Clinical trials: sponsored by Vanderbilt University Medical Center
Cervical Spine Degeneration, ACDF Surgery
Function After Anterior Cervical Discectomy and Fusion Surgery: Timing of Physical Therapy
The goal of this two-group randomized clinical trial is to examine the effects of early postoperative PT compared to delayed postoperative PT for improving outcomes after hospital discharge for ACDF surgery.
- Trial name
- FAST-PT (NCT06202443)
- Testing
- Early PT, Delayed PT
- Where
- 4 sites in United States
- Volunteers
- 76 people
- Sponsor
- Vanderbilt University Medical Center
Obesity, Hypertension
Sympathetic Mechanisms in Obesity-Crossover Design
We will study obese hypertensive subjects in a randomized, crossover study to determine if two weeks sympathetic blockade improves endogenous glucose production.
- Trial name
- NCT05312892
- Testing
- Amlodipine, Moxonidine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Vanderbilt University Medical Center
Bloodstream Infection, Sepsis Bacterial
Effect of Direct-from-blood Bacterial Testing on Antibiotic Administration and Clinical Outcomes
Bacterial blood stream infections are common and life-threatening. Bloodstream infections have historically been identified using blood cultures, which often take 24-72 hours to result and are imperfectly sensitive.
- Conditions
- Bloodstream Infection, Sepsis Bacterial, MRSA Bacteremia, Vancomycin
- Trial name
- NCT06069206
- Testing
- T2Bacteria® Panel (direct-from-blood testing), Usual Care
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Vanderbilt University Medical Center
Community-acquired Pneumonia
Swab Testing to Optimize Pneumonia Treatment With Empiric Vancomycin
This is a single center, pragmatic, randomized clinical trial (pRCT) examining whether reporting the results of a negative rapid PCR back to the provider via a pager alert results in decreased vancomycin utilization for…
- Trial name
- STOP-Vanc (NCT06272994)
- Testing
- MRSA Nasal Swab PCR
- Where
- United States
- Volunteers
- 277 people
- Sponsor
- Vanderbilt University Medical Center
Respiratory Failure
Mode Of Ventilation During Critical IllnEss Pilot Trial
Landmark trials in critical care have demonstrated that, among critically ill adults receiving invasive mechanical ventilation, the use of low tidal volumes and low airway pressures prevents lung injury and improves patient…
- Trial name
- MODE (NCT05563779)
- Testing
- Volume Control mode, Pressure Control mode, Adaptive Pressure Control mode
- Where
- United States
- Volunteers
- 566 people
- Sponsor
- Vanderbilt University Medical Center
Empyema, Pleural, Pleural Infection
Chest Drain Regular Flushing in Complicated Parapneumonic Effusions and Empyemas
Infections of the pleural space are common, and patients require antibiotics and chest drain placement to evacuate the chest from the infected fluid. Chest drains can get blocked by the drainage fluid and material.
- Trial name
- RELIEF (NCT06427538)
- Testing
- Saline Flush
- Where
- 5 sites in United States
- Volunteers
- 96 people
- Sponsor
- Vanderbilt University Medical Center
Epilepsy
Bridging the Childhood Epilepsy Treatment Gap in Africa
About half of the world's children with epilepsy do not receive treatment - known as the epilepsy treatment gap - with significantly higher rates (67%-90%) in low- and middle-income countries (LMICs).
- Trial name
- BRIDGE (NCT04290975)
- Testing
- Task-shifting epilepsy care to epilepsy-trained community health workers (CHWs), Enhanced usual care for epilepsy (EUC)
- Where
- 3 sites in Nigeria
- Volunteers
- 1,672 people
- Sponsor
- Vanderbilt University Medical Center
ARDS, Sepsis
The APS Phenotyping Study
The goal of the observational APS phenotyping study is to better understand risk factors, potential biomarkers, length and severity of illness, and recovery for adults with ARDS, pneumonia, and/ or sepsis.
- Conditions
- ARDS, Sepsis, Pneumonia
- Trial name
- NCT06521502
- Testing
- Blood collection, Urine Collection, Nasal, oral, and rectal swabs
- Where
- 20 sites in United States
- Volunteers
- 4,000 people
- Sponsor
- Vanderbilt University Medical Center
Colorectal Cancer
Precision-Based Magnesium Trial
Colorectal cancer is the fourth most common incident cancer and the second most common cause of cancer death in the United States, with approximately 150,000 new cases and 57,000 deaths per year.
- Trial name
- NCT01105169
- Testing
- Magnesium glycinate
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Childhood Onset Obesity, Pediatric Obesity
Vanderbilt Childhood Obesity Registry
In order to better understand early onset obesity and to identify patients in interested in future research studies, including clinical trials, we aim to develop a registry for patients with early onset obesity.
