Clinical trials: sponsored by University of Zurich
Breast Cancer, Microcalcification
Imaging Quality and Potential Clinical Relevance of Phase Contrast Mammography In-vivo: a Single-center, Prospective Study
Conventional mammography, breast sonography and breast MRI have specific weaknesses. In particular, mammography has a low sensitivity for the detection of mammary carcinoma in patients with a dense breast.
- Conditions
- Breast Cancer, Microcalcification, Image
- Trial name
- NCT06489665
- Testing
- Experimental Intervention
- Where
- 2 sites in Switzerland
- Volunteers
- 350 people
- Sponsor
- University of Zurich
Primary Hyperparathyroidism
Is Intraoperative PTH Monitoring Obsolete in Times of Choline PET/CT? a Prospective Multicenter Cohort Study to Determine Whether the Regular Preoperative Use of Choline-PET/CT Scan Obviate the Need for Intraoperative PTH-measurement in Patients with Primary Hyperparathyreoidism
In patients with primary hyperparathyreoidism (pHPT) in 80-90% only one of the four parathyroid glands has developed an autonomy and is causative for the disease.
- Trial name
- NCT06804681
- Where
- Switzerland
- Volunteers
- 1,000 people
- Sponsor
- University of Zurich
Sexual Health
Real Risks of the Online World
Development and validation of questionnaire/scale to assess problematic online dating app (ODA) use in a sub-cohort of the SwissPrEPared cohort study (validation sample: n=229).
- Trial name
- NCT04714034
- Testing
- to develop and validate a scale measuring problematic online dating app (ODA) use in sexual minorities
- Where
- Switzerland
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Amyotrophic Lateral Sclerosis
Tideglusib for the Treatment of Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative condition, mainly characterized by progressive weakness and wasting of the limbs, the respiratory and bulbar muscles.
- Trial name
- TIDALS (NCT05105958)
- Testing
- Tideglusib
- Where
- 5 sites in Switzerland
- Volunteers
- 98 people
- Sponsor
- University of Zurich
Chronic Obstructive Pulmonary Disease
Visa-versa! Breaking Instead of Pushing the Pedals-B
Eccentric muscle work is defined as lengthening of a muscle while applying force. It was shown that with eccentric work, muscles are able to perform four times as much power compared to usual concentric work, which results in…
- Trial name
- NCT05185856
- Testing
- 15 minutes eccentric cycling, 15 minutes concentric (normal) cycling
- Where
- Switzerland
- Volunteers
- 17 people
- Sponsor
- University of Zurich
Spinal Cord Injury + Peripheral Nerve Diseases
Assessment of Neuropathic Pain
Development of neuropathic pain is one of the most disabling sequels after spinal cord injury (SCI) and in peripheral nerve diseases.
- Trial name
- NCT02138344
- Where
- Switzerland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Suicidality, EEG
Nitrous Oxide in the Treatment of Acute Suicidal Ideation
The primary aim of the NITOS study is to investigate the potential rapid antisuicidal effects of N2O in the transdiagnostic treatment of suicidal ideation.
- Conditions
- Suicidality, EEG, Suicidal Ideation, Nitrous Oxide
- Trial name
- NITOS (NCT06636357)
- Testing
- 50% N2O plus 50% O2, Oxygen (O2)
- Where
- Switzerland
- Volunteers
- 85 people
- Sponsor
- University of Zurich
Hemophilia a, Hemophilia B
Measurement Properties in People with Hemophilia
The aim of this project is to determine the measurement properties (namely reliability and validity) of a set of clinical assessments, measuring different aspects of physical function.
- Conditions
- Hemophilia a, Hemophilia B, Musculoskeletal Complication, Measurement Error
- Trial name
- HEMOPRO (NCT06565481)
- Testing
- Measurement Properties (Reliability and Validity) of a Set of Assessments evaluating Physical Function in adult Participants with Hemophilia
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University of Zurich
Intermittent Fasting, Obesity
Longitudinal Monitoring During Intermittent Fasting Protocols in Obese Adults
LIMITFOOD2 is a randomized clinical intervention study that investigates the effects of two different intermittent fasting protocols compared to a control group on the health of obese adults.
- Conditions
- Intermittent Fasting, Obesity, Time Restricted Eating
- Trial name
- LIMITFOOD2 (NCT06323889)
- Testing
- Modified Alternate Day Fasting, Time-Restricted Eating, Weight-loss counseling
- Where
- Switzerland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Zurich
HIV Infections
Characterization of Acute and Recent HIV-1 Infections in Zurich.
Aim of the study: To study and to describe factors which could influence the course of primary HIV infection (PHI) and factors that in turn could be influenced through PHI.
