Clinical trials: sponsored by Uppsala University
Cervical Spondylotic Myelopathy
Fusion or no Fusion After Decompression of the Spinal Cord in Patients With Degenerative Cervical Myelopathy
Background: Degenerative cervical myelopathy (DCM) is characterized by neck pain, neck stiffness, weakness, paresthesia, sphincter disturbance and balance disorder.
- Trial name
- MyRanC (NCT04936074)
- Testing
- Muscle preserving selective laminectomy, Laminectomy with instrumented fusion
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Uppsala University Hospital
Mastocytosis, Systemic
Quality of Life and Disease-related Symptoms in Individuals With Systemic Mastocytosis
Systemic Mastocytosis is a rare and complex disease caused by accumulation of mast cells. The skin, bones, gastrointestinal tract, bone marrow and liver are the organs most often affected.
- Trial name
- NCT06065007
- Testing
- No intervention
- Where
- 2 sites in Sweden
- Volunteers
- 400 people
- Sponsor
- Uppsala University
Myasthenia Gravis
Digital Phenotyping and Lifestyle Intervention in Patients with Myasthenia Gravis
Myasthenia Gravis (MG) is a chronic autoimmune neurological disorder where an antibody attack of muscle receptors causes fatigable skeletal muscle weakness. In addition to fatigue, several MG patients experience general fatigue.
- Trial name
- DIG-MG (NCT05992025)
- Testing
- Physical activity, Sleep hygiene
- Where
- Sweden
- Volunteers
- 83 people
- Sponsor
- Uppsala University
Renal Blood Flow, Anesthesia
MR-Evaluation of Renal Function in Anesthetized Pediatric Patients
The goal of this study is to investigate the effect of the anesthetic agents sevoflurane or propofol on the blood flow and oxygen delivery to the kidneys.
- Conditions
- Renal Blood Flow, Anesthesia, MRI, Renal Oxygenation
- Trial name
- MERAPED (NCT06876870)
- Testing
- Anesthesia Maintenance Agent
- Volunteers
- 50 people
- Sponsor
- Uppsala University
Myocardial Infarction Type 2
Effect of Classic Secondary Prevention in Type 2 MI: A Target Trial Emulation Study
A classic heart attack is caused by a blockage to the coronary arteries that supplies the heart muscle with oxygenated blood. The medical term for this condition is type 1 myocardial infarction.
- Trial name
- NCT06736353
- Testing
- Beta Blocker Therapy or No Therapy (Control), RAAS blocker Therapy or No therapy (Control), Statin Therapy or No Therapy (Control)
- Where
- Sweden
- Volunteers
- 14,000 people
- Sponsor
- Uppsala University
Hodgkin Lymphoma
Clinical Investigation of Proton Treatment in Hodgkin Lymphoma Patients - PRO-Hodgkin
Hodgkin Lymphoma patients with limited stage are commonly cured with limited chemotherapy followed by radiotherapy. Studies have shown a risk of late toxicity from the radiotherapy, such as second cancer, heart failure and lung…
- Trial name
- PRO-Hodgkin (NCT06883604)
- Testing
- Proton therapy.
- Where
- 6 sites in Sweden
- Volunteers
- 75 people
- Sponsor
- Uppsala University Hospital
Coronary Disease, Coronary Arteriosclerosis
Effects of a Healthy Nordic Diet on Atherosclerosis in Patients with Coronary Heart Disease
Diet can play a key role in atherosclerosis and coronary heart disease (CHD), but little interventional data exists, and the mediators of possible anti-atherosclerotic effects of diet are unclear.
- Conditions
- Coronary Disease, Coronary Arteriosclerosis, Myocardial Infarction, Chronic Coronary Syndrome
- Trial name
- NORDHEART (NCT06701968)
- Testing
- Healthy Nordic Diet, Usual Care
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Uppsala University
Sleep Apnea, Obstructive, Metabolism
Treatment of Sleep Apnea to Improve Metabolic Health
Diabetes and prediabetes prevail among obstructive sleep apnea (OSA) patients. OSA and short sleep both detrimentally affect glycemic control regardless of obesity.
- Conditions
- Sleep Apnea, Obstructive, Metabolism, CPAP, Patients Above 18 Years
- Trial name
- GLYCOSACT (NCT06848647)
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Uppsala University
General Anesthetic Drug Adverse Reaction
Predicting Outcomes Using Infra-red SEnsors, a Feasibility Study.
The aim of this study is to investigate if it is feasible to use a protocol in which avoiding oxygen desaturation in the brain during general anaesthesia can reduce the risk of negative postoperative behavior changes in children.
- Trial name
- PORPOISE-F (NCT06515080)
- Testing
- Near Red Infrascopy
- Where
- 5 sites in Australia, Belgium and 3 more
- Volunteers
- 500 people
- Sponsor
- Uppsala University
Schizophrenia; Psychosis
Uppsala Psychosis Cohort
A multimodal longitudinal study in early stage psychosis patients and individuals at high risk for psychosis. Healthy controls are included for baseline comparisons.
- Trial name
- UPC (NCT05763966)
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Major Depressive Disorder, Unipolar Depression
RTMS Feasibility Study on Adolescent Depression Stimulation
This is an open-label study, in which all participants receives an active treatment with repetitive transcranial magnetic stimulation (rTMS) according to clinical protocol.
- Conditions
- Major Depressive Disorder, Unipolar Depression, Bipolar Depression
- Trial name
- NCT06126198
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Uppsala University
Depression - Major Depressive Disorder, Attachment
Baby Swim As an Intervention for Depressive Symptoms and Lacking Attachment During the Postpartum Period
Mental health issues are very common during and after pregnancy, and studies from around the world indicate that 10-15% of all pregnant and postpartum women experience depression.
- Conditions
- Depression - Major Depressive Disorder, Attachment, Postpartum
- Trial name
- BIDAP (NCT06807801)
- Testing
- Baby swimming
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Uppsala University
Psychological Distress, Malnutrition, Child
Transforming Health and Resilience in Vulnerable Environments: Mental Health, Psychosocial Support, and Climate-Smart Farming in Nakivale
The study aims to evaluate if enhancing the mental health of refugee mothers can make them better able to implement new farming methods that are meant to improve food security in the face of climate change.
- Conditions
- Psychological Distress, Malnutrition, Child, Dietary Deficiency, Mental Health
- Trial name
- THRIVE (NCT06425523)
- Testing
- Home Gardening Intervention (HGI), Self-Help Plus (SH+), Enhanced Usual Care (EUC)
- Where
- Uganda
- Volunteers
- 904 people
- Sponsor
- Uppsala University
Eating Disorders, Anorexia Nervosa
Evaluation of Radically Open Dialectical Behavior Therapy for Youth At Risk for Developing Severe and Enduring Eating Disorders
The goal of this experimental interventional study is to learn if the psychological treatment Radically Open Dialectical Behavior Therapy (RO-DBT), is feasible to conduct and provide positive effects for adolescents with eating…
- Conditions
- Eating Disorders, Anorexia Nervosa, Anorexia Nervosa, Atypical, Feeding and Eating Disorders
- Trial name
- RO-SEED (NCT06792071)
- Testing
- Radically Open Dialectical Behavior Therapy (RO DBT)
- Where
- Sweden
- Volunteers
- 18 people
- Sponsor
- Uppsala University Hospital
Fibromyalgia, Sleep Disorder
Fibromyalgia and Sleep Disorder Treatment
This longitudinal study will investigate impact of improved sleep quality on chronic pain, fibromyalgia and how the disrupted sleep pattern alters the neuroenvironment.
- Trial name
- HOPES (NCT06786845)
- Testing
- Treatment lege artis
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Uppsala University
Cervical Cancer
Strategies to Improve the Experience of Gynaecological Screening
The aim is to evaluate different strategies to improve the experience and effect of the first visit for a cervical screening test (CST). 1.
- Trial name
- NCT05131581
- Testing
- Changed clinical context, Extra time allotted, RLP-information
- Where
- Sweden
- Volunteers
- 206 people
- Sponsor
- Uppsala University
Emergencies
Machine Learning Assisted Differentiation of Low Acuity Patients at Dispatch
BACKGROUND: At Emergency Medical Dispatch (EMD) centers, Resource Constrained Situations (RCS) where there are more callers requiring an ambulance than there are available ambulances are common.
- Trial name
- MADLAD (NCT04757194)
- Testing
- openTriage - Alitis algorithm
- Where
- 2 sites in Sweden
- Volunteers
- 2,499 people
- Sponsor
- Uppsala University Hospital
Eating Disorders, Anorexia Nervosa
A Longitudinal Study of Severe and Enduring Eating Disorders
The goal of this observational longitudinal study is to investigate characteristics and factors associated with the development of Severe and Enduring Eating Disorders (SEED).
- Conditions
- Eating Disorders, Anorexia Nervosa, Bulimia Nervosa, Binge Eating Disorder
- Trial name
- Long-SEED (NCT06752304)
- Where
- Sweden
- Volunteers
- 800 people
- Sponsor
- Uppsala University Hospital
Malignant Melanoma
A Randomized Trial to Assess the Role of Imaging During Follow Up After Radical Surgery of High Risk Melanoma
It is not known whether radiological assessments during follow up after surgery for high risk melanoma improve survival. Since radiological examinations are resource demanding, could inflict worry and cause irradiation exposure…
- Trial name
- TRIM (NCT03116412)
- Testing
- CT or PET scans
- Where
- 20 sites in Sweden
- Volunteers
- 1,300 people
- Sponsor
- Uppsala University
Head and Neck Neoplasms, Radiotherapy Side Effect
Nutrition and Inflammation in Patients With Head and Neck Cancer
An estimated 1500 people in Sweden will annually be diagnosed with head and neck cancer (HNC). Five year survival is approximately 69%. Long-term sequelae are common and in particular nutritional problems and fatigue.
- Conditions
- Head and Neck Neoplasms, Radiotherapy Side Effect, Inflammation, Metabolism
- Trial name
- NCT03343236
- Testing
- Radiotherapy
- Where
- Sweden
- Volunteers
- 522 people
- Sponsor
- Uppsala University