Clinical trials: sponsored by Vanderbilt University Medical Center
Heart Failure, Diabetes Mellitus, Type 2
Efficacy and Safety of Dapagliflozin in Acute Heart Failure
This is a randomized trial of the addition of dapagliflozin to patients with or without type 2 diabetes hospitalized with acute decompensated heart failure (ADHF).
- Trial name
- DICTATE-AHF (NCT04298229)
- Testing
- Dapagliflozin 10 MG, Protocolized Diuretic Therapy
- Where
- 6 sites in United States
- Volunteers
- 240 people
- Sponsor
- Vanderbilt University Medical Center
Antibiotic Allergy
Penicillin Allergy Risk-Stratification and Delabeling of Low-Risk Patients
Children are often reported to have antibiotics allergies, with approximately 10% of the US population labeled as allergic to an antibiotic, however, recent studies have demonstrated that the majority of symptoms reported as an…
- Trial name
- NCT05561777
- Testing
- Physician-targeted CDS tool for PCN allergy delabeling
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Non-pharmacologic Management of Chronic Pain
Pragmatic Implementation of Mindful Awareness in Body Oriented Therapy
This is a one group study using a hybrid implementation design.
- Trial name
- NCT05289024
- Testing
- Mindful Awareness in Body-Oriented Therapy
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Vanderbilt University Medical Center
Peripheral Arterial Disease
The Impact of Branched-Chain Amino Acid Metabolism on Limb Dysfunction in PAD
Test the theory that abnormalities in the large blood vessels that deliver blood to your leg and the very small blood vessels in your leg's muscles (invisible to the eye) work together to worsen your leg function and walking.
- Trial name
- NCT03490968
- Testing
- Supervised Exercise, Vascular Assessment
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
COVID-19
Trial of Early Therapies During Non-hospitalized Outpatient Window for COVID-19
Blinded, multicenter, placebo-controlled, randomized clinical trial evaluating lopinavir/ritonavir vs placebo in early outpatient treatment of adults with COVID-19
- Trial name
- TREATNOW (NCT04372628)
- Testing
- Lopinavir/Ritonavir 400 mg/100 mg
- Where
- 6 sites in United States
- Volunteers
- 452 people
- Sponsor
- Vanderbilt University Medical Center
Social Stress, Parenting
Parents' and Clinicians' Perspectives of the Quick Parenting Assessment (QPA)
A quality improvement (QI) study that integrates an adverse childhood experiences (ACEs) instrument, including the Quick Parenting Assessment (QPA), into pediatric primary care visit.
- Trial name
- NCT04179825
- Where
- United States
- Volunteers
- 582 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Schizophrenia; Psychosis
Pharmacological Modulation of Hippocampal Activity in Psychosis 2
The purpose of this study is to test whether administration of levetiracetam (LEV), a commonly used anti-epileptic that alters neurotransmitter release, can reduce hippocampal hyperactivity in people with psychotic disorders.
- Trial name
- NCT04559529
- Testing
- Levetiracetam (LEV) 500 mg
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Opioid Use, Spinal Diseases
Opioid Free vs. Standard Perioperative Pain Regimen for Anterior Cervical Discectomy and Fusion (ACDF) Surgery
Patients undergoing 1-3 level Anterior Cervical Discectomy and Fusion (ACDF) at the levels between C2 and T1 will be enrolled into this randomized prospective study.
- Conditions
- Opioid Use, Spinal Diseases, Surgery--Complications, Surgery
- Trial name
- NCT04990804
- Testing
- Opioid Analgesic, Opioid-Free Postoperative Pain Regimen
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Vanderbilt University Medical Center
Schizophrenia and Related Disorders
Increasing Medication Check Participation Through Applying CT-r
The goal of this feasibility and acceptability trial is to learn about the acceptability of adding a recovery-oriented, psychological framework to a standard medication management appointment with a psychiatrist and any impact on…
- Trial name
- IMPACT (NCT06231407)
- Testing
- Recovery Oriented CBTp Medication Management, Treatment as Usual
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Vanderbilt University Medical Center
Obstructive Sleep Apnea
Pharyngeal Anatomy In Obstructive Sleep Apnea With HRM
This is a single-arm study involving the use of a high resolution manometry (HRM) diagnostic device that is not utilized in any clinical decision-making processes.
- Trial name
- NCT03198416
- Testing
- High-resolution pharyngeal manometry catheter
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Vanderbilt University Medical Center
Hypertension
Nashville - Hypertension Management Model
Black men face a shorter life expectancy than white men due to poorer health outcomes associated with many chronic diseases, most notably hypertension and its cardiovascular complications.
