Clinical trials: sponsored by Vanderbilt University Medical Center
ACL Injury, ACL - Anterior Cruciate Ligament Rupture
Improving ACL Reconstruction Outcomes: CBPT
The overall objective of this study is to conduct a two-group randomized trial to examine the efficacy of cognitive-behavioral based physical therapy (CBPT) for improving knee function, return to sport, and quality of life…
- Conditions
- ACL Injury, ACL - Anterior Cruciate Ligament Rupture, ACL Sprain, ACL Tear
- Trial name
- NCT03243162
- Testing
- CBPT-ACLR, Education
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Vanderbilt University Medical Center
Pulmonary Arterial Hypertension, Healthy
Right Ventricular Metabolism in Pulmonary Arterial Hypertension
The purpose of this study is to use non-invasive imaging to determine the metabolic phenotype of the right ventricle in patients with pulmonary arterial hypertension across a spectrum of disease severity.
- Trial name
- NCT02763735
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Lipedema, Secondary Lymphedema
Complete Decongestive Therapy With Negative Pressure for Lipedema and Lymphedema Therapy
This study is designed to investigate the therapy outcomes from routine physical therapy in persons with lipedema and secondary limb lymphedema.
- Trial name
- NCT03634462
- Testing
- CDT with graded negative pressure
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Thoracic Insufficiency Syndrome (TIS)
Vertical Expandable Prosthetic Titanium Rib (VEPTR) for Thoracic Insufficiency Syndrome
The hypothesis of the study is that individuals with poor pulmonary function secondary to TIS will benefit from expansion thoracoplasty. The investigators specific aims are to: 1.
- Trial name
- VEPTR (NCT02241954)
- Testing
- Synthes VEPTR (Vertical Expandable Prosthetic Titanium Rib)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Vanderbilt University Medical Center
Birth Setting, Maternal Health
Traditional Ethiopian Coffee Ceremony in a Rural Ethiopian Hospital to Increase Hospital-based Delivery Rates
This study evaluates if organizing a postpartum traditional Ethiopian coffee ceremony will provide an incentive for our antenatal care patients to eventually deliver in our hospital.
- Trial name
- NCT04232137
- Testing
- Postpartum coffee ceremony
- Volunteers
- 439 people
- Sponsor
- Vanderbilt University Medical Center
Sepsis, Procalcitonin
Impact of a Procalcitonin Testing and Treatment Algorithm on Antibiotic Use and Outcomes in the Pediatric Intensive Care Unit
The timely use of antibiotics can reduce morbidity and mortality associated with bacterial infections, particularly in the intensive care unit setting (ICU).
- Conditions
- Sepsis, Procalcitonin, Antimicrobial Stewardship
- Trial name
- ProPICU (NCT03440918)
- Testing
- Procalcitonin-Guided Antimicrobial Stewardship, Baseline Antimicrobial Stewardship
- Where
- United States
- Volunteers
- 271 people
- Sponsor
- Vanderbilt University Medical Center
Chronic Pain
Chronic Pain Skills Study - Vanderbilt University Medical Center
The Osher Center for Integrative Medicine (OCIM) at Vanderbilt is a multidisciplinary outpatient clinic treating patients with chronic pain and complex health issues via integrative services, with goals of improving overall…
- Trial name
- NCT03384953
- Testing
- Clinical Hypnosis - Group Treatment, Clinical Hypnosis - Individual Treatment
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Vanderbilt University Medical Center
Burnout, Professional, Burnout Syndrome
Evaluation of a Daily Brief Exercise Intervention on Resident Physician Personal Resiliency and Burnout
This study seeks to evaluate the prevalence and characterize predictors of physician burnout in the anesthesia residency at Vanderbilt University Medical Center.
- Trial name
- NCT03489720
- Testing
- Prescribed Exercise Program, Usual Exercise Program
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Anxiety, Depression
Impact of Journal Program on Wellbeing of NICU Parents
The purpose of this study is to investigate the impact of a journaling program on rates of anxiety and depression in neonatal intensive care unit (NICU) parents.
- Trial name
- NCT04331925
- Testing
- Anxiety and depression screening, Journaling
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Type 1 Diabetes Mellitus
Pilot Sleep Intervention to Improve Diabetes Management in School-Aged Children
Evaluate the feasibility, acceptability, and preliminary efficacy of a sleep-promoting intervention for school-aged children with type 1 diabetes and their caregivers in a pilot randomized trial.
