Clinical trials: sponsored by Uppsala University
Fluid Overload, Fluid Therapy
The Effect of Maintenance Fluids on Overall Fluid Balance in ICU Patients
The amount of fluids characterized as non-resuscitation fluids given to ICU patients are likely to be high and will probably have a substantial impact on the total amount of fluid administered to ICU patients daily.
- Conditions
- Fluid Overload, Fluid Therapy, Critical Care
- Trial name
- NCT03972475
- Where
- 6 sites in Sweden
- Volunteers
- 200 people
- Sponsor
- Uppsala University
FBSS, Pain, Intractable
PET Patterns, Biomarkers and Outcome in Burst SCS Treated FBSS Patients
The primary aim of this study is to investigate cerebral mechanisms of burst stimulation in Failed Back Surgery Syndrome (FBSS) patients treated with Burst Spinal Cord Stimulation (SCS) for chronic back and leg pain.
- Conditions
- FBSS, Pain, Intractable, Low Back Pain, Radicular; Neuropathic, Lumbar, Lumbosacral
- Trial name
- PET-SCS (NCT03419312)
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Uppsala University
Ileostomy Closure in Rectal Cancer
Day-Case Closure of Loop Ileostomy in Rectal Cancer
The aim of this study is to investigate if day-case closure of ileostomy is feasible and safe.
- Trial name
- NCT02774447
- Testing
- ileostoma closure
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Uppsala University
Nocturnal Enuresis
Nocturnal Enuresis and Rapid Maxillary Expansion
Nocturnal enuresis (NE) is the involuntary loss of urine that occurs only at night in children aged 5 years or more. NE is a common problem, affecting about 10% of school children.
- Trial name
- NERME (NCT02178826)
- Testing
- Rapid Maxillary Expansion
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Uppsala University Hospital
Type 2 Diabetes Mellitus, Obesity
Bariatric Surgery for the Treatment of Type 2 Diabetes - Clinical Effects and Underlying Mechanisms
The main purpose of this project is to further explore the metabolic effects and the mechanisms underlying the improvement in glucose homeostasis following bariatric surgery.
- Trial name
- Bariglykos (NCT02729246)
- Testing
- Laparoscopic Gastric Bypass
- Where
- Sweden
- Volunteers
- 21 people
- Sponsor
- Uppsala University
Surgical Adhesions
Does Icodextrin Reduce the Risk of Small Bowel Obstruction?
The study aims at investigating if icodextrin 4% instilled in abdominal cavity during surgery can reduce the risk of surgery and hospitalisation for small bowel obstruction in patients with colorectal cancer.
- Trial name
- NCT02318888
- Testing
- Surgery, Icodextrin
- Where
- 13 sites in Sweden
- Volunteers
- 1,808 people
- Sponsor
- Uppsala University
Comorbidities, Critical Care
Method of Measuring Comorbidity to Predict Outcome After Intensive Care
In this study the investigators will validate the impact of comorbidity on readmission to intensive care unit (ICU) and mortality after ICU and which method of measuring comorbidity that is most predictive.
- Trial name
- AA (NCT04109001)
- Volunteers
- 223,495 people
- Sponsor
- Uppsala University
Musculoskeletal Pain
A Stepped-care Model of Tailored Behavioural Medicine Pain Intervention in Primary Care
Background: This study is based on an innovative stepped-care protocol for the management of musculoskeletal pain in primary care, which is evaluated in a RCT.
- Trial name
- STEP-UP (NCT01992770)
- Testing
- Hierarchical graded exposure, Graded activity, Physical exercises
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Uppsala University
Healthy Subjects
The Link Between Mental Imagery and the Reduction of Fear in Imaginal Extinction
Imaginal exposure is a widely used psychological treatment technique. Imaginal extinction is an experimental analogue of imaginal exposure, that allows the study of this treatment technique under controlled circumstances (Agren…
- Trial name
- NCT03989518
- Testing
- Fear acquisition, Imaginal extinction, Reinstatement
- Where
- Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Acute Kidney Injury
Acute Kidney Injury in Major Abdominal Surgery: Retrospective Study of 501 Patients
Retrospective study that aims to examine the presence of acute kidney injury (AKI) during major abdominal surgery, non- cardiac surgery. Using clinical and biochemical data in order to establish AKI frequency and risk factors.
