Clinical trials: sponsored by Uppsala University
Low Back Pain, Mechanical, Degenerative Disc Disease Lumbar
Fusion or Not - a Study on Low Back Pain
Problems from the musculoskeletal system are one of the most common reasons for disability and sick leave. These problems include low back pain. Low back pain affects as many as 8 out of 10 individuals at some point in life.
- Trial name
- NCT06709391
- Testing
- Fusion surgery, Non-fusion surgery
- Where
- 4 sites in Sweden
- Volunteers
- 90 people
- Sponsor
- Uppsala University
Cardiometabolic Syndrome, Obesity and Cardiovascular Risk
Lifestyle Changes, Mushroom Supplementation, and Bupropion to Reduce Adiposity and Cardiometabolic Risk
The increasing prevalence of obesity, its serious health consequences, and the substantial economic burden on healthcare systems underscore a pressing need for effective, long-term prevention strategies that can be implemented in…
- Conditions
- Cardiometabolic Syndrome, Obesity and Cardiovascular Risk, Overweight , Obesity
- Trial name
- NCT07806279
- Testing
- Bupropion 150 mg, Lyophilized powder from edible mushrooms, Lifestyle Management
- Where
- 3 sites in Sweden
- Volunteers
- 250 people
- Sponsor
- Uppsala University
Head and Neck Cancer Squamous Cell Carcinoma, Head and Neck Cancer
Improved Oral Health in Head and Neck Cancer Survivors
The goal of this clinical trial is to learn if an oral care programme, designed as a multicentre two-armed randomised controlled trial (RCT), can prevent or mitigate late oral sequalae following completion of head and neck cancer…
- Trial name
- OHHNC (NCT07173270)
- Testing
- Oral health support
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Uppsala University
Juvenile Idiopathic Arthritis
Treatment With Specific Carbohydrate Diet in Children With Juvenile Idiopathic Arthritis
The aim of this study is to explore if an already established diet with anti-inflammatory effect in paediatric inflammatory bowel disease would have an anti-inflammatory effect in children with JIA.
- Trial name
- JIA (NCT04205500)
- Testing
- Specific carbohydrate diet
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Uppsala University
Sleep Deprivation, Sleep
Metabolic and Cognitive Parameters Following Partial Sleep Deprivation
The purpose of this study is to determine whether partial sleep deprivation, as compared with normal sleep, influences certain metabolic and cognitive parameters, related to food intake, hunger and memory functions, when…
- Trial name
- NCT01823263
- Testing
- Portion Size Task, Blood sample, Interference task
- Where
- Sweden
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Anxiety, Depression
Feasibility, Acceptability and Preliminary Clinical Outcome Signals Following a Digital Things You Do (TYD) Intervention in Primary Care: A Single-case Study
This study evaluates potential help for mild to moderate psychological distress in primary care patients. The study offers a choice between two interventions, both offered online (in a digital format).
- Trial name
- NCT07721870
- Testing
- Things You Do (TYD), REACH
- Where
- Sweden
- Volunteers
- 14 people
- Sponsor
- Uppsala University
Surgical Incision, Wound Dehiscence
Treating Emergency Laparotomy Incisions With Negative Pressure Wound Therapy
The goal of this clinical trial is to investigate Negative Pressure Wound Therapy (NPWT) in adults undergoing emergency laparotomy.
- Conditions
- Surgical Incision, Wound Dehiscence, Surgical Site Infection, Incisional Hernia
- Trial name
- TELIN (NCT07003906)
- Testing
- Negative pressure wound therapy, Standard postoperative dressing
- Where
- 6 sites in Sweden
- Volunteers
- 720 people
- Sponsor
- Uppsala University
Attention Deficit Hyperactivity Disorder
A Systematic Study of Assessment of Attention-Deficit/Hyperactivity Disorder (ADHD)
ADHD is one of the most prevalent psychiatric conditions, consuming a large proportion of resources in psychiatric care, often accompanied by long waiting lists to receive proper assessment.
- Trial name
- NCT05588713
- Testing
- Brief assessment protocol, Comprehensive assessment protocol
- Where
- Sweden
- Volunteers
- 142 people
- Sponsor
- Uppsala University
Parotid Neoplasms, Post-operative Complications
Swedish National Parotidectomy Study (SNaPs): Drainless Versus Standard Surgery
The purpose of this study The purpose of this study is to find out if it is safe to perform surgery on the parotid gland (the large salivary gland in front of the ear) without using a wound drain.
- Conditions
- Parotid Neoplasms, Post-operative Complications, Seroma as Procedural Complication
- Trial name
- SNaPs (NCT07620184)
- Testing
- Active wound drainage (Standard of Care), Omission of active wound drain
- Where
- 3 sites in Sweden
- Volunteers
- 600 people
- Sponsor
- Uppsala University Hospital
Intimate Partner Violence, Resilience, Psychological
Shame, Resilience and Well-being After Intimate Partner Violence: an Intervention Study With Replicated Single-Subject Design.
