Clinical trials: sponsored by Uppsala University
Ischemic Heart Disease
A Clinical Trial on No-touch Vein Graft (NT-graft) in Coronary Surgery
The primary objective in this study is to investigate if vein grafts harvested and implanted with the non-touch technique are superior to conventional vein graft technique with respect to mid-term patency, in patients undergoing…
- Trial name
- SWEDEGRAFT (NCT03501303)
- Testing
- No touch technique, Control technique
- Where
- 9 sites in Denmark, Sweden
- Volunteers
- 902 people
- Sponsor
- Uppsala University
Atrial Fibrillation
ABC-Scores for Reduction of Stroke and Mortality in Atrial Fibrillation - The ABC-AF Study
The primary study objective is to evaluate if personalized treatment by decision support, based on the biomarker-based risk prediction (ABC-scores) guided strategy, reduces the occurrence of the composite outcome of stroke or…
- Trial name
- ABC-AF (NCT03753490)
- Testing
- ABC score guided therapy, Standard care
- Where
- Sweden
- Volunteers
- 3,933 people
- Sponsor
- Uppsala University
Chronic Obstructive Pulmonary Disease
Tissue Regeneration in Patients With Chronic Obstructive Pulmonary Disease After an Exercise Intervention.
The main objective of this project is to identify mechanisms for lung regeneration in patients with COPD induced by exercise training.
- Trial name
- T-Rex (NCT06335992)
- Testing
- Exercise regime
- Where
- 2 sites in Sweden
- Volunteers
- 80 people
- Sponsor
- Uppsala University
Neuroendocrine (NE) Tumors, Endocrine Cancer
Study of Acquired Resistance to Alkylator Chemotherapy in Endocrine Neoplasms
It has been showed that alkylating chemotherapy, particularly the widely used agent temozolomide, may cause high tumor mutational burden (TMB) in certain tumors by causing inactivating mutations in the DNA mismatch repair (MMR)…
- Trial name
- PROGRESS-TMZ (NCT07121998)
- Testing
- Core needle biopsy, Phlebotomy
- Where
- Sweden
- Volunteers
- 94 people
- Sponsor
- Uppsala University
ST-Elevation Myocardial Infarction (STEMI), Heart Failure With Preserved Ejection Fraction (HFpEF)
Platelet Derived Growth Factor Receptor ß (PDGFRß) Imaging in Cardiac Fibrosis
An observational, cross-sectional, longitudinal, microdosing Position Emission Tomography (PET) imaging study to investigate platelet derived growth factor receptor beta (PDGFRß) expression in the heart of patients with high or…
- Trial name
- PARIS (NCT06956560)
- Testing
- PET/MRI or separate PET/CT and MRI
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Uppsala University
Aortic Regurgitation
Mild and Moderate Aortic Regurgitation: Risk Factors for Progress and Outcome
This observational study aims to evaluate risk factors of progress and adverse outcome of aortic regurgitation
- Trial name
- NCT07104968
- Where
- Sweden
- Volunteers
- 35,000 people
- Sponsor
- Uppsala University
Premenstrual Dysphoric Disorder
Emotion Regulation-based Internet-delivered Cognitive Behavioural Therapy for Premenstrual Dysphoric Disorder
Premenstrual dysphoric disorder (PMDD) is a debilitating cyclic mental disorder affecting about 2-5% of women of reproductive age.
- Trial name
- Premensis-s (NCT06496139)
- Testing
- Therapist-guided internet-delivered cognitive behavioural therapy
- Where
- Sweden
- Volunteers
- 164 people
- Sponsor
- Uppsala University
Material and Social Deprivation: An Enforced Lack of Necessary and Desirable Items to Lead an Adequate Life
A Randomised Controlled Trial of Healthier Wealthier Families in Sweden
Healthier Wealthier Families is a way of working, where child health nurses ask parents about their financial situation and connect them to a free financial help service, if needed.
- Trial name
- ACCESS (NCT05511961)
- Testing
- Healthier Wealthier Families
- Where
- Sweden
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Colorectal Cancer
Colonoscopy and FIT as Colorectal Cancer Screening Test in the Average Risk Population
Colorectal cancer (CRC) is a major cause of death in Sweden. There are approximately 6000 new cases each year in Sweden and the disease specific mortality is more than 40%.
- Trial name
- NCT02078804
- Testing
- Colonoscopy
- Volunteers
- 278,000 people
- Sponsor
- Uppsala University Hospital
Sepsis, Infection, Bacterial
Point-of-care Monitoring of Antibiotic Concentration in Blood With UV-VIS Absorption Spectroscopy
This prospective clinical study will investigate if antibiotic concentrations in patients with severe infections can be monitored by the UV-VIS spectroscopy.
- Trial name
- NCT04282785
- Testing
- Concentration monitoring of antibiotics in plasma
- Where
- Sweden
- Volunteers
- 36 people
- Sponsor
- Uppsala University
Atrial Fibrillation (AF)
Exercise-induced Cardioversion in Persistent Atrial Fibrillation
This study aims to to evaluate the feasibility of conducting a larger randomized controlled trial (RCT) to assess whether an exercise stress test on an ergometer bicycle could induce sinus rhythm in patients with persistent AF…
- Trial name
- ExPAF (NCT07008066)
- Testing
- Bicycle ergometer excercise, Standard care with electrical cardioversion
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Uppsala University
Colorectal Cancer, Peritoneal Metastases
Efficacy of Hyperthermic Intraperitoneal Chemotherapy
A dose titration study and a combined superiority registry-based open-label randomized control trial is planned to answer the trial objectives. The study will be registry-based to allow simpler and more comprehensive follow-up.
- Trial name
- EFFIPEC (NCT04861558)
- Testing
- 5Fluorouracil, Irinotecan, Oxaliplatin
- Where
- 5 sites in India, Sweden
- Volunteers
- 213 people
- Sponsor
- Uppsala University
Cardiac; Arteriosclerosis, Aortic Valve Disease
The Association Between Delivered Oxygen and Cerebral Impact During the Use of Cardiopulmonary Bypass.
Investigating the connection between delivered oxygen index and cerebral impact with COx (cerebral oximetry index) och cerebral injury markers during the routine use of cardiopulmonary bypass.
- Trial name
- NCT05620875
- Testing
- Cerebral injury markers, Cerebral oximetry index
- Where
- Sweden
- Volunteers
- 106 people
- Sponsor
- Uppsala University
Obesity and Overweight, Type 2 Diabetes
Sleep, Glucose, and Brain Health in Obesity and Overweight Individuals
The primary aim of the NNF study is to investigate both cross-sectional and longitudinal associations between sleep patterns-measured over two consecutive weeks at baseline and again one year later-and indicators of glycemic…
- Conditions
- Obesity and Overweight, Type 2 Diabetes, Sleep, Brain Health
- Trial name
- NNF (NCT06968728)
- Volunteers
- 400 people
- Sponsor
- Uppsala University
Abdominal Aneurysm, Endovascular Aortic Repair
Pre-emptive Coil Embolization in Endovascular Aortic Repair
Abdominal aortic aneurysms are often treated with a minimally invasive procedure called endovascular aortic repair (EVAR). While EVAR is widely used, it can sometimes lead to complications over time, and some patients may require…
- Conditions
- Abdominal Aneurysm, Endovascular Aortic Repair, Endoleak
- Trial name
- PRIZE (NCT06975215)
- Testing
- Concomitant embolization, EVAR
- Volunteers
- 332 people
- Sponsor
- Uppsala University
Cardiac Surgery Requiring Cardiopulmonary Bypass
Oxygen Consumption, Hypoperfusion and Organ Injury After Cardio-pulmonary Bypass
The goal of this observational study is to understand how oxygen consumption after heart surgery relates to blood flow problems and organ injury.
- Trial name
- VO2-EPOC (NCT06930443)
- Testing
- Oxygen consumption measurement
- Where
- Sweden
- Volunteers
- 65 people
- Sponsor
- Uppsala University Hospital
Colorectal Cancer Metastatic, Peritoneal Metastases From Colorectal Cancer
NeoRes Study - Preoperative Chemotherapy in Colorectal Peritoneal Disease Prior to Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC)
Study Title: Neores Study - Evaluating Systemic Chemotherapy Efficacy in Colorectal Peritoneal Metastases Principal Investigator: Peter Cashin Akademiska sjukhuset / Uppsala universitet Background: Peritoneal metastases from…
- Trial name
- NEORES (NCT06903039)
- Where
- Sweden
- Volunteers
- 185 people
- Sponsor
- Uppsala University
Thoracic Surgery, Ultrasonography
Lung Ultrasound as Alternative to Radiography in Thoracic Surgery
This projects aim is to study the effects of substitute conventional chest x-ray with lung ultrasound for patients undergoing thoracic surgery.
- Trial name
- LUS-ART (NCT06261411)
- Testing
- Lung Ultrasound
- Where
- Sweden
- Volunteers
- 140 people
- Sponsor
- Uppsala University Hospital
Prolonged Grief Disorder
A Swedish Internet CBT for Prolonged Grief Disorder: a Three-armed RCT
The goal of this clinical trial is to evaluate the effectiveness of internet-delivered Cognitive Behavioral Therapy (iCBT) in reducing symptoms of prolonged grief in adults diagnosed with prolonged grief disorder.
- Trial name
- NCT06667674
- Testing
- iCBT for prolonged grief, Active control
- Where
- 2 sites in Sweden
- Volunteers
- 270 people
- Sponsor
- Uppsala University
Heart Failure
Uppsala Self-SCREENing of Heart Failure Study
The goal of this clinical trial is to investigate whether a stepwise multimodal home-based screening strategy with rapid point-of-care testing can detect undiagnosed heart failure (HF) in high-risk patients compared to usual…
- Trial name
- U-SCREEN-HF (NCT06940544)
- Testing
- Stepwise Multimodal Home-Based HF Screening
- Where
- Sweden
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Uppsala University