studied in detail.
- Trial name
- NCT01021969
- Testing
- Fructose
- Where
- Switzerland
- Volunteers
- 36 people
- Sponsor
- University of Zurich
Hepatectomy
Organ Protection With Sevoflurane Postconditioning
Organ protection, volatile anesthetics, postconditioning, hepatic surgery
- Trial name
- NCT00518908
- Testing
- Sevoflurane
- Where
- Switzerland
- Volunteers
- 125 people
- Sponsor
- University of Zurich
Gastroesophageal Reflux Disease
Structure and Function of the Gastro-esophageal Junction
Aims of research project: To identify key features of the gastro-esophageal junction (structure and function) that protects the esophagus from gastro-esophageal reflux investigated by combined high resolution manometry and…
- Trial name
- NCT01053585
- Testing
- Baclofen
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- University of Zurich
Critically Ill Patients
ICG- Livertest Versus New Biomarkers as Prognostic Markers in Critically Ill ICG- Livertest Versus New Biomarkers as Prognostic Markers in Critically Ill
ICG- Leberfunktionstest versus "neue" Biomarker als prognostischer Marker bei intensivmedizischen Patienten
- Trial name
- (Greenpep) (NCT01317381)
- Testing
- Observational
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Burns
Early Fluid Resuscitation With Balanced HES 130/0.4 [6%] in Severe Burn Injury
RCT colloids versus cristalloids only in severe burn victims. Trial with medicinal product
- Trial name
- NCT01012648
- Testing
- Fluid resuscitation, HES 130/0.4 (6%), Voluven balanced vs. Lactated Ringer's solution
- Where
- Switzerland
- Volunteers
- 48 people
- Sponsor
- University of Zurich
Allergies
Study of Specific Allergen Immunotherapy in Grass Pollen Allergic Subjects by Epicutaneous Allergen Administration
Evaluation of patch as specific immunotherapy in allergic patients
- Trial name
- NCT00719511
- Testing
- Purified allergen dose 1 integrated in a Patch system, Purified allergen dose 2 integrated in a Patch system, Purified allergen dose 3 integrated in a Patch system
- Where
- Switzerland
- Volunteers
- 132 people
- Sponsor
- University of Zurich
Allergic Rhinoconjunctivitis
Study of Specific Allergen Immunotherapy in Grass Pollen Allergic Subjects With Epicutanoeus Allergen Administration
Seasonal rhinoconjunctivitis or hay fever is a common atopic condition that is frequently seen in clinical practice. Grass pollen is the major cause of pollinosis in many parts of the world.
- Trial name
- ZU-SkinSIT-003 (NCT00777374)
- Testing
- Patch
- Where
- Switzerland
- Volunteers
- 97 people
- Sponsor
- University of Zurich
Symptomatic Gallstone Disease
Cosmesis and Body Image After Single Port or 4-Port Laparoscopic Cholecystectomy
Laparoscopic Cholecystectomy (LC) is the treatment of choice for symptomatic gallstone disease. Single-port access cholecystectomy (SL) has been recently introduced using only one, trans-umbilical placed port.
- Trial name
- NCT01278472
- Testing
- Single Port Cholecystectomy, 4 Port Cholecystectomy
- Where
- Switzerland
- Volunteers
- 110 people
- Sponsor
- University of Zurich
Dermatologic Disease of Inpatients in Internal Medicine
Prevalence and Subjective Impairment of Quality of Life (QoL) Due to Dermatologic Diseases in Internal Medicine Patients
This is a 3 months single centre clinical patient-oriented study to evaluate the prevalence and impairment in QOL of dermatologic diseases in patients hospitalised in internal medicine.
- Trial name
- NCT01044043
- Testing
- clinical examination and quality of life questionnaire
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University of Zurich
Anesthesia Team Coordination
Adaptive Coordination in Anaesthesia Teams and Its Relationship to Clinical Performance.
The impact of different coordination patterns on team performance during anesthesia inductions are analyzed using videotapes. These records are examined using various categorization systems (ETHZ), focussing on changes of…
- Trial name
- RACoP (NCT00706108)
- Testing
- Observational study
- Where
- Switzerland
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Glaucoma Patients and Healthy Controls
Reproducibility of Nerve Fiber Layer Thickness Measurements in Patients With Glaucoma and Healthy Controls Using Spectral-Domain and Time-Domain OCT
To assess the reproducibility of Spectral-Domain-OCT (SD-OCT) retinal nerve fiber layer thickness (RNFL) thickness measurements in healthy volunteers and patients with glaucoma and to compare these results to conventional…
- Trial name
- NCT01273285
- Testing
- Spectralis® SD-OCT, Heidelberg Engineering GmbH, H
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University of Zurich
Lyme Disease
Safety, Skin and Plasma Concentration of Azithromycin Dermal Formulation
IXODES GmbH intends to develop SHB001, an azithromycin dermal formulation in order to prevent Lyme disease at early stages of infection after tick bite.
- Trial name
- IXO-01 (NCT01243008)
- Testing
- Application of SHB001
- Where
- Switzerland
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Glaucoma
Reproducibility of Retinal Nerve Fiber Layer Thickness Measurements Using the Eye Tracker and Retest Function of Spectralis® SD-OCT in Glaucomatous Eyes and Healthy Controls
PURPOSE. To evaluate the impact of self-acting eyetracking and retest software on the reproducibility of retinal nerve fiber layer (RNFL) thickness measurements in glaucoma patients and healthy control subjects using Spectralis®…
- Trial name
- NCT01228721
- Testing
- Spectralis® SD-OCT, Heidelberg Engineering GmbH, H
- Where
- Switzerland
- Sponsor
- University of Zurich
Renal Transplant Patients, Metabolic Acidosis
Metabolic Acidosis in Renal Transplant Patients
Acidosis (accumulation of acid in the body) may be an underrecognized problem in patients after renal transplantation. It may have consequences on physical performance due to negative effects on bone and muscle metabolism.
- Conditions
- Renal Transplant Patients, Metabolic Acidosis, Physical Capacity, Bone Disease
- Trial name
- MART (NCT00913796)
- Testing
- Potassium citrate, Potassium chloride
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Glioblastoma
Combined Approach to Resection of Glioblastoma (GBM) by 5-Aminolevulinic Acid (5-ALA) and Intraoperative Magnetic Resonance Imaging (MRI)
In the treatment of glioblastoma (GBM) neurosurgical resection of the tumor is usually considered a a first step of effective therapy.
- Trial name
- NCT01208909
- Testing
- diagnostic 5-ALA and MRI for tumor resection
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University of Zurich
Gram-Positive Bacterial Infections
Daptomycin Pharmacokinetics in Critically Ill Patients Undergoing Continuous Veno-venous Hemodiafiltration, a Dose Finding Study
Daptomycin kinetics in CRRT Trial with medicinal product
- Trial name
- NCT01212432
- Testing
- Daptomycin
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- University of Zurich
Pancreatic Neoplasms
Expression of Inflammatory Proteins in Pancreatic Cancer
The purpose of this trial is to investigate the expression of different inflammatory proteins in cancer and normal pancreatic tissue.
- Trial name
- NCT00551057
- Testing
- Expression type
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- University of Zurich
Reperfusion Injury
Role of Volatile Anesthetics for Hepatic Protection
This study aims to evaluate the attenuation of ischemic-reperfusion injury in the liver after sevoflurane preconditioning. In the presence of sevoflurane, an attenuation of liver injury is hypothesized (diminished increase of…
- Trial name
- NCT00516711
- Testing
- Sevoflurane
- Where
- Switzerland
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Zurich
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