- Trial name
- ZPHI (NCT00537966)
- Where
- Switzerland
- Volunteers
- 800 people
- Sponsor
- University of Zurich
Obstructive Sleep Apnea of Adult
Acute and Long-term Effects of CPAP in OSA
Two-phase interventional non-inferiority trial (phase 1: at least 8 weeks of CPAP; phase 2: 2 weeks of CPAP withdrawal) including 32 patients with moderate to severe OSA to compare the physiological consequences of a short-term…
- Trial name
- NCT06277115
- Testing
- Continuous positive airway pressure (CPAP)
- Where
- Switzerland
- Volunteers
- 36 people
- Sponsor
- University of Zurich
Chronic Disease, Lung Diseases, Obstructive
Holistic Wellbeing in COPD: Communication About Sexuality (COSY)
The aim of this study is to assess the effectiveness of a communication intervention about sexuality on quality of life and other outcomes like physical activity, exercise capacity and health status in people with chronic…
- Conditions
- Chronic Disease, Lung Diseases, Obstructive, Respiratory Disease
- Trial name
- NCT05696730
- Testing
- Communication intervention about sexuality in people with COPD
- Where
- Switzerland
- Volunteers
- 36 people
- Sponsor
- University of Zurich
Psychological Distress, Anxiety
The Short-term Effects of PRISMA on Mental Health
Given the high prevalence of mental health issues, such as anxiety and depression, in pretrial detainees, the Swiss Federal Justice Department (SFJD) approved a model trial ("Modellversuch Untersuchungshaft", MV).
- Conditions
- Psychological Distress, Anxiety, Depression, Suicidal Ideation
- Trial name
- PRISMA (NCT06197711)
- Testing
- PRISMA
- Where
- Switzerland
- Volunteers
- 1,480 people
- Sponsor
- University of Zurich
Diuresis Under Eletrical Stimulation
The Effect of Lower Urinary Tract Electrical Stimulation on Renal Urine Production (diuresis)
In previous studies, in which the perception threshold and / or sensory evoked potentials at different points of the lower urinary tract were examined and measured by means of electrical stimulation, a clear increase in the…
- Trial name
- EFFLUENT (NCT03256656)
- Testing
- electrical stimulation (non painful) of the lower urinary tract to determine the current perception threshold and record sensory evoked potentials
- Where
- Switzerland
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Zurich
Verticality Perception in Healthy Human Subjects, Individual Contribution of Different Sensory Systems
Verticality Perception - Multisensory Contribution
The purpose of this study is to evaluate the relative contribution of head- and trunk-based sensory systems to internal estimates of direction of gravity in healthy human subjects.
- Trial name
- NCT02212704
- Testing
- Vestibular stimulation by use of the turntable (static roll-tilt while the head is roll-tilted relative to the trunk), 3D-video-head impulse testing, Vestibular-evoked myogenic potentials (VEMPs)
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Pyrexia
Pyrexia Management Using an IL-6 Antibody in BRAF+ Melanoma Patients Treated with Dabrafenib/ Trametinib +/- Immunotherapy
The study examines the development of fever after administration of Actemra (tocilizumab) in patients who have fever and other cytokine release symptoms (headache, nausea, palpitations, low blood pressure) due to cancer therapy…
- Trial name
- Nov IIT- Pyrex (NCT04652258)
- Testing
- Actemra
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Zurich
Complex Regional Pain Syndromes, Complex Regional Pain Syndrome Type I of the Upper Limb
Embodied Virtual Reality for Chronic Pain
Virtual reality creates interactive, multimodal sensory stimuli that have demonstrated considerable success in reducing pain. Much research so far has focused on VR's ability to shift patients' attention away from pain; however…
- Conditions
- Complex Regional Pain Syndromes, Complex Regional Pain Syndrome Type I of the Upper Limb, Complex Regional Pain Syndrome I (CRPS I), Complex Regional Pain Syndrome I of Upper Limb
- Trial name
- NCT05160038
- Testing
- Embodied virtual reality
- Where
- Switzerland
- Volunteers
- 29 people
- Sponsor
- University of Zurich
Postoperative Wound Infection Deep Incisional Surgical Site, Prosthesis and Implants
Effect of Photodynamic Therapy on Skin Microbiome. Single Center Study (PHOMIC-II)
The overarching aim of this research project is to prevent orthopedic implant-associated infections. This study aims to investigate if PDT has an effect on bacterial skin colonization in order to improve skin antisepsis…
- Conditions
- Postoperative Wound Infection Deep Incisional Surgical Site, Prosthesis and Implants, Surgical Site Infection, Prosthetic Joint Infection
- Trial name
- NCT04618276
- Testing
- Photodynamic Therapy
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Parkinson Disease
Precision Sensorimotor Neurorehabilitation Through Personalized Stimulation Loops
Parkinson's disease (PD) is a neurodegenerative disease that affects about 1% of the elderly population and accounts for substantial disability and health care costs.
- Trial name
- StimuLOOP-PD (NCT06608875)
- Testing
- Hyper-personalized feedback (HPF intervention), Targeted auditory stimulation during sleep (TASS verum intervention)
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University of Zurich
Efficacy of Preoperative Microbial Reduction in the Nasal Cavity Using Antimicrobial Photodynamic Therapy (aPDT)
Preoperative Microbial Reduction of the Nasal Cavity With Antimicrobial Photodynamic Therapy (aPDT).
The goal of this clinical trial is to investigate the preoperative microbial reduction of the nasal cavity using Photodynamic Therapy (aPDT) in adult patients undergoing surgical intervention at the Department for…
- Trial name
- NCT06570252
- Testing
- activated Light Source (aPDT), non activated Light Source (Control)
- Volunteers
- 208 people
- Sponsor
- University of Zurich
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