Clinical trials: sponsored by Vanderbilt University Medical Center
Forearm Fractures (Both Bone Forearm Fractures, Isolated Ulnar Shaft, Isolated Radial Shaft)
Complications Related To Activity After Pediatric Both Bone Fractures: Exploring the Effects of Activity on Fracture Displacement
The goal of this randomized clinical study is to understand the effect of activity on the re-displacement of pediatric forearm fractures in patients ages 8-18 years old excluding those with known metabolic bone disease or obvious…
- Trial name
- CRABB-Y (NCT06799377)
- Testing
- Restricted Activity Reccomendations, Full Activity/Limited Activity Reccomendations
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Vanderbilt University Medical Center
Schizophrenia Disorders
Volatility in Paranoia (VIP) Trial: An RCT of Changes in Volatility With Psychotherapy
The goal of this clinical trial is to learn whether learning and belief updating change in response to the treatment of persecutory delusions, in individuals with schizophrenia-spectrum disorders. The main questions are: 1.
- Trial name
- VIP (NCT06835556)
- Testing
- Cognitive Behavioral Therapy, TAU
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Vanderbilt University Medical Center
Opioid Use Disorder
Measurement-Based Care to Support Buprenorphine-Naloxone Treatment in Outpatient Addiction Clinics
People receiving buprenorphine-naloxone (bup-nx) for opioid use disorder often face changes in cravings, withdrawal, and return to use risk between clinic visits, but their care team may not know about these changes until the…
- Trial name
- Bup-MBC (NCT07839182)
- Testing
- Bup-MBC
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Vanderbilt University Medical Center
Acute Respiratory Failure
INtubation With Sedation Only to Preserve Independent Respiratory Effort Trial
The INtubation with Sedation Only to Preserve Independent Respiratory Effort (INSPIRE) trial is a pragmatic, non-blinded, parallel-group, randomized clinical trial comparing the effect of intubation with sedation only…
- Trial name
- INSPIRE (NCT07845305)
- Testing
- Intubation with a sedative medication only, Intubation with a sedative medication and neuromuscular blockade agent
- Where
- United States
- Volunteers
- 228 people
- Sponsor
- Vanderbilt University Medical Center
Parasite and Infestation Physician-Patient Diagnostic Incongruency
The Parasite and Infestation Study
Many people have evidence of bugs, parasites, and infestation, but are told by others that they cannot find a cause. This distressing and frustrating experience can last for years, as the person seeks answers.
- Trial name
- NCT07849907
- Testing
- No intervention - observational study
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Vanderbilt University Medical Center
Behavior, Health, Child Obesity
Greenlight Plus Study: Approaches to Early Childhood Obesity Prevention
A randomized controlled trial enrolling 900 parent-infant dyads (English and Spanish speaking) comparing Greenlight (control), a behavioral intervention focusing on nutrition, physical activity, media use, and sleep as compared…
- Trial name
- NCT04042467
- Testing
- Greenlight Plus, Greenlight
- Where
- 6 sites in United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Postural Orthostatic Tachycardia Syndrome, Acute Hepatic Porphyria
Evaluating the Prevalence of Acute Hepatic Porphyria in Postural Tachycardia Syndrome
Postural Tachycardia Syndrome (POTS) is the most common autonomic disorder and is estimated to affect 3,000,000 individuals in the United States, with 80-85% of patients being women.
- Trial name
- NCT05344599
- Testing
- Autonomic Function Testing, Genetic Testing, Urine Testing
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Vanderbilt University Medical Center
Diabetic Macular Edema (DME), Diabetic Retinopathy
Corticosteroid for Diabetic Macular Edema (DME) Study
Our current goals include confirming inflammation mediators are biomarkers of DR and DME The Aim of this project is to measure aqueous PGE2 and inflammatory cytokines before and after treatment of DME with intravitreal…
- Trial name
- NCT07843849
- Testing
- Intravitreal dexamethasone implant
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Idiopathic Pulmonary Arterial Hypertension, Heritable Pulmonary Arterial Hypertension
Hormonal, Metabolic, and Signaling Interactions in PAH
Our hypothesis is that optimal treatment of the dysfunctional metabolic pathways which underlie PAH will improve pulmonary vascular function and consequences of the disease.
- Conditions
- Idiopathic Pulmonary Arterial Hypertension, Heritable Pulmonary Arterial Hypertension, Scleroderma Associated Pulmonary Arterial Hypertension, Appetite Suppressant Associate PAH
- Trial name
- NCT01884051
- Where
- United States
- Volunteers
- 1,899 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
End Stage Liver DIsease
Adding Specialist Palliative Care to Transplantation Pilot Trial
Specialist palliative care has been shown to be beneficial for patients experiencing serious illness, but has not been studied for patients being evaluated for liver transplantation.