The EMBER protocol is a health care method that is designed to increase resilience, in order to improve well-being and overall health in women who have experienced violence by a partner.
- Trial name
- EMBER-4 (NCT07618754)
- Testing
- Resilience enhancing intervention, individual format, Resilience enhancing intervention, group format
- Where
- Sweden
- Volunteers
- 8 people
- Sponsor
- Uppsala University
Intimate Partner Violence, Intimate Partner Violence Against Women
Resilience and Recovery After Intimate Partner Violence - Evaluation of the EMBER-IPV Protocol
The EMBER-protocol is an intervention used at the NCK clinic at Uppsala University Hospital with the purpose of helping women utilize their resilience and strengths in order to recover after intimate partner violence.
- Conditions
- Intimate Partner Violence, Intimate Partner Violence Against Women, Shame, Domestic Abuse
- Trial name
- EMBER-3 (NCT07606586)
- Testing
- Biopsychosocial Resilience Intervention for Women Subjected to IPV
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Uppsala University
Burn Injury
Fatigue After Burn
The goal of this observational, prospective cohort study is to learn more about fatigue after burn injury and how it associates with daily activities, health-related quality of life, and return to work.
- Trial name
- NCT07592845
- Where
- Sweden
- Volunteers
- 85 people
- Sponsor
- Uppsala University Hospital
Any Condition Underlying Critical Illness
SWedish Intensive Care Biobank
The goal of this observational study is to understand the genetic and molecular risk factors for developing critical illness in adult intensive care unit (ICU) patients in Sweden.
- Trial name
- SWIC-B (NCT07582601)
- Volunteers
- 25,000 people
- Sponsor
- Uppsala University
Lactate, Sepsis
Establishment of Reference Limits for Blood Lactate Levels in Intensive Care Patients With a Particular Focus on Age and Sex
The goal of this observational study is to learn whether there are age- and sex-specific threshold levels of blood lactate that can better predict the risk of death and serious illness in people receiving intensive care…
- Conditions
- Lactate, Sepsis, Emergency Department Patient, ICU
- Trial name
- NCT07582614
- Where
- Sweden
- Volunteers
- 16,000 people
- Sponsor
- Uppsala University
Psychological Disorder
Transdiagnostic Internet Intervention to Improve Mental Health Among University Students
This study offers transdiagnostic CBT-based treatment for symptoms of depression and anxiety to university students who have previously responded to the WHO-WMH-ICS survey.
- Trial name
- NCT05085756
- Testing
- Puma
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Uppsala University
Technical Feasibility, Ambulances
Technical Feasibility Study of a Novel Wearable Capnograph (MARIE) in an Emergency Care Environment, Part 1
You have been assessed by paramedics as needing to go to the emergency department. During transport, the paramedics will monitor you by, for example, measuring your blood pressure and checking your pulse.
- Trial name
- MARIE (NCT06905613)
- Testing
- Technical feasibility study of a novel wearable capnograph (MARIE) in an emergency care environment
- Where
- Sweden
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Eating Disorders
Comparing Neural Responses to Food Images in EDNOS Patients and Healthy Controls Using fMRI
Currently, there is not a robust, testable neural model available that sufficiently explains the development and maintenance of anorexia nervosa (AN) a severe, often fatal, adolescent-onset eating disorder.
- Trial name
- ANfMRI (NCT01882023)
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Uppsala University
COVID-19
Optimal Timing for Tracheostomy in Invasively Mechanically Ventilated COVID-19 Patients
Tracheostomy is a medical procedure performed on the front of a persons neck. It is used to create a connection between the persons trachea and a mechanical ventilator instead of using a tube going through the mouth into the…
- Trial name
- NCT06346210
- Testing
- Tracheostomy
- Where
- Sweden
- Volunteers
- 4,000 people
- Sponsor
- Uppsala University
Intensive Care (ICU), Age Over 80 Years
Pre-ICU Hospital Length of Stay and 30-day Mortality in the Very Old: a National Cohort of 315 042 ICU Admissions
How does waiting in hospital before intensive care affect older patients?Patients who become seriously ill are sometimes admitted to a regular hospital ward first, and only transferred to the intensive care unit (ICU) when their…
- Conditions
- Intensive Care (ICU), Age Over 80 Years, Hospital Length of Stay, Mortality
- Trial name
- NCT07571213
- Testing
- Time in hospital before ICU admission.
- Where
- Sweden
- Volunteers
- 315,042 people
- Sponsor
- Uppsala University
Idiopathic Normal Pressure Hydrocephalus (INPH)
Acetazolamide Trial in Normal Pressure Hydrocephalus
A pharmacological treatment to patients with normal pressure hydrocephalus (NPH) is missing. The aim is to investigate if acetazolamide given to patients with NPH improves gait function and study the pathophysiological mechanisms…
- Trial name
- DRAIN (NCT04975269)
- Testing
- Acetazolamide
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Uppsala University Hospital