- Conditions
- Childhood Onset Obesity, Pediatric Obesity, Childhood Obesity
- Trial name
- VCOR (NCT02957916)
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- Vanderbilt University Medical Center
Critical Illness, Delirium
Maximizing trEatment of Neurological Dysfunction Using INtravenous Guanfacine Study
This proof-of-concept study examines whether the acute brain dysfunction that occurs in critically ill patients is improved by administration of intravenous guanfacine.
- Conditions
- Critical Illness, Delirium, Cognitive Impairment
- Trial name
- MENDING (NCT04742673)
- Testing
- Guanfacine
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Vanderbilt University Medical Center
Venothromboembolism
AI-driven Clinical Decision Support to Reduce Hospital-Acquired Venous Thromboembolism: Study Protocol for the VTE-AI Randomized Trial.
Hospital-acquired blood clots (HA-VTE) are the leading cause of death in hospitalized patients in the US. Each year, about 900,000 people get blood clots, costing between $7 and $10 billion in medical expenses.
- Trial name
- VTE-AI RCT (NCT06939803)
- Testing
- Risk model-driven CDS
- Where
- United States
- Volunteers
- 2,236 people
- Sponsor
- Vanderbilt University Medical Center
Anemia, Sickle Cell, Sickle Cell Disease
Epidemiology of Silent and Overt Strokes in Sickle Cell Disease
Sickle Cell Disease (SCD) is a rare disease occurring in an estimated 100,000 individuals, often poor and underserved, in the US.
- Conditions
- Anemia, Sickle Cell, Sickle Cell Disease, Stroke, Sickle Cell Thalassemia
- Trial name
- ESCD (NCT03376893)
- Where
- 4 sites in United States
- Volunteers
- 102 people
- Sponsor
- Vanderbilt University Medical Center
Neuromuscular Blockade
Understanding the Cognition and Decision Making of Community Anesthesiologists
The investigators are interested in studying why experienced clinicians make specific decisions regarding the monitoring of patients' physiological states and why clinicians might make decisions that are contrary to current best…
- Trial name
- NCT04195178
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Vanderbilt University Medical Center
Chronic Stroke, Weakness, Muscle
Use of Hand-held Dynamometry to Obtain Objective Measures of Lower Extremity Force Production With Chronic Stroke
This study wants to know if using handheld dynamometry (HHD) to test leg strength in persons who have had a stroke, will reduce mistakes and give therapists better information to use for therapy.
- Trial name
- NCT05941962
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Aging, Alzheimer Disease
Tennessee Alzheimer's Project
The primary objective of the Vanderbilt Alzheimer's Disease Research Center (VADRC) is to provide local and national researchers with access to a well-characterized and diverse clinical cohort, including participant referrals…
- Conditions
- Aging, Alzheimer Disease, Biomarker, Cognitive Dysfunction
- Trial name
- TAP (NCT05372172)
- Testing
- none, observational study
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Critical Illness, Sepsis
Measuring Outcomes of Activity in Intensive Care
Millions of older adults are hospitalized for a critical illness each year and although they are more likely than ever to survive this illness, they commonly face significant morbidity in the form of disabilities in basic…
- Conditions
- Critical Illness, Sepsis, Mechanical Ventilation, Physical Activity
- Trial name
- MOSAIC (NCT03115840)
- Where
- 2 sites in United States
- Volunteers
- 312 people
- Sponsor
- Vanderbilt University Medical Center
Delirium, Cognition Disorders
The BRAIN Intensive Care Unit (ICU) Study: Bringing to Light the Risk Factors
The primary purpose of this proposal will be to identify potentially modifiable risk factors of long-term cognitive impairment (i.e. development of delirium and exposure to sedative and analgesic medications) in ICU patients.
- Conditions
- Delirium, Cognition Disorders, Dementia
- Trial name
- BRAIN-ICU (NCT00392795)
- Where
- 2 sites in United States
- Volunteers
- 826 people
- Sponsor
- Vanderbilt University Medical Center
Autism Spectrum Disorder
Enhancing Social Competence in Adults With Autism
SENSE Theatre®, combines several well-documented, effective behavioral strategies, such as the inclusion of trained peer models, theatre play techniques involving predictable (i.e., scripted) and flexible (improvised) role-play…
- Trial name
- NCT04349644
- Testing
- SENSE Theatre
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Vanderbilt University Medical Center
Cancer
Surgery for Cancer With Option of Palliative Care Expert
Frequently people diagnosed with cancer experience physical and emotional symptoms during the course of their disease. These symptoms can be very distressing to both the patient and the family members.
- Trial name
- SCOPE (NCT03436290)
- Testing
- Palliative Care Intervention
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Vanderbilt University Medical Center