- Trial name
- ASPECT-Pilot (NCT05147935)
- Testing
- Palliative Care Consultation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Vanderbilt University Medical Center
Long COVID, POTS - Postural Orthostatic Tachycardia Syndrome
Long COVID Immune Profiling
Parasympathetic nervous system (PNS) is part of the body's autonomic nervous system(PNS) protects body against inflammation. Study shows that reduced PNS function activity is associated with persistent inflammation.
- Conditions
- Long COVID, POTS - Postural Orthostatic Tachycardia Syndrome, Autonomic Dysfunction
- Trial name
- NCT06027255
- Testing
- IL-6, cytokines (IL-17, and IFN-ɣ), Compass 31
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Kidney Stones
Evaluation of Eye Gaze Sharing in the Operating Room
This project aims to develop an augmented reality (AR) tool to enhance skill acquisition for endoscopic kidney stone surgery. Of the 100,000 patients who undergo an endoscopic kidney stone treatment annually in the United States…
- Trial name
- NCT07173309
- Testing
- Augmented reality
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Post-operative Pain, DIEP Flap Breast Reconstruction
Suzetrigine Post DIEP
This research study is being conducted to see whether adding suzetrigine (Journavx), an FDA-approved non-opioid pain medication, to the standard Enhanced Recovery After Surgery (ERAS) pain management protocol can improve pain…
- Conditions
- Post-operative Pain, DIEP Flap Breast Reconstruction, DIEP Flap, Opioid
- Trial name
- NCT07839715
- Testing
- Suzetrigine Group
- Volunteers
- 198 people
- Sponsor
- Vanderbilt University Medical Center
Cochlear Implant, Cochlear Implant Users
Patient-Oriented Research to Optimize Cochlear Implant Outcomes
The rationale is that only through understanding how individual Cochlear Implant (CI) patients respond to interventions investigators further develop precision-medicine approaches to optimize outcomes.
- Conditions
- Cochlear Implant, Cochlear Implant Users, Cochlear Implant Recipients, Cochlear Implant Listeners
- Trial name
- NCT07678879
- Testing
- AC Group, CA group
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Vanderbilt University Medical Center
Heart Failure, Acute Heart Failure
Randomized Controlled Trial of urinE chemiStry Guided aCute heArt faiLure treATmEnt (ESCALATE)
This is a randomized trial of protocolized diuretic therapy guided by urinary sodium compared to structured usual care in ED patients with AHF.
- Trial name
- ESCALATE (NCT04481919)
- Testing
- Protocolized diuretic therapy
- Where
- 2 sites in United States
- Volunteers
- 474 people
- Sponsor
- Vanderbilt University Medical Center
Parkinson Disease
Neurophysiology Biomarkers of Cognitive Impairment Associated With Deep Brain Stimulation
The study aims to investigate cognitive impairment associated with Deep Brain Stimulation (DBS) in Parkinson's Disease patients, with a focus on identifying neurophysiology biomarkers of DBS associated cognitive changes.
- Trial name
- NCT05933681
- Testing
- Neural recordings and stimulation
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Vanderbilt University Medical Center
Dysphagia, Heart Transplant Recipients
Respiratory Strength Training in Heart Transplant Recipients
This research study is investigating whether completing breathing exercises before surgery helps heart transplant patients recover after surgery.
- Trial name
- NCT06190171
- Testing
- Active respiratory muscle strength training
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Vanderbilt University Medical Center
Blood Clot, Thrombosis
Inpatient Monitoring of Unfractionated Heparin
Unfractionated heparin (UFH) is the most widely used intravenous (IV) anticoagulant for treating and preventing thromboembolic disease (e.g., blood clots ). UFH must be closely monitored and adjusted in the hospital.
- Trial name
- NCT06329921
- Testing
- PTT protocol, anti-Xa protocol
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Vanderbilt University Medical Center
Childhood Obesity
The Dose Trial: Dose Intensity of Behavioral Interventions for Childhood Obesity
The research team is recruiting 900 children between the ages 5-17 with obesity from Tennessee and Louisiana. The team is assigning children and their caregivers by chance to one of five groups.
- Trial name
- NCT06654323
- Testing
- Intensive Behavioral Lifestyle Modification
- Where
- 2 sites in United States
- Volunteers
- 900 people
- Sponsor
- Vanderbilt University Medical Center
Obesity and Obesity-related Medical Conditions, Bariatric Surgery
Transition to Ambulatory Bariatric Surgery (TABS) Trial
This study will compare same day discharge and at least one night stay in the hospital after bariatric surgery. Patients undergoing bariatric surgery will be randomized (i.e. have an equal chance of either plan) to either group.
- Trial name
- TABS (NCT07011628)
- Testing
- Same Day Discharge
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Vanderbilt University Medical Center