Clinical trials: sponsored by Uppsala University
Pulmonary Disease, Chronic Obstructive
Behavioral Intervention to Maintain Physical Capacity and Activity in Patients With Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this study is to investigate to what extent patients with COPD, who have participated in physical training for 12 weeks, can maintain their physical activity behaviour and physical capacity on a long-term basis if…
- Trial name
- COPD (NCT01539434)
- Testing
- Behavioural intervention, Usual care group
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Uppsala University
ST-segment Elevation Myocardial Infarction, Non ST-segment Elevation Myocardial Infarction
Bivalirudin vs Heparin in NSTEMI and STEMI in Patients on Modern Antiplatelet Therapy in SWEDEHEART
In this trial we test the hypothesis that PCI and bivalirudin is superior to heparin alone (according to local protocol) in reducing death, MI, and major bleeding in patients with NSTEMI or STEMI at 180 days (primary end point)…
- Trial name
- VALIDATE (NCT02311231)
- Testing
- bivalirudin, Heparin
- Where
- Sweden
- Volunteers
- 6,012 people
- Sponsor
- Uppsala University
Spinal Fractures
Survival After Surgical Treatment of Axis Fractures in Elderly
Fractures of the second cervical vertebra (C2) are the most common spinal fracture among the elderly. Non-surgical treatment comprises of cervical collar treatment for 12 weeks, while surgical treatment for elderly could mean…
- Trial name
- NCT02839057
- Testing
- Non-surgical treatment, Surgical treatment
- Volunteers
- 6,231 people
- Sponsor
- Uppsala University
Arthralgia, TMJ
Arthralgia of the Temporomandibular Joint. Pain Relief Following One Intra-articular Injection of Methylprednisolone
The hypothesis is that a single dose intra-articular injection of corticosteroids are effective in relieving temporomandibular arthralgia pain.
- Trial name
- NCT01995019
- Testing
- Methylprednisolone, Physiologic saline
- Where
- 7 sites in Sweden
- Volunteers
- 56 people
- Sponsor
- Uppsala University
Atrial Fibrillation
Single Versus Double Cryoballoon Ablation for Pulmonary Vein Isolation in Patients With Atrial Fibrillation
This is a clinical study where the investigators will assess the efficacy of a single cryoballoon application per vein guided by a multipolar recording catheter as compared with a conventional technique with 2 cryoballoon…
- Trial name
- SD-CRYO-AF (NCT03003975)
- Testing
- PVI by single cryoballoon application guided by Achieve Mapping Catheter, PVI by 2 routine cryoballoon applications
- Where
- Sweden
- Volunteers
- 140 people
- Sponsor
- Uppsala University Hospital
Atrial Fibrillation, Quality of Life
Catheter Ablation Compared With Pharmacological Therapy for Atrial Fibrillation (CAPTAF Trial)
The objective is to compare the efficacy of 2 treatment strategies, catheter ablation of atrial fibrillation versus optimized pharmacological therapy, in patients with symptomatic atrial fibrillation.
- Trial name
- CAPTAF (NCT02294955)
- Testing
- Catheterablation, Amiodarone, Sotalol
- Where
- Sweden
- Volunteers
- 152 people
- Sponsor
- Uppsala University Hospital
Atrial Fibrillation
Cryoballoon Ablation in Patients With Longstanding Persistent Atrial Fibrillation
Prospective and explorative clinical study. The objective is to assess the clinical efficacy of pulmonary vein isolation using the Arctic Front Advance cryoballoon in patients with longstanding persistent atrial fibrillation (AF)…
- Trial name
- CRYO-LPAF (NCT02294929)
- Testing
- Atrial fibrillation ablation
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Uppsala University Hospital
Sexual Behavior, Lifestyle
Reproductive Life Plan-based Counseling With Men
Many women and men in fertile age are at risk for sexual transmitted infections and unwanted pregnancies, and have insufficient knowledge of health promoting lifestyle prior to conception.
- Conditions
- Sexual Behavior, Lifestyle, Fertility, Pregnancy
- Trial name
- NCT02736214
- Testing
- Reproductive Life Plan (RLP)
- Where
- 2 sites in Sweden
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Inpatient Facility Diagnoses, Psychiatric Disorders
Behavioral Activation - From Inpatient to Outpatient Services
The purpose of this study is to compare the effectiveness of Behavioral Activation and Supportive Therapy added to the standard acute psychiatric inpatient care.
- Conditions
- Inpatient Facility Diagnoses, Psychiatric Disorders, Depressive Symptoms
- Trial name
- NCT01786733
- Testing
- Behavioral Activation, Supportive Therapy
- Volunteers
- 64 people
- Sponsor
- Uppsala University
Substance Use Disorders
Substance Use Disorders and Tobacco Habits
In the department for substance use disorders at Uppsala University Hospital there are two wards. One that is locked, where the patients that are emitted can not go out to smoke and another ward where there is a possibility to go…
- Trial name
- NCT03118011
- Testing
- No smoking, Smoking
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Uppsala University
Myocardial Infarction
Pattern of Repeat Cardiovascular Events During Follow-up After First Diagnosed Event-MI
Recurrent myocardial infarctions (reinfarctions) can be due to recurrence at the original treatment site, the presence of untreated lesions elsewhere, or in progressive lesions.
- Trial name
- PRECLUDE-MI (NCT03099395)
- Volunteers
- 100,000 people
- Sponsor
- Uppsala University
Chronic Pain, Insomnia
Insomnia and Cognitive Performance in Chronic Pain
The aim of the present study is to examine cognitive function in a patient population with complex chronic pain to test the hypothesis that insomnia severity on its own predicts objective cognitive function, and that a…
- Trial name
- NCT03072745
- Testing
- Neuropsychological assessment
- Where
- Sweden
- Volunteers
- 22 people
- Sponsor
- Uppsala University
Cancer, Anxiety
Internet Based Screening and Stepped Care for Cancer Patients With Anxiety and Depression Symptoms
The aim is to evaluate the effects of Internet based Stepped Care on anxiety, depression and health related quality of life in cancer patients with anxiety and depression symptoms, compared to Standard Care, and to evaluate the…
- Conditions
- Cancer, Anxiety, Depression
- Trial name
- AdultCan (NCT01630681)
- Testing
- Internet-based stepped care
- Where
- 3 sites in Sweden
- Volunteers
- 229 people
- Sponsor
- Uppsala University
Breastfeeding, Quality of Life
The Effectiveness of Proactive Telephone Support Provided to Breastfeeding Mothers of Preterm Infants
Although breast milk has numerous benefits for infants' development, with heightened effects in those born preterm (at < 37 gestational weeks), mothers of preterm infants have shorter breastfeeding duration than mothers of term…
- Conditions
- Breastfeeding, Quality of Life, Parental Stress, Attachment
- Trial name
- NCT01806480
- Testing
- Person-centred proactive breastfeeding telephone support
- Where
- 6 sites in Sweden
- Volunteers
- 493 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Angina Pectoris, Acute Myocardial Infarction
Evaluation of iFR vs FFR in Stable Angina or Acute Coronary Syndrome
Previous trials have demonstrated that the use of physiological assessment of stenosis severity using fractional flow reserve (FFR) is superior to angiographic assessment in percutaneous coronary intervention (PCI) and improves…
- Trial name
- iFR Swedeheart (NCT02166736)
- Testing
- iFR, FFR
- Where
- 14 sites in Denmark, Iceland and 1 more
- Volunteers
- 2,037 people
- Sponsor
- Uppsala University
Diabetes Mellitus, Type 2
A Single-dose Cross-over Study to Assess Direct and Indirect Effects of Dapagliflozin on Pancreatic Alpha and Beta Cells in Patients With Type 2 Diabetes
The purpose of this study is to evaluate if Dapagliflozin has direct effect on alpha cell glucagon release.
- Trial name
- NCT02765204
- Testing
- Dapagliflozin, Saxagliptin, Glucose
- Where
- Sweden
- Volunteers
- 15 people
- Sponsor
- Uppsala University
Obesity
Exploratory Study to Investigate the Effect of Dapagliflozin and Exenatide Combined on Body Weight
Obesity is a medical condition which increases the risk of other diseases, such as type 2 diabetes and cardiovascular disease. Obesity-related risk factors for the development of other metabolic diseases include unstable glucose…
- Trial name
- Dapalost (NCT02313220)
- Testing
- Dapagliflozin, Exenatide
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Uppsala University
Neonatal Disorder, Asphyxia Neonatorum
Early or Late Cord Clamping in the Depressed Neonate
This study evaluates the hypothesis that delayed compared to early umbilical cord clamping will improve neonatal transition in terms of circulation and breathing during resuscitation.
- Trial name
- NepCordIII (NCT02727517)
- Testing
- Early (≤ 60 seconds) cord clamping, Delayed (≥ 180 seconds) cord clamping
- Where
- Nepal
- Volunteers
- 90 people
- Sponsor
- Uppsala University
Oral Mucositis, Pain
Cryotherapy for Prevention of Oral Mucositis in Children Undergoing Hematopoietic Stem Cell Transplantation
Oral mucositis (OM) is a common adverse effect of chemotherapy, radiotherapy and conditioning regimens before Hematopoietic Stem Cell Transplantation (HSCT).
- Conditions
- Oral Mucositis, Pain, Infection, Nutrition Aspect of Cancer
- Trial name
- NCT01789658
- Testing
- Cryotherapy
- Where
- 5 sites in Sweden
- Volunteers
- 53 people
- Sponsor
- Uppsala University
Obesity, Overfeeding
Overeating Different Fats and Influence on Muscle Mass and Body Fat Accumulation
To investigate metabolic and molecular response to fatty acid-specific overfeeding in overweight subjects, in relation to changes in ectopic fat, lean tissue mass and insulin sensitivity
- Conditions
- Obesity, Overfeeding, Muscle Mass, Body Composition
- Trial name
- LIPOGAIN-2 (NCT02211612)
- Testing
- PUFA-group, SFA-group
- Where
- Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Uppsala University