Clinical trials: sponsored by Vanderbilt University Medical Center
Breast Cancer
BRAVE Strategy - Breast Cancer Risk Assessment -achieVing Equity
The central goal of this study is to test strategies to implement evidence-based breast cancer risk assessment in healthcare clinics in Tennessee.
- Trial name
- BRAVE (NCT05051631)
- Testing
- Intervention plus 12 months maintenance, Intervention plus 10 months maintenance, Intervention plus 8 months maintenance
- Where
- United States
- Volunteers
- 1,071 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Autism Spectrum Disorder
Can a Novel Telemedicine Tool Reduce Disparities Related to the Identification of Preschool Children With Autism?
Families seeking evaluation for autism spectrum disorder (ASD) often face barriers such as low availability of specialists, lengthy waitlists, and long distances to tertiary care diagnostic centers.
- Trial name
- TAP-P (NCT05373173)
- Testing
- Tele-assessment + In-person assessment, Tele-assessment only
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
End-Stage Liver Disease
Surprise Question in End of Life (SeQuEL) Care and the Effect of Prompting Palliative Care Consultation: End-Stage Liver Disease
This is a single center randomized platform trial determining whether prompting consideration of palliative care consultation through the electronic health record impacts the number of palliative consultations placed and…
- Trial name
- SeQuEL (NCT06400498)
- Testing
- Prompted Palliative Care Consult
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Vanderbilt University Medical Center
Gestational Diabetes, Type2 Diabetes
Mobilizing Doulas to Empower Black Women in Post-partum Diabetes Prevention
Black and White mothers have similar prevalence of gestational diabetes mellitus (GDM). However Black mothers are more likely to develop Type 2 Diabetes Mellitus (T2DM) after a diagnosis of GDM.
- Trial name
- NCT04406792
- Testing
- DPP only, Diabetes Prevention Program (DPP) online + doula divas
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Parkinson Disease, Sleep
Quantitation of Glymphatic Functioning in Sleep and Meditative States
This involves development and application of magnetic resonance imaging (MRI) methods for visualizing hemodynamic and metabolic relationships in healthy volunteers with advanced meditation experience.
- Trial name
- NCT04506892
- Testing
- Meditation
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Pneumothorax, Trauma
Suction Versus Water Seal for Initial Treatment of Traumatic Pneumothorax Trial
The goal of this clinical trial is to compare the effect of placing chest tubes to water seal versus suction initially, in patients with traumatic pneumothoraces, on overall chest tube duration.
- Trial name
- SEAL IT (NCT06688734)
- Testing
- Inital water seal, Initial suction
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Vanderbilt University Medical Center
Hypertension
Mechanism(s) Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 1
The purpose of this study is to test the hypothesis that combined angiotensin receptor blockade (ARB)/neprilysin (NEP) inhibition potentiates the effects of exogenous bradykinin, substance P, and brain natriuretic peptide (BNP)…
- Trial name
- NCT03738878
- Testing
- Valsartan, LCZ696, Bradykinin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Vanderbilt University Medical Center
Speech Intelligibility Intervention in Down Syndrome
Predictors of Speech Ability in Down Syndrome
Speech is a critical aspect of the human experience and usually develops in a "seemingly automatic process that continues from birth through adolescence and underlies many related abilities" (e.g., language and reading, see…
- Trial name
- NCT05016037
- Testing
- Lexically based speech recast
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Vanderbilt University Medical Center
Healthy
Multi-organ Transit Time Acquisition Using Contrast Ultrasound
Echocardiographic contrast will be administered to volunteers for the purpose of measuring transit time through various organs/vascular beds
- Trial name
- NCT05135169
- Testing
- Definity Suspension for Injection
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Malnutrition, Obesity
Small Bowel Length and Bariatric Surgery Outcomes
The purpose of this study is to determine whether or not the total length of small intestine effects outcomes after bariatric surgery in a cohort of patients preoperatively and up to ten years postoperatively.
- Conditions
- Malnutrition, Obesity, Weight Loss, Micronutrient Deficiency
- Trial name
- NCT02872493
- Testing
- Small bowel length measurement
- Where
- United States
- Volunteers
- 470 people
- Sponsor
- Vanderbilt University Medical Center
Alzheimer Disease, Mild Cognitive Impairment
Disclosing Dementia Risk Based on Plasma Phosphorylated Tau
Novel blood-based biomarkers of Alzheimer's disease (AD), such as plasma levels of tau phosphorylated at threonine 181 (p-tau181), have shown great promise in detecting early AD pathology.
