Clinical trials: sponsored by Vanderbilt University Medical Center
Chronic Interstitial Cystitis, Bladder Pain Syndrome
Optimizing Psychosocial Treatment of Interstitial Cystitis/Bladder Pain Syndrome
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a severe pain condition affecting 3-8 million people in the United States lacking treatments that work.
- Conditions
- Chronic Interstitial Cystitis, Bladder Pain Syndrome, Cystitis, Interstitial, Painful Bladder Syndrome
- Trial name
- NCT04275297
- Testing
- Psychosocial Treatment, Attention Control
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Vanderbilt University Medical Center
Diabetes Mellitus
Evaluation of a Patient Portal Intervention to Address Diabetes Care Gaps
The purpose of this study is to evaluate the usability of a novel patient portal intervention designed to: (a) notify patients when selected, clinically meaningful, evidence-based diabetes monitoring \& preventative care (e.g.…
- Trial name
- NCT04728620
- Testing
- Diabetes Care Gaps Patient Portal Intervention
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Vanderbilt University Medical Center
Normal Pressure Hydrocephalus
CPT-3 in Normal Pressure Hydrocephalus
The study will collect prospective cohort data of individuals that are undergoing routine clinical care for suspected idiopathic Normal Pressure Hydrocephalus (NPH).
- Trial name
- NCT03521518
- Testing
- Conner's Continuous Performance Test-3
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Vanderbilt University Medical Center
Polypharmacy, Care Transitions
A Randomized Controlled Trial to Deprescribe for Older Patients With Polypharmacy
This randomized, controlled trial will evaluate the effects of an intervention to reduce exposure to medications among hospitalized older adults discharged to skilled nursing facilities (SNFs).
- Conditions
- Polypharmacy, Care Transitions, Geriatric Syndromes
- Trial name
- Shed-Meds (NCT02979353)
- Testing
- Shed-Meds: A Patient-Centered Deprescribing Intervention
- Where
- United States
- Volunteers
- 372 people
- Sponsor
- Vanderbilt University Medical Center
Laceration
Trial Comparing Cosmetic Outcomes of Pediatric Laceration Closure Using Skin Glue, Medical Tape Versus Stitches
There are several methods of closing a skin cut: stitches, skin glue, and medical tape. Stitches have been used for a long time to close skin cuts.
- Trial name
- NCT03280628
- Testing
- Absorbable Sutures, Steri-Strips, Dermabond
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Vanderbilt University Medical Center
Wound Heal
Enhanced Secondary Intention Healing vs. Standard Secondary Intention Healing in Mohs Surgical Defects on the Head and Distal Lower Extremities
The purpose of this study is to elucidate if a novel biomaterial containing gelatin, manuka honey, and hydroxyapatite enhances secondary intention healing when compared to conventional secondary intention healing for surgical…
- Trial name
- NCT04545476
- Testing
- Participants in this group will receive the experimental APIS Biomaterial on the Head., Participants in this group will receive the experimental APIS Biomaterial on the Lower Extremities., Standard Secondary Intention Healing on the Head
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Vanderbilt University Medical Center
Type 1 Diabetes
Impact of a Low-Carbohydrate Diet in Pediatric Type 1 Diabetes
Dietary carbohydrate consumption is a key factor influencing postprandial glycemia for patients with type 1 diabetes mellitus (T1DM).
- Trial name
- NCT03997409
- Testing
- Dietary Intervention
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Vanderbilt University Medical Center
Diabetes Mellitus, Type 2
Usability of Diabetes Dashboard Embedded Within a Patient Web Portal
The purpose of this study is to conduct a prospective, longitudinal study to evaluate the usability of a patient-facing diabetes dashboard delivered via an established patient web portal.
- Trial name
- NCT03786718
- Testing
- Patient-facing Diabetes Dashboard
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Vanderbilt University Medical Center
Exercise, Pacemaker
Study of the Loss of AV Synchrony at Maximum Exercise
Investigators will identify a group of patients with complete heart block and a dual chamber pacemaker who will be expected to be able to exercise on a treadmill.
- Conditions
- Exercise, Pacemaker, Blood Pressure
- Trial name
- SLAVSME (NCT03859167)
- Testing
- Stress Test
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Vanderbilt University Medical Center
Inflammatory Bowel Diseases
Cytokines and Genes in Therapeutic Response in Crohn's Disease
Inflammatory bowel disease (IBD), consisting of two major forms, Crohn's disease (CD) and ulcerative colitis (UC), affects more than 1.6 million people in the United States alone.
