Clinical trials: sponsored by Uppsala University
Myocardial Infarction
RElevance of Biomarkers for Future Risk of Thromboembolic Events in UnSelected Post-myocardial Infarction Patients
The study is an open, single center, observational study at the Cardiology Dept at Uppsala University Hospital. The number of patients included will be 410.
- Trial name
- REBUS (NCT01102933)
- Where
- Sweden
- Volunteers
- 425 people
- Sponsor
- Uppsala University
Prostate Cancer
Dose Finding Study of a DNA Vaccine Delivered With Intradermal Electroporation in Patients With Prostate Cancer
This study will assess the feasibility and safety of vaccination with increasing doses of xenogenic DNA administered intradermally in combination with electroporation in patients with relapse of prostate cancer.
- Trial name
- NCT00859729
- Testing
- pVAXrcPSAv53l (DNA encoding rhesus PSA), DERMA VAX™ intradermal DNA delivery system
- Where
- Sweden
- Volunteers
- 15 people
- Sponsor
- Uppsala University
Myocardial Ischemia, Hypotension
Cardiac Effects of Oxytocin Administrated During Cesarean Section, Signs of Myocardial Ischemia
Oxytocin has cardio vascular effects as hypotension, tachycardia and possibly coronary spasm. The uterotonic effect of the drug is used during cesarean section, to minimize blood loss.ECG changes suggestive of cardiac ischemia…
- Conditions
- Myocardial Ischemia, Hypotension, Bloodloss
- Trial name
- NCT00777166
- Testing
- oxytocin
- Where
- Sweden
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Smoking Cessation, Tobacco Cessation
Effectiveness of the Swedish National Tobacco Quitline
The purpose of this study was to compare the effectiveness of the high-intensity proactive service with the low-intensity reactive service at the Swedish National Tobacco Quitline (SNTQ).
- Trial name
- SNTQ (NCT02085616)
- Testing
- Proactive service, Reactive service
- Where
- 3 sites in Sweden
- Volunteers
- 586 people
- Sponsor
- Uppsala University
Rectal Cancer
IPC Status as a Surgical Quality Marker in Rectal Cancer Surgery
Risk of local recurrence after rectal surgery is nationally 8% after curative surgery to 5%. Local recurrence rate after curative surgery varies between 3-7% in the variety of regions in the country.
- Trial name
- NCT02081547
- Where
- 2 sites in Sweden
- Volunteers
- 50 people
- Sponsor
- Uppsala University
Type 1 Diabetes
Studies of Pancreatic Islet Mass by Positron Emission Tomography (PET)
This study investigates the hypothesis that differences in beta-cell mass in patients with diabetes and healthy individuals can be monitored by the positron emission tomography (PET) tracer [11C]5-hydroxytryptophane.
- Trial name
- NCT01552811
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Uppsala University Hospital
Type 1 Diabetes
Treatment of Patients With Newly Onset of Type 1 Diabetes With Mesenchymal Stem Cells
The main hypothesis of the investigators study is that the development of autoimmune diabetes may be halted att diagnosis by the immune modulatory properties of mesenchymal stem cells.
- Trial name
- NCT01068951
- Testing
- Mesenchymal stem cells
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Uppsala University Hospital
Varicose Veins
Prospective Randomized Trial Comparing the New Endovenous Procedures Versus Conventional Surgery for Varicose Veins Due to Great Saphenous Vein Incompetence
Through a prospective RCT evaluate and compare the three new endovenous methods for great saphenous vein ablation (Radiofrequency, endovenous laser and foam sclerotherapy) versus high ligation and stripping.
- Trial name
- RAFPELS (NCT00621062)
- Testing
- High Ligation of the GSV, Endovenous Laser Ablation, Radiofrequency ablation
- Where
- Sweden
- Volunteers
- 540 people
- Sponsor
- Uppsala University
Sleep Deprivation, Sleep
The Effects of Acute Total Sleep Deprivation Versus Normal Sleep on Metabolism
The study proposes to investigate whether acute total deprivation affects metabolism as measured through blood and peripheral tissues.
- Trial name
- NCT01800253
- Testing
- Inhibitory task, Blood samples, Tissue samples
- Where
- Sweden
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Hypercholesterolemia
Role of Milk Fat Globule Membranes in Dairy Foods: Health Effects in Humans
Investigate the effects of milk fat with or without milk fat globule membranes (MFGM) on blood lipid profile, vascular function, insulin sensitivity, inflammation and gene expression.
- Trial name
- MFGM (NCT01767077)
- Testing
- Butter oil, Cream
- Where
- Sweden
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Eating Behavior, Obesity
Caffein Consumption and Response Inhibition
With the abundance of energy-dense foods that are designed for ease of consumption in the current environment, it is of importance to better understand the factors that may undermine the control of energy intake at healthy…
- Trial name
- NCT01815203
- Testing
- Caffeine
- Where
- Sweden
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Obesity, Eating Behavior
The Role of the FTO Gene in Reward System Activation in Obese and Healthy Subjects
In order to investigate if individuals, carrying genetic variants predisposing to obesity, respond differently to visual presented food images than non-carriers the investigators aim to screen 500 people for a common risk variant…
- Trial name
- FTO (NCT01863212)
- Testing
- Blood sampling for genetic analyse, Stroop test, fMRI
- Where
- 2 sites in Sweden
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Implementation Strategies, Nutritional Outcome of Nursing Home Residents
Implementation of Nutritional Guidelines and Effects in Nursing Home Residents
The aim of this study is to examine two implementation strategies (external facilitation and educational outreach visit) when introducing nutritional guidelines in the elderly care setting and to evaluate the results of the…
- Trial name
- NCT01861366
- Testing
- A one year multifaceted implementation strategy, A three hour lecture about the guidelines
- Where
- Sweden
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Obesity
Changes in Body- and Liver-composition During Low Calorie Diet in Morbidly Obese
The purpose of this study is to determine what changes occur in body- and liver-composition during four weeks of low calorie diet in morbidly obese females
- Trial name
- NCT01842425
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Uppsala University
Delayed Sleep Phase Syndrome
Does Cognitive Behaviour Therapy (CBT) Improve the Effect of Light Therapy
Delayed sleep phase syndrome (DSPS) is the most common of the circadian rhythm sleep disorders (CRSD). A person with DSPS have sufficient sleep quality, but their circadian clock is delayed compared to the normal 24-h period.
- Trial name
- NCT01419938
- Testing
- Light therapy and Cognitive behaviour therapy, Light therapy
- Where
- Sweden
- Volunteers
- 57 people
- Sponsor
- Uppsala University
Varicose Veins
The Long-term Value of Preoperative Duplex Before Surgery for Varicose Veins
Duplex imaging is costly and time-consuming, but is used increasingly for preoperative evaluation of varicose veins. Its value in terms of the long-term results of surgery is not clear.
- Trial name
- NCT01195623
- Testing
- preoperative duplex examination, Preoperative duplex
- Where
- Sweden
- Volunteers
- 293 people
- Sponsor
- Uppsala University Hospital
IgA Nephropathy
Probiotics in IgA Nephropathy
Recent studies have shown an increased gastrointestinal reactivity and increased intestinal permeability in IgA nephropathy (IgAN).
- Trial name
- NCT01781312
- Testing
- ProTectis, Gastrus
- Where
- 3 sites in Sweden
- Volunteers
- 20 people
- Sponsor
- Uppsala University Hospital
Delayed Childbearing, Pregnancy
The Reproductive Life Plan in Midwifery Counseling
Many women and men are at risk for sexual transmitted infections and unwanted pregnancies and have unrealistic family planning intentions and insufficient knowledge of health promoting lifestyle prior to conception.
- Conditions
- Delayed Childbearing, Pregnancy, Health Behavior, Lifestyle
- Trial name
- NCT01739101
- Testing
- Reproductive Life Plan
- Where
- Sweden
- Volunteers
- 299 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Nausea, Vomiting
Treatment of Chemotherapy-induced Nausea and Vomiting
Delayed nausea is a common problem after high dose chemotherapy for bone marrow transplantation. This study wants to compare standard prophylactic anti-emetic therapy with the same treatment plus the drug aprepitant (Emend).
- Trial name
- NCT01101529
- Testing
- Aprepitant (Emend)
- Where
- Sweden
- Volunteers
- 90 people
- Sponsor
- Uppsala University Hospital
Sleep Deprivation, Sleep
Sleep Deprivation's Regulation of Immune System Function and Behavior
The study proposes to investigate whether sleep deprivation will affect a variety of measures, including hormones, immune system functioning, and behaviors related to food intake and hunger.
- Trial name
- SS (NCT01730742)
- Testing
- Neuroeconomics task, Portion Size Task, Blood sample
- Where
- Sweden
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Uppsala University