- Trial name
- NCT05377060
- Testing
- Plasma p-tau risk disclosure, Standard risk disclosure
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Vanderbilt University Medical Center
HIV/AIDS, Albuminuria
Optimal Management of HIV Infected Adults at Risk for Kidney Complications in Nigeria
In this study, the Investigators plan to determine the optimal means to prevent or slow the progression of kidney disease among genetically at-risk northern Nigerian HIV-infected adults.
- Conditions
- HIV/AIDS, Albuminuria, Kidney Diseases, Genetic Predisposition
- Trial name
- R3 (NCT03201939)
- Testing
- Lisinopril
- Where
- Nigeria
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
HIV Infected Individuals
Piloting Eye Movement Desensitization and Reprocessing (EMDR) Therapy in People Living With HIV and Trauma
Eye Movement Desensitization and Reprocessing therapy is a time-limited trauma-response therapy that treats symptoms of stress that result disturbing life experiences.
- Trial name
- NCT06730867
- Testing
- EMDR Therapy Protocol
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Vanderbilt University Medical Center
Acute Hypoxemic Respiratory Failure, Anticoagulant-induced Bleeding
Strategies for Anticoagulation During Venovenous ECMO
Moderate intensity titrated dose anticoagulation has been used in patients receiving extracorporeal membrane oxygenation (ECMO) to prevent thromboembolism and thrombotic mechanical complications.
- Conditions
- Acute Hypoxemic Respiratory Failure, Anticoagulant-induced Bleeding, Thromboembolism
- Trial name
- SAFE-ECMO (NCT04997265)
- Testing
- Low intensity anticoagulation, Moderate Intensity Anticoagulation
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Vanderbilt University Medical Center
Measurement of Blood Parameter Equivalency
Study to Investigate Blood Samples Drawn With the HemoIV System
The goal of this study is to compare blood drawn using a device called HemoIV to standard-of-care blood drawn from a vein in the arm or from an IV catheter. The HemoIV is a device that is attached to an IV line.
- Trial name
- NCT06415058
- Testing
- HemoIV
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Atrial Fibrillation, Device Related Thrombus
Efficacy of Short Term Dabigatran Etexilate Followed by Aspirin Monotherapy After LAA (Left Atrial Appendage) Device Closure (the DEA-LAA Study).
Single arm, prospective unblinded study on post Watchman LAA closure device implant anti-coagulation management at a primary center (Vanderbilt Medical Center) and up to 5 additional high volume LAA implant centers.
- Conditions
- Atrial Fibrillation, Device Related Thrombus, Left Atrial Appendage Thrombosis, Watchman LAA Closure Device
- Trial name
- DEA-LAA (NCT03539055)
- Testing
- Dabigatran Etexilate Oral Capsule
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Vanderbilt University Medical Center
Cochlear Implants, Sensory-Neural Hearing Loss
Balance in Children With Cochlear Implants
Cochlear implantation is performed in children with sensorineural hearing loss to restore hearing. Fifty percent of children with sensory neural hearing loss, who are candidates for cochlear implant, have vestibular (inner ear)…
- Conditions
- Cochlear Implants, Sensory-Neural Hearing Loss, Balance Disorder
- Trial name
- NCT03620500
- Testing
- Gross motor and developmental balance testing
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
CIDP
Validation of Cutaneous Nerve Demyelination in Diagnosis and Treatment of CIDP
The goal of this observational study is to learn about chronic inflammatory demyelinating polyneuropathy. The main question the investigators would like to answer is 1) can skin biopsy identify demyelination better than nerve…
- Trial name
- NCT05614128
- Testing
- IVIg
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Vanderbilt University Medical Center
Health Care Utilization, Health Care Seeking Behavior
Connecting Low-Income Adults to Primary Care After Inpatient Discharge
Healthcare systems and insurers have tried to reduce costs by improving the care and coordination provided to patients with high healthcare spending.
- Trial name
- NCT05567224
- Testing
- Access to primary care services
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Vanderbilt University Medical Center
Peripheral Pulmonary Lesions
Robotic Versus Electromagnetic Bronchoscopy for Pulmonary LesIon AssessmeNT: (the RELIANT Trial)
This is an investigator-initiated, cluster randomized controlled trial. The primary objective is to compare the diagnostic yield of the Ion™ Endoluminal System (SSCB) to the ILLUMISITE™ Platform (EMN bronchoscopy) in patients…
- Trial name
- RELIANT (NCT05705544)
- Testing
- ILLUMISITE™ Platform (EMN bronchoscopy), Ion™ Endoluminal System (SSCB bronchoscopy)
- Where
- United States
- Volunteers
- 447 people
- Sponsor
- Vanderbilt University Medical Center