Clinical trials: sponsored by Uppsala University
Fibromyalgia
Breathing and Chest Wall Mobility in People With Fibromyalgia.
The aim of this study is to examine differences between respiratory function in female fibromyalgia patients and healthy controls. The study will also examine differences in spine mobility and pain intensity.
- Trial name
- NCT03495687
- Where
- Sweden
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Sepsis
Mortality of Sepsis in Swedish Intensive Care Units 2008-2016
A study of short and long term mortality in patients treated with or without a diagnosis of sepsis in Swedish intensive care units (ICU) 2008 - 2016.
- Trial name
- NCT03489447
- Testing
- ICU care
- Volunteers
- 252,245 people
- Sponsor
- Uppsala University
Pulmonary Arterial Hypertension
BEET PAH: a Study to Assess the Effects of Beetroot Juice in Patients With Pulmonary Arterial Hypertension
The study is a single center randomised, double-blind, placebo-controlled crossover study to assess the effects of beetroot juice in patients with pulmonary arterial hypertension.
- Trial name
- BEET-PAH (NCT02000856)
- Testing
- Beetroot juice
- Where
- Sweden
- Volunteers
- 15 people
- Sponsor
- Uppsala University
Dyssomnias
iCBT for Adolescents With Co-morbid Insomnia
Insomnia is a commonly reported comorbidity for adolescents with psychiatric conditions. It is well-known that insomnia can exacerbate the concurrent psychiatric symptom load.
- Trial name
- NCT02612987
- Testing
- Internet-based Cognitive Behaviour Therapy (iCBT)
- Where
- Sweden
- Volunteers
- 21 people
- Sponsor
- Uppsala University Hospital
Trauma Injury
Implementation of New Trauma Triage Criteria and Implications on Under- and Overtriage.
New trauma alert criteria has been introduced in Sweden, and our aim in this study is to evaluate the outcome of the old and new trauma alert criteria in a cohort of 1.300.000 inhabitants at six hospitals regarding over- and…
- Trial name
- Traumalert (NCT03395158)
- Testing
- Implementation of new alert criteria
- Volunteers
- 2,200 people
- Sponsor
- Uppsala University
Anxiety, Chronic Pain
Return To Work for People on Long Term Sick Leave
Vitalis was a randomized controlled intervention study that addressed women on long-term sick leave in Uppsala County. Participants were on sick leave due to mental illness and/or pain and were expected to reach the time limit…
- Trial name
- Vitalis (NCT03343457)
- Testing
- Cognitive therapy
- Volunteers
- 400 people
- Sponsor
- Uppsala University
Obstructive Sleep Apnea
Oral Appliance in Obstructive Sleep Apnea. A Randomized Controlled Blinded Multicenter Study Comparing Two Devices
The hypothesis of the study is that a bibloc-apnea splint has a comparable efficacy on respiratory measures as a monobloc-apnea splint and that the cost of treatment is the same.
- Trial name
- NCT02148510
- Testing
- Monobloc, Bibloc
- Where
- 2 sites in Sweden
- Volunteers
- 313 people
- Sponsor
- Uppsala University
Sleep Apnea, Obstructive, Obesity
Life-style Changes in Obstructive Sleep Apnea
The primary aim is to study whether a tailored behavioural medicine intervention addressing physical activity and eating habits have additional effects to continuous positive airways pressure (CPAP) in patients with moderate or…
- Trial name
- NCT01102920
- Testing
- Behavioural strategies to promote physical activity and weight loss, CPAP
- Where
- Sweden
- Volunteers
- 86 people
- Sponsor
- Uppsala University
Peripheral Nerve Injuries
Chronic Neuropathic Pain After Nerve Repair Hand Surgery
This study intends to compare the patients with pain with those who underwent same procedure without developing pain. The patients with pain and without pain will be further analyzed in respect to clinical differences, biomarkers…
- Trial name
- NCT03174665
- Testing
- No intervention
- Volunteers
- 990 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Arthritis of the Knee
Dosing of Intra-articular Triamcinolone Hexacetonide for Knee Synovitis in Chronic Polyarthritis
This prospective randomised controlled single blind trial comparing the relapse rate in 6 months for 20 mg versus 40 mg intraarticular triamcinolone hexacetonide (Lederspan®) for knee synovitis in patients with rheumatoid…
- Trial name
- NCT02437461
- Testing
- Triamcinolone hexacetonide
- Where
- Sweden
- Volunteers
- 159 people
- Sponsor
- Uppsala University
Ankylosing Spondylitis, Spinal Fractures
Effect of Biological Disease Modifying Anti Rheumatic Drug (bDMARD) Treatment on Spinal Fracture Incidence in Patients With Ankylosing Spondylitis (AS)
Ankylosing spondylitis (AS) is a rheumatoid disease affecting all segments of the axial skeleton, leading to the complete fusion of all spinal segments - the bamboo-spine.