- Trial name
- NCT04130347
- Volunteers
- 499 people
- Sponsor
- Uppsala University
Irritable Bowel Syndrome
Identification of IBS Metabotypes Based on Physiological Responses to Food
Irritable bowel syndrome (IBS) is a condition characterized by abdominal pain, bloating, constipation, diarrhea and gas and affects up to 15% of the Western population.
- Trial name
- NCT03653689
- Testing
- FODMAP, Gluten
- Where
- Sweden
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Intracranial Embolism
Electrical Cardioversion of Recent Onset Atrial Fibrillation - Silent Thromboembolic Events, Reverse Atrial Remodeling
The purpose of this study is to study the effects of transthoracic electrical cardioversion for restoration of sinus rhythm in patients who present with recent onset atrial fibrillation, with regard to new silent cerebral…
- Trial name
- ECAF-STAR (NCT02955004)
- Testing
- Electrical cardioversion
- Where
- 3 sites in Sweden
- Volunteers
- 43 people
- Sponsor
- Uppsala University Hospital
Chronic Pain, Self-Criticism
Psychological Treatment Targeting Acceptance and Compassion in Chronic Pain Patients
This trial is a randomized controlled study aiming to investigate the effect of an 8-week internet-based intervention focused on acceptance and compassion or a wait-list control group.
- Trial name
- NCT03504904
- Testing
- Internet-Delivered ACT and CFT
- Where
- Sweden
- Volunteers
- 71 people
- Sponsor
- Uppsala University
Attention Deficit and Disruptive Behavior Disorders, Problem Behavior
Effectiveness of Behavioral Preschool Teacher Training for Externalizing
A cluster randomized controlled pre-post effectiveness trial of behavioral preschool teacher training (BPTT) delivered in a practitioner assisted group format for children with externalizing behavior problems.
- Conditions
- Attention Deficit and Disruptive Behavior Disorders, Problem Behavior, Attention Deficit Disorder With Hyperactivity
- Trial name
- BPTT (NCT03967509)
- Testing
- Comet
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Uppsala University
Individuals With Fear of Spiders
Neural Activations During Imaginal Exposure in Individuals Fearful of Spiders
This study explores the brain basis of imaginal exposure, a widely used psychological treatment technique. Specifically, this study uses functional magnetic resonance imaging to examine brain areas activated during imaginal…
- Trial name
- NCT03969160
- Testing
- Imaginal exposure
- Where
- 2 sites in Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Cholesterol, LDL
Effectiveness of Written Dietary Advice on Lipoproteins - a Pragmatic Randomized Controlled Trial
This study investigates the effect of detailed, written dietary advice for improving blood lipids, in a primary care setting. n=222 participants will be randomized to Active Intervention or Control Group.
- Trial name
- MYDICLIN (NCT03528252)
- Testing
- Written advice LDL Cholesterol, Written advice Triglycerides
- Where
- Sweden
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Burns, Nutritional Deficiency
The Role of Nutrition After Minor Burns
Nutrition therapy has an important role in burn care to optimize wound healing, prevent muscle wasting, improve immune function and decrease risk of infection and sepsis.
- Trial name
- NCT03867565
- Testing
- Nutritional intervention
- Volunteers
- 84 people
- Sponsor
- Uppsala University
Ulcerative Colitis Flare
Lactobacillus Reuteri ATCC PTA 4659 in Ulcerative Colitis
Explorative investigation to study the effect of the endogenous bacterium Lactobacillus reuteri ATCC PTA 4659 as a nutrient additive against relapse in ulcerative colitis.
- Trial name
- COLUS (NCT03798210)
- Testing
- Lactobacillus reuteri
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Uppsala University
Fecal Incontinence, Anorectal Malformation
NASHA/Dx as a Perianal Implant for the Treatment of Persistent Fecal Incontience After Anorectal Malformation
Persistent fecal incontinence (FI) after anorectal malformations (ARM) is a common occurence. During the last two decades perianal injection therapy has emerged as an option for treating patients with FI due to other causes than…
- Trial name
- NCT03746834
- Testing
- NASHA/Dx (Solesta®)
- Volunteers
- 7 people
- Sponsor
- Uppsala University
Dyslipidemias
Fatty Acid Biomarkers of Carbohydrate Intake
The overall aim is to investigate if circulating fatty acids and lipids are influenced by alterations in carbohydrate amount and quality.
- Trial name
- CARBIO (NCT03295448)
- Testing
- Low carbohydrate diet, High carbohydrate, high sugar diet, High carbohydrate, low sugar diet
- Where
- Sweden
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Uppsala University