- Trial name
- NCT04232124
- Testing
- Hypertension Management Model
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Vanderbilt University Medical Center
Adhesive Capsulitis, Adhesive Capsulitis of Unspecified Shoulder
Intra-articular Doxycycline: A Novel Treatment of Adhesive Capsulitis
We will recruit a total of 40 patients from the Vanderbilt Sports Medicine Clinics who have been diagnosed with adhesive capsulitis and have not undergone any previous treatment.
- Conditions
- Adhesive Capsulitis, Adhesive Capsulitis of Unspecified Shoulder, Frozen Shoulder
- Trial name
- DOXY (NCT03479502)
- Testing
- Methylprednisolone Injectable Product, Doxycycline Injection
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Head and Neck Cancer, Depression
Venlafaxine for the Prevention of Depression in Patients With Head and Neck Cancer
This is a pilot double-blinded, randomized, placebo-controlled trial to determine if venlafaxine prevents depression in patients undergoing surgery for Head and Neck Cancer (HNC).
- Trial name
- NCT05724849
- Testing
- Venlafaxine
- Sponsor
- Vanderbilt University Medical Center
Type 2 Diabetes
Mobile Phone Support for Adults and Support Persons to Live Well With Diabetes
This study evaluates a mobile phone-delivered intervention (FAMS 2.0; Family/friend Activation to Motivate Self-care) designed to help adults with type 2 diabetes set and achieve self-care goals and improve the quality of…
- Trial name
- FAMS 2 (NCT04347291)
- Testing
- FAMS 2.0, Print Materials
- Where
- United States
- Volunteers
- 638 people
- Sponsor
- Vanderbilt University Medical Center
Idiopathic Pulmonary Fibrosis
Telenursing and Remote Monitoring in Idiopathic Pulmonary Fibrosis (IPF)
Numerous studies show that remote monitoring and/or telenursing improves outcomes for patients especially those with chronic diseases.
- Trial name
- NCT03562247
- Testing
- Usual Care of IPF, Telenursing, Telenursing and Remote Monitoring
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Vanderbilt University Medical Center
Renal Cell Carcinoma, Hypertension
Novel Mechanisms and Predictors of VEGF Receptor Inhibitor- or Immune Checkpoint Inhibitor-Associated Hypertension and Cardiovascular Disease
The purpose of this study is to understand the effect of vascular endothelial growth factor tyrosine kinase (VEGF) inhibitor, immune checkpoint-inhibitor (ICI), and combination treatment on blood pressure and blood vessel…
- Conditions
- Renal Cell Carcinoma, Hypertension, Melanoma, Cancer
- Trial name
- NCT03709771
- Testing
- Ambulatory Blood Pressure Measurement
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Vanderbilt University Medical Center
Peripheral Artery Disease
Best Practice Advisory to Initiate High-Intensity Statin Therapy in Patients With Peripheral Artery Disease
The purpose of this study is to understand how a Best Practice Advisory (BPA) for high-intensity statin therapy in patients with Peripheral Artery Disease impacts prescription rates.
- Trial name
- NCT05166187
- Testing
- Best Practice Advisory
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- Vanderbilt University Medical Center
Elbow Fracture
Steroid Administration for Articular Fractures of the Elbow (SAFE Trial)
The primary purpose of this study is to determine if perioperative glucocorticoid administration (IV intra-operative followed by a post-operative oral taper course) improves post-operative range of motion in a patient population…
- Trial name
- SAFE (NCT04738318)
- Testing
- Glucocorticoids, Saline
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Vanderbilt University Medical Center
Obesity, Pre-diabetes
SGLT2 Inhibitor Effects on Inflammation and Heart Disease in Obesity Pilot
Obesity is associated with increased cardiometabolic disease risk due, in part, to heightened chronic inflammation arising from adipose tissue.
- Trial name
- NCT04907214
- Testing
- Empagliflozin 25 MG
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Vanderbilt University Medical Center
Mechanical Ventilation Complication, Acute Respiratory Failure
Protocolized Post-Extubation Respiratory Support Study
Invasive mechanical ventilation is common in the medical intensive care unit, and the period of time following extubation remains high risk as 11 to 15% of patients require reintubation after their first extubation.
- Conditions
- Mechanical Ventilation Complication, Acute Respiratory Failure, Intubation Complication
- Trial name
- PROPER (NCT03288311)
- Testing
- Protocolized post-extubation respiratory support, Usual Care
- Where
- United States
- Volunteers
- 751 people
- Sponsor
- Vanderbilt University Medical Center