Clinical trials: sponsored by Vanderbilt University Medical Center
Autism Spectrum Disorder, Autism
Advocating for Supports to Improve Service Transitions
This is a randomized intervention study to develop and test the national curriculum of a parent intervention training targeting parent's ability for advocate for services to improve the transition to adulthood for their youth…
- Trial name
- ASSIST (NCT04173663)
- Testing
- ASSIST
- Where
- 3 sites in United States
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Depression, Anxiety
Mechanisms of Mindfulness-based Interventions
Mindfulness-based Interventions (MBIs) are a family of standardized cognitive and behavioral therapies that focus on cultivating mindfulness-related skills for improving maladaptive cognitive, emotional, and behavioral processes.
- Conditions
- Depression, Anxiety, Stress
- Trial name
- MBI (NCT03571386)
- Testing
- Mindfulness-based Cognitive Therapy (MBCT), Mindfulness-based Stress Reduction (MBSR)
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Vanderbilt University Medical Center
Colorectal Cancer
Calcium: Magnesium Balance, Microbiota, and Necroptosis and Inflammation
Transient receptor potential melastatin 7 (TRPM7), a magnesium (Mg) -regulated chanzyme possessing both ion channel and kinase activities, has a much stronger affinity to Mg2+ than calcium (Ca)2+.
- Trial name
- NCT04229992
- Testing
- Magnesium glycinate
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Ankle Sprain 1St Degree, Ankle Sprain 2Nd Degree
The Effect of Low-Intensity Blood Flow Restriction Therapy on the Management of Acute Ankle Sprains
The primary objective of this study is to evaluate the feasibility of implementing BFR in the rehabilitation treatment of isolated ankle sprains as well as to evaluate the clinical benefits of BFR when compared to standard…
- Conditions
- Ankle Sprain 1St Degree, Ankle Sprain 2Nd Degree, Musculoskeletal Injury
- Trial name
- NCT05596162
- Testing
- Blood Flow Restriction Therapy, Standard Physical Therapy
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Sickle Cell Disease
Using Patient-Centered Guidelines in a Technology Platform to Improve Health Care in Adults With Sickle Cell Disease
SCD is an inherited disorder of hemoglobin that affects over 100,000 Americans, most of whom live in low-resourced neighborhoods.
- Trial name
- NCT03629678
- Testing
- mobile health application
- Where
- 2 sites in United States
- Volunteers
- 67 people
- Sponsor
- Vanderbilt University Medical Center
Rupture of Anterior Cruciate Ligament
Anterior Cruciate Ligament (ACL) Reconstruction- Bioabsorbable Screw
To evaluate the knee functionality, screw integrity, graft integrity, cartilage effect, and bony ingrowth in patients treated with the CALAXO screw and MILAGRO screw two years after ACL reconstruction.
- Trial name
- NCT01069588
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Vanderbilt University Medical Center
Pulmonary Arterial Hypertension
TranspulmonarY Estrogen Gradient and Estrogen Receptors (TYEGER) in PAH
Pulmonary arterial hypertension (PAH) is a disease characterized by elevated pressures in the blood vessels of the lungs that is not caused by another disease processes.
- Trial name
- TYEGER (NCT04280523)
- Testing
- ESR-specific PET scan
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Colonoscopy
Visualization of the Colon Through Use of the Magnetic Flexible Endoscope (MFE)
In this study, the investigators will evaluate the ability of the Magnetic Flexible Endoscope (MFE) to travel through the human colon.
- Trial name
- NCT05833789
- Testing
- Magnetic Flexible Endoscope (MFE)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Vanderbilt University Medical Center
Parenting, Violence
Mitigating ACEs in Pediatric Primary Care: Cohort #2 With 6-24 Month Old Children
The aim is to determine if a brief intervention can affect parents' attitudes about physical punishment and other parenting behaviors.
- Conditions
- Parenting, Violence, Child Abuse
- Trial name
- NCT04160013
- Testing
- Discipline education, Cavity Prevention
- Where
- United States
- Volunteers
- 533 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Penicillin Allergy
The Effect of Providing Stratification of Low Risk Penicillin Allergies on Penicillin Allergy Label Removal
Currently it is estimated that at least 25 million people in the United States are labeled as penicillin allergic although less than 1.5 million of these are truly allergic.
- Trial name
- NCT03702270
- Testing
- Penicillin Allergic Risk Stratification Best Practice Alert
- Where
- United States
- Volunteers
- 2,052 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Acute Respiratory Failure
Pragmatic Trial Examining Oxygenation Prior to Intubation
Clinicians perform rapid sequence induction, laryngoscopy, and tracheal intubation for more than 5 million critically ill adults as a part of clinical care each year in the United States.