- Trial name
- NCT03266471
- Testing
- Baseline blood sample, Baseline intestinal biopsies, Crohn's disease activity index (CDAI)
- Where
- 2 sites in United States
- Volunteers
- 96 people
- Sponsor
- Vanderbilt University Medical Center
Chronic Pain, Pain, Chronic
Investigating Biological Targets, Markers, and Intervention for Chronic Pain
This multi-modal methods study will investigate neurophysiological, endocrinological, cognitive, psycho-social-emotional markers of chronic pain, and therapeutic targets using integrative health treatments.
- Conditions
- Chronic Pain, Pain, Chronic, Pain Syndrome, Pain, Neuropathic
- Trial name
- NCT04625504
- Testing
- Mindfulness Based Intervention
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Diabetes Mellitus, Endocrine System Diseases
Soluble Epoxide Hydrolase Inhibition and Insulin Resistance
The purpose of this study is to test how soluble epoxide hydrolase (sEH) inhibition with GSK2256294 affects tissue sEH activity and insulin sensitivity.
- Conditions
- Diabetes Mellitus, Endocrine System Diseases, Glucose Metabolism Disorders, PreDiabetes
- Trial name
- NCT03486223
- Testing
- GSK2256294
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Suicide, Attempted, Suicidal Ideation
Clinical Decision Support to Prevent Suicide
Suicide kills 132 Americans every day. The first step of suicide prevention is risk identification and prognostication. Researchers like this study team have developed and validated predictive models that use routinely collected…
- Trial name
- CDS_PS (NCT05312437)
- Testing
- Interruptive Alert, CDS, Passive Prompt, CDS
- Where
- United States
- Volunteers
- 596 people
- Sponsor
- Vanderbilt University Medical Center
Low Back Pain, Headache
Safe Harbors in Emergency Medicine, Specific Aim 3
Many patients who present to the emergency department (ED) receive a vast array of diagnostic tests, some of which might not be useful.
- Conditions
- Low Back Pain, Headache, Head Injury, Minor
- Trial name
- NCT05410366
- Testing
- Safe harbor clinical practice guideline
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Post-operative Atrial Fibrillation
Preemptive Pharmacogenetic-guided Metoprolol Management for PostoperativeAtrial Fibrillation in Cardiac Surgery
Metoprolol is frequently administered to cardiac surgery patients to reduce the incidence of postoperative atrial fibrillation (PoAF).
- Trial name
- PREEMPTIVE (NCT03943927)
- Testing
- Guided Metoprolol Management
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- Vanderbilt University Medical Center
Obese, Diabetes Mellitus, Type 2
Investigating Effects of BOTOX on Weight Loss and Glucose Tolerance in Obese, Type 2 Diabetic Subjects
The investigators will recruit obese subjects with pre-diabetes or type 2 diabetes for the proposed clinical study for 5 visits.
- Trial name
- NCT03991299
- Testing
- Botox 200 UNT Injection
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Vanderbilt University Medical Center
Tourette Syndrome in Adolescence, Tourette Syndrome
Influence of Stress and Psychiatric Symptoms on Children With Tourette Syndrome
Investigators propose a cross-sectional, observational pilot study to examine the contribution of stress, family dynamics, and peer relationships to quality of life (QOL) in adolescents with Tourette syndrome (TS).
- Conditions
- Tourette Syndrome in Adolescence, Tourette Syndrome, Tourette Syndrome in Children
- Trial name
- InSPSCTS (NCT04449003)
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Vanderbilt University Medical Center
Self-compassion, Burnout
Mindfulness-Based Stress Reduction for Metro Nashville Public School Employees
Stress, anxiety, and depression are common symptoms among public school teachers. Public school teachers are among the top professions reporting stress, anxiety, and depression.
- Conditions
- Self-compassion, Burnout, Stress, Anxiety
- Trial name
- NCT05051969
- Testing
- Remote Mindfulness-Based Stress Reduction Program
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Vanderbilt University Medical Center
Obesity
Effect of Ghrelin on Glucose Metabolism After Bariatric Surgery
The purpose of this study is to determine if the altered nutrient exposure to the GI tract after bariatric surgery reveals a negative incretin effect of ghrelin.
- Trial name
- NCT02953587
- Testing
- Oral Glucose Tolerance Test (OGTT), Human Ghrelin, Saline
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Vanderbilt University Medical Center
Community-acquired Pneumonia, Cognition Disorder
Corticosteroids in Community Acquired Pneumonia
This is a single-center, blinded, placebo-controlled pilot RCT evaluating corticosteroids for the treatment of Community Acquired Pneumonia (CAP) that will enroll 100 adults hospitalized with community-acquired pneumonia.
- Trial name
- NCT04652414
- Testing
- Prednisone
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center