Clinical trials: sponsored by Vanderbilt University Medical Center
Clubfoot
Clubfoot Tenotomy Trial
Infants undergoing Ponseti treatment for idiopathic clubfoot often require percutaneous tendoachilles lengthening (TAL) after serial casting.
- Trial name
- ClubTT (NCT04766684)
- Testing
- Jet injection of 1% lidocaine, 4% liposomal lidocaine cream
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- Vanderbilt University Medical Center
Renal Transplant
Cognitive Outcomes in Stable Renal Transplant Patients Switched fromTacrolimus to Envarsus XR™
The purpose of this study is to assess cognitive outcome and quality of life in stable renal transplant patients treated with twice daily tacrolimus at baseline and after switching to Envarsus XL.
- Trial name
- OPERATOR (NCT04838288)
- Testing
- Change from Prograf to Envarsus XR
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Vanderbilt University Medical Center
Obesity, Cardiovascular Risk Factor
Visualizing Vascular Mechanisms of Salt Sensitivity
This study aims to assess the salt sensitive blood pressure response to dietary salt load compared with radiological markers of salt handling.
- Conditions
- Obesity, Cardiovascular Risk Factor, Salt; Excess
- Trial name
- NCT03696433
- Testing
- Low-salt diet, High-salt diet
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Kidney Stones
AR Projections for Eye-gaze Evaluation in Phantoms
This project aims to develop an augmented reality (AR) tool to enhance skill acquisition for endoscopic kidney stone surgery. Of the 100,000 patients who undergo an endoscopic kidney stone treatment annually in the United States…
- Trial name
- NCT07161024
- Testing
- Augmented reality
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Rheumatoid Arthritis
2-HOBA Phase 2 Clinical Trial in Rheumatoid Arthritis
This is a phase 2 study to determine 2-HOBA's tolerability, safety, and effect on isoLG-adducts in patients with rheumatoid arthritis (RA) patients.
- Trial name
- NCT05274243
- Testing
- 2-HOBA
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Vanderbilt University Medical Center
Acute Respiratory Failure
Randomized Trial of Sedative Choice for Intubation
Among critically ill adults undergoing emergency tracheal intubation, one in five experience hypotension, cardiac arrest, or death.
- Trial name
- RSI (NCT05277896)
- Testing
- Ketamine, Etomidate
- Where
- 6 sites in United States
- Volunteers
- 2,367 people
- Sponsor
- Vanderbilt University Medical Center
Hearing Loss, Language Impairment
Retrieval Practice for Word Learning for Deaf and Hard of Hearing Children
This study is designed to advance the promising yet underutilized research on retrieval practice by evaluating the effectiveness and efficiency of two key retrieval practice features (feedback and spacing).
- Trial name
- NCT05512000
- Testing
- Feedback with massed trials, Feedback with spaced trials, No feedback with massed trials
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Vanderbilt University Medical Center
Hypertension, Pregnancy-Induced, Postpartum Preeclampsia
Comprehensive Postpartum Management for Women With Hypertensive Disorders of Pregnancy
Investigators propose a comprehensive management program for postpartum patients with HDP who are at risk for severe maternal morbidity and mortality.
- Conditions
- Hypertension, Pregnancy-Induced, Postpartum Preeclampsia, Hypertension; Maternal
- Trial name
- NCT05849103
- Testing
- Blood Pressure Control Targets, Hypertension Management
- Where
- United States
- Volunteers
- 343 people
- Sponsor
- Vanderbilt University Medical Center
Community-acquired Pneumonia
Swab Testing to Optimize Pneumonia Treatment With Empiric Vancomycin
This is a single center, pragmatic, randomized clinical trial (pRCT) examining whether reporting the results of a negative rapid PCR back to the provider via a pager alert results in decreased vancomycin utilization for…
- Trial name
- STOP-Vanc (NCT06272994)
- Testing
- MRSA Nasal Swab PCR
- Where
- United States
- Volunteers
- 277 people
- Sponsor
- Vanderbilt University Medical Center
Bloodstream Infection, Sepsis Bacterial
Effect of Direct-from-blood Bacterial Testing on Antibiotic Administration and Clinical Outcomes
Bacterial blood stream infections are common and life-threatening. Bloodstream infections have historically been identified using blood cultures, which often take 24-72 hours to result and are imperfectly sensitive.
