Clinical trials: sponsored by Vanderbilt University Medical Center
Pleural Effusion
Gravity- Versus Suction-driven Large Volume Thoracentesis
Thoracentesis is a very common procedure, rarely associated with severe complications. One relatively common complication is chest discomfort, which is most of the time felt to be secondary to negative pleural pressures generated…
- Trial name
- GRAVITAS (NCT03591952)
- Testing
- Suction-Driven Thoracentesis, Gravity-Driven Thoracentesis
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- Vanderbilt University Medical Center
Delirium, Cognitive Impairment
Cholinesterase Activity and DeliriUm During Critical Illness Study
Delirium is a syndrome of acute brain dysfunction involving attention and cognition that affects up to half of older hospitalized patients and 50%-75% of critically ill ICU patients, such that millions of patients worldwide…
- Trial name
- CADUCeuS (NCT03098472)
- Where
- United States
- Volunteers
- 279 people
- Sponsor
- Vanderbilt University Medical Center
Heterotopic Ossification
Defining the Pathophysiology of Heterotopic Ossification: A Prospective Study
Our overarching aim is to define the pathophysiology, epidemiology, and natural history of HO by following patients from date of injury until full wound healing has occurred and the window for HO has passed.
- Trial name
- NCT04867018
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Transfusion Related Complication, Liver Transplant
Utilization of Donor Whole Blood for Blood Transfusion in Deceased Donor Liver Transplantation
We will study 40 matched patients. 20 patients will receive leukoreduced whole blood from the solid organ donor. These 20 patients will be compared to 20 historical matched controls with regards to allogenic blood product usage…
- Trial name
- NCT04383756
- Testing
- Donor Blood, Banked Blood
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Bile Leak
Plastic vs. Fully Covered Self Expanding Stents (FCSEMS) for Treatment of Anastomotic Bile Leaks
Standard endoscopic management for anastomotic bile leaks following OLT has been endoscopic retrograde cholangiopancreatography (ERCP) with placement of a temporary plastic biliary endoprosthesis (stent) across the site of…
- Trial name
- NCT03333382
- Testing
- Plastic biliary stent, FCSEMS
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Vanderbilt University Medical Center
Autism Spectrum Disorder
SeRenade Parent-Child Music Class Program
This pilot study examines the impact of the SeRenade Parent-Child Music Class Program, which emphasizes parent training, peer inclusion, and musical play combined with established behavioral techniques, on the development of…
- Trial name
- NCT03560297
- Testing
- SeRenade Parent-Child Music Class, Delayed Intervention
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Sensorineural Hearing Loss
Electrode Placement and Audiologic Outcomes With the Advanced Bionics HiFocus L23 Electrode
The goal of this study is to measure patient performance after cochlear implantation with the Food and Drug Administration (FDA) approved Advanced Bionics HiFocus L23 device. The specific aims of the project are as follows: 1.
- Trial name
- NCT03858647
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Vanderbilt University Medical Center
Obesity, Childhood
Association Between Mother and Child Weight Gain: Statistical Methods With Validation
Using retrospective data from the Vanderbilt University Medical Center electronic health record, the investigators will study the association between mother's weight / weight change before and during pregnancy and the development…
- Trial name
- NCT04174521
- Where
- United States
- Volunteers
- 20,670 people
- Sponsor
- Vanderbilt University Medical Center
Breast Cancer
Surgical Site Infection With 0.05% Chlorhexidine (CHG) Compared to Triple Antibiotic Irrigation
The investigators intend to perform a prospective randomized study and compare the incidence of surgical wound infection between mastectomy wounds irrigated with triple antibiotic solution (one side) and 0.05% CHG (opposite side)…
- Trial name
- NCT02395614
- Testing
- Chlorhexidine irrigation, triple antibiotic irrigation
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Vanderbilt University Medical Center
Postural Orthostatic Tachycardia Syndrome
Dietary Sodium's Effect on Urinary Sodium and Dopamine Excretion in Patients With Postural Tachycardia Syndrome
Patients with Postural Tachycardia Syndrome (POTS) may not adequately expand their plasma volume in response to a high sodium diet.