- Trial name
- PREOXI (NCT05267652)
- Testing
- Preoxygenation with Non-Invasive Positive Pressure Ventilation, Facemask Oxygen
- Where
- 16 sites in United States
- Volunteers
- 1,301 people
- Sponsor
- Vanderbilt University Medical Center
Obsessive-Compulsive Disorder, Pain, Intractable
Psychosocial, Behavioral, and Radiologic Changes Following Radiosurgery for Benign Neurologic Disease
A number of studies from the literature suggest important behavioral, psychosocial, or radiologic changes occur following significant neurologic events or interventions such as stroke, neurosurgery, medications, radiation…
- Conditions
- Obsessive-Compulsive Disorder, Pain, Intractable, Depression
- Trial name
- NCT04688554
- Testing
- fMRI and DTI, Behavioral questionnaires, Disease-Specific Patient-Reported Outcomes
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Vanderbilt University Medical Center
Hypertension, Pulmonary Arterial Hypertension
Tamoxifen Therapy to Treat Pulmonary Arterial Hypertension
The main purpose of this clinical trial is to examine the feasibility and effects of tamoxifen in subjects with pulmonary arterial hypertension (PAH).
- Conditions
- Hypertension, Pulmonary Arterial Hypertension, Familial Primary Pulmonary Hypertension, Primary Pulmonary Hypertension
- Trial name
- T3PAH (NCT03528902)
- Testing
- Tamoxifen
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Vanderbilt University Medical Center
Primary Ciliary Dyskinesia
PCD New Gene Discovery
This is a new gene discovery program for individuals with PCD who do not have a specific genetic etiology identified. Research procedures involve a single blood draw from the affected individual and from unaffected family members…
- Trial name
- NCT03801395
- Testing
- There is no intervention
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Vanderbilt University Medical Center
Atrial Fibrillation
2-Hydroxybenzylamine (2-HOBA) to Prevent Early Recurrence of Atrial Fibrillation After Catheter-based Ablation
The proposed studies will test this hypothesis by randomizing patients with AF to 2-HOBA or placebo 7 days prior to AF ablation to allow 2-HOBA to reach steady-state levels.
- Trial name
- NCT04433091
- Testing
- 2-Hydroxybenzylamine
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Vanderbilt University Medical Center
Asthma; Status, Asthma in Children
Pragmatic RCT of High-dose Oral Montelukast for Moderate and Severe Pediatric Acute Asthma Exacerbations
Objective: To determine the extent to which high-dose (30mg) oral montelukast, added to standard treatment in children with moderate and severe acute exacerbations improves outcomes.
- Conditions
- Asthma; Status, Asthma in Children, Asthma Acute, Asthma Attack
- Trial name
- NCT03277170
- Testing
- Montelukast Oral Granules
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Diabetes, Hyperglycemia
Comparison of Intraoperative Best Practice Advisory Reminders to Protocolize Insulin Administration Versus Standard Care in Patients at High Risk of Hyperglycemia
This study will assess the implementation of a glucose management clinical decision support tool. The specific objective is to determine if supplementing the existing glucose check reminder with a best practice advisory (BPA), an…
- Trial name
- NCT05426096
- Testing
- Best Practice Advisory
- Where
- United States
- Volunteers
- 7,232 people
- Sponsor
- Vanderbilt University Medical Center
Autism Spectrum Disorder, Depression
Group Depression Treatment for Autistic Youth
Higher rates of depression are reported by autistic adolescents as compared to their non-autistic peers, which is problematic given adverse outcomes (e.g., negative self-esteem, lower academic performance) that are associated…
- Conditions
- Autism Spectrum Disorder, Depression, Suicidal Ideation, Self Esteem
- Trial name
- NCT05430022
- Testing
- Autism-adapted Group Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Vanderbilt University Medical Center
Alzheimer Disease, Caregiver Burden
Voice and Swallowing Disorders in Adults With and Without Alzheimer's Disease
This research study is investigating whether people with Alzheimer's disease experience more changes to voice and swallowing than their healthy age-matched peers.
- Conditions
- Alzheimer Disease, Caregiver Burden, Healthy Aging, Dysphonia
- Trial name
- NCT06328374
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Intraoperative Fluorescence Angiography
Intraoperative Fluorescence Angiography in Debridement of Open Fractures
The proposed research aims to be a pilot feasibility study to evaluate intraoperative fluorescence angiography (IFA) as an aid for acute debridement in orthopaedic trauma.
- Trial name
- NCT05006313
- Testing
- Intraoperative fluorescence angiography
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center