- Trial name
- NCT02840695
- Testing
- bDMARD treatment
- Volunteers
- 9,858 people
- Sponsor
- Uppsala University
Shock, Hemorrhagic, Fractures, Bone
Retroperitoneal Packing or Angioembolization for Hemorrhage Control of Pelvic Fractures
This study is designed to answer whether minimal invasive vessel clotting (angioembolization) or open surgery (retroperitoneal packing) is more effective for pelvic fractures with massive bleeding.
- Conditions
- Shock, Hemorrhagic, Fractures, Bone, Multiple Trauma
- Trial name
- NCT02535624
- Testing
- PACKING, ANGIO
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Uppsala University
B Cell Lymphoma, B Cell Leukemia
CD19-targeting 3rd Generation CAR T Cells for Refractory B Cell Malignancy - a Phase I/IIa Trial.
Chimeric antigen receptor (CAR) T cells targeting CD19 will be evaluated for safety and efficacy in patients with B cell lymphoma or leukemia.
- Trial name
- NCT02132624
- Testing
- Autologous 3rd generation CD19-targeting CAR T cells
- Where
- Sweden
- Volunteers
- 15 people
- Sponsor
- Uppsala University
Type2 Diabetes, Weight Loss
Improving Glucose and Lipid Metabolism Through Caloric Restriction Using Diet or Surgery (CRUDOS)
In this explorative randomized clinical study, the investigators aim to study metabolic, cellular, and molecular changes that occur during weight loss in obese subjects with and without type 2 diabetes.
- Conditions
- Type2 Diabetes, Weight Loss, Insulin Sensitivity, Metabolism and Nutrition Disorder
- Trial name
- CRUDOS (NCT02988011)
- Testing
- Gastric by-pass surgery, Low-caloric diet
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Uppsala University
Neoplasms
Malignancies in Transplanted Patients
The aim of the project is to improve the overall treatment and outcome of renal, pancreas or liver transplanted patients who have encountered a malignancy by a structured treatment program for diagnosis and treatment of the…
- Trial name
- MALTX (NCT02241564)
- Testing
- Referral to a multidisciplinary expert panel at the Uppsala University Hospital after tumor detection, Switch from calcineurin inhibitor to an mTOR inhibitor
- Where
- Sweden
- Volunteers
- 95 people
- Sponsor
- Uppsala University
Sleep Deprivation, Metabolic Disturbance
Biorhythms in Metabolic Tissues
Metabolism is increasingly recognized as being highly regulated by anticipatory biological rhythms (circadian rhythms or "biorhythms"), which are driven by molecular feedback loops, and which are approximately 24 hours long…
- Conditions
- Sleep Deprivation, Metabolic Disturbance, Biological Clocks, Healthy
- Trial name
- NCT03276442
- Testing
- Low-fat dietary intervention, High-fat dietary intervention
- Where
- Sweden
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Human Papillomavirus, Cervix Cancer
Prevention of HPV in the School Health Service
The last ten years sexually transmitted infections (STI) have substantially increased among adolescents. STI can lead to individual suffering and have a negative effect on the future reproductive health and also increase the need…
- Trial name
- NCT02280967
- Testing
- Education about HPV by school nurse
- Where
- Sweden
- Volunteers
- 832 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Neuroendocrine Tumors
Biomarker Study in Pancreatic Neuroendocrine Tumours
The biology of pancreatic neuroendocrine tumors can change during the disease course. This evolution of disease can manifest through increases in tumor proliferation rate, resistance to medical therapy and/or a change in tumor…
- Trial name
- PROGRESS (NCT03130205)
- Testing
- Core Needle Biopsy, Computed Tomography, 18F-FDG-PET
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Uppsala University
Osteoarthritis, Sedentary
Swedish PAP in Osteoarthritis - a RCT Study
The purpose of this study is to determine whether an intervention with Physical activity on prescription (PAP) to individuals in primary care with knee or hip osteoarthritis would result in effects on physical activity level…
- Trial name
- NCT02387034
- Testing
- Physical activity on prescription, General advice
- Where
- Sweden
- Volunteers
- 140 people
- Sponsor
- Uppsala University
Complex Regional Pain Syndromes
Exposure Therapy Combined With Cortical Interventions for CRPS-II
Consecutive patients with long-standing complex regional pain syndrome II in a lower limb are treated with graded exposure therapy in vivo in combination with methods targeting cortical reorganisation.
- Trial name
- ETHICS (NCT03174249)
- Testing
- Exposure therapy
- Where
- Sweden
- Volunteers
- 4 people
- Sponsor
- Uppsala University