- Trial name
- NCT01563107
- Testing
- Plasma Volume, Exercise Capacity Test - Bicycle, Posture Study
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Breast Reconstruction, Anesthesia
Comparing Local Anesthetics for TAP Block During Abdominally-based Free Flap for Breast Reconstruction
This study will compare the efficiency of transversus abominus plane (TAP) block using liposomal bupivacaine versus plain bupivacaine that is administered in the operating room under ultrasound guidance prior to the in patients…
- Conditions
- Breast Reconstruction, Anesthesia, Transverse Abdominis Plane Block
- Trial name
- NCT03700970
- Testing
- Liposomal bupivacaine, Regular bupivacaine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Vanderbilt University Medical Center
Cochlear Implant
Trial of Image-Guided Cochlear Implant Programming Versus Standard of Care
Cochlear implants are surgically implanted devices which restore the ability to hear to the hearing impaired. While remarkably successful, even in the best of performers restoration of hearing to levels of normal listeners is…
- Trial name
- IGCIP vs SOC (NCT02815124)
- Testing
- Standard of Care, Image-Guided Cochlear Implant Programming
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Acoustic Neuroma
Evaluating the Pre-Positioning Frame for Robotic Acoustic Neuroma Removal Surgery
Otologic surgery often involves a mastoidectomy to safely access the inner ear. In this procedure, a portion of the mastoid part of the temporal bone is removed.
- Trial name
- PPF (NCT03057678)
- Testing
- Testing of Pre-Positioning Frame
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Sickle Cell Disease, Sickle Cell Anemia
Moderate Dose Hydroxyurea for Secondary Stroke Prevention in Children With Sickle Cell Disease in Sub-Saharan Africa
The overall goal of the proposed study is to determine the effectiveness of hydroxyurea therapy for secondary stroke prevention and prevention of other neurological events in children with SCA with an acute overt stroke.
- Conditions
- Sickle Cell Disease, Sickle Cell Anemia, Stroke
- Trial name
- SPRINT (NCT02675790)
- Testing
- Moderate Dose Hydroxyurea, Low Dose Hydroxyurea
- Where
- 2 sites in Nigeria
- Volunteers
- 120 people
- Sponsor
- Vanderbilt University Medical Center
Dementia
Team-based Technology-enabled Integrated Patient/Caregiver-focused Dementia Study
Dementia patients experience memory and other cognitive function deterioration leading to loss of independent function. Care required for dementia is multifactorial, spanning cognitive, behavioral, emotional, and physical…
- Trial name
- T2IP-DS (NCT04631120)
- Testing
- Integrated Dementia Practice Unit Design, Standard of Care
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Postural Tachycardia Syndrome (POTS)
Effect of Dietary Sodium Intake on Vascular Endothelium
The investigators will test the hypothesis that markers of vascular endothelial dysfunction will be exaggerated acutely with an extreme high sodium diet compared to an extreme low-sodium diet.
- Trial name
- NCT01550315
- Testing
- Pulsitile Arterial Tonometry (PAT) Protocol, Calf Blood Flow in Reactive Hyperemia (CBF-RH), Evaluation of Forearm-Mediated Dilation
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
COVID-19
COVID-19 Patient Positioning Pragmatic Trial
This study aims to determine if provider-recommended guidance on supine (on back) vs. prone (on stomach) positioning of patients testing positive for COVID-19 requiring supplemental oxygen, but not yet mechanically ventilated…
- Trial name
- NCT04359797
- Testing
- Prone, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 501 people
- Sponsor
- Vanderbilt University Medical Center
Liver Transplant; Complications
Study to Compare the Incidence of Biliary Complications After Liver Transplantation
A randomized prospective study will be conducted of patients at Vanderbilt University Medical Center who undergo liver transplantation from March 2014 until approximately 120 patients are randomized.
- Trial name
- NCT03165916
- Testing
- Bard 5 Fr diameter feeding tube
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- Vanderbilt University Medical Center
Asthma, Croup
Comparison of Dexamethasone Oral Preparations to Assess Taste and Acceptance in Children With Asthma and Croup
Study of the palatability and acceptability of dexamethasone oral tablets crushed and placed in apple sauce or pudding in comparison with the IV solution mixed with sugar syrup and given orally.
- Trial name
- NCT03705273
- Testing
- Dexamethasone IV for PO, Dexamethasone crushed tablets
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
Idiopathic Subglottic Stenosis (iSGS)
Treatment Alternatives in iSGS (NoAAC PR-02 Study)
The study is aimed at answering the questions; (1) How well do the most commonly used treatments in iSGS work? and (2) What quality-of-life trade-offs are associated with each approach? With the results of this trial, the…
- Trial name
- NoAAC PR-02 (NCT02481817)
- Testing
- Endoscopic dilation of subglottic stenosis, Endoscopic resection of the stenosis, Tracheal Resection
- Where
- 42 sites in United States, Australia and 2 more
- Volunteers
- 1,239 people
- Sponsor
- Vanderbilt University Medical Center