- Trial name
- NCT03397147
- Testing
- Sleep Coach Jr.
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
Obesity, Childhood
Competency-based Approaches to Community Health
This study is a family-centered, community-based intervention to prevent and treat childhood obesity among 3-5 year old children from undeserved communities.
- Trial name
- COACH (NCT03141151)
- Testing
- COACH: Healthy Bodies, COACH: Strong Minds
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Neonatal Abstinence Syndrome, Withdrawal
Feasibility of Auricular Acupressure as an Adjunct Treatment for Neonatal Abstinence Syndrome (NAS)
This study will assess the feasibility of implementing auricular acupressure as an additional non-pharmacologic therapy for neonates at risk for developing neonatal abstinence syndrome (NAS) at Monroe Carrell Jr Children's…
- Trial name
- NCT03973801
- Testing
- Auricular acupuncture
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Vanderbilt University Medical Center
Post-Intensive Care Syndrome
Collaborative Assessment of ICU Recovery Needs
The primary purpose of this study is to better understand the impact of the Society of Critical Care Medicine (SCCM) THRIVE Collaboratives on patients, their families and clinicians.
- Trial name
- CAIRN (NCT03513289)
- Testing
- Patient, Carer, and Clinician Interviews
- Where
- 2 sites in United States, Australia
- Volunteers
- 66 people
- Sponsor
- Vanderbilt University Medical Center
Heparin-induced Thrombocytopenia
Immunogenetics of Heparin-Induced Thrombocytopenia: Aim 2
The purpose of this research is to identify genomic markers that can predict heparin-induced thrombocytopenia (HIT), which is a very serious side effect to heparin.
- Trial name
- NCT02526485
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Vanderbilt University Medical Center
Opioid Use
Discharge Opioid Education to Decrease Opioid Use After Cesarean
Background: The number of opioid overdose deaths in the United States has quadrupled in 15 years, a dramatic manifestation of the current opioid abuse epidemic.
- Trial name
- NCT03678870
- Testing
- Opioid Education Handout
- Where
- United States
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Cervical Dystonia, Movement Disorders
Non-Motor Features of Cervical Dystonia (CD)
This study will examine the prevalence of four previously identified non-motor markers in a population of cervical dystonia patients, unaffected family members, and healthy volunteers in an attempt to identify a distinct…
- Conditions
- Cervical Dystonia, Movement Disorders, Focal Dystonia, Signs and Symptoms
- Trial name
- NCT03471923
- Testing
- Neurological Examination, Assessment of Non-Motor Features
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Parkinson Disease
Norepinephrine-targeted Therapy for Action Control in Parkinson Disease
The purpose of this study is to find out whether droxidopa, a medication that increases norepinephrine levels, may be effective in improving some aspects of cognition and movement in Parkinson's disease (PD).
- Trial name
- NCT03115827
- Testing
- Droxidopa, Carbidopa
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Vanderbilt University Medical Center
Chemo Brain, Chemotherapy-related Cognitive Impairment
Nicotinic Treatment of Post-Chemotherapy Subjective Cognitive Impairment: A Pilot Study
The purpose of this study is to evaluate the use of a nicotine patch as a treatment for problems with attention, learning and memory in breast cancer patients who are 1-5 years post chemotherapy.
- Conditions
- Chemo Brain, Chemotherapy-related Cognitive Impairment, Chemo Fog, Breast Cancer
- Trial name
- NCT02312934
- Testing
- Transdermal nicotine
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Vanderbilt University Medical Center
Diabetes Mellitus, Type 1
Sleep Promotion to Improve Diabetes Management in Adolescents With T1D
Adolescents with type 1 diabetes (T1D) are at increased risk for problems with adherence and suboptimal glycemic control, and novel approaches are needed to improve outcomes in this high-risk population.
- Trial name
- NCT02786953
- Testing
- Sleep Promotion
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
Charcot-Marie-Tooth Disease
Change in MUNIX in Patients With CMT1A Undergoing a Home Ankle Strengthening Program Versus Standard of Care
Here the investigators aim to show that a focused lower extremity resistance strength training program in patients with Charcot-Marie-Tooth disease (CMT) results in increased motor strength of ankle plantar- and dorsi-flexion.
- Trial name
- NCT03715283
- Testing
- Home Ankle Strengthing Program, Standard of Care
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center