- Conditions
- Bloodstream Infection, Sepsis Bacterial, MRSA Bacteremia, Vancomycin
- Trial name
- NCT06069206
- Testing
- T2Bacteria® Panel (direct-from-blood testing), Usual Care
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Vanderbilt University Medical Center
Respiratory Failure
Mode Of Ventilation During Critical IllnEss Pilot Trial
Landmark trials in critical care have demonstrated that, among critically ill adults receiving invasive mechanical ventilation, the use of low tidal volumes and low airway pressures prevents lung injury and improves patient…
- Trial name
- MODE (NCT05563779)
- Testing
- Volume Control mode, Pressure Control mode, Adaptive Pressure Control mode
- Where
- United States
- Volunteers
- 566 people
- Sponsor
- Vanderbilt University Medical Center
Colorectal Cancer
Precision-Based Magnesium Trial
Colorectal cancer is the fourth most common incident cancer and the second most common cause of cancer death in the United States, with approximately 150,000 new cases and 57,000 deaths per year.
- Trial name
- NCT01105169
- Testing
- Magnesium glycinate
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Epilepsy
Bridging the Childhood Epilepsy Treatment Gap in Africa
About half of the world's children with epilepsy do not receive treatment - known as the epilepsy treatment gap - with significantly higher rates (67%-90%) in low- and middle-income countries (LMICs).
- Trial name
- BRIDGE (NCT04290975)
- Testing
- Task-shifting epilepsy care to epilepsy-trained community health workers (CHWs), Enhanced usual care for epilepsy (EUC)
- Where
- 3 sites in Nigeria
- Volunteers
- 1,672 people
- Sponsor
- Vanderbilt University Medical Center
Critical Illness, Delirium
Maximizing trEatment of Neurological Dysfunction Using INtravenous Guanfacine Study
This proof-of-concept study examines whether the acute brain dysfunction that occurs in critically ill patients is improved by administration of intravenous guanfacine.
- Conditions
- Critical Illness, Delirium, Cognitive Impairment
- Trial name
- MENDING (NCT04742673)
- Testing
- Guanfacine
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Vanderbilt University Medical Center
Neuromuscular Blockade
Understanding the Cognition and Decision Making of Community Anesthesiologists
The investigators are interested in studying why experienced clinicians make specific decisions regarding the monitoring of patients' physiological states and why clinicians might make decisions that are contrary to current best…
- Trial name
- NCT04195178
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Vanderbilt University Medical Center
Autism Spectrum Disorder
Enhancing Social Competence in Adults With Autism
SENSE Theatre®, combines several well-documented, effective behavioral strategies, such as the inclusion of trained peer models, theatre play techniques involving predictable (i.e., scripted) and flexible (improvised) role-play…
- Trial name
- NCT04349644
- Testing
- SENSE Theatre
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Vanderbilt University Medical Center
Cancer
Surgery for Cancer With Option of Palliative Care Expert
Frequently people diagnosed with cancer experience physical and emotional symptoms during the course of their disease. These symptoms can be very distressing to both the patient and the family members.
- Trial name
- SCOPE (NCT03436290)
- Testing
- Palliative Care Intervention
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Vanderbilt University Medical Center
Traumatic Brain Injury
Pilot and Feasibility of MEMI for Chronic Traumatic Brain Injury
This is a pilot and feasibility study for a mobile phone-delivered intervention for memory, called MEMI (memory ecological momentary intervention), that was designed to support adults with chronic traumatic brain injury with…
- Trial name
- NCT06375421
- Testing
- MEMI (Memory Ecological Momentary Intervention) Spaced Retrieval, Blocked Retrieval
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Delirium, Cognitive Decline
Early Cognitive Intervention in Delirium
This is a randomized control trial to determine if early cognitive training and rehabilitation improve 4-month cognition in hospitalized older (>=65 years old) delirious patients with and without Alzheimer's disease and related…
- Conditions
- Delirium, Cognitive Decline, Dementia
- Trial name
- ECID (NCT04740567)
- Testing
- Cognitive Training, Goal Management Training
- Where
- 2 sites in United States
- Volunteers
- 283 people
- Sponsor
- Vanderbilt University Medical Center
HIV/AIDS
PeerNaija: A Mobile Health Platform Incentivizing Medication Adherence Among Youth Living With HIV in Nigeria
The PEERNaija application will feature routine medication reminders, along with individual adherence monitoring with adherence scores, anonymized peer adherence scores (from peers attending the same clinic; social incentive), and…
- Trial name
- NCT04930198
- Testing
- PeerNaija
- Where
- 2 sites